R(obert) Wayne Alexander 1 CURRICULUM VITAE May 2013 1. Name: R(obert) Wayne Alexander 2. Office Address: Emory University Hospital 1364 Clifton Road NE, H-153-D Atlanta, Georgia 30322 Telephone: 404-727-8181 Fax: 404-727-3099 3. E-mail Address: [email protected] 4. Citizenship: 5. Current Titles and Affiliations: USA a. Academic appointment: R. Bruce Logue Professor and Chairman, Department of Medicine Emory University School of Medicine b. Clinical appointments: Chief, Section of Internal Medicine, The Emory Clinic Chief, Section of Primary Care, The Emory Clinic Chief, Section of Hospital Medicine, The Emory Clinic 6. Previous Academic and Professional Appointments: 1976-1977 Junior Associate in Medicine 1976-1982 Assistant Professor of Medicine 1977-1982 Tutor in Medical Sciences 1977-1982 Associate in Medicine 1982-1988 Associate Professor of Medicine 1982-1988 Associate Physician 1982-1988 Assistant in Medicine 1988-1999 R. Bruce Logue Professor of Medicine and Division Director of Cardiology Peter Bent Brigham Hospital Harvard Medical School Harvard Medical School Brigham & Women's Hospital Harvard Medical School Brigham & Women's Hospital Beth Israel Hospital Emory University School of Medicine 7. Licensures / Boards: 1974 North Carolina License Registration (#19201) 1976 Massachusetts License Registration (#39838)-inactive 1977 Diplomate in Cardiovascular Disease, ABIM 1988 Georgia License Registration (#030936) 8. Specialty Boards: 1973 Diplomate American Board of Internal Medicine 1977 Diplomate American Board of Internal Medicine (Subspecialty Board in Cardiovascular Diseases) 9. Education: 1962 A.B. 1967 M.S. 1968 Ph.D. 1969 M.D. University of Mississippi Emory University (Physiology) Emory University (Physiology) Duke University School of Medicine R(obert) Wayne Alexander 10. Postgraduate Training: Duke University, Durham, NC Intern in Medicine, 1969-1970 University of Washington, Seattle, WA Resident in Medicine, 1970-1971 Duke University, Durham, NC Fellow in Cardiology, 1974-1976 11. Military or Government Service: 2 Staff Associate (Senior Surgeon), National Heart and Lung Institute, Experimental Therapeutics Branch; National Institutes of Health, United States Public Health Service, Bethesda, Maryland; 1971-1974 12. Committee Memberships: a. National and International: Pharmacy and Therapeutics Committee, Brigham and Women's Hospital, 1976-1988 Animal Resources Committee, Brigham and Women's Hospital, 1977-1988 Pharmacy and Therapeutics Committee, Chair, Brigham and Women's Hospital, 1978-1980 Ad Hoc Grant Review Committee, National Heart, Lung and Blood Institute, 1980- 1981 Pharmacology Study Section, Ad Hoc Member, National Institutes of Health, 1982 Pharmacology Study Section, National Institutes of Health, 1983-1987 Pharmacy and Therapeutics Committee, Chair, Brigham and Women's Hospital, 1985-1998 Animal Resources Committee, Brigham and Women's Hospital, Chairman, 1985-1988 Pharmacology Study Section, Chairman, National Institutes of Health, 1985-1987 Chairman, Conference on Renin-Angiotensin, Gordon Research Conferences, 1985 Nominating and Membership Committee, High Blood Pressure Research Council, American Heart Association, 1986-1988 Executive Committee, High Blood Pressure Research Council, American Heart Association, 1987-1990 Public Affairs Policy Committee, American Heart Association; 1989-1992, Co-Chair, 1990 Study Section, American Heart Association, 1989-1993 Program Committee, American College of Cardiology, 1989-1994 Association of American Physicians (AAP), Member, 1990 FASEB Summer Conference on the Endothelium, Co-Chair, 1991 Research Committee, American College of Cardiology, 1992-present Hypertension Committee, American College of Cardiology, 1992-2002 Research Policy and Evaluation Committee, American Heart Association, 1992-1997 American College of Cardiology, Member, Hypertensive Diseases Committee, 1992-1998 American College of Cardiology Foundation, Member, Cardiovascular Research Committee, 1998-2004 Research Policy and Evaluation Committee, Co-Chair, American Heart Association, 1993-1994 Board of Directors, Atherogenics, Atlanta Georgia, 1993-present Program Committee Council for High Blood Pressure Research, American Heart Association 1994-1996 FASEB Summer Conference on the Endothelium, Chair, 1994 Research Policy and Evaluation Committee, Chair, American Heart Association, 1995-1997 Vice President for Research, American Heart Association, 1995-1997 Board of Directors, American Heart Association, 1995-1999 Program Committee, Scientific Sessions, Co-Chair, American College of Cardiology, 1997-1999 Science Advisory and Coordinating Committee, American Heart Association, 1995-1998 Science and Medicine Information Committee, Chair, American Heart Association, 1997-1998 American Society of Internal Medicine, 1997-1998 American College of Cardiology Foundation, Member, Training Directors Committee, 1997-2000 Nominating Committee, American Heart Association, 1998 American College of Cardiology Foundation, Member, Cardiology Training and Workforce Committee, 2000-2003 Program Committee, Association of Professors of Medicine, 2001-2002 R(obert) Wayne Alexander Research Committee, Association of Professors of Medicine, 2002-present Reviewer for the Medical Research Program, Doris Duke Charitable Foundation, 1999 Training Directors’ Committee, American College of Cardiology, 2000-2003 Advocacy Advisory Board, Association of Professors of Medicine, 2001 Finance and Management Committee, Association of Professors of Medicine, 2000-2002 Cardiovascular Research Committee, American College of Cardiology, 2001-2003 Finance Committee, American Clinical and Climatological Association, 2004-2006 Nominating and Membership Committee, Association of Professors of Medicine, 2004 Board of Directors President, American Clinical and Climatological Association, 2005 Awards Committee, American College of Cardiology, 2005-present Councilor, Southern Society for Clinical Investigation, 2005-2008 Publications Committee, Southern Society for Clinical Investigation, 2005-present Chairman, A.M. Pappas & Associates, Scientific Advisory Board, 2005 Nominating Committee, American Clinical & Climatological Association, 2006 Queen’s University Advisory Board, Belfast, Ireland, 2007-present Association of Professors of Medicine, Board of Directors, 2007-2010 Association of Professors of Medicine (APM) Research Committee, 2010 Alliance for Academic Internal Medicine (AAIM), Audit Committee, 2010-2012 Association of Professors of Medicine (APM) Nominating Committee, 2011 Chairs Council, Southern Society for Clinical Investigation, 2012 Association of Professors of Medicine (APM) Program Planning Committee, 2012-present b. Regional and State: Research Allocations Committee, Massachusetts Affiliate, American Heart Assoc, 1978-1981 Georgia Affiliate, American Heart Association, Board of Directors, 1995-1997 Southeastern Affiliate, American Heart Association, Board of Directors, 1998-1999 Board of Advisors for the R. Bruce Logue Award, American Heart Association, SE Affiliate, 2000 c. Institutional Board of Directors, The Emory Clinic, 1992-1998 and 2006-2008 Presidential Advisory Committee, Emory University School of Medicine, 1996-2012 Committee on Conflict of Interest, Chair, Emory University School of Medicine, 1996-present Search Committee for Dean, Emory University School of Medicine, 1996 Search Committee for Provost, Emory University, 1997 Research Advisory Committee, Emory University School of Medicine, 1997-present Emory Healthcare Board, 1998-2002 Research Advisory Committee, Subcommittee on Clinical Research, Emory University, 1998 Clinical Council of Chairs’ Advisory Committee to Executive Vice President for Health Affairs, Woodruff Health Sciences Center Emory University, 2000-present External Advisory Board, Petit Institute for Bioengineering and Bioscience (IBB), Emory University and Georgia Tech, 2000-present Allocations Committee, The Emory Clinic, 2000-present Governor’s Advisory Council for American College of Physicians & American Society of Internal Medicine, 2001 Health Sciences Development Committee, Robert W. Woodruff Health Sciences Center, 2001 Research Strategic Plan Committee, Emory University School of Medicine, 2002 Organizational Reassessment Committee, Emory University School of Medicine, 2002 Organizational Reassessment Committee, Emory Healthcare, 2002 Board of Directors, The Emory Clinic, 2002-present Grady Renovation Coordinating Committee for Emory University School of Medicine, 2002 Research Advisory Committee, Emory University, 2001-2004 Emory Healthcare Allocation Committee, 2003 Executive Committee, Emory Center for Clinical and Molecular Nutrition, 2003 Onassis Cardiac Surgery Center Collaboration, Athens, Greece, 2003 Emory Healthcare Advisory Committee, 2004 3 R(obert) Wayne Alexander 4 Steering Committee for Medical School Curriculum Enhancement, Emory University, 2004 Board of Directors, Clifton Casualty, Emory University, 2000-2006 Strategic Plan Steering Committee, Woodruff Health Sciences Center, 2005 Sustainability Committee, Emory University, 2005-present Search Advisory Committee for Director of Sustainability Initiatives, March-May, 2006 Palliative Care Task Force/WHSCAB, 2006 Compliance Committee, Emory Medical Care Foundation, 2005-present Task Force on Conflict of Interest, Emory University School of Medicine, 2006 Emory Healthcare Quality Council, 2006-present (reconfigured 2010) Search Committee for Emory Surgery Chair, 2007 Academic Clinical Integration Committee, Chair, 2007 LCME Task Force, 2007-2008 Assistant Dean for Staff Development Selection Committee, Emory Univ School of Medicine 2008 Emory-Georgia Tech Predictive Health Institute Steering Committee, 2008-current Data Access Monitoring Committee, Emory Predictive Health, Center for Health Discovery and Well Being, 2008 Critical Care Center Director Committee, 2008 Emory Healthcare Quality Academy, Leadership for Healthcare Improvement, 2008 Presidential Advisory Committee, Charles Howard Candler Professor of Public Health, 2009-2012 WHSC Research Strategic Plan Foster Interdisciplinary Research Committee, 2009 WHSC Strategic Planning Executive Committee for Plan, 2009 WHSC Funds Flow Task Force, 2009 Heart & Vascular Charter Committee, Woodruff Health Sciences Center, Emory University, 2009 Heart & Vascular Executive Director Search Committee, Emory University, 2009 PEP, The Executive Program, Honorary Member, 2009 Emory University Presidential Advisory Committee 2009-2012 Advisory Panel on Glycoscience of Inflammation and Thrombosis, 2010 Emory/Georgia Tech Regenerative Medicine Charter Committee, 2010 Emory Palliative Care Center Core Steering Committee, 2010 Public Website Committee, 2011 Predictive Health