cmi
Prof. Riemer Slart MD, PhD
Prof. Lioe-Fee De Geus-Oei MD, PhD
Prof. Philip Elsinga, PhD
Marcel Greuter, PhD
Ronald Borra MD, PhD
Erik Jippes, PhD
Michaël Lamsbergen MD, PhD, PDEng
Mark Rijpkema, PhD
Prof. Wiendelt Steenbergen, PhD
Jai Prakash, PhD
Jos Paulusse, PhD
Christoph Brune, PhD
Prof. Sarthak Misra, PhD
Kees Smaling
Dennis Valk
Abe van der Werf
Kaspar Koch, PhD
Renske van Wijk, PhD
Elra Eppink
Dutch delegates
NEN
preliminary version
CENTER
FOR
MEDICAL
IMAGING
“Imaging the future”
University Medical Center of Groningen
Leiden University Medical Center
University Medical Center of Groningen
University Medical Center of Groningen
University Medical Center of Groningen
University Medical Center of Groningen
ZGT Hospital Group Twente
Radboud University Medical Center Nijmegen
University of Twente
University of Twente
University of Twente
University of Twente
University of Twente
Siemens
Mallinckrodt Pharmaceuticals
Machnet
Future Chemistry
CMI
CMI
Nuclear Medicine Physician
Nuclear Medicine Physician
PET Radiochemist
Medical Physicist, Radiology
Assistant Professor Radiology and Molecular Imaging
Manager at UMCG Research B.V.
Medical physicist, Radiology
Assistant Professor Molecular Imaging
Professor Biomedical Photonic Imaging
Assistant Professor Targeted Therapeutics
Assistant Professor Controlled Drug Delivery
Assistant Professor Applied Mathematics
Assistant Professor Surgical Robotics Laboratory
CEO Healthcare Siemens Netherland
Salesmanager Benelux
President
President
Project manager knowledge transfer
Project manager innovation cluster
MEDICAL TOUR 2015
Dutch delegates
University of Twente
The University of Twente is where talent can best realize its full potential.
Students and staff are the key. Together, 3,300 scientists and professionals
carry out ground-breaking research, bring about socially relevant innovation,
and provide inspiring teaching for more than 9,000 students. To us, entrepreneurship comes as second nature. This entrepreneurial approach is noted for
Excellent education & research, New technology as motor for change, innovation and progress, Combination of technology & social sciences and the
Entrepreneurial attitude in everything we do. Themes: at the moment are
Nanotechnology, Sustainability, Health, Governance, ICT and Biomedical
technology.
MIRA, Institute for Biomedical Technology and Technical Medicine
“Top technology for patients.” Technological science is the catalyst for innovation in healthcare. MIRA, Institute for Biomedical Technology and Technical
Medicine combines fundamental and applied research with clinical practice.
This unique scientific path stimulates a successful application of fundamental
concepts and enables healthcare to rapidly introduce new treatments. MIRA
works closely with hospitals, the business community and governmental organizations, aiming to secure its leading position in Europe. Our multidisciplinary approach enables us to make innovative contributions across a wide
spectrum within healthcare. MIRA’s research will result into the development
of new techniques to repair damaged tissue, such as bone and skin. It helps
to create drugs that are targeted in their effects and enables doctors to diagnose more effectively through the use of improved imaging techniques. Furthermore, MIRA offers patient-focused solutions in rehabilitation technology.
www.utwente.nl/mira
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University of Twente Institute for Biomedical Technology and
Technical Medicine
University of Twente Campus
Jai Prakash, PhD graduated cum laude from the Graduate School for Drug
exploration at the University of Groningen in 2006. After that, he worked for a
few years at a joint position in a spin-off company BiOrion Technologies as
Vice President and the University of Groningen, where he worked on preclinical tumor imaging of tumor stroma and also co-supervised 2 PhD students. In 2011, he joined Karolinska Institutet in Sweden as Assistant Professor and investigated new targets in tumor stroma for imaging and drugdelivery. Since 2012, he has been working as Assistant Professor at the MIRA
Institute for Biomedical Technology and Technical Medicine, University of
Twente, the Netherlands. His main line of research is to develop novel peptide-based nanosystems to target tumor stroma and fibrotic diseases for imaging and therapeutics. Currently, he is supervising 5 PhD students and 2
postdocs who are actively working on these topics. He also holds an associated scientist position at the Karolinska Institute and conducting collaborative
projects. Besides that, he is acting as guest associate editor for Frontiers in
Oncology journal.
