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Event Summary
2014 World Alliance Forum in San Francisco
Theme:
The Impact of Regenerative Medicine 2014; From the Laboratory to Clinical Application
Date & Time:
Thursday, November 6th, 2014 9:00 am – 5:10pm (Reception: 5:30 pm – 7:00 pm)
Friday, November 7th, 2014 9:00 am – 4:45 pm (Reception: 4:45 pm – 6:00 pm)
Location:
Mission Bay Conference Center at UCSF
1675 Owens Street, San Francisco, CA 94143
Organizers:
Alliance Forum Foundation (AFF)
Government of Japan (Consulate General of Japan in San Francisco)
Gold
Sponsors:
DEFTA PARTNERS
Mitsui Fudosan Co., Ltd.
ROHTO Pharmaceutical Co., Ltd.
Takeda Pharmaceutical Company Ltd.
MUFG Union Bank
Silver
Sponsors:
Astellas Pharma Inc.
Chugai Pharmaceutical Co., Ltd.
Bronze
Sponsors:
Cellular Dynamics International
Juventas Therapeutics, Inc.
Lonza Walkersville, Inc.
MEDIPOST Co., Ltd.
Megakaryon Corporation
Yorozu Law Group
Wi-Fi
Sponsor:
Lonza Walkersville, Inc.
In-Kind
Sponsors:
AlphaGraphics
Ms. Tomoko Tsuji (IKENOBO Flower Arrangement)
Major
Supporting
Organizations:
Alliance for Regenerative Medicine (ARM)
BayBio
California Institute for Regenerative Medicine CIRM
California Institute for Quantitative Biosciences (QB3)
Center for iPS Cell Research and Application (CiRA), Kyoto University
Forum for Innovative Regenerative Medicine (FIRM)
Gladstone Institutes
Hara Research Foundation
The Japanese Society for Regenerative Medicine (JSRM)
Supporting
Organizations:
Alliance Forum Executive Club
Japan Bio Community (JBC)
Japan Society of Northern California
Japanese Chamber of Commerce of Northern California (JCCNC)
Japanese University Network of the Bay Area (JUNBA)
Keizai Society
Student Society for Stem Cell Research (SSSCR)
US-Asia Technology Management Center at Stanford University
Advisory
Board:
(Chair)Mr. Hiro Ogawa, Chair, Global Advisory Committee, International Society for Stem Cell Research
Dr. Ken-ichi Arai, MD, PhD, Professor Emeritus and former Dean of the Institute of Medical Science,
The University of Tokyo (IMSUT), Founder & Chairman, SBI Biotech, Co., Ltd.
Dr. Regis Kelly, Director, California Institute for Quantitiative Biosciences (QB3)
Dr. Henry A. McKinnell, Jr., former Chairman and CEO of Pfizer, Inc.
Dr. Hiromitsu Nakauchi, Professor, Stanford University
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Program (Thursday, November 6, 2014)
Day 1 – Morning: Thursday, November 6
Master of Ceremonies
Elona Baum, Esq., VP, Ass. General Counsel, Coherus BioSciences, Inc.
(former General Counsel & Vice President of Business Development, California Institute for Regenerative Medicine (CIRM)
8:20–9:00
Conference Registration
9:00–9:10
Opening & Welcome Remarks:
Isao “Steve” Matsuura, Conference Co-chair and Council Member,
Alliance Forum Foundation
The Honorable Masato Watanabe, Consul General,
The Consulate General of Japan in San Francisco
THE LANDSCAPE OF STEM CELL RESEARCH AND REGENERATIVE MEDICINE
Session I
Regenerative Medicine 2014
Session Chair: Michael Werner
9:10–10:40
Opening Address:
"The State of the IndustryーProgress, Promise, and Challenges"
Michael Werner, Executive Director, Alliance for Regenerative Medicine (ARM)
Presentations:
"My Journey Advocating for Stem Cell Research and Cures"
Roman Reed, President, Roman Reed Foundation; Chairman,
The Alabama Institute of Medicine; President, Sacred Cell Research Partners
“A Nonprofit Biotech's Role in Accelerating Cures through Stem Cell Research”
Susan L. Solomon, JD, CEO, New York Stem Cell Foundation
"Realizing the Promise of Stem Cell Research"
Arlene Chiu, PhD, Director, Office of New Research Initiatives,
Beckman Research Institute, City of Hope
“Ten @ Ten & CIRM 2.0: How the Numbers Tell the Story”
Jonathan Thomas, PhD, JD,
Chair, Governing Board of the CIRM (Independent Citizens Oversight Committee)
“Development of Japanese Regenerative Medicine Industry”
Yuzo Toda, Representative Director, Chairman, Forum for Innovative Regenerative Medicine
Discussion moderated by Michael Werner:
Roman Reed, Arlene Chiu, Susan L. Solomon, Jonathan Thomas,and Yuzo Toda
10:40–10:55
Coffee Break
6
Program (Thursday, November 6, 2014)
Session II
Business Perspectives on the Regenerative Medicine Space
Session Chair: Elona Baum
10:55–11:50
Panel Discussion moderated by Elona Baum, Esq., VP, Ass. General Counsel, Coherus BioSciences,
Inc. (formerly VP, General Counsel and Business Development, CIRM):
Rahul Aras, PhD, President and Chief Executive Office, Juventas Therapeutics
Edward Lanphier, President and CEO, Sangamo BioSciences Inc.
