Product Pipeline Overview The biotech R&D sector is dynamic and highly innovative. This overview gives an idea about the innovation spirit of some member companies January 2014 of the Swiss Biotech Association. This overview will be updated regularly. The content is aimed at the stakeholder community of the industry. The SBA Mission: Contact + The Swiss Biotech Association represents the interests of the biotech sector, supports the entrepreneurship of biotech companies, and accrues value for them through the following activities: + + Development of optimal operation conditions for the biotech sector: Dissemination of accomplishments in biotechnology: For more information on becoming a member of SBA please contact: + + + + + + + + • Representation of the biotech interests to policy makers • Support of: • Knowledge and technology transfer • Financing conditions for biotech companies • Education and professional development • To the political audience and to the general public • Through the national biotech platform • Increase of the visibility at national and international level + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Logo Company Product Therapeutic Area Indication Partnering Status 4-Antibody !"# !"#$# Collaboration with strategic partners: Stakeholders’ linking at national and international level: • Through the development and maintenance of biotechnologyspecific platforms • Organisation of and participation to national and international events Notice: The information and data contained in this document are believed to be correct and are given in good faith. However, no liability, warranty or guarantee of final product performance is created by this document. No freedom from any patent is granted or to be inferred. This document does not constitute a specification of any sort. Preclinical Phase I Phase II Phase III Filing On Market Where For more information on our products and licensing opportunities please contact [email protected] AC Immune ACI-24 (anti-Abeta vaccine) CNS Alzheimer´s Disease AC Immune Crenozumab (Anti-Abeta mAb) CNS Alzheimer´s Disease AC Immune ACI-812 (Abeta inhibitor) CNS Alzheimer´s Disease AC Immune ACI-35 (Tau Vaccine) CNS Alzheimer´s Disease AC Immune Anti-Tau mAb CNS Alzheimer´s Disease AC Immune Morphomer (Tau Inhibitor) CNS Alzheimer´s Disease AC Immune IVD (pTau, Abeta) Diagnostic Alzheimer´s Disease AC Immune PET Imaging Agent (Tau) Diagnostic Alzheimer´s Disease AC Immune ACI-24 Genetic Disorders Down Syndrome AC Immune ACI-260 Ophtalmology Glaucoma Available Addex Therapeutics Dipraglurant (ADX48621) CNS Parkinson’s Disease Levodopa-induced Dyskinesia Available Addex Therapeutics Dipraglurant (ADX48621) CNS DYT 1 Dystonia Available Addex Therapeutics ADX71149 CNS Anxious Depression Janssen Pharmaceuticals Inc. Addex Therapeutics ADX71149 CNS Schizophrenia Janssen Pharmaceuticals Inc. Addex Therapeutics ADX71441 CNS CNS Available Addex Therapeutics mGluR2 NAM CNS not disclosed Available Discovery Addex Therapeutics mGluR4 PAM CNS Parkinson's Disease, MS Available Discovery Addex Therapeutics mGluR7 NAM CNS not disclosed Available Discovery Addex Therapeutics GLP1R PAM Metabolic Disorders Type 2 Diabetes Available Discovery Addex Therapeutics FSH NAM Female Health not disclosed Available Discovery Addex Therapeutics TNF-R1 NAM Inflammation/CNS not disclosed Available Discovery Addex Therapeutics A2A PAM CNS not disclosed Available Discovery Addex Therapeutics TrkB PAM CNS Neurodenegerative Disorders Available Discovery AmVac AMV100 Gynecology Bacterial Vaginitis, Trichomoniasis AmVac AMV110 Urology BPH, Prostatitis AmVac AMV601/602/603 Infectious Diseases RSV AmVac AMV611 Infectious Diseases RSV AmVac AMV401 Infectious Diseases Pandemic Influenza AmVac AMV411 Infectious Diseases Seasonal Influenza Anergis