[email protected]
Dutch delegates
University of Twente Institute for Biomedical Technology and
Technical Medicine
University of Twente, Department of Biomedical Photonic Imaging
Jos Paulusse, PhD obtained his PhD degree in organic chemistry in 2006
from Eindhoven University of Technology, the Netherlands. He then moved to
UC Santa Barbara to work as a postdoctoral fellow at the Materials Research
Laboratory on the development of responsive nanomaterials for biomedical
applications. In 2009 he was appointed assistant professor in bionanotechnology at the University of Wageningen, the Netherlands, working on the functionalization of inorganic materials for sensing applications. In 2012, he was
offered a position as assistant professor at the University of Twente, the
Netherlands, where he currently leads a research group on controlled drug
delivery and targeted imaging. Dr. Paulusse is founder of PACA Chem, a
startup company developing functional monomers and polymers for biomedical applications, as well as co-founder of QuantiS, a company developing non
-toxic, renewable quantum dots for imaging and lighting applications. He is
organizer of the European Symposium on Controlled Drug Delivery and board
member of the Dutch Society for Biomaterials [email protected]
The Biomedical Photonic Imaging group (www.utwente.nl/bmpi) investigates
the use of light for medical purposes. Our final aim is to develop optical and
hybrid optical-acoustical technologies for diagnosis, in particular in the fields
of oncology and wound healing. Our current technologies include photoacoustics, acousto-optics, and coherent optical methods. Properties of primary
interest are vascularisation, hemoglobin concentrations, and blood oxygenation. Furthermore we focus on the quantified detection and imaging of functionalized contrast agents and optically labeled targeted drugs.
Our main involvement in the Center for Medical imaging—North East Netherlands focuses on the photoacoustic detection of cancer. We develop photoacoustic mammography which now undergoes clinical testing together with the
MST Hospital. Together with the Medical Oncology department of the UMC
Groningen we will investigate photoacoustic detection of fluorescently labeled
antibody drugs.
Christoph Brune, PhD is a tenure track assistant professor for computational
mathematics in the Department of Applied Mathematics at the University of
Twente. In the group Applied Analysis and Computational Science his mentor
is Prof. Stephan van Gils. In 2011-2012 he was a CAM Assistant Adjunct
Professor in the Department of Mathematics at University of California Los
Angeles (UCLA) working on projects in inverse problems, 4D imaging/image
processing, optimal transport and machine learning. He earned a Ph.D. degree in applied mathematics under at the University of Münster. His doctoral
thesis was entitled "4D imaging in tomography and optical nanoscopy". Christoph received a double diploma in mathematics and computer sciences with a
topic in image processing and optimal control with PDEs. Current research
applications range from 4d imaging in biomedicine (e.g. live microscopy and
tomography) to crime modeling and atomic force microscopy in nanotechnology. [email protected]
Prof. Wiendelt Steenbergen, PhD obtained an MSc degree in aerospace
engineering at the Delft University of Technology, a PhD at the Technical
University Eindhoven and started as postdoc at the University of Twente,
Enschede, in 1995. After an assistant and associate professor position he is
now the full professor and head of the Biomedical Photonic Imaging group in
the MIRA Institute.
He is Technical Scientific Director and track leader Optics in CMINEN.
His research is focused on biomedical photonics, specializing in photoacoustic imaging , acousto-optic sensing, and speckle-related perfusion imaging techniques such as laser Doppler perfusion imaging and laser speckle
contrast analysis.