Jay Lee, PhD, Senior Director, Business Development, MEDIPOST Co., Ltd.
Emile Nuwaysir, PhD, COO, Cellular Dynamics International
11:50–12:10
Company Presentations:
ROHTO Pharmaceutical Co., Ltd., Katsuya Hisamichi, MD, Executive Officer
Maxcyte, Inc., Madhusudan V. Peshwa, PhD, Executive Vice President, Cellular Therapies
12:10–13:00
Complimentary Lunch in the Fischer Banquet Room (1st Floor)
Day 1 - Afternoon: Thursday, November 6
Session III
Frontiers of Regenerative Medicine
Session Chair: Hiromitsu Nakauchi
13:00–14:15
Presentations:
“Cell Fiber Technology for Regenerative Medicine”
Shoji Takeuchi, PhD, Professor, The Biohybrid Systems Laboratory,
The University of Tokyo
"Realization of iPSC-organ Bud Transplantation Therapy”
Takanori Takebe, MD, Associate Professor,
Department of Regenerative Medicine, Yokohama City University
“From Cells to Organs – Generation of Functional Organs from Pluripotent Stem Cells”
Hiromitsu Nakauchi, MD, Professor, Stanford University and The University of Tokyo
14:15–14:35
Company Presentations:
Kuraray Co., Ltd., Yoko Ejiri, Microdevices Development Team
“From the Nobel Prize to the Clinic: One Step Closer to iPSC- based Therapies”
Lonza Walkersville, Inc., Don Paul Kovarcik, MBA, Business Development Manager,
Cell Therapy, Custom Manufacturing Organization (CMO)
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Program (Thursday, November 6, 2014)
FROM THE LABORATORY TO CLINICAL APPLICATION
Master of Ceremonies
Diane Dwyer, Reporter, NBC Bay Area News
14:35–14:45
Introduction of Shinya Yamanaka: Robert Mahley, MD, PhD, Founder & President Emeritus,
Gladstone Institutes; Professor of Pathology and Medicine, University of California, San Francisco
14:45–15:15
Keynote Speech:
"Recent Progress in iPS Cell Research and Application”
Shinya Yamanaka, MD, PhD, Nobel Laureate, Professor and Director of the Center for
iPS Cell Research and Application (CiRA), Kyoto University; Senior Investigator,
L.K. Whittier Foundation Investigator in Stem Cell Biology, Gladstone Institutes; Professor,
Anatomy, University of California, San Francisco
15:15–15:30
Coffee Break
Session IV
From the Laboratory to Clinical Application:
Session Chair: Shinya Yamanaka
15:30–16:50
Presentations:
"iPS Cell Technologies : Significance and Applications to CNS Regeneration and Disease
Research"
Hideyuki Okano, MD, PhD, Professor, Department of Physiology, Graduate School of
Medicine, Keio University; Chairman, Graduate School of Medicine, Keio University
“Pre-clinical Development of a Humanized Anti-CD47 Antibody Targeting AML Stem Cells”
Ravi Majeti, MD, PhD, Assistant Professor of Medicine (Hematology), Stanford University
"Cell Sheet Tissue Engineering for Clinical Applications"
Teruo Okano, PhD, Director & Professor, Institute of Advanced Biomedical Engineering
and Science, Tokyo Women's Medical University; President, The Japanese Society for
Regenerative Medicine
"Induction of immunological tolerance by T regulatory cells: from discovery to clinical
application"
Maria-Grazia Roncarolo, MD, Co-director, Institute for Stem Cell Biology and
Regenerative Medicine; George D. Smith Professor in Stem Cell and Regenerative Medicine;
Chief of the Division of Pediatric Translational and Regenerative Medicine; Professor of
Pediatrics and of Medicine, Stanford University
16:50–17:20
Discussion moderated by Ravi Majeti:
Hideyuki Okano, Teruo Okano, Maria-Grazia Roncarolo, Shinya Yamanaka, and
Paul Berg, PhD, Nobel Laureate, Director Emeritus, Beckman Center and Professor
Emeritus Biochemistry, Stanford University School of Medicine
17:20–17:30