Transition Committee, 2011 Predictive Health Institute Executive Director, 2011 WHSC Informatics Strategy Council, 2012 Tenure Committee with Provost and Dr. Caughman, 2012 Emory Medical Executive Committee, 2006 EUH Planning and Programming Leadership Team, 2013 Emory Medical Care Foundation (EMCF), Finance Committee, 2012-present Graduate Medical Education (GME) Strategic Plan Steering Committee, 2012 Family & Preventive Medicine Search Committee, Co-Chair, 2012 Regenerative Medicine Charter Committee, 2012 Emory Health Care, Board of Directors, 2013 Emory University Orthopedics & Spine Hospital, Medical Advisory Committee, 2013 Emory Healthcare, Medical Advisory Committee, 2013 GT-Emory Faculty Task Force, Immunology Engineering, 2013 13. Technology Transfer/Development Endeavors: Co-founder-Atherogenics, Inc.,- pharmaceutical company focusing on development of anti-inflammatory drugs 14. Editorships and Editorial Boards: Editor, Hurst’s The Heart Journal of Clinical Investigation 1992 1992-1998 R(obert) Wayne Alexander 5 Circulation Research 1989-1993 Advances in Pharmacology 1993 Advances in Hypertension 1993 Co-Editor, Hurst's The Heart, 8th edition 1994 Co-Editor, Hurst’s The Heart Companion Handbook, 8th edition 1994 Hypertension 1993-2000 Circulation Consulting Editor 1993-1996 Journal of American College of Cardiology 1993 Proceedings of the Association of American Physicians 1997-present Current Cardiology Reports 1998-present Associate Editor, ACCEL, American College of Cardiology 1998-2000 Senior Editor, Hurst's The Heart, 9th Edition 1998 Senior Editor, Hurst’s The Heart Companion Handbook, 9th Ed'n 1999 Editor, Hurst The Heart online site, McGraw-Hill Publishing Co., since initiation in 2001-present at http://www.cardiology.accessmedicine.com Editor, Hurst’s The Heart, 10th Edition 2001 Editor, Hurst’s The Heart Manual of Cardiology, 10th Edition 2001 th Editor, Hurst’s The Heart, 11 Edition 2004 Editor, Hurst’s The Heart Manual of Cardiology, 11th Edition 2005 15. Manuscript reviewer: American Journal of Cardiology American Journal of Physiology American Heart Journal Atherosclerosis, Thrombosis, and Vascular Biology Circulation Circulation Research Hypertension JAMA Journal of the American College of Cardiology Journal of Biological Chemistry Journal of Clinical Investigation Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Nature New England Journal of Medicine Science 16. Honors and Awards: Predoctoral Fellow, American Cancer Society, 1964-1969 National Science Foundation Undergraduate Research Program (Molecular Biology), California Institute of Technology. Woods Hole Oceanographic Institute Fellowship (Microbiology), 1973 Medical Scientist Training Program (Pharmacology) University of Rochester, Rochester, NY, 1975-1981 Alpha Omega Alpha, Robert Kates Memorial Prize in Research Doran J. Stephens Prize in Medicine, 1981 Research Career Development Award, 1977-1982 Fellow, American Heart Association, Council for High Blood Pressure Research, 1982 American Society for Clinical Investigation, 1983 Pfizer Travelling Fellow of the Clinical Research Institute of Montreal, 1983 Young Investigators Award, American College of Cardiology, 1985 Clinical Investigator Award, NIH-NHLBI, Clinician Scientist Award, AHA (deferred), 1986 Chairman, Pharmacology Study Section, NIH, 1984-1987 Katz Prize Finalist, American Heart Association, 1988 Roon Lecturer, Scripps Clinic and Research Foundation, La Jolla, California, 1989 R(obert) Wayne Alexander 6 Guest Lecturer, The Orgain Symposium, Duke University, Durham, North Carolina, 1989 Association of University Cardiologists, 1990 Association of American Physicians, 1990 Honorary Life Member High Blood Pressure Research Council of Australia, 1994 First Honored Lecturer, Theodore Cooper Memorial Lectureship for Hypertension, Oschner Medical Foundation, New Orleans LA, 1994 Plenary Lecturer - European Cardiac Society/World Congress of Cardiology, Berlin, 1994 Chair, FASEB Conference on the Endothelium, 1994 Outstanding Doctors in America, 1995 Witham Lecturer - Medical College of Georgia, 1995 Vice President for Research American Heart Association, 1995-1997 Fellow, American Association for the Advancement of Science, 1995 American Clinical and Climatological Association, 1996 Plenary Lecturer - Japanese Hypertension Society, 1996 Plenary Lecturer - International Hypertension Society - Glasgow, 1996 Who's Who in America, 1996 President – Association of University Cardiologists, 1997 Russek Memorial Lecture – American College of Cardiology, New York Vascular Symposium, 1997 Session Chair - Angiotensin Gordon Conference, 1998 Plenary Lecturer - International Hypertension Society - Amsterdam, 1998 Plenary Lecturer - World Congress of Cardiology - Rio de Janeiro, 1998 Fellow, American Heart Association and the Council for High Blood Pressure Research, 2001 Plenary Lecture - Hellenic Cardiac Society, Athens, Greece, 2001 Session Chair - Keystone Symposium, 2002 Metzger Lecture - American Clinical and Climatological Association, 2002 Laennec Clinician/Educator Lecture - American Heart Association Scientific Sessions, Orlando FL, 2003 Plenary Lecture – Hellenic Cardiac Society, Athens, Greece, 2003 Honorary Citizen, City of Athens, Greece, 2004 Highly Cited Researcher - Thomson Scientific-ISI, 2004 Visiting Scholar, University of Arkansas for Medical Seiences, Central Arkansas Veterans Healthcare System, Division of Cardiovascular Medicine, Little Rock, AR, 2004 Plenary Lecture – "75 Years of Discovery in Cardiology" Symposium, Duke University, 2005 Lifetime Scholar of The Barton F. Haynes Society, Duke University, 2005 Invited Speaker, Gordon Conference on Angiotensin II, 2006 Fellow, American College of Physicians, 2007 Achievement in Technology and Innovation "Translating Ideas into Products" Emory Univ. 2007 First Keynote Lecture, Nuclear Cardiology Foundation Invitational Conf, Annapolis MD, 2008 President, American Clinical and Climatological Association, 2009 Emory University Millipub Club, 2009 Biomedical Community Award, 2011 17. Society Memberships: Angiotensin Gordon Conference, Session Chair, 1985 Alliance for Academic Internal Medicine (AAIM) American Association for Advancement in Science, 1995 American Association for Advancement of Science, Fellow, 1996 American Association of University Professors (AAUP) American Clinical and Climatological Association (ACCA), 1994 American College of Cardiology Fellow (ACC) Fellow, 1982 American College of Physicians (ACP), 1998 American College of Physicians Fellow (ACP), 2007 American Federation for Clinical Research, 1977 American Heart Association, 1976 R(obert) Wayne Alexander American Medical Association, 1986 American Society of Clinical Investigation, Physician-scientist, 1982 Association of American Physicians, 1990 Association of Professors of Medicine (APM) 1999 Association of University Cardiologists, President, 1997 Federation of American Societies for Experimental Biology Henderson Medical Society, 1981-1987 Honorary Life Member High Blood Pressures Research – Council of Australia, 1995 Massachusetts Affiliate, American Heart Association, 1976-1988 Massachusetts Medical Society, 1983-1988 Medical Association of Georgia (MAG), 2004 New York Academy of Sciences (NYAC), Fellow, 1996 North American Vascular Biology Association, 2005 Research American Heart Association, Vice President, 1995-1997 Richards Lecturer High Blood Pressure Research – Council of Australia, 1993 Southern Society for Clinical Investigation, 2004-present Theodore Cooper Memorial Lecture – Oschner Clinic, 1995 18. Organization of National or International Conferences; Sessions as Chair: Chairman, Gordon Conference on Angiotensin II, 1985. Chairman, FASEB Conference on the Endothelium, 1994. 19. Research focus: My research interests are the biology of blood vessels and the pathogenesis of vascular disease at the fundamental cell biology and clinical levels. A major focus has been on the mechanisms by which angiotensin II regulates blood vessel function. In particular, we are interested in the role of oxidative stress and vascular cell signaling at the basic and clinical levels. The general objectives have been to define molecular mechanisms involved in the pathogenesis of human disease and to develop new diagnostic and therapeutic approaches. 20. Patents: US No 5,380,747 Treatment of Atherosclerosis and Other Cardiovascular and Inflammatory Diseases US No 5,750,351 Treatment for Atherosclerosis and Other Cardiovascular and Inflammatory Diseases US No 5,846,959 Treatment of Atherosclerosis and Other Cardiovascular and Inflammatory Diseases US No 5,998,624 Haloisoquinoline Carboxamide. 21. Grant Support a. Active support, Federally funded: 1. Co-Investigator; UO1 HL80711-01 "Center for Translational Cardiovascular Nanomedicine" Project Total $67,642 8/20/2010-8/19/2015; (PI: Gang Bao) b. Previous Support (current position): 1. Co-investigator; NHLBI R29 HL38206 “Diacylglycerol signalling in vascular smooth muscle” $349,967; 4/1/87-3/30/92 2. Principal Investigator; NIH PO1 HL48667 “Initiating events in vascular lesion formation” $6,680,900; 9/30/92-8/31/97 3. Co-investigator; NHLBI RO1 HL38206 “Vascular smooth muscle phospholipase $486,890; 1/1/93-12/31/95 7 R(obert) Wayne Alexander 4. 5. 6. 7. 8. 9. 10. 22. 