[email protected]
Sarthak Misra, PhD “...” [email protected]
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Dutch delegates
University Medical Center Groningen
University Medical Centre Groningen
UMCG is one of the largest public healthcare institutions in the Netherlands.
With more than 10,000 employees, UMCG is constantly building on the future
of health, based on bringing together clear ideas, brilliant people and excellent infrastructure. UMCG aims to be an internationally leading University
Medical Center, where knowledge about health, disease and healthcare is
generated, tested, shared and applied. UMCG’s core activities are to carry
out cutting-edge scientific research from ‘bench to bedside’ and to provide
state-of-the-art healthcare. In addition, UMCG is leading in the educational
training of students, medical and biomedical researchers, doctors and other
academic professionals. Breaking new ground, sharing knowledge and caring
for people are the core values that reflect UMCG’s strategic choices with
respect to investment, collaboration and innovation.
Prof. Matthijs Oudkerk, MD PhD received his medical training and PhD
(Infusion rate in the enterclysis examinations, 1982) at the University of Leiden. He was head of the Department of Radiology of the Daniel den Hoed
Clinic in Rotterdam from 1988—2000. In September 2000, Prof. Oudkerk
became full professor and chair of Radiology at the University of Groningen
and was assigned at the University Medical Center Groningen. He was president of the European Society of Cardiac Radiology (ESCR) from 2003—2008
and member and fellow of many national and international radiological societies. He is (co-)author of over 370 publications in international journals and
editor of several books. His main radiological interests are in (non-)invasive
vascular imaging and oncological imaging. He is Medical Scientific Director of
CMINEN since January 2011.
Healthy Ageing is the central theme of all UMCG’s core activities. Healthy
ageing is a lifelong process that starts before conception, with parents who
pass on their genes and with these the risks and opportunities for either a
healthy life course or the occurrence of various illnesses. In addition, lifestyle
and various other, environmental factors have a major influence on the balance between health and illness. The UMCG’s multidisciplinary research teams
extend from fundamental biological and (pre)clinical research through applied
research into social-societal effects of disease and health. In this way results
can be translated rapidly into adequate and/or improved prevention and treatment methods, leading to new insights, know-how and products.
[email protected]
www.umcg.nl/EN
5
Dr. Erik Jippes is Managing Director of the Center for Medical Imaging North
East Netherlands on behalf of the UMCG. His areas of expertise are project
management, grant applications, public private partnerships and change
management. He holds a PhD in the role of social communication networks in
healthcare innovation processes, with a background in management and
organization. He is also manager of the UMCG Research BV.
[email protected]
Dutch delegates
University Medical Centre Groningen
University Medical Centre Groningen
Prof. dr. Riemer Slart, MD PhD received his medical training at the Medical
University in Groningen, The Netherlands. He obtained his PhD in 2005 (New
nuclear medicine techniques for the assessment of myocardial viability) at the
University of Groningen, The Netherlands. Since 2001 he is member of the
permanent medical staff as nuclear medicine physician of the Department of
Nuclear Medicine and Molecular Imaging at the University Medical Center
Groningen. In 2014 he became part-time clinical professor “Molecular Imaging” at the University Twente, Enschede, department Biomedical Photonic
Imaging, The Netherlands. He is involved in cardiovascular imaging with a
main focus on myocardial innervation, myocardial perfusion & viability, cardiorenal axis and atherosclerosis. Further he is involved in infection and inflammation imaging projects. He is author of over 145 peer-reviewed publications
in international journals, 130 abstracts and 11 book chapters. In 2011 he
became discipline leader Molecular Imaging for the Center of Medical Imaging in the Netherlands (CMINEN), and in 2014 he became Board member of
the EANM Cardiovascular Committee. [email protected]
