Ultra High-Throughput Protein Bioinformatics

Spring 2015 Seminar Series
Dr. Lukasz Kurgan
Electrical & Computer Engineering
University of Alberta
Title: Ultra high-throughput protein bioinformatics
Abstract: “Bioinformatics concerns the collection, classification, storage, and analysis of biochemical
and biological information using computers especially as applied to molecular genetics and genomics”
[Merriam-Webster dictionary]. Bioinformatics of proteins, the ultimate products of a genome, concerns
computational prediction, characterization and analysis of their sequences and structures. Current highthroughput efforts in protein bioinformatics rely of predictive models that are generated from relatively
small experimentally annotated data to analyze proteins on a much larger scale of an organism or a protein
family. Given the exponential growth of the protein data that are now available for over half a million
organisms, we specialize in the design, development, deployment and use of advanced models that have
three orders of magnitude higher throughput. In this talk, we will discuss our recent efforts related to target
selection for structural genomics, prediction of protein-drug interactions and its application in
polypharmacology, and characterization of intrinsic disorder. Throughout the talk we will explain how
protein structures are obtained, why these structures are needed, and how often and why protein are
Bio: Dr. Kurgan received Ph.D. from the University of Colorado at Boulder in 2003. He is a Professor in
the department of Electrical and Computer Engineering at the University of Alberta. Dr. Kurgan leads a
successful research program in big data-driven (ultra) high-throughput bioinformatics focused on protein
and RNA structure and function characterization and protein-ligand/drug interactions. He authored over
100 peer-reviewed journal articles and serves on editorial boards of seven journals and CIHR review panel
in genomics. You can find more details at http://biomine.ece.ualberta.ca/.
When: 12:00pm-1:00pm, Monday, March 23, 2015
Where: Room E2221, School of Engineering-East Hall, Monroe Campus