8 Principal Investigator; NHLBI RO1 HL47557 “Vascular angiotensin II receptors” $769,708; 2/1/92-1/31/96 Principal Investigator; T32 HL07745 NIH “Research Training in Academic Cardiology”, $1,208,664; 7/1/94-6/30/99 Principal Investigator; Whitaker Foundation “Cellular engineering at Emory and Georgia Tech” $225,000; 9/1/95-8/31/98 Principal Investigator; NSF (Ga. Tech. Sub-contract BES 961458000) “Tissue engineering – A blood vessel” $46,020; 2/1/98-4/30/99 Project Leader; NIH PO1 HL58000 “Molecular control of vascular function by oxidant stress” $836,968; 4/1/98-3/31/03 Co-investigator; NHLBI RO1 HL38206 “Role of vascular NADPH/NADH oxidases in vascular hypertrophy” $1,060,473; 7/1/96-6/30/01 Principal Investigator; NHLBI RO1 HL60728 "Angiotensin II receptor signaling domains” $901,261; 2/1/07-11/30/2010 Supervisory Teaching, Post-doctoral fellows directly supervised: J. Anderson, MD, PhD Bradford C. Berk, MD, PhD Quinn Capers, MD David C. Chappell, MSc, PhD Wilson S. Colucci, MD L. Van Crisco, MD Gilles De Keulenaer Patrick Delafontaine, MD Farshad Forouzandeh, MD, PhD Mitsuaki Fujimoto, PhD Peter. Ganz, MD John B. Gordon, MD Sharon Grant, PhD Kathy Griendling, PhD Stephen Gunther, MD Satoshi Ikeda, MD, PhD Nobukazu Ishizaka, MD, PhD Hisashi Kai, MD, PhD Bobby Khan, MD, PhD Bernard Lassegue, PhD Leonard Stuart Lilly, MD N. Marui, MD. PhD T. J. Murphy, PhD Rafal Nazarewicz, PhD K. Nishida, PhD Jeremy Ollerenshaw, PhD N. Scott, MD, PhD L. S. Socorro, PhD K. Takeuchi, MD, PhD Yan Tang, PhD Yoshihiro Taniyama, MD, PhD Mark Taubman W.R. Taylor, MD, PhD Minako Yamaoka-Tojo, MD,PhD Taiki Tojo, MD, PhD C.B. Treasure, MD T. Tsuda, MD, PhD Professor and Chair, Cell Biology, Yale University Senior VP Health Sciences, Univ of Rochester, Rochester NY Physician, Page-Campbell Cardiology, Vanderbilt University Instructor, Thames Valley University, UK Chief, Cardiology Medicine, Boston University Private Practice, Atlanta GA Professor of Physiology, Antwerp University, Belgium Chief of Cardiology, Tulane University Cardiology Fellow, PGY-4, Emory University Assistant Professor, Yamaguchi University, Japan Professor, Harvard University San Diego Cardiac Center, San Diego, CA Research Officer, Metabolic Pharmaceuticals, Ltd., Australia Professor, Emory University Associate Professor, Wayne State University, Detroit MI Assistant Professor, Nagasaki University, Nagasaki, Japan Assistant Professor, Tokyo University, Tokyo, Japan Associate Professor, Kurume University, Kurume City, Japan Assistant Professor, Emory University Assistant Professor, Emory University Professor, Harvard University Kyoto Prefectural University, Japan Associate Professor, Emory University Research Instructor, Vanderbilt University Medical Center Daiichi Pharmaceuticals, Tokyo Japan Senior Scientist, Cryolife, Atlanta Assistant Professor, Emory University Pharmaceutical Company, University of Cincinnati Assistant Professor, Tohoku University, Japan Postdoctoral Fellow, NHLBI Assistant Professor, Kinki University, Japan Professor and Chair, Dept of Medicine, Rochester University Professor, Emory University Assistant Professor, Kitazato University, Tokyo, Japan Assistant Professor, Kitazato University, Tokyo, Japan Assistant Professor, Emory University Assistant Professor, Kobe University, Hyogo, Japan R(obert) Wayne Alexander T. Tsujino, MD, PhD Prad E. Tummala, MD Masuko Ushio-Fukai Greg B. Wright, MD Shiqin Xiong, PhD Lian Zuo, PhD 23. 9 Research Associate, Kobe University, Hyogo, Japan Private Practice, Gainesville GA Assistant Professor, University of Illinois at Chicago Physician, Children's Heart Clinic, Minneapolis, Minnesota Postdoctoral Fellow, Emory University Postdoctoral Fellow, Emory University Lectureships, Seminar Invitations, Symposiums, and Visiting Professorships: Duke University Medical Center, Durham, North Carolina, Visiting Professor and Moderator “Duke Spring Cardiovascular Symposium” 1986 University of Texas, Southwestern Medical Center, Dallas, Texas; Visiting Professor, 1988 Mt. Sinai Medical Center, New York, New York; Visiting Professor, 1990 University of Tennessee, Knoxville, Visiting Professor; 1991 Kobe University, Kobe, Japan; Visiting Professor, 1992 University of Michigan; Pfizer Visiting Professor, 1993 Theodore Cooper Memorial Lectureship for Hypertension, Alton Ochsner Medical Foundation, New Orleans, LA, 1994 Ohio State University; Visiting Professor; 1995 Mt. Sinai Medical Center, New York, New York; Simon Dack Visiting Professor, 1995 Hanneman/Medical College of Pennsylvania; Pfizer Visiting Professor, 1997 Brigham & Women's Hospital, Boston MA; Astra Merck NE Visiting Professor of Medicine, 1998 UCLA, Los Angeles, California; Borun Visiting Professor of Medicine, 1999 Boston University Medical Center, Boston MA, Visiting Professor of Cardiology, 2000 Brigham & Women's Hospital, Boston MA; Laurence Green Visiting Professor, 2000 Cleveland Clinic Foundation, Cleveland Ohio, Visiting Professor, 2001 University of Iowa; Visiting Professor, 2002 American Clinical and Climatological Assn, Jeremiah Metzger Lecture, Visiting Professor, 2002 Laennec Society Lecture - American Heart Association Scientific Sessions, Orlando Fl, 2003 University of Virginia Health System, George A. Beller Cardiovascular Symposium, Visiting Professor, 2004 University of Tennessee, Memphis, Tennessee; Neuton S Stern Distinguished Visiting Professor, 2004 University of Arkansas for Medical Sciences, Little Rock, Arkansas; Visiting Professor, 2004 Louisiana State University, New Orleans, Louisiana, Visiting Professor, 2005 75 Years of Discovery in Cardiology Symposium, Duke University Medical Center, NC, 2005 Mt Sinai Medical Center, New York, New York, Visiting Professor, 2006 Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE): “Antioxidants & Vitamins”, 2007 Hypertension & CV Preventive Symposium, Greece, 2007 Ebert Visiting Professor, University of Arkansas, Little Rock, Arkansas, 2008 th 10 Anniversary Symposium, Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, 2008 GTEC Winter Symposium, “Plaque Imaging Biomarkers”, 2008 Greece Symposium, “Vascular Protection” & Commentator: “Current Research in Greece, 2008 LSU Medical Grand Rounds, “Diet & Exercise in Health & Disease: New Insights”, 2009 Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), "Cardiometabolic Disease: Update on Pathophysiology & Implications for Management, 2009 GA Tech Retreat, “Inflammation, the Immune System, and Regeneration”, 2009 Emory University Predictive Health Undergraduates, Nutrition Lecture, 2009 Southern Illinois University Grand Rounds, Sergio Rabinovich Distinguished Lecture, Springfield, Illinois, 2010 R(obert) Wayne Alexander 10 Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “The Optimal Diet to Prevent Atherosclerosis”, 2010 Emory Celebratory Medical Grand Rounds, 2010 Emory University Predictive Health Undergraduates, Nutrition Lecture, 2010 Emory GA Tech PEN PI Lecture, “Mediterranean Diet & Health”, 2010 Ordos Center Hospital, Inner Mongolia, China Visiting Professor, 2010 Dr. Michael A. Gimbrone Jr. Symposium, Harvard Medical School, “Endothelial Dysfunction and Vascular Disease”, 2011 AUC Emeritus Meeting, Lecturer-“Endothelial Dysfunction: A 25 Year Perspective”, 2011 Emory Celebratory Medical Grand Rounds, 2011 Emory DOM Faculty Research Day, “Research in DOM”, 2011 Emory University Predictive Health Undergraduates, Nutrition Lecture, 2011 Association of Professors of Medicine (APM), Moderator, “Value vs. Quality”, 2012 American Clinical and Climatological Association (ACCA), Presidential Address, 2012 Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “New Insights into the Role of Exercise and Supplements in CV Health”, 2012 Association of University Cardiologists (AUC), “Optimizing Paracrine Effects of Stem Cells Using Cellular Encapsulation Strategies for Regenerative Medicine”, 2012 Emory University Eighth Annual Symposium on Predictive Heath, “Common Mechanisms of Multiple Diseases: Effects of Lifestyle”, 2012 Emory University Medical Grand Rounds, Faculty Meeting, 2012 Emory CV Research Institute, Moderator, 2013 Emory University Predictive Health Undergraduates, Nutrition Lecture, 2013 Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “Words from the Heart and Diet, Exercise, and Chronic Disease-Informing Therapy”, 2013 Formatted: Font: Bold, Underline 24. Invitations to National or International Conferences: European Cardiac Society/World Congress of Cardiology, Berlin, Plenary Lecturer, 1994 Japanese Hypertension Society, Plenary Lecturer, 1996 International Hypertension Society, Glasgow, Plenary Lecturer, 1996 International Hypertension Society, Amsterdam, Plenary Lecturer, 1998 World Congress of Cardiology, Rio de Janeiro, Plenary Lecturer, 1998 Gordon Research Conference, Ventura, CA, Leader, “Signaling of AT1 Receptors” discussion, and presenter, “Role of Caveolae in angiotensin II signaling.” 1998 The Sixth International Kawasaki Disease Symposium, Waikoloa, Hawaii; “Long-term Implications for the Endothelium” 1999 International Symposium, Galveston TX, "Coronary Thrombosis and Atherosclerosis: Update on Theories, Trials and Treatment" 1999 Hellenic Cardiac Society, Athens Greece, Plenary Lecturer, 2001 Gordon Research Conference, Ventura, CA, Leader, “AT1R signal transduction: intracellular pathways” discussion, 2001 Hellenic Cardiac Society, Athens Greece, Plenary Lecturer, 2003 International Meeting on Clinical Cardiology, Plenary Lecturer, Athens, Greece, 2004 Gordon Research Conference, Aussois,, France, Leader, “A functional role for the renin angiotensin system in T-lymphocytes” discussion, and presenter, "Oxidative signaling through c-Abl.", 2006 25. Bibliography: a. Published and accepted research articles (clinical, basic science, other) in refereed journals: 1. Pavone M, Alexander RW, Geering RB, Galletti PM. Parabiotic dialysis. Trans Amer Soc Artif Internal Organs 1964;10:285-291. R(obert) Wayne Alexander 2. Alexander RW, Galletti PM. The transfer of macromolecules in an artificial kidney. Trans Amer Soc Artif Internal Organs 1965;11:95-98. 3. Horwitz D, Alexander RW, Lovenberg W, Keiser HR. Human serum dopamineß-hydroxylase. Relationship to hypertension and sympathetic activity. Circ Res 1973;32:594-599. 4. Alexander RW, Gill JR, Yamabe H, Lovenburg W, Keiser HR. Effects of dietary sodium and acute saline infusion on the interrelationship between dopamine excretion and adrenergic activity in man. J Clin Invest 1974;54:194-200. 5. Margolius HS, Horwitz D, Geller RG, Alexander RW, Gill JR, Pisano JJ, Keiser HR. Urinary kallikrein excretion in normal man: Relationships to sodium intake and to sodium-retaining steroids. Circ Res 1974;35:812-819. 6. Brereton HD, Halushka PV, Alexander RW, Mason DM, Keiser HR, Devita VT. Indomethacin-responsive hypercalcemia in a patient with renalcell adenocarcinoma. N Engl J Med 1974;291:83-86. 7. Alexander RW, Kent KM, Pisano JJ, Keiser HR, Cooper T. Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart. J Clin Invest 1975;55:1174-1181. 8. Gimbrone M, Alexander RW. Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science 1975;189:219-220. 9. Alexander RW, Williams LT, Lefkowitz RJ. Identification of cardiac ß-adrenergic receptors by - [3H]alprenolol binding. Proc Nat Acad Sci 1975;72:1564-1568. 10. Alexander RW, Davis JN, Lefkowitz RJ. Direct identification and characterisation of ß-adrenergic receptors in rat brain. Nature 1975;258:437-440. 11. Alexander RW, Gimbrone MA. Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells. Proc Nat Acad Sci 1976;73:1617-1620. 12. Lefkowitz RJ, Mukherjee C, Limbird LE, Caron MG, Williams LT, Alexander RW, Mickey JV, Tate R. Regulation of adenylate cyclase coupled ß-adrenergic receptors. Recent Progress in Hormone Research 1976;32:597-632. 13. Alexander RW, Cooper B, Handin RI. Characterization of the human platelet alpha-adrenergic receptor. Correlation of [3H]-dihydroergocryptine binding with aggregation and adenylate cyclase inhibition. J Clin Invest 1978;61:1136-1144. 14. Cooper B, Handin RI, Young LH, Alexander RW. Agonist regulation of the human platelet alpha-adrenergic receptor. Nature 1978;274:703-706. 15. Schaffer AI, Alexander RW, Handin RI. Inhibition of platelet function by organic nitrate vasodilators. Blood 1980;55:649-654. 