Wellcome Trust Scientific Conferences
Longitudinal Studies: Maximising their Value for Ageing Research
21-23 July 2015
Wellcome Trust Genome Campus, Hinxton, UK
Lectures to be held in Kendrew Auditorium, EBI-South
Poster sessions to be held in Chestnut Suite, Hinxton Hall
Draft Conference Programme
Tuesday 21 July
12:00 - 13:00
Registration & buffet lunch
13:00 - 13.10
Welcome and Introductions
Diana Kuh, University College London, UK
13.10 - 15.10
Session 1: Conceptual frameworks for ageing research: building
a consensus and use of longitudinal studies
Chair: Luigi Ferrucci
13.10 - 13:40
The challenge for life course epidemiology of ageing research
Yoav Ben-Shlomo, University of Bristol, UK
14.10 - 14.40
The challenge for ageing research of life course epidemiology
Anne Newman, University of Pittsburgh, USA
14.40 - 15.10
Open discussion and debate
15.10 - 15:40
Afternoon Tea
15:40 - 18:10
Session 2: The value of longitudinal studies for understanding
the natural history of physiological systems, reserve and
compensation
Chair: Diana Kuh
15:40 Change in mobility across life: drivers and trajectories
Luigi Ferrucci , National Institute on Aging, USA (with Rachel
Cooper, UCL, UK)
16.10 Change in cognition across life: drivers and trajectories
Carol Brayne, University of Cambridge, UK (with Daniel Davis,
UCL, UK)
16:40 Cardio-metabolic function across life
Laura Howe (with Debbie Lawlor), University of Bristol, UK
17:10 Chesty children and chesty adults: a life course perspective on
lung health and disease
David Strachan, St George’s Medical School, UK (with James
Allinson, National Heart and Lung Institute, UK),
17.40 Selected talk from submitted abstract (#1)
17.55 Selected talk from submitted abstract (#2)
18.30 - 19:00
19:00
Poster Session I (odd numbers) with Drinks Reception
Dinner
Wednesday 22 July
08.45 - 10:45
Session 3: The value of longitudinal studies in identifying drivers
of functional ageing and disease development
Chair: Rachel Cooper
08.45 Body composition across life and the obesogenic environment
Rebecca Hardy, University College London, UK (with Tamara
Harris, NIA, USA)
09.15 Physical activity and energetics
Jennifer Schrack, Johns Hopkins University, USA
09.45 Exploring the mechanistic basis of longitudinal changes in
physical function: a focus on the insulin and nitric oxide
pathways
Mario Siervo, Newcastle University, UK
10.15 Selected talk from Submitted Abstract (#3)
10.30 Selected talk from Submitted Abstract (#4)
10.45 - 11.15
Morning Coffee
11:15 - 13.30
Session 4: What do the ‘omics technologies add to longitudinal
studies:
Chair: Eline Slagboom
11:15 ‘Omics and traditional parameters in Dutch studies on healthy
ageing, morbidity and mortality
Eline Slagboom, University of Leiden, The Netherlands
11.45 ‘Omics studies in large Finnish prospective cohorts reveal
novel pathways contributing to complex trait aetiology: tales of
mortality, morbidity and menopause
Markus Perola, University of Helsinki, Finland
12:15 Epigenetic analysis in longitudinal studies: identifying variation
and exploring persistence over time
Caroline Relton, University of Bristol, UK
12.45 An ‘omic analysis of diet-microbiota interactions and their
implications for healthy ageing
Ian Jeffrey, University College Cork, Ireland
13.15 Selected talk from Submitted Abstract (#5)
13:30 - 14:30
Lunch
14.30 - 16:30
Session 5: Integrated analysis of longitudinal studies of
ageing
Chair: Andrea Piccinin
14:30 Integrative data analysis of longitudinal studies: approaches
and examples of reproducible multiple-study research
Scott Hofer, University of Victoria, Canada
15:00 Reproducibility in the personality-smoking-mortality mediation
pathway: an integrated data analysis with 12 studies
Daniel Mroczek, Northwestern University, USA
15:30 Longitudinal data analysis of longitudinal studies: are effects of
age, sex and education consistent across studies and models?
Graciela Muniz Terrera, University College London, UK
16.00 Selected talk from Submitted Abstract (#6)
16:15 Selected talk from Submitted Abstract (#7)
16:30 - 17:00
17.00 - 19.00
Afternoon Tea
Poster session II (even numbers) with drinks reception
19:00
Conference Dinner
Thursday 23 July
09:00 - 10:30
Session 6: The value of longitudinal studies for understanding
the impact of the environment and psychological and social
resilience
Chair: Marcus Richards
09.00 Stress resistance and stress recovery: how longitudinal data
at multiple time scales can elucidate the resilience process
Cindy S. Bergeman, University of Notre Dame, USA
09:30 Mental health and wellbeing during ageing
Dorly Deeg (with Martijn Huisman and Oliver Schilling), VU
University Amsterdam, The Netherlands
10.00 From observation to intervention for physical function and
resilience: an opportunity for longitudinal studies in ageing
research
Avan Aihie Sayer, University of Southampton, UK
10.30 Selected talk from Submitted Abstract (#8)
10.45 Selected talk from Submitted Abstract (#9)
11.00 - 11.30
Morning Coffee
11:30 - 13.30
Session 7: The future agenda for longitudinal studies of ageing
Chairs: Luigi Ferrucci and Ben Cairns
11:30 Gazing into the crystal ball: what opportunities and challenges
does the future hold?
Rachel Cooper, UCL, UK (with Richard Dodds, University of
Southampton and other members of the mid-career
committee)
11:45 Characterising the exposome: evolving methods of capturing
health behaviours and people’s interactions with their
environment
Barbara Jefferis, UCL, UK (with Tamara Harris, NIA, USA)
12:00 Within-individual variability (pt1): new opportunities to
investigate very short through to long term changes in
physiological function
Debbie Lawlor (with Laura Howe, University of Bristol, UK and
Andrew Steptoe, UCL, UK)
12:15 Within-individual variability (pt2): new opportunities to
investigate very short through to long term changes in
psychological function
Jonathan Rush (with Scott Hofer), University of Victoria,
Canada
12:30 Future directions for ‘omics research
Cathy Elks, University of Bristol, UK, and Marian Beekman,
University of Leiden, The Netherlands (with Aroon Hingorani,
UCL, UK)
12:45 The use of everyday technology: case study – the assessment
of visual function
Andrew Bastawrous, LSHTM, UK
13:00 Three blind men and an elephant: drawing data together on
the same people from different sources to better understand
what happens to who, where and when
Daniel Davis, UCL, UK
13:15 Session summary/discussion led by Chairs
13:25 Closing remarks
Diana Kuh
13.30 Lunch and departure