Prof. Philip H. Elsinga, PhD is an organic chemist by training and and obtained his PhD in 1995 at the University of Groningen (promotor Prof W. Vaalburg). He is involved in PET-related radiopharmaceutical research and translation of radiopharmaceuticals to the clinic. Main focus was firstly directed to
PET-labelled amino acids, receptor ligands for the beta-adrenergic receptor
and substrates for P-glycoprotein. Later on, his interest broadened to other
PET-radiopharmaceuticals, such as 18F-labelled peptides, sigma receptor
antagonists and artificial amino acids for neuroendocrine tumors. In 2006 he
was appointed as quest professor at the University of Ghent, Belgium and in
2011 as full professor PET-radiochemistry. He is author of >170 peerreviewed articles. International activities are (amongst others) Chairman of
the EANM Radiopharmacy Committee, member of Board of Directors of Society of Radiopharmaceutical Sciences and invited expert for IAEA. During the
course of 2015 he will become Editor-in-Chief of the newly to be established
journal European Journal of Nuclear Medicine and Molecular Imaging Radiopharmaceuticals. [email protected]
Dr. Marcel Greuter PhD obtained his PhD in 1993 in nuclear solid state
physics at the University of Groningen, the Netherlands. After working several
years in R&D and ICT, in 2002 he became head of the medical physics group
at the radiology department of the University Medical Center Groningen. His
group is responsible for the quality and safety of radiologic equipment, in
addition to research, education and teaching. His main research focus is on
phantom design and development for image quality assessment and validation in radiologic procedures, especially in computed tomography, as well as
the optimization of breast cancer screening. He is author of over 60 peerreviewed publications in international journals, over 130 abstracts, and three
book chapters. He is active in several national and international committees
on radiation safety, medical physics and biomedical engineering.
[email protected]
Ronald J.H. Borra, MD, PhD
Associate Professor in Nuclear Medicine & Molecular Imaging
“...”
[email protected]
6
Dutch delegates
University of Twente Innovation Cluster
Radboud University Medical Centre - Nijmegen
The Center for Medical Imaging - North East Netherlands (CMINEN) is the
result of a joint initiative of University Twenten/Institute for Biomedical Technology and Technical Medicaine MIRA , University Medical CenterGroningen/
University of Groningen and Siemens Healthcare. Clinical needs will drive the
CMINEN ’s research agenda. Research at CMINEN is focused on the use of
current and new imaging technologies to address clinical demands for early
diagnosis, early intervention and minimally-invasive therapies.
In our opinion, it is important to form complementary teams with a broad
spectrum of knowledge in order to effectively transfer technology to the market. In our network there are many companies which can help with licensing,
patenting, commercialization or valorization.
The Innovation Cluster of CMINEN has an important role in bringing people
together. We organize get-together meetings, initiate new projects, provide
project management support and help to allocate for funding sources. This all
happens in close cooperation with Kennispark, Healthvalley and OostNV.
www.cmi-nen.nl/business
Radboud university medical center is a leading academic center for patient
care, education and research, with the mission ‘to have a significant impact
on healthcare’. Our activities help to improve healthcare and consequently
the health of individuals and of society. We believe we can achieve that by
providing excellent quality, participatory and personalized healthcare, operational excellence and by working together in sustainable networks. Patients
deserve the best possible care. This is why we aim to deliver excellent quality
that has to be proven. From patient care to the most prestigious research
programs
We work with regional, national and international partners. Patients receive
the best possible care where ever their needs can be best met.
Renske van Wijk, PhD is a health scientist and obtained her PhD at the Department of Health Technology and Services Research of the University of
Twente. Within CMI she is responsible for the valorization of scientific
knowledge. Her work includes advising, supporting or coordinating with regard to fund raising, writing of proposals, project management, building consortia and business development.
[email protected]
Elra Eppink has a background in new business development in (private)
healthcare. She highly appreciates to have the opportunity to organize this
Medical Tour.