16. Colucci WS, Gimbrone MA, Alexander RW. Characterization of postsynaptic alpha-adrenergic receptors by [3H]-dihydroergocryptine binding in muscular arteries from the rat mesentery. Hypertension 1980;2:149-155. 11 R(obert) Wayne Alexander 17. Gunther S, Gimbrone MA, Alexander RW. Identification and characterization of the high affinity vascular angiotensin II receptor in rat mesenteric artery. Circ Res 1980;47:278-286. 18. Gunther S, Gimbrone MA, Alexander RW. Regulation by angiotensin II of its receptors in resistance blood vessels. Nature 1980;287:230-232. 19. Marsh JD, Barry WH, Neer EJ, Alexander RW, Smith TW. Evidence for uncoupling of the beta receptor-adenylate cyclase complex. Circ Res 1980;47:493-501. 20. Colucci WS, Gimbrone MA, Alexander RW. Regulation of the postsynaptic alpha-adrenergic receptor in rat mesenteric artery. Effects of chemical sympathectomy and epinephrine treatment. Circ Res 1981;48:104-111. 21. Anderson JM, Gimbrone MA, Alexander RW. Angiotensin II stimulates phosphorylation of myosin light chain in cultured vascular smooth muscle cells. J Biol Chem 1981;256:4693-4696. 22. Colucci WS, Alexander RW, Williams GH, Rude RE, Holman BL, Konstam MA, Wynne J, Mudge GH, Braunwald E. Decreased lymphocyte beta-adrenergicreceptor density in patients with heart failure and tolerance to the betaadrenergic agonist pirbuterol. N Engl J Med 1981; 305:185-190. 23. Colucci WS, Alexander RW, Mudge GH, Rude RE, Holman BL, Wynne J, Grossman W, Braunwald E. Acute and chronic effects of pirbuterol on left ventricular ejection fraction and clinical status in severe congestive heart failure. Am Heart J 1981;102:564-568. 24. Colucci WS, Williams GH, Alexander RW, Braunwald E. Mechanisms and implications of vasodilator tolerance in the treatment of congestive heart failure. Am J Med 1981;71:89-99. 25. Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH, Grossman W. Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. N Engl J Med 1981;305:1171-1175. 26. Ertl G, Kloner RA, Alexander RW, Braunwald E. Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor. Circulation 1982;65:40-48. 27. Gunther S, Alexander RW, Atkinson WJ, Gimbrone MA. Functional angiotensin II receptors in cultured vascular smooth muscle cells. J Cell Biol 1982;92:289298. 28. Wright GB, Alexander RW, Ekstein LS, Gimbrone MA. Sodium, divalent cations, and guanine nucleotides regulate the affinity of the rat mesenteric artery angiotensin II receptor. Circ Res 1982;50:462-469. 29. Mooney JJ, Horne WC, Handin RI, Schildkraut JJ, Alexander RW. Sodium inhibits both adenylate cyclase and high-affinity [3H]-labeled p-aminoclonidine binding to alpha2-adrenergic receptors in purified human platelet membranes. Mol Pharmacol 1982;21:600-608. 12 R(obert) Wayne Alexander 30. Colucci WS, Gimbrone MA, McLaughlin MK, Halpern W, Alexander RW. Increased vascular catecholamine sensitivity and alpha-adrenergic receptor affinity in female and estrogen-treated male rats. Circ Res 1982;50:805-811. 31. Alexander RW, Galper JB, Neer EJ, Smith TW. Non-coordinate development of beta-adrenergic receptors and adenylate cyclase in chick heart. Biochem J 1982;204:825-830. 32. Wright GB, Alexander RW, Ekstein LS, Gimbrone MA. Characterization of the rabbit ventricular myocardial receptor for angiotensin II: Evidence for two sites of different affinities and specificities. Mol Pharmacol 1983;24:213-221. 33. Ertl G, Alexander RW, Kloner RA. Interactions between coronary occlusion and the renin-angiotensin system in the dog. Basic Res Cardiol 1983;78:518-533. 34. Colucci WS, Brock TA, Gimbrone MA, Alexander RW. Regulation of alpha1adrenergic receptor-coupled calcium flux in cultured vascular smooth muscle cells. Hypertension 1984;6:I-19--I-24. 35. Ganz P, Gaspar J, Colucci WS, Barry WH, Mudge GH, Alexander RW. Effects of prostacyclin on coronary hemodynamics at rest and in response to cold pressor testing in patients with angina pectoris. Am J Cardiol 1984;53:1500-1504. 36. Larson DM, Fujiwara K, Alexander RW, Gimbrone MA. Heterogeneity of myosin antigenic expression in vascular smooth muscle in vivo. Lab Invest 1984;50:401407. 37. Colucci WS, Gimbrone MA Jr, Alexander RW. Regulation of myocardial and vascular alpha-adrenergic receptor affinity: Effects of guanine nucleotides, cations, estrogen and catecholamine depletion. Circ Res 1984;55:78-88. 38. Larson DM, Fujiwara K, Alexander RW, Gimbrone MA Jr. Myosin in cultured vascular smooth muscle cells: Immunofluorescence and immunochemical studies of alterations in antigenic expression. J Cell Biol 1984;99:1582-1589. 39. Colucci WS, Brock TW, Atkinson WJ, Alexander RW, Gimbrone MA Jr. Cultured vascular smooth muscle cells: An in vitro system for study of alpha-adrenergic receptor coupling and regulation. J Cardiovasc Pharmacol 1985;7(Suppl. 6):S79S86. 40. Berk BC, Brock TA, Webb RC, Taubman MB, Atkinson WJ, Gimbrone MA Jr, Alexander RW. Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction. J Clin Invest 1985;75:1083-1086. 41. Brock TA, Alexander RW, Ekstein LS, Atkinson WJ, Gimbrone MA Jr. Angiotensin increases cytosolic free calcium in cultured vascular smooth muscle cells. Hypertension 1985;7(Suppl. I):I-105--I-109. 42. Alexander RW, Brock TA, Gimbrone MA Jr, Rittenhouse SE. Angiotensin increases inositol triphosphate and calcium in vascular smooth muscle. Hypertension 1985;7:447-451. 43. Colucci WS, Brock TA, Gimbrone MA Jr, Alexander RW. Nonlinear relationship between alpha1- adrenergic receptor occupancy and norepinephrine-stimulated 13 R(obert) Wayne Alexander calcium flux in cultured vascular smooth muscle cells. Mol Pharmacol 1985;27:517-524. 44. Brock TA, Rittenhouse SE, Powers CW, Ekstein LS, Gimbrone MA Jr, Alexander RW. Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells. J Biol Chem 1985;260:14158-14162. 45. Lilly LS, Pratt RE, Alexander RW, Larson DM, Ellison KE, Gimbrone MA Jr, Dzau V. Renin expression by endothelial vascular cells in culture. Circ Res 1985;57:312-318. 46. Colucci WS, Gimbrone MA Jr, Alexander RW. Phorbol diester modulates alphaadrenergic receptor-coupled calcium efflux and alpha-adrenergic receptor number in cultured vascular smooth muscle cells. Circ Res 1986;58:393-398. 47. Colucci WS, Alexander RW. Norepinephrine-induced alteration in the coupling of alpha1-adrenergic receptor occupancy to calcium efflux in rabbit aortic smooth muscle cells. Proc Natl Acad Sci USA 1986;83:1743-1746. 48. Ganz P, Sandrock AW, Landis SC, Leopold J, Gimbrone MA Jr, Alexander RW. Vasoactive intestinal peptide: Vasodilatation and cyclic AMP generation. Am J Physiol 1986;250:H755-H760. 49. Berk BC, Alexander RW, Brock TA, Gimbrone MA Jr, Webb RC. Vasoconstriction: A new activity for platelet-derived growth factor. Science 1986;232:87-90. 50. Griendling KK, Rittenhouse SE, Brock TA, Ekstein LS, Gimbrone MA Jr, Alexander RW. Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem 1986;261:5901-5906. 51. Ganz P, Davies PF, Leopold JA, Gimbrone MA Jr, Alexander RW. Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: Effects on cyclic GMP production. Proc Natl Acad Sci USA 1986;83:3552-3556. 52. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-1051. 53. Presant CA, Russell WO, Alexander RW, Fu YS. Soft-Tissue and Bone Sarcoma Histopathology Peer-Review - the Frequency of Disagreement in Diagnosis and the Need for 2nd Pathology Opinions the Southeastern-Cancer-Study-Group Experience. Journal of Clinical Oncology. Nov 1986;4(11):1658-1661. 54. Berk BC, Aronow MS, Bock TA, Cragoe E Jr, Gimbrone MA Jr, Alexander RW. Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells: Evidence for protein kinase C- dependent and -independent pathways. J Biol Chem 1987;262:5057-5064. 55. Berk BC, Brock TA, Gimbrone MA Jr, Alexander RW. Early agonist-mediated ionic events in cultured vascular smooth muscle cells: Calcium mobilization is associated with intracellular acidification. J Biol Chem 1987;262:5065-5072. 14 R(obert) Wayne Alexander 56. Griendling KK, Delafontaine P, Rittenhouse SE, Gimbrone MA, Alexander RW. Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem 1987;262:14555-14562 57. Delafontaine P, Griendling KK, Gimbrone MA Jr, Alexander RW. Potassium depletion selectively inhibits sustained diacylglycerol formation from phosphatidylinositol in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem 1987;262:14549-14554. 58. Griendling KK, Berk BC, Alexander RW. Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells. J Biol Chem 1988;263:10620-10624. 59. Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW. Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112. 60. Nabel EG, Ganz P, Gordon JB, Alexander RW, Selwyn AP. Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation 1988;77:43-52. 61. Vallega GA, Canessa ML, Berk BC, Brock TA, Alexander RW. Vascular smooth muscle Na+-H+ exchanger kinetics and its activation by angiotensin II. Am J Physiol 1988;254(6 Pt1):C751-C758. 62. Fish RD, Nabel EG, Selwyn AP, Ludmer PL, Mudge GH, Kirshenbaum JM, Schoen FJ, Alexander RW, Ganz P. Responses of coronary arteries of cardiac transplant patients to acetylcholine. J Clin Invest 1988;81:21-31. 63. Berk BC, Canessa M, Vallega G, Alexander RW. Agonist-mediated changes in intracellular pH: Role in vascular smooth muscle cell function. J Cardiovas Pharmacol 1988;12(Suppl 5):S104-S114. 64. Berk BC, Vallega G, Griendling KK, Gordon JB, Cragoe EJ Jr, Canessa M, Alexander RW. Effects of glucocorticoids on Na+/H+ exchange and growth in cultured vascular smooth muscle cells. J Cell Physiol 1988;137:391-401. 65. Tsuda T, Griendling KK, Alexander RW. Angiotensin II stimulates vimentin 2+ phosphorylation via a Ca -dependent, protein kinase C-independent mechanism in cultured vascular smooth muscle cells. J Biol Chem 1988;263:19758-19763. 66. Stamler JS, Vaughan DE, Rudd A, Mudge GH, Kirschenbaum J, Young P, Alexander RW, Loscalzo J. Frequency of hypercholesterolemia after cardiac transplantation. Am J Cardiol 1988;62:1268-1272. 67. Taubman MB, Berk BC, Izumo S, Alexander RW, Nadal-Ginard B. Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation. J Biol Chem 1989;264:526-530. 68. Griendling KK, Tsuda T, Alexander RW. Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells. J Biol Chem 1989;264:8237-8240. 15 R(obert) Wayne Alexander 69. Gordon JB, Ganz P, Nabel EG, Fish RD, Zebede J, Mudge GH, Alexander RW, Selwyn AP. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest 1989;83:1946-1952. 70. Berk BC, Vallega G, Muslin AJ, Gordon HM, Canessa M, Alexander RW. Spontaneously hypertensive rat vascular smooth cells in culture exhibit increased growth and Na+/H+ exchange. [erratum appears in J Clin Invest 1989;84(6):2029] J Clin Invest 1989;83:822-829. 71. Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, Selwyn AP. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation 1989;80:458-465. 72. Socorro L, Alexander RW, Griendling KK. Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells. Biochem J 1990;265:799-807. 73. Tsuda T, Alexander RW. Angiotensin II stimulates phosphorylation of nuclear lamins via a protein kinase C-dependent mechanism in cultured vascular smooth muscle cells. J Biol Chem 1990;265:1165-1170. 74. Berk BC, Weintraub WS, Alexander RW. Elevation of C-reactive protein in "active" coronary artery disease. Am J Cardiol 1990;65:168-172. 75. Treasure CB, Vita JA, Cox DA, Fish RD, Selwyn AP, Alexander RW, Ganz P. Acute myocardial infarction with normal coronary arteries associated with acetylcholine-induced vasoconstriction in the absence of a positive ergonovine test. Am J Cardiol 1990;65:255-257. 76. Treasure CB, Vita JA, Cox DA, Fish RD, Gordon JB, Mudge GH, Colucci WS, Sutton MG, Selwyn AP, Alexander RW, Ganz P. Endothelium-dependent dilation of the coronary microvascular is impaired in dilated cardiomyopathy. Circulation 1990;81:772-779. 77. Vekshtein VI, Alexander RW, Yeung AC, Plappert T, Sutton MG, Ganz P, Selwyn AP, Bittl JA. Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis. Circulation 1990;82:2068-2074. 78. Lassègue B, Alexander RW, Clark M, Griendling KK. Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells: Regulation and localization. Biochem J 1991;276:19-25. 79. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 1991;351:233-236. 80. Delafontaine P, Bernstein KE, Alexander RW. Insulin-like growth factor I gene expression in vascular cells. Hypertension 1991;17:693-699. 81. Griendling KK, Taubman MB, Akers M, Mendlowitz M, Alexander RW. Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells. J Biol Chem 1991;266:15498-15504. 16 R(obert) Wayne Alexander 82. Delafontaine P, Lou H, Alexander RW. Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells. Hypertension 1991;18:742-747. 83. Corson MA, Alexander RW, Berk BC. 5-HT2 receptor mRNA is overexpressed in cultured rat aortic smooth muscle cells relative to normal aorta. Am J Physiol 1992;262(2 Pt1):C309-15. 84. Geiger RV, Berk BC, Alexander RW, Nerem RM. Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis. Am J Physiol (Cell Physiol) 1992;262:C1411-C1417. 85. Weintraub WS, Boccuzzi SJ, Brown CL, Cohen CL, Hirsch LJ, King SB, Alexander RW, and the Lovastatin Restenosis Trial Study Group. Background and methods for the lovastatin restenosis trial after percutaneous transluminal coronary angioplasty. Am J Cardiol 1992;70:293-299. 86. Teutsch B, Bihoreau C, Monnot C, Bernstein KE, Murphy TJ, Alexander RW, Corvol P, Clauser E. A recombinant rat vascular AT1 receptor confers growth properties to angiotensin II in Chinese hamster ovary cells. Biochem Biophys Res Commun 1992;187:1381-1388. 87. Treasure CB, Vita JA, Ganz P, Ryan TJ Jr, Schoen FJ, Vekshtein VI, Yeung AC, Mudge GH, Alexander RW, Selwyn AP, Fish DR. Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients. Circulation 1992;86:1156-1164. 88. Treasure CB, Manoukian SV, Klein JL, Vita JA, Nabel EG, Renwick GH, Selwyn AP, Alexander RW, Ganz P. Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients. Circ Res 1992;71:776-781. 89. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 1992;90:2092-2096. 90. Appelbe AF, Martin TD, Alexander RW, Martin RP. The thoracic aorta as a source of emboli and the role of transesophageal echocardiography in diagnosis. Emory Univ J Med 1992;6:121-123. 91. Taylor WR, Nerem RM, Alexander RW. Polarized secretion of IGF-I and IGF-I binding protein activity by cultured aortic endothelial cells. J Cell Physiol 1993;154:139-142. 92. Treasure CB, Klein JL, Vita, JA, Manoukian, SV, Renwick GH, Selwyn AP, Ganz P, Alexander RW. Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels. Circulation 1993;87:86-93. 93. Fath KA, Alexander RW, Delafontaine P. Abdominal coarctation increases insulin-like growth factor I mRNA levels in rat aorta. Circ Res 1993;72:271-277. 94. Rao GN, Lassègue B, Griendling KK, Alexander RW, Berk BC. Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C. Nucleic Acids Research 1993;21:1259-1263. 17 R(obert) Wayne Alexander 95. Mitsumata M, Fishel RS, Nerem RM, Alexander RW, and Berk BC. Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells. Am J Physiol 1993;265:H3-H8. 96. Rao GN, Lassègue B, Griendling KK, Alexander RW. Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid. Oncogene 1993;8:2759-2764. 97. Serruys PW, Klein W, Tijssen JPG, Rutsch W, Heyndrickx GR, Emanuelsson H, Ball SG, Decoster O, Schroeder E, Liberman H, Eichhorn E, Willerson JT, Anderson HV, Khaja F, Alexander RW, Baim D, Melkert R, van Oene JC, Gool RV. Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty; A multicenter randomized double-blind placebo-controlled trial. Circulation 1993;88:1588-1601. 98. Paxton WG, Runge M, Horaist C, Cohen C, Alexander RW, Bernstein KE. Immunohistochemical localization of rat angiotensin II AT1 receptor. Am J Physiol 1993;264:F989-F995. 99. Murphy TJ, Nakamura Y, Takeuchi K, Alexander RW. A cloned angiotensin receptor isoform from the turkey adrenal gland is pharmacologically distinct from mammalian angiotensin receptors. Mol Pharmacol 1993;44:1-7. 100. Hanson MC, Fath KA, Alexander RW, Delafontaine P. Induction of cardiac insulin-like growth factor I gene expression in pressure overload hypertrophy. Am J Med Sci 1993;306:69-74. 101. Tsuda T, Griendling KK, Ollerenshaw JD, Lassègue B, Alexander RW. Angiotensin-II- and endothelin-induced protein phosphorylation in cultured vascular smooth muscle cells. J Vasc Res 1993:30:241-249. 102. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell adhesion molecular-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993;92:18661874. 103. Taylor WR, Alexander RW. Autocrine control of wound repair by insulin-like growth factor I in cultured endothelial cells. Am J Physiol 1993;265:C801-C805. 104. Takeuchi K, Alexander RW, Nakamura Y, Tsujino T, Murphy TJ. Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene. Circ Res 1993;73:612-621. Lassègue B, Alexander RW, Clark M, Akers M, Griendling KK. Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells. Biochem J 1993;292:509-517. 105. 106. Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ. Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochimica et Biophysica Acta 1994;1218:413-420. 18 R(obert) Wayne Alexander 107. Rao GN, Griendling KK, Frederickson RM, Sonenberg N, Alexander RW. Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells. J Biol Chem 1994;269:7180-7184. 108. Rao GN, Lassègue B, Alexander RW, Griendling KK. Angiotensin II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth-muscle cells. Biochem J 1994;299:197-201. 109. Ziegler T, Alexander RW, Nerem RM. Effect of shear stress on the morphology and growth of endothelial cells co-cultured with smooth muscle cells. J Cell Physiol 1994;269;410-414. 110. Kai H, Griendling KK, Lassègue B, Ollerenshaw JD, Runge MS, Alexander RW. Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor. Hypertension 1994;24:523-527. 111. Delafontaine P, Ku L, Ververis JJ, Cohen C, Runge MS, Alexander RW. Epitope mapping of the alpha-chain of the insulin-like growth factor I receptor using antipeptide antibodies. J Mol Cell Cardiol 1994;26:1659-73. 112. Weintraub WS, Boccuzzi SJ, Klein JL, Kosinski AS, King SB, Ivanhoe R, Cedarholm JC, Stillabower ME, Talley JD, DeMaio SJ, O'Neill WW, Frazier JE, Cohen-Bernstein CL, Robbins DC, Brown CL, Alexander RW, and The Lovastatin Restenosis Trial Study Group. Lack of effect of lovastatin on restenosis after coronary angioplasty. N Engl J Med 1994;331:1331-1337. 113. Rao GN, Baas AS, Glasgow WC, Eling TE, Runge MS, Alexander RW. Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells. J Biol Chem 1994;269:3258632591. 114. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994;74:1141-1148. 115. Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, Zhang J, Boccuzzi SJ, Cedarholm JC and Alexander RW. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995;332:481-487. 116. Rao GN, Runge MS, Alexander RW. Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells. Biochimica et Biophysica Acta 1995;1265:67-72. 117. Khan BV, Parthasarathy SS, Alexander RW, Medford RM. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest 1995;95:1262-1270. 118. Ahmad M, Marui, N, Alexander RW, Medford RM. Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappaB enhancer motif. J Biol Chem 1995;270:8976-8983. 119. Rao GN, Alexander RW, Runge MR. Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-fos, c-jun, and c-myc mRNA 19 R(obert) Wayne Alexander expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. J Clin Invest 1995;96:842-847. 120. Lassègue B, Alexander RW, Nickenig G, Clark M, Murphy TJ, Griendling KK. Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: Evidence for homologous and heterologous regulation. Mol Pharmacol 1995;48:601-609 121. Ziegler T, Alexander RW, Nerem RM. An endothelial cell-smooth muscle cell coculture model for use in the investigation of flow effects on vascular biology. Annals of Biomedical Engineering 1995;23:216-225. 122. Ziegler T, Robinson KA, Alexander RW, Nerem RM. Co-culture of endothelial cells and smooth muscle cells in a flow environment: An improved culture model of the vascular wall? Cells & Materials 1995;5:115-124. 123. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 1995;269(Cell Physiol 38):C1371C1378. 124. Howard AB, Alexander RW, Taylor WR. Effects of magnesium on nitric oxide synthase activity in endothelial cells. Am J Physiol (Cell Physiol) 1995;269(3 Pt1):C612-C618. 125. Fukui T, Lassègue B, Kai H, Alexander RW, Griendling KK. Cytochrome b-558 -subunit cloning and expression in rat aortic smooth muscle cells. Biochimica et Biophysica Acta 1995;1231:215-219. 126. Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ. Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J Biol Chem 1996;271:13266-13272. 127. Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA 1996;93:9114-9119. 128. Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. Cyclic strain induces an oxidative stress in endothelial cells. Am J. Physiol-Cell Physiol 1997;272(41,2 Part 1):C421-C427. 129. th Capers Q 4 , Laursen JB, Fukui T, Rajagopalan S, Mori I, Lou P, Freeman BA, Berrington WR, Griendling KK, Harrison DG, Runge MS, Alexander RW, Taylor WR. Vascular thrombin receptor regulation in hypertensive rats. Circulation Research 1997;80:838-844. 130. Ishizaka N, De Leon H, Laursen JB, Fukui T, Wilcox JN, DeKeulenaer G, Griendling KK, Alexander RW. Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Circulation 1997;96:1923-9. 131. Ishizaka N, Alexander RW, Laursen JB, Kai H, Fukui T, Opperman M, Lefkowitz RJ, Lyons PR, Griendling KK. G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta: Regulation by angiotensin II and hypertension. J Biol Chem 1997;272:32482-32488. 