AllerT Respiratory Birch pollen allergy Available Anergis AllerR Respiratory Ragwood pollen allergy Available Anergis AllerDM Respiratory House dust mites allergy Available ARIAD Pharmaceuticals, Inc Iclusig® (ponatinib) Oncology resistant/intolerant CML, Ph+ ALL ARIAD Pharmaceuticals, Inc ponatinib Oncology CML (newly diagnosed) ARIAD Pharmaceuticals, Inc ponatinib Oncology CML (Japanese patients) ARIAD Pharmaceuticals, Inc ponatinib Oncology Lung cancer (FGFR) ARIAD Pharmaceuticals, Inc ponatinib Oncology Ph+ ALL (newly diagnosed) ARIAD Pharmaceuticals, Inc ponatinib Oncology Gastrointestinal stromal tumors ARIAD Pharmaceuticals, Inc ponatinib Oncology Acute meloid leukemia ARIAD Pharmaceuticals, Inc ponatinib Oncology Lung cancer (RET) ARIAD Pharmaceuticals, Inc ponatinib Oncology Medullary thyroid cancer (RET) ARIAD Pharmaceuticals, Inc AP26113 Oncology non-small cell lung cancer (ALK) Baliopharm AG ATROSAB Inflammation Rheumatoid Arthritis Avaiable Baliopharm AG ATROSAB-MS Inflammation Multiple Sclerosis Avaiable Baliopharm AG NOVOTARG Inflammation Multiple Sclerosis Avaiable Baliopharm AG NOVOTARG Cancer Leukemia Avaiable Basilea Pharmaceutica International AG Toctino (alitretinoin) Dermatology Severe Chronic Hand Eczema refractory to potent topical corticosteroids Exclusive worldwide agreement with Stiefel a GSK company Basilea Pharmaceutica International AG Ceftobiprole Infectious Diseases Hospital treated Pneumonia Available Basilea Pharmaceutica International AG Isavuconazole Infectious Diseases Aspergillosis Exclusive license, co-development and co-promotion agreement with Astellas Pharma, Inc. Basilea Pharmaceutica International AG Isavuconazole Infectious Diseases Candidemia Exclusive license, co-development and co-promotion agreement with Astellas Pharma, Inc. Basilea Pharmaceutica International AG BAL30072 Infectious Diseases Multidrug-resistant Gram-Negative Bacterial Infections Basilea Pharmaceutica International AG BAL101553 Oncology Taxane-resistant Cancer Basilea Pharmaceutica International AG BAL19403 Dermatology Moderate Inflammatory Acne Available Basilea Pharmaceutica International AG Anti-inflammatory Macrolide Inflammation COPD, Asthma, IBD, Psoriasis, and other Inflammatory Disorders Available Exclusively licensed to Genentech Exclusively licensed to Genentech Discovery pTau exclusively licensed to Genentech Discovery Discovery U.S. and EU Europe, Canada Biogen Idec For more information on our products and licensing opportunities please visit: www.biogenidec.ch Biopartners GmbH For more information on our products and licensing opportunities please contact: [email protected] BioVersys BV660 Infectious Diseases Anti-Tuberculosis Available BioVersys BV100 Infectious Diseases Nosocomial Infections Available BV200 Infectious Diseases Nosocomial Infections Available r-Urokinase Cardiovascular (thrombolytic) Peripheral Arterial Occlusion - Catheter clearance etc. Available Covagen COVA322 (bispecific anti-TNF/IL17A FynomAb) Inflammation RA, psoriatic arthritis, psoriasis, other Available Covagen bispecific FynomAb Inflammation Covagen COVA208 (anti-HER2 bispecific) Oncology Covagen FynomAb Covagen BioVersys • As a member of national and international umbrella organisations • Through collaborations with life sciences clusters / initiatives • With national and EC funding agencies Projekt Logoentwicklung Bioversys Kunde Bioversys Datei Datum Projekt 2008-06-25 - Beschreibung Cerbios-Pharma SA Logoentwicklung Phase 1 Version Auﬂösung / Format 1 - Freigabe Design Freigabe Produktion - - Lektor Freigabe Kunde Partnered with Mitsubishi Tanabe Pharma diverse cancers Available Discovery Oncology Available Discovery FynomAb Oncology Available Discovery CT Atlantic AG Human-Derived Antibodies Oncology Cytos CYT003 Respiratory Allergic Asthma Cytos