Spatially Resolved Spectroscopy: toward release in real time Workshop directed by Dr. Fabien CHAUCHARD INDATECH Dr. Fabien CHAUCHARD [email protected] Dr. Fabien CHAUCHARD [email protected] Spatially Resolved Spectroscopy: Theoretical and chemometrics implementation for PAT (May 6th - 9am to 11am) Workshop EUROPACT 2014 - Barcelona – Spain Spatially Resolved Spectroscopy was developed in the 90’s for medical applications because it provided better information for carcinoma cells. Several research centers have then demonstrated the interest for industrial applications in order to provide both physical and chemical information. The technique is now considered as a major technology breakthrough in real time released in the PAT. This webinar will be divided into three main parts: A - Theoretical aspect of spatially resolved spectroscopy and time for liquid and solid. This part will explain what the basis of this technology are and how to build a spatially resolved system. Analytical equation will be presented and compared to Beer’s Lambert Law. Simulation tool will be presented so as to give an example. B- Chemometrics approaches are dedicated to SRS signal. SRS provides a new way of extracting information from the data (3 D data). Some approaches are even easier to use than with classical spectroscopy. Several examples will be presented. Some exercises will be performed using INDATECH data (blending validation, API concentration, Fermentation monitoring and even Raman measurement). C- Practical aspect on the hardware for implementing SRS in-line. Different configurations for industry application are possible. This section will present how to analyse your needs by taking into account the possibility of Spatially Resolved Spectroscopy. The exercises will be performed using Eigenvector toolbox. Some equipment and SRS probes will be available for practical hand-on. Audience: Industrial people involved in process control of complex powder, liquid and release in real time with first experience in classical VIS-NIR spectroscopy and chemometrics. About: INDATECH provides Innovative Optical Solutions for Process Optimization, a new optical measurements vision in real-time, flexible and sensitive, taking advantage of spectroscopy and hyperspectral imaging. The technology is based on R and D project from Lund University, Birmigham University and Irstea but also on other work from Reutling University and VTT. Dr. Fabien CHAUCHARD [email protected]