20 R(obert) Wayne Alexander 21 132. Capers Q 4th, Alexander RW, Lou P, DeLeon H, Wilcox JN, Ishizaka N, Howard AB, Taylor WR. Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats. Hypertension 1997;30:1397-1402. 133. Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Research 1998;82:532-539. 134. De Keulenaer GW, Alexander RW, Ushio-Fukai, M, Ishizaka N, Griendling, KK. Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle. Biochem J 1998;329:653-657. 135. De Keulenaer GW, Chappell DC, Ishizaka N, Nerem RM, Alexander RW, Griendling KK. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: Role of a superoxide-producing NADH oxidase. Circ Res 1998;82:1094-1101. 136. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II: role in vascular smooth muscle cell hypertrophy. J Biol Chem 1998;273:15022-15029. 137. Ushio-Fukai M, Griendling KK, Akers M, Lyons PR, Alexander RW. Temporal dispersion of activation of phospholipase C-1 a nd - is oforms by angiotensin II G prote in s ubunits . J in vascular smooth muscle cells: role of q/11, 12, and Biol Chem 1998;273:19772-19777. 138. Kai H, Alexander RW, Ushio-Fukai M, Lyons PR, Akers M, Griendling KK. GProtein binding domains of the angiotensin II AT1A receptors mapped with synthetic peptides selected from the receptor sequence. Biochem J 1998;332(Part 3):781-787. 139. Ishizaka N, Griendling KK, Lassègue B, Alexander RW. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension 1998;32:459-466. 140. Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM. Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Circ Res 1998;83:952-959. 141. Ushio-Fukai M, Alexander RW, Akers M. Lyons PR, Lassègue B, Griendling KK. Angiotensin II receptor coupling to phospholipase D is mediated by the βγ subunits of heterotrimeric G proteins in vascular smooth muscle cells. Mol Pharmacol 1999;55:142-149. 142. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK. Reactive oxygen species mediate the activation of Akt/Protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 1999;274(32):22699-22704. 143. Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes P, Alexander RW, Harrison DG, Medford RM. Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the reninangiotensin system and atherosclerosis. Circulation 1999;100:1223-1229. R(obert) Wayne Alexander 144. Alexander RW. Treating hypertension: how low is optimal and does aspirin help? Current Hypertension Reports. 1999;1:59-61. 145. DeKeulenaer GW, Ushio-Fukai M, Yin Q, Chung AB, Lyons PR, Ishizaka N, Rengarajan K, Taylor WR, Alexander RW, Griendling KK. Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-α-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000;20:385-391. 146. Grant SL, Lassègue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander RW. Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells. Mol Pharm 2000;57:460-467. 147. Ushio-Fukai M, Griendling KK, Becker PL, Hilenski L, Halleran S, Alexander RW. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Atheroscler Thromb Vasc Biol 2001;21:489-495. 148. Ushio-Fukai M, Hilenski L, Santanam N, Becker PL, Ma Y, Griendling KK, Alexander RW. Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. J Biol Chem 2001;276:48269-48275. 149. Ahmad M, Zhang Y, Zhang Y, Papharalambus C, Alexander RW. Role of isoprenylcysteine carboxyl methyltranferase in tumor necrosis factor-α stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler Thromb Vasc Biol. 2002;22:759-764. 150. Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fujimoto M, Quinn MT, phox Pagano PJ, Johnson C, Alexander RW. Novel Role of gp91 -containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis. Circ Res 2002;91:1160-1167. 151. Taniyama Y, Weber DS, Rocic P, Hilenski L, Akers ML, Park J, Hemmings BA, Alexander RW, Griendling KK. Pyk2-and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Mol Cell Biol 2003;23:80198029. 152. Crist TB, Walsh RA, Alexander RW, Bremner WJ, Schafer AI, Swain JL, Thorner MO, Weisfeldt ML. Association of Professors of Medicine. The research community now and in the future: APM’s recommendations for NIH priorities. Am J Med 2003;114:710-713. 153. Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA, Alexander RW, Medford RM, Saxena U. AGI-1067: A multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. J Pharmacol Exp Ther 2003;305:1116-1123. 154. Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber DS, Alexander RW, Griendling KK. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am J Physiol/Cell Physiol 2004;287:C494-9. 22 R(obert) Wayne Alexander 155. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ Res 2004;95:276-283. 156. Tojo T, Ushio-Fukai M, Yamaoka-Tojo M, Ikeda S, Patrushev N, Alexander RW. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation 2005;111:2347-2355. 157. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW for the AMISTAD-II Investigators. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol 2005;45:1775-1780. 158. Papaharalambus C, Sajjad W, Syed A, Zhang C, Bergo MO, Alexander RW, Ahmad M. Tumor necrosis factor alpha stimulation of Rac1 activity Role of isoprenylcysteine carboxylmethyltransferase. J Biol Chem 2005;280:18790-6 159. Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: The AMISTAD-2 Trial. European Heart Journal 2006;27:2400-5. 160. Ashfaq S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS, Hooper WC, Vaccarino V, Alexander RW, Harrison DG, Quyyumi AA. Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults. Hypertension 2008;52:80-85. 161. Subramaniyam V, Waller EK, Murrow JR, Manatunga A, Lonial S, Kasirajan K, Sutcliffe D, Harris W, Taylor WR, Alexander RW, Quyyumi AA. Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves endothelial dysfunction and exercise capacity in patients with peripheral arterial disease. Am Heart J. 2009 Jul;158(1):53-60.e1. doi: 10.1016/j.ahj.2009.04.014 162. Xiong S, Salazar G, San Martin A, Ahmad M, Patrushev N, Hilenski L, Nazarewicz R, Ma M, Ushio-Fuki M, Alexander RW. PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drie Catalase Down-regulation and Vascular Hypertrophy. J Biol Chem 2009; 285: 2474-87. 163. Linzer M, Warde C, Alexander RW, et al. Part-Time Careers in Academic Internal Medicine: A Report from the Association of Specialty Professors Part-Time Careers Task Force on Behalf of the Alliance for Academic Internal Medicine. Academic Medicine. Oct 2009;84(10):1395-1400. 164. Park Y, Kim SB, Wang B, Alexander R. Wayne, et al. Individual Variation in Macronutrient Regulation Measured by Proton Magnetic Resonance Spectroscopy of Human Plasma. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. Jul 2009;297(1):R202-R209. 165. Nazarewicz R, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S, Alexander RW. Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes. J Biol Chem 2010; 286: 2886-95. 23 R(obert) Wayne Alexander b. 166. Xiong S, Salazar G, Patrushev N, Alexander RW. Fox01 Mediates an Autofeedback Loop Regulating SIRT 1 Expression. J Biol Chem 2011 Feb 18;286(7):5289-99. PMID: 21149440. 167. Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K, Brigham K, Hooper WC, Alexander RW, Jones DP, Quyyumi AA. Oxidative Stress Is Associated with Impaired Arterial Elasticity Atherosclerosis. 2011 Sep;218(1):90-5. doi: 10.1016/j.atherosclerosis.2011.04.033. Epub 2011 May 6. 168. Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L, Kavtaradze N, Uphoff I, Hooper C, Tangpricha V, Alexander RW, Brigham K, Quyyumi AA. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol. 2011 Jul 5;58(2):186-92. doi: 10.1016/j.jacc.2011.02.051. 169. Patel RS, Morris AA, Ahmed Y, Kavtaradze N, Sher S, Su S, Zafari AM, DinDzietham R, Waddy SP, Vaccarino V, Alexander RW, Gibbons G, Quyyumi AA. A genetic risk variant for myocardial infarction on chromosome 6p24 is associated with impaired central hemodynamic indexes. Am J Hypertens. 2012 Jul;25(7):797-803. doi: 10.1038/ajh.2012.41. Epub 2012 Apr 19. 170. Mavromatis K, Aznaouridis K, Al Mheid I, Veledar E, Dhawan S, Murrow JR, Forghani Z, Sutcliffe DJ, Ghasemzadeh N, Alexander RW, Taylor WR, Quyyumi AA. Circulating proangiogenic cell activity is associated with cardiovascular disease risk. J Biomol Screen. 2012 Oct;17(9):1163-70. Epub 2012 Aug 10. 171. Mavromatis K, Sutcliffe DJ, Joseph G, Alexander RW, Waller EK, Quyyumi AA, Taylor WR. Proangiogenic cell colonies grown in vitro from human peripheral blood mononuclear cells. J Biomol Screen. 2012 Oct;17(9):1128-35. Epub 2012 Aug 17. 172. Xiong S, Salazar G, Patrushev N, Ma M, Forouzandeh F, Hilenski L, Alexander RW. Peroxisome Proliferator-Activated Receptor ү Coactivator-1αIs a Central Negative Regulator of Vascular Senescence. Arterioscler Thromb Vasc Biol 2013 Feb 21 [Epub ahead of print]; 33: 988-998. PMID: 23430617. Review articles: 1. Griendling KK, Berk BC, Ganz P, Gimbrone MA Jr, Alexander RW. Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State-ofthe-Art Lecture. Hypertension 1987;9(Suppl III):III-181--III-185. 2. Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW. Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112. 3. Berk BC, Canessa M, Vallega G, Alexander RW. Agonist-mediated changes in intracellular pH: Role in vascular smooth muscle cell function. J Cardiovasc Pharmacol 1988;12:S104-S114. 4. Berk BC, Alexander RW. Vasoactive effects of growth factors. Biochem Pharm 1989;38:219-225. 5. Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II stimulation of vascular smooth muscle. J Cardiovas Pharmacol 1989;14(Suppl 6):S27-S33. 24 R(obert) Wayne Alexander 6. Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II-stimulation of vascular smooth muscle cells. Secondary signalling mechanisms. Am J Hypertens 1989;2:659-665. 7. Berk BC, Gordon JB, Alexander RW. Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty. J Am Clg Cardiol 1991;17(6 Suppl B):111B-117B 8. Bernstein KE, Alexander RW. Counterpoint: Molecular analysis of the angiotensin II receptor. Endoc Rev 1992;13:381-386. 9. Murphy TJ, Takeuchi K, Alexander RW. Molecular cloning of AT1 angiotensin receptors. Am J Hypertens 1992;5:236S-242S. 10. Griendling KK, Alexander RW. The angiotensin (AT1) receptor. Semin Nephrol 1993;13:558-566. 11. Nerem RM, Harrison DG, Taylor WR, Alexander RW. Hemodynamics and vascular endothelial biology. J Cardiovasc Pharmacol 1993;21(Suppl 1):S6-S10. 12. Treasure CB, Alexander RW. The dysfunctional endothelium in heart failure. J Am Clg Cardiol 1993;22(4 Suppl A):129A-134A. 13. Griendling KK, Murphy TJ, Alexander RW. Molecular biology of the reninangiotensin system. Circulation 1993;87:1816-1828. 14. Berk BC, Alexander RW. Regulation of Intracellular pH and cell volume. Hypertension Primer 1993; Chapter A26. 