CYT003 Respiratory Allergic Rhinitis Cytos CAD106 CNS Alzheimer's Disease Novartis Cytos PF-06444753/752 Respiratory Allergic Rhinitis Pfizer Cytos gH-Qb VLP Infectious diseases Influenza Government of Singapore Cytos CYT012 (Fel-Qb VLP) Respiratory Cat Allergy Cytos CSP-Qb VLP Infectious diseases Malaria Debiopharm Debio 8206 CPP Endocrinology Central Precocious Puberty Debiopharm Debio 025/Alisporivir Infectious diseases HCV Licensed to Novartis worldwide except Japan Debiopharm Debio 0932 NSCLC Oncology NSCLC in development Debiopharm Debio 025 Infectious diseases HCV Available in Japan Debiopharm Debio 1143 Oncology Solid tumors in development Debiopharm Debio 1347 Oncology advanced solid tumors with FGFR alterations in development Debiopharm Debio 0930 Metabolic diseases diabetes Available Debiopharm Debio 1144 Oncology Solid tumors Not available Debiopharm Debio 0617 Oncology in development Debiopharm Debio 1036 Autoimmune diseases Not available Debiopharm Debio 0929 Oncology Debiopharm Debio 0826 Oncology Discovery Debiopharm Debio 1348 Infectious diseases Discovery Debiopharm Debio 1246 Oncology Discovery Delenex Therapeutics AG DLX105 Inflamation Behçet’s disease Available Delenex Therapeutics AG DLX105 Dermatology Psoriasis Available Delenex Therapeutics AG DLX2560 Dermatology/Inflamation Available Delenex Therapeutics AG DLX2323 Dermatology/Inflamation Available Delenex Therapeutics AG DLX2201 Dermatology Available Delenex Therapeutics AG DLX1008 Dermatology/Oncology Available Delenex Therapeutics AG DLX521 Oncology Available Delenex Therapeutics AG DLX212 CNS Available Dybly DYB186 Cardiovascular For more information on our products and licensing opportunities please contact: [email protected] HDL stimulation, Bromodomain inhibition WRAIR (CRADA) Available EffRx Pharmaceuticals SA For more information on our products and licensing opportunities please contact: [email protected] Evolva For information on our ingredients, please visit www.evolva.com/products Data verified by Biotechgate.com, part of Venture Valuation. Swiss Biotech Association Wengistrasse 7 CH-8004 Zurich Tel. +41 (0)44 455 56 78 Fax +41 (0)44 786 16 81 www.swissbiotech.org [email protected] Logo Company Product Therapeutic Area Indication Partnering Status Finox AG BEMFOLA Women's Health/ Reproductive Health Superovulation/ Induction of ovulation / Spermatogenesis Preclinical Phase I Phase II Phase III Available Gene Signal Aganirsen Ophthalmology Orphan Corneal Neovascularisation in Graft patients (CNV-CG) Gene Signal Aganirsen Ophthalmology Orphan Neovascular Glaucoma (NVG) Gene Signal Aganirsen Ophthalmology Orphan Retinopathy of Prematurity (ROP) Gene Signal Aganirsen Ophthalmology - NonOrphan wet Age Related Macular Degeneration (wet AMD) Gene Signal Aganirsen Ophthalmology - NonOrphan Diabetic Macular Edema in Diabetic Retinopathy (DME) Gene Signal Aganirsen Dermatology Psoriasis GeNeuro SA GNbAC1 Neurology CIDP-Neuropathy Available GeNeuro SA GNbAC1 CNS MS Available GeNeuro SA GNbAC1 CNS Schizophrenia Available GeNeuro SA GNbAC2 Metabolism Type 1 diabetes Available Glenmark Crofelemer Gastrointestinal HIV related Diarrhea In-licensed for ROW markets Glenmark Crofelemer Gastrointestinal Adult Acute Infectious Diarrea and Cholera In-licensed for ROW markets Glenmark Vatelizumab Inflammation Ulcerative Colitis Out-licensed to Sanofi Glenmark mPGES-1 inhibitors Inflammation/Pain Chronic imflammatory conditions including Pain Glenmark GRC 15300 Pain Neuropathic Pain Outlicensed to Sanofi Glenmark GRC 17536 Pain Neuropathic Pain Available Glenmark GRC 17536 Respiratory Respiratory Disorders Available Glenmark GBR 900 Pain Chronic Pain Available Glenmark GBR 830 Immunology Autoimmune Disorders Available GlycoVaxyn AG Pneumo Glycoconjugate Vaccine Infectious Diseases Staphylococcus