[email protected]
7
Mark Rijpkema, PhD, studied chemistry at the Radboud University Nijmegen, where he graduated in 1996. After graduation he started as a PhD student at the department of Radiology of the UMC Nijmegen and obtained his
doctoral degree with his thesis on MR imaging and MR spectroscopy. Subsequently, he worked as a postdoc at the University of Utrecht. In 2006, he
moved back to Nijmegen to work at the Center for Cognitive Neuroscience of
the Donders Institute, where he started a research line investigating the genetic underpinnings of brain structure and function, in close collaboration with
the Human Genetics department of the UMC Nijmegen. In 2011 he returned
to the field of oncology at the department of Nuclear Medicine to start a research group working on molecular imaging in translational research, focusing on intraoperative fluorescence imaging and multimodal image-guided
surgery.
[email protected]
Dutch delegates
Leiden University Medical Center (LUMC)
ZGT, Hospital Group Twente
LUMC is a modern university medical center for research, education and
patient care with a high quality profile and a strong scientific orientation. Its
unique research practice, ranging from pure fundamental medical research to
applied clinical research, places LUMC among the world top. This enables
LUMC to offer patient care and education that is in line with the latest international insights and standards – and helps it to improve medicine and
healthcare both internally and externally.
LUMC acts as a knowledge center for topics in the field of public health with
an impact on society, it has a directive function in the region and it acts as a
centre for continuing education and further training for medical professionals.
The collaboration between LUMC, Leiden University and the Leiden Bio Science Park creates unique possibilities for medical innovation in Leiden and
the surrounding area.
Ziekenhuisgroep Twente (ZGT, Hospital Group Twente) has hospitals in Almelo and Hengelo. They are a general hospital group with 3,500 employees
and a catchment area of 300,000 inhabitants. ZGT delivers high quality specialist medical diagnostics and treatments. ZGT renews and improves its
overall care constantly. The health needs of the patient is a deciding factor.
ZGT works closely with the University of Twente and Saxion University of
Applied Sciences on several projects. The department of Nuclear Medicine
has four SPECT(CT) and a PET-CT camera available.
www.zgt.nl
Prof. Lioe-Fee de Geus-Oei, MD PhD graduated at the Erasmus University
in Rotterdam in 1996. After her residencies at Leiden University Medical Center she started in 2000 as a Nuclear Medicine Physician at the Radboud University Medical Center Nijmegen, where she worked until December 2014 as
RGS-certified Residency Program Director. Beside this job, she has been
Editor-in-Chief (2007-2012) of the Netherlands Journal of Nuclear Medicine.
Since April 2013 she is President of the Dutch Society of Nuclear Medicine
and since December 2013 part-time clinical professor “Molecular Imaging,
Innovation and Translation” at the University of Twente, Enschede. Her multidisciplinary line of research, in which 9 of her 11 PhD candidates are active,
focuses on tumor characterization using multimodality functional imaging
techniques. Since January 2015 she is full-time professor in Nuclear Medicine
and Molecular Imaging at Leiden University Medical Center.
Michaël Lansbergen, MSc, Ph.D, PDEng, graduated from Delft Technical
University (MSc) and Eindhoven University of Technology (Professional Doctorate). After four years as a Medical Physicist Trainee at University Hospital
Maastricht he started in 2002 as Medical Physicist at ZGT: He is Chair of the
department of Health-Technology, Medical Safety Officer and Board Member
of the Medical Staff. His Ph.D thesis ‘Resolving Complexity?!’ is about a
system of quality, risk management and control for medical technology is
hospitals. He is Associate Professor in Organizational Development, Quality,
Safety and Technology in Healthcare at Saxion University of Applied Sciences.
[email protected]
[email protected]
8
Dutch delegates
Siemens Netherlands
Mallinckrodt Pharmaceuticals
The Healthcare Sector stands for innovative products and complete solutions,
but also for services and counseling in healthcare. With a growing and aging
population, more and more people try most of their lives to get to old age and
a healthy quality of life to lead. Siemens plays a unique role: they support
care with their medical technology. Siemens offers advanced solutions in the
field of imaging techniques, diagnosis, treatment and IT systems for
healthcare. The innovative technology makes 'tailored' medicine possible and
also ensures better differential diagnoses and treatment decisions.
