1. No category

ECMO OXYGENATORS
• Silicone Rubber Sheet Membranes
– Medtronic/Avecor
• Range of 5 sizes 0.8 - 4.5 M2
• FDA Approved for long term use
• Microporous Hollow Fiber Devices
– Limited duration of use do to plasma leak
– Medtronic Minimax - Polypropylene hollow fibers
• Infant/Pediatric
• Plasma resistant fibers (PRF)
• Carmeda Coated (Heparin Bioactive surface)
– Medtronic Affinity - Polypropylene hollow fibers
• Large Peds and Adults
– Jostra Quadrox D
• Polymethylpentene fibers
• No Plasma leak
MICRO POROUS
POLYPROPYLENE HOLLOW
FIBERS
MICRO POROUS
POLYPROPYLENE HOLLOW
FIBERS
QUADROX
Oxygenation System
Quadrox De-airing
de-airing
blood in
Quadrox Rear view
gas in
luer port
water out
water in
recirculation
temperature probe
blood out
sampling port
gas out
Blood Flow
De-airing
membrane
Luer port
pre chamber
blood in
blood out
Blood Flow
chamber B
chamber A
Gas Distribution
chamber B
chamber A
Distribution of Water Flow
chamber A
chamber B
Membrane Structure
Microporous membrane
pore size max. <0.2 µm
7000 nm
0,12 nm
blood
path
gas
path
Polypropylene Membrane
Structure
Quadrox Diffusion Membrane
Technical Data
Blood flow
rate
Priming
volume
Oxygenation
membrane
Max. O2-
Quadrox
Quadrox D
0.5 – 7 l/min
0.5 – 7 l/min
250 ml
250 ml
1.8 m²
1.8 m²
polypropylen polymethylpe
e
ntene
425 ml/min
425 ml/min
Gas Exchange in the Artificial
Lung
• Diffusion controlled fixed variables
Surface area, membrane material,
blood path thickness (boundary layer)
• Gradient driven
– Fio2 for O2 Transfer
– Net Gas flow for CO2 Transfer
Membrane Structure
Microporous membrane
pore size max. <0.2 µm
7000 nm
0,12 nm
blood
path
gas
path