pneumoniae Available GlycoVaxyn AG Shigella Glycoconjugate Vaccine Infectious Diseases Shigella Available GlycoVaxyn AG Staphylococcus aureus Glycoconjugate Vaccine Infectious Diseases Staphylococcus aureus Available Horizon Pharma, Inc. Lodotra (Rayos) Rheumatology Rheumatoid Arthritis and other musculoscelatal Partnered in Europe, Asia Pacific, LATAM EU, US, Australia, South Korea Horizon Pharma, Inc. Duexis Pain, musculoscelatal Osteoarthritis ex US pending US Humabs BioMed SA CMV MoAb Viral Infection CMV Partnered Humabs BioMed SA Flu MoAb Viral Infection Flu A and B Partnered Humabs BioMed SA RSV/MPV MoAb Viral Infection RSV/MPV Available Humabs BioMed SA HBV MoAb Viral Infection Chronic HBV infection Available Humabs BioMed SA Dengue MoAb Viral Infection Dengue Fever Available Humabs BioMed SA JCV/BKV Moabs Viral Infection Transplant and immuncompromized patients Available Humabs BioMed SA Rabies Moab Viral Infection Therapeutic after exposure Available Humabs BioMed SA S aureus MoAb Bacterial Infection Sepsis, Pneumonia Available Humabs BioMed SA Cytokine MoAbs Autoimmunity TBD Available Humabs BioMed SA Anti Tumor MoAbs Cancer TBD Available Kenta Biotech Panobacumab, KBPA101 Anti-infectives Nosocomial Pneumonia Available EU Kenta Biotech KBPA104 (monoclonal antibody) Anti-infectives Nosocomial Pneumonia Available EU Kenta Biotech KBSA301 (monoclonal antibody) Anti-infectives Staphylococcus aureus Infections Available EU Kenta Biotech KBRV201 (monoclonal antibody) Anti-infectives RSV infections Available Kenta Biotech KBAB401 (monoclonal antibody) Anti-infectives Acinetobacter baumanii Infections Kuros Biosurgery AG KUR-111 Trauma Tibia Plateau Fractures Kuros Biosurgery AG KUR-112 Trauma Bone Cysts (Orphan) Kuros Biosurgery AG KUR-113 Trauma Tibial Shaft Fractures Kuros Biosurgery AG KUR-212 Wound Mesh Burns Kuros Biosurgery AG KUR-213 Wound Abdominoplasty Kuros Biosurgery AG KUR-023 Wound Dural Sealant Kuros Biosurgery AG KUR-115 Spine Spinal Fusion Lumavita AG For more information on our products and licensing opportunities please contact: [email protected] Med Discovery SA For more information on our products and licensing opportunities please contact: [email protected] Molecular Partners For more information on our products and licensing opportunities please contact [email protected] Mymetics Corporation For more information on our products and licensing opportunities please contact: [email protected] Nano Bridging Molecules SA SurfLink® Dental Implants Osseointegration Filing On Market Where CE marked Medical Device NBE Therapeutics For more information on our products and licensing opportunities please contact [email protected] Neurimmune Therapeutics AG NI-101 CNS Alzheimer’s disease partnered with Biogen Idec Neurimmune Therapeutics AG NI-202 CNS Parkinson’s disease partnered with Biogen Idec Neurimmune Therapeutics AG NI-105 CNS Alzheimer’s disease partnered with Biogen Idec Neurimmune Therapeutics AG NI-205 CNS Neurodegenerative disease partnered with Biogen Idec Neurimmune Therapeutics AG NI-203 CNS Amyotrophic Lateral Sclerosis Available neurotune NT-11624 Neuropathic Pain Anti-Retroviral Therapy Induced Pain, Osteoarthritic Pain Partnered neurotune NT-13317/24336 Neuropathic Pain Chemotherapy-Induced Pain, Diabetic Neuropathy Partnered neurotune NT-biological Musculo-Skeletal Sarcopenia, Neuromuscular Diseases Available neurotune NT-small molecules Musculo-Skeletal Sarcopenia Available neurotune Diagnostic Musculo-Skeletal Sarcopenia, Kidney Disorders Available NovImmune NI-0401 Autoimmune / Inflammatory Transplant; Crohn’s Disease Available NovImmune NI-0801 Inflammatory Primary Biliary Cirrhosis (PBC), others Available NovImmune NI-0701 Inflammatory N/A Available NovImmune NI-0501 Autoimmune / Inflammatory Hemophagocytic NovImmune