For nearly 150 years, the Mallinckrodt name has represented quality products, business integrity, and service – to patients, customers and the communities in which we live and work. Now once again an independent global
specialty pharmaceutical company, at Mallinckrodt Pharmaceuticals we continue to apply our unique strengths, experience and expertise to bring products
to the market that provide enormous value for physicians and the patients we
jointly serve.
www.corporate.siemens.nl/nl
“Health is our greatest asset.
Without health we lose the freedom
to achieve our goals and dreams.”
Kees Smaling has an extensive background in telecommunications. He majored in telecommunications, subsequently followed a number of general
study courses. He completed a global Siemens executive MBA study at Duke
University.
He started at the Electro Medical department at Siemens Nederland N.V. to
grow towards the communications department of Siemens where he made
career and became CEO at Siemens Information and Communication Mobile
and Networks, which later on merged into Nokia Siemens Networks B.V.
After a short period there, he was appointed to CEO at Siemens Healthcare
Sector in 2008.
[email protected]
nl.linkedin.com/pub/kees-smaling/4/416/12b
9
The common thread critical to our past and future success is that strong ability to master and manage complexity. Simply put – we strive to make the complex simple.
Our core strengths provide the catalysts for future success, including the
acquisition and management of highly regulated raw materials; deep regulatory knowledge; distinctive manufacturing and logistics skills where vertical
integration is an advantage; expertise in specialized chemistry, development
and formulation; and global commercial reach.
www.mallinckrodt.com
Dennis Valk is trained as Radiographer (Rijnstate Hospital, Zevenaar , The
Netherlands) and moved after several years to Mallinckrodt (former Tyco/
Covidien). Starting as Sales Representative he became Product Manager
and is now responsible for the Sales Department of the Benelux Area.
[email protected]
Dutch delegates
Machnet
Future Chemistry
Machnet was founded in 1992 in Utrecht, The Netherlands. At the end of
2001 Machnet merged with MR Products. Machnet design, manufacture and
market specialty coils for MRI all around the globe. The most important products are the PACC (carotid coil) MICS (breast coil) and Coils for rheumatology. Machnet is concentrating their effort in specific illness where specialist
need the support from radiology with MRI as the modality to scan. The company is independent and situated in Roden (headquarters) and Maarn
(research and development) in The Netherlands. Machnet is constantly improving their business connections with radiologists and specialists all
over the world. Momentary we investigate the possibilities of designing coils
for a 3T PET-MRI of Siemens what will be installed at CMI. Machnet is also a
partner of University of Utrecht and University Leiden where they work on
high field 7T coils. As an example Machnet is the pioneer in the field of scanning vulnerable plaque in the carotid artery. There is a range of products
supplied by Machnet that can fulfill this method. There are product for 1.5T,
3.0T and also 7 T of different brand of MRI scanners.
Kaspar Koch, PhD “…”
[email protected]
www.machnet.nl
Abe van der Werf is the president at Machnet. He has a background in electronic engineering and is active since 1985 in the medical equipment market
on global sales. He started in Gas and liquid –chromatography and broaden
his portfolio first with dental equipment and later on in stress test equipment.
Since 2000 Abe is active in the MRI industry. Business development in medical equipment and specially business development for global selling is his
strong point.
[email protected]
10
cmi
NEN
CENTER
FOR
MEDICAL
IMAGING
CMINEN Medical Tour 2015 made possible by:
CMI founding partners:
Organizer
CMINEN Innovation Cluster Elra Eppink
Copyright
All rights reserved. No part of this publication may be
reproduced, stored in a retrieval system or transmitted in
any form or by any means, electronic, mechanical, photo
copying, recording or otherwise, without the prior written
permission of the University of Twente.
Address
PO Box 217
7500 AE Enschede
The Netherlands
Telephone
+31 (0)681419493
Website
www.cmi-nen.nl/business