15. Griendling KK, Lassègue B, Alexander RW. The vascular angiotensin (AT1) receptor. Thromb Haemost 1993;70:188-192. 16. Griendling KK, Lassègue B, Murphy TJ, Alexander RW. Angiotensin II receptor pharmacology. Adv Pharmacol 1994;28:269-306. 17. Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis: Oxidative stress and the mediation of arterial inflammatory response: A new perspective. Hypertension 1995:25:155-161. 18. Alexander RW. Investigative Developments in Atherosclerosis Introduction by the Guest Editor. Cardiovasc Drugs Ther 1995;9:9-11. 19. Treasure CB, Alexander RW. Relevance of vascular biology to the ischemic syndromes of coronary atherosclerosis. Cardiovas Drugs Ther 1995;9:13-19. 20. Griendling KK, Alexander RW. Endothelial control of the cardiovascular system: Recent advances. FASEB J 1996;10:283-292. 21. Chobanian AV, Alexander RW. Exacerbation of atherosclerosis by hypertension: Potential mechanisms and clinical implications. Arch Intern Med 1996;156:19526. 22. Griendling KK, Lassègue B, Alexander RW. Angiotensin receptors and their therapeutic implications. Annu Rev Pharmacol Toxicol 1996;36:281-306. 25 R(obert) Wayne Alexander 23. Alexander RW, Griendling KK. Signal transduction in vascular smooth muscle. J Hypertension 1996;14:(5)S51-S54. 24. Griendling KK, Ushio-Fukai M, Lassègue B, Alexander RW. Angiotensin II signaling in vascular smooth muscle: New concepts. State-of-the-Art Lecture. Hypertension 1997;29(1 Pt 2):366-373. 25. Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR. The study of the influence of flow on vascular endothelial biology. Am J Med Sci 1998;316(3):169-175. 26. Alexander RW. Atherosclerosis as disease of redox-sensitive genes. Trans Am Clin Climatol Assoc 1998;109:129-145; discussion 145-146. 27. Hurst JW, Morris, DC, Alexander RW. The use of the New York Heart Association’s classification of cardiovascular disease as part of the patient’s complete Problem List. Clin Cardiol 1999;22:385-390. 28. Alexander RW, Dzau VJ. Vascular Biology: The Past 50 Years. Circulation 2000;102(20 Suppl 2):IV112-IV116. 29. Alexander RW. The Jeremiah Metzger Lecture. Pathogenesis of atherosclerosis: redox as a unifying mechanism. Trans Am Clin Climatol Assoc 2003;114:273304. 30. Alexander RW, Franciosa JA. Background and overview of a symposium to update the biology of atherosclerosis and Its Implications for treatment strategies. Am J Cardiol 2003;91(3A):1A-2A. 31. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F. Markers of inflammation and cardiovascular Disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107:499-511. 32. Ushio-Fukai M, Alexander RW. Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem 2004;264:85-97. 33. Ushio-Fukai M, Alexander RW. Caveolin-dependent angiotensin II type 1 receptor signaling in vascular smooth muscle. Hypertension 2006;48:797-803. 34. Alexander RW. President's address. Common mechanisms of multiple diseases: why vegetables and exercise are good for you. Trans Am Clin Climatol Assoc. 2010;121:1-20. No abstract available. 35. Linzer M, Warde C, Alexander RW, Demarco DM, Haupt A, Hicks L, Kutner J, Mangione CM, Mechaber H, Rentz M, Riley J, Schuster B, Solomon GD, Volberding P, Ibrahim T; Part-time careers in academic internal medicine: a report from the association of specialty professors part-time careers task force on behalf of the alliance for academic internal medicine. Association of Specialty Professors Part-Time Careers Task Force. Acad Med. 2009 Oct;84(10):1395400. doi: 10.1097/ACM.0b013e3181b6bf8c. 26 R(obert) Wayne Alexander c. Symposium contributions: 1. Ganz P, Alexander RW. New insights into the cellular mechanisms of vasospasm. A Symposium: Experimental and Clinical Aspects of Coronary Vasoconstriction. Am J Cardiol 1985;56:11E-15E. 2. Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW. Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112. 3. Ollerenshaw JD, Lassegue B, Alexander RW, Griendling KK. Intracellular Signaling in Arteries and Vascular Smooth-Muscle Cells in Culture. 3rd International Symp On Resistance Arteries, Rebild, Denmark, 1991;974 4. Nerem RM, Mitsumata M, Ziegler T, Berk BC, Alexander RW. Mechanical-Stress Effects on Vascular Endothelial-Cell Growth. Tissue Engineering: Current Perspectives, Tissue Engineering Meeting, Keystone, CO, 1993. 5. Nerem RM, Harrison DG, Taylor WR, Alexander RW. Hemodynamics and Vascular Endothelial Biology. Satellite Symp On Vascular Remodeling, at the 2nd International Symp on Endothelium-Derived Vasoactive Factors. Journal of Cardiovascular Pharmacology. 1993;21:S6-S10. 6. Treasure CB, Alexander RW. The Dysfunctional Endothelium in Heart-Failure. Symposium on Mechanisms and Management of Heart Failure: Implications of Clinical Trials for Clinical Practice. Journal of the American College of Cardiology. Oct 1993;22(4):A129-A134. 7. Treasure CB, Alexander RW. Relevance of Vascular Biology to the Ischemic Syndromes of Coronary Atherosclerosis. 5th International Symposium on Cardiovascular Pharmacotherapy. Cardiovascular Drugs and Therapy. Jan 1995;9:13-19. 8. Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR. The Study of the Influence of Flow on Vascular Endothelial Biology. Symposium on Cellular Deformation: Mechanics and Mechanisms of Physiologic Response. American Journal of the Medical Sciences. Sep 1998;316(3):169-175. 9. Varner SE, Alexander RW, Medford RM, Nerem RM. Endothelial Vcam-1 Gene Regulation by Steady and Oscillatory Shear Stress. In: Jacotot B, Mathe D, Fruchart JC, eds. Atherosclerosis XI. 1998;1155:957-961. 10. Grant SL, Lasseegue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander RW. Specific Regulation of Rgs2 Messenger Rna by Angiotensin II in Cultured Vascular Smooth Muscle Cells. Experimental Biology Meeting. Molecular Pharmacology. Mar 2000;57(3):460-467. 11. Franciosa JA, Alexander RW, Guest Editors. A Symposium: Biology of Atherosclerosis and Its Implications for Treatment Strategies. American Journal 27 R(obert) Wayne Alexander of Cardiology Supplement based on the AtheroGenics Scientific Symposium held March 16, 2002. Am J Cardiol 2003;91(3A):1A-53A. 12. d. Myers GL, Rifai N, Tracy RP, Roberts WL, Alexander RW, Biasucci LM, Catravas JD, Cole TG, Cooper GR, Khan BV, Kimberly MM, Stein EA, Taubert KA, Warnick GR, Waymack PP. CDC/AHA Workshop on markers of inflammation and cardiovascular disease: application to clinical and public health practice: report from the Laboratory Science Discussion Group. Circulation 2004;110:e545-e549. Book chapters: 1. Lovenberg W, Bruckwick EA, Alexander RW, Horwitz D, Keiser HR. Evaluation of serum dopamine-ß-hydroxylase activity as an index of sympathetic nervous activity in man. In: Usdin E (ed.). Neuropsychopharmacology of Monoamines and Their Regulator Enzymes New York: Raven Press, 1974. 2. Gimbrone MA Jr, Alexander RW. Prostaglandin production by human vascular endothelium and smooth muscle in culture. In: Silber MJ (ed.). Proceedings of the International Symposium on Prostaglandin in Hematology New York: Spectrum Publishers, 1977;121-134. 3. Alexander RW. Hormone receptors in cultured vascular smooth muscle. In: Bevan JA, Godfraind T, Maxwell RA, Vanhouette P (eds.). Vascular Neuroeffector Mechanisms. New York: Raven Press, 1980;15-16. 4. Wright GB, Alexander RW, Gimbrone MA Jr. Cardiovascular angiotensin receptors. In: Receptor Science in Cardiology Mt. Kisco, New York: Futura Publishers, 1984;163-203. 5. Alexander RW. Adrenergic receptors in cardiovascular disease. In: Insel PA (ed.). Adrenergic Receptors in Man New York: Marcel Dekker, 1986. 6. Gimbrone MA Jr, Alexander RW. Vasoactive hormone receptor expression in cultured vascular smooth muscle cells. In: Campbell JH, Campbell GR (eds.). Vascular Smooth Muscle in Culture CRC Press, 1986. 7. Griendling KK, Alexander RW. Angiotensin, other pressor and the transduction of vascular smooth muscle contraction. In: Hypertension: Pathophysiology, Diagnosis and Management Laragh JH and Brenner BM (eds.). New York: Raven Press, 1989, Chapter 38. 8. Alexander RW, Griendling KK. Blood Vessels. In: Frohlich ED, Kotchen TA. (eds.) Advances in Hypertension Philadelphia: J.B. Lippincott, 1991;49-88. 9. Berk BC, Alexander RW. Biology of the vascular wall in hypertension. In: Brenner BM (ed) Brenner & Rector’s The Kidney, 4th Edition. Saunders, 1991 10. Ollerenshaw JD, Lassègue B, Alexander RW, Griendling KK. Intracellular signalling in arteries and vascular smooth muscle cells in culture. In: Mulvany MJ, Aalkjaer C, Heagerty AM, Nyborg NCB, Strandgaard S, (eds.) Resistance Arteries, Structure and Function Amsterdam: Elsevier, 1991; Excerpta Medica 974:73-76. 11. Griendling KK, Alexander RW. Cloning of the angiotensin AT-1 receptor and its expression in cardiac tissue. In: Lindpainter K and Ganten D, eds. The Cardiac 28 R(obert) Wayne Alexander Renin-Angiotensin System, Mount Kisco, NY: Futura Publishing Company, 1993, pp. 89-100. 12. Griendling KK, Alexander RW. Renin-angiotensin system: cellular mechanisms of angiotensin II action. In: Swales, JD (eds.) Textbook of Hypertension, Oxford: Blackwell, 1994, pp 244-253. 13. Alexander RW. Dyspnea and fatigue. In: Schlant, RC and Alexander, RW (eds.) Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994, Chapter 20, pp 469474. Translated into Spanish. 14. Griendling KK, Alexander RW. Cellular biology of blood vessels. In: Schlant, RC and Alexander, RW (eds.) Hurst's The Heart, 8th ed. New York McGraw-Hill, 1994, Ch 2, pp 31-45. Translated into Spanish. 15. Alexander RW. The coronary ischemic syndromes: Relationship to the biology of atherosclerosis. In: Schlant RC, Alexander RW (eds.) Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994, Chapter 56, pp 1021-1031. Translated into Spanish. 16. Schlant RC, Alexander RW. Diagnosis and management of chronic ischemic heart disease. In Schlant RC, Alexander RW (eds.) Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994; Chapter 58, pp 1055-1082. Translated into Spanish. 17. Roberts R, Morris D, Pratt C, Alexander RW. Pathophysiology, recognition, and treatment of acute myocardial infarction and its complications. In Schlant RC, Alexander RW (eds.) Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994, Chapter 60, pp 1107-1184. Translated into Spanish. 18. Lassègue B, Griendling KK, Alexander RW. Molecular biology of angiotensin II receptors. In: Saavedra JM and Timmermans PBUWM, (eds.) Angiotensin Receptors, New York: Plenum Press, 1994, Chap 17. 19. Griendling KK, Alexander RW. Angiotensin, other pressors and the transduction of vascular smooth muscle contraction. In: Laragh JH and Brenner BM, (eds.) Hypertension: Pathophysiology, Diagnosis and Management, 2nd edn. New York: Raven Press, 1994. 20. Griendling KK, Alexander RW. Cellular Mechanisms of Angiotensin II Action. In: Swales, JD. Textbook of Hypertension, Oxford: Blackwell, 1994, Chapter 11, pp 244-253. 21. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension: Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, Vol 1 Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed). Philadelphia: Current Medicine, 1995, Chapter 4, pp 4.1-4.15. 22. Berk BC, Alexander RW. Biology of the vascular wall in hypertension. In: Brenner BM (ed) Brenner & Rector’s The Kidney, 5th edn, Vol II. Saunders, 1996, Chapter 45, pp 2049-2070. 23. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension: Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, 2nd 29 R(obert) Wayne Alexander edn, Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed). Philadelphia: Current Medicine, 1998, Chapter 4, pp 4.1-4.18. 24. Griendling KK, Alexander RW. Cellular biology of blood vessels. In Hurst's The Heart, 9th edn. New York: McGraw Hill, 1998, Chapter 4, pp 125-141. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 25. Alexander RW, Griendling KK. Coronary ischemic syndromes: Relationship to the biology of atherosclerosis. In Hurst's The Heart, 9th edn. New York: McGraw Hill, 1998, Chapter 44, pp 123-1274. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 26. Schlant RC, Alexander RW. Diagnosis and management of patients with chronic ischemic heart disease. In Hurst's The Heart, 9th edn. New York: McGraw Hill, 1998, Chapter 45, pp 1275-1305. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 27. Alexander RW, , Pratt CM, Roberts R. Diagnosis and management of patients with acute myocardial infarction. In Hurst's The Heart, 9th edn. New York: McGraw Hill, 1998, Chapter 47, pp 1345-1433. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 28. Schlant RC, Alexander RW. Stable Angina Pectoris. In Alexander RW, Schlant RC, Fuster V, et al., (eds.) Hurst's The Heart Companion Handbook, 9th edn. New York: McGraw Hill, 1999. Chapter 8, pp 135-152. Translated into: Chinese Short Form, Greek, Italian, Portuguese, Russian, Spanish and Turkish. 29. Alexander RW. Diagnosis and Management of Patients with Acute Myocardial Infarction. In Alexander RW, Schlant RC, Fuster V, et al, (eds) Hurst's The Heart Companion Handbook, 9th edn. New York: McGraw Hill, 1999. Chapter 10, pp 161-214. Translated into: Chinese Short Form, Greek, Italian, Portuguese, Russian, Spanish and Turkish. 30. Alexander RW, Branch WT Jr. Episodic Chest Discomfort, in Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, eds. Cardiology in Primary Care. New York: McGraw-Hill, 2000. Chapter 2, pp 9-20. 31. Alexander RW. Dyspnea and Fatigue, in Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, eds. Cardiology in Primary Care. New York: McGraw-Hill, 2000. Chapter 3, pp 21-27. 32. Alexander RW, Roberts DL. Acute Myocardial Infarction and Unstable Angina, in Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, eds. Cardiology in Primary Care. New York: McGraw-Hill, 2000. Chapter 26, pp 311-354. 33. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension: Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, 3rd edn, Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed). Philadelphia: Current Medicine, 2001, Chapter 4, pp 80-99. 34. Griendling KK, Harrison, DG, Alexander RW. Molecular and Cellular Biology of Blood Vessels. In Fuster V, Alexander RW, O’Rourke RA, et al (eds.) Hurst’s The Heart, 10th edn. New York: McGraw Hill, 2001, Chapter 6, pp 127-145. Translated into: Chinese Short Form, Greek, Italian, Spanish and Turkish. 30 R(obert) Wayne Alexander e. 35. Alexander RW, Pratt, Ryan TJ, Roberts R. Diagnosis and Management of Patients with Acute Myocardial Infarction. In Fuster V, Alexander RW, O’Rourke RA, et al (eds.) Hurst’s The Heart, 10th edn. New York: McGraw Hill, 2001, Chapter 42, pp 1275-1359. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 36. Alexander RW, Pratt CM, Ryan TJ, Roberts R. Diagnosis and Management of Patients with Acute Myocardial Infarction. In O’Rourke RA, Fuster V, Alexander RW, et al (eds.) Hurst's The Heart Manual of Cardiology, 10th edn, New York: McGraw Hill, 2001. Chapter 15, pp 277-325. Translated into: Chinese Short Form, Greek, Italian, Portuguese, Russian, Spanish, and Turkish. 37. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension: Vascular Mechanisms. In Hollenberg NK (Ed) Atlas of Hypertension, 4th edn. Philadelphia, Current Medicine, 2003, Chapter 4, pp 85-107. 38. Alexander RW, Ryan TJ, Pratt CM, Roberts R. ST-Segment-Elevation Myocardial Infarction: Clinical Presentation, Diagnostic Evaluation, and Medical Management. In Fuster V, Alexander RW, O’Rourke RA, et al (eds). Hurst’s The Heart, 11th edn. New York: McGraw Hill. 2004, Chapter 52, pp 1277-1349 39. Griendling KK, Harrison DG, Alexander RW. Molecular and Cellular Biology of Blood Vessels. In Fuster V, Alexander RW, O’Rourke, et al (eds.) Hurst’s The Heart, 11th edn. New York: McGraw Hill. 2004, Chapter 7, pp 135-154. 40. Alexander RW, Ryan TJ, Pratt CM, Roberts R. Diagnosis and Management of Patients with ST-Segment-Elevation Myocardial Infarction. In O’Rourke RA, Fuster V, Alexander RW, et al (eds). Hurst’s The Heart Manual of Cardiology, 11th edn. New York: McGraw Hill, 2005, Chapter 16 pp 251-285. 41. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension: Vascular Mechanisms. In Hollenberg NK (ed) Atlas of Hypertension, 5th edn. Philadelphia, Current Medicine, 2005, Chapter 4, pp 87-109. 42. Ushio-Fukai M, Alexander RW. Redox State and Regulation of Angiogenic Responses. In Simons M, Rubanyi GM (Eds) Modern Concepts in Angiogenesis. London, Imperial College Press. 2007, Chapter 8, pp 217-252. 43. Griendling KK, Harrison DG, Alexander RW. Biology of the Vessel Wall. In Fuster V, O’Rourke RA, Walsh RA, et al (eds) Hurst’s The Heart, 12th edn. McGraw-Hill, New York, 2008. Chapter 7, pp 135-154. 44. Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of hypertension: Vascular Mechanisms: Hollenberg NK, Braunwald,E (eds.). Atlas of Hypertension, 6th edn. New York: Springer, 2009. Books edited: 1. Schlant RC, Alexander RW, (eds.) Hurst's The Heart, 8th edn. New York: McGraw Hill, 1994. Translated into Spanish. 2. Schlant RC, Alexander RW, (eds.) Hurst's The Heart Companion Handbook, 8th edn. New York: McGraw Hill, 1994. Translated into Spanish. 3. Schlant RC, Alexander RW, Lipton MJ (eds.) Diagnostic Atlas of the Heart. New York, McGraw-Hill, 1996. International Edition, 1996. 31 R(obert) Wayne Alexander 4. Alexander RW, Schlant RC, Fuster V, (eds.) Hurst's The Heart, 9th edn. New York: McGraw Hill, 1998. Translated into: Chinese Short Form, Greek, Italian, Spanish and Turkish. 5. Alexander RW, Schlant RC, Fuster V, O'Rourke R, Roberts R, Sonnenblick E, (eds.) Hurst's The Heart Companion Handbook, 9th edn. New York: McGraw Hill, 1999. Translated into: Chinese Short Form, Greek, Italian, Portuguese, Russian, Spanish and Turkish. 6. Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, (eds). Cardiology in Primary Care. New York: McGraw-Hill, 2000. 7. Fuster V, Alexander RW, O’Rourke RA, et al (eds.) Hurst’s The Heart, 10th edn. New York: McGraw Hill, 2001. Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish. 8. O’Rourke RA, Fuster V, Alexander RW, et al (eds.) Hurst's The Heart Manual of Cardiology, 10th edn, New York: McGraw Hill, 2001. Translated into: Chinese Short Form, Greek, Italian, Portuguese, Russian, Spanish, and Turkish. 9. Fuster V, Alexander RW, O’Rourke RA, et al (eds) Hurst’s The Heart 11th edn. New York: McGraw Hill 2004. Translated into: Italian. 10. O’Rourke RA, Fuster V, Alexander RW, et al (eds.) Hurst’s The Heart Manual of Cardiology 11th edn. New York: McGraw Hill, 2005. Translated into: Italian and Spanish. f. 1. Other publications: Alexander RW, Handin RI. Agonist regulation of alpha-adrenergic receptor numbers (Reply to Ltr to Editor). Nature 1979;279:170. 2. Handin RI, Alexander RW. Humoral heartache – Do platelets have a role? (Editorial) N Engl J Med 1981;304:1035-1036. 3. Alexander RW. Inflammation and coronary artery disease. (Editorial) N Engl J Med 1994;331:468-469. 4. de Gasparo M, Husain A, Alexander W, Catt KJ, Chiu AT, Drew M, Goodfriend T, Harding JW, Inagami T, Timmermans PB. Proposed update of angiotensin receptor nomenclature. Hypertension 1995; 25:924-927. 5. Alexander RW. The vessel wall (Editorial). Am J Cardiol 1995;75:63B-64B. 6. Griendling KK, Alexander RW. Oxidative stress and cardiovascular disease (Editorial). Circulation 1997;96:3264-3265. 7. Alexander RW. Cytokine receptor CX3CR-1 and fractalkine: New factors in the atherosclerosis drama? (Editorial) Circ Res 2001;89:376-7. 8. Alexander RW. Oxidized LDL autoantibodies, endothelial dysfunction, and transplant-associated arteriosclerosis (Editorial). [Erratum appears in Arterioscler Thromb Vasc Biol 2003;23:363] Arterioscler Thromb Vasc Biol 2002;22:1950-1951. 32 R(obert) Wayne Alexander 9. Alexander RW: Middle-aged women and men have a very high residual lifetime risk for developing hypertension. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/amed/hurst/ex_editorials/ edl1029_p01.html, March 18 2002 10. Alexander RW: Relationship between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/server-java/Arknoid/ amed/hurst/ex_editorials/edl1042_p01.html, April 17, 2002 11. Alexander RW: Diffuse coronary inflammation and unstable angina. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/amed/ hurst/ex_editorials/edl1118_p01.html, August 6, 2002 12. Patel S, Alexander RW: Black-blood coronary MRA can evaluate early stages of atherosclerosis. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/ serverjava/Arknoid/amed/hurst/ex_editorials/edl1128_p01.html, August 22 2002 13. Alexander RW: Obesity, congestive heart failure, and inflammation. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/ amed/hurst/ex_editorials/edl1137_p01.html, September 5, 2002 14. Alexander RW: Inflammation, infection, and coronary artery disease. Hurst's The Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/ amed/hurst/ex_editorials/edl1146_p01.html, September 10, 2002 15. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui MH, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F, American Heart Association. Inflammatory markers in coronary heart disease: Coronary Vascular versus myocardial origin? (Reply to Ltr to Editor) Circulation 2003;108:e4. 16. Alexander RW. Getting stents to go with the flow (Editorial). J Clin Invest 2004;113:1532-4. 17. Alexander RW. Leukocyte and endothelial angiotensin II type 1 receptors and micro-vascular thrombotic and Inflammatory responses to hypercholesterolemia (Editorial). Arterioscler Thromb Vasc Biol 2006;26:240-1 18. Alexander RW. Memorial: R. Bruce Logue MD. Trans Am Clin Climatol Assoc 2008 119:xc-xcii. 33
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