NI-1401 Autoimmune / Inflammatory N/A Partnered with Genentech/Roche NovImmune NI-0101 Autoimmune / Inflammatory N/A Available NovImmune NI-1201 Inflammatory N/A Available NovImmune NI-1601 Oncology Cancer Available Discovery NovImmune NI-1701 Oncology Cancer Available Discovery Numab ND003 Respiratory Asthma / COPD Partnered Numab ND004 Pain Proprietary Numab ND007 Autoimmune/ Inflammatory Proprietary Numab ND009 undisclosed Partnered Lymphohistiocytosis (HLH) Available Orphanbiotec AG For more ifnormation on our products and licensing opportunities please contact: [email protected] PharMida AG Transbucal Insulin Metabolic Diseases Diabetes PharMida AG Transbuccal GLP-1 Metabolic Diseases Diabetes Philochem/Philogen L19-131I Oncology Hodkin Lymphoma Available Europe Philochem/Philogen L19-TNF + doxorubicine Oncology Sarcoma Available Europe Philochem/Philogen L19-IL2 + dacarbazine Oncology Melanoma Available Europe Philochem/Philogen L19-IL2 + L19-TNF Oncology Melanoma (intralesional) Available Europe Philochem/Philogen L19-IL2 + gemcitabine Oncology Pancreatic Cancer Available Europe Philochem/Philogen F16-IL2 + cytarabine Oncology AML Available Europe Philochem/Philogen F16-IL2 + paclitaxel Oncology Breast Cancer Available Europe Philochem/Philogen F16-IL2 + paclitaxel Oncology Merkel Cell Carcinoma Available Europe Philochem/Philogen F8-IL10 + methotrexate Chronic Inflammation Rheumatoid Arthritis Pfizer Europe Philochem/Philogen F8-IL4 Chronic Inflammation Psoriasis Available Europe Proreo Pharma Nepolong (R) Cardio-Vascular Pulmonary Hypertension available Proreo Pharma PP-012 CNS Aura Migraine in preparation Infectious Diseases CMV, Influenza Available Redbiotec AG Negotiations Santhera Catena ® Neurology Primary progressive Multiple Sclerosis Santhera Catena ® Neuromuscular, Neurology Duchenne Muscular Dystrophy Santhera Raxone ® Senexta Therapeutics SA SNX-001 CNS Alzheimer’s Disease Available Senexta Therapeutics SA SNX-001 CNS Post Stroke Cogntive Impairment Available Sompharmaceuticals S.A. Somreotide Endocrinology Resistant Acromegaly Available Sompharmaceuticals S.A. Somreotide Oncology Resistant Neuroendocrine Tumours Available Sompharmaceuticals S.A. SomtoScan Diagnostics/Imaging Neuroendocrine Tumours Available Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Neurology Ischemic stroke Available USA Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Cardiovascular Acute Myocardial Infarction Available USA Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Cardiovascular Acute Myocardial Infarction Not available KH Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Dermatology Skin Photoaging Not available USA Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Neurology Alzheimer's disease Available CH Stemedica ischemic tolerant Mesenchymal Stem Cells (itMSC) Ophtalmology Diabetic retinopathy Available USA Stemedica ischemic tolerant Neural Stem Cells CNS Spinal Cord Injury Available USA Leber's Hereditary Optic Neuropathy Stemergie Biotechnology SA For more information on our products and licensing opportunities please contact: [email protected] Stragen Pharma For more information on our products and licensing opportunities please contact [email protected] Telormedix SA TMX-101 Oncology Bladder Cancer Available Telormedix SA TMX-202 Oncology Tumor Immunology Available Telormedix SA TMX-30X Immunology Inflammation/Autoimmune Diseases Available Telormedix SA TMX-20X Immunology/Oncology Vaccine Adjuvant/Tumor immunology Available Virometix VMT-01 Inectious Diseases Next-generation Pneumococcal Vaccine Available Virometix VMT-02 Oncology Cervical Cancer Vaccine Available Discovery Virometix VMT-03 Respiratory RSV Available Discovery Virometix VMT-04 Oncology Available Discovery Data verified by Biotechgate.com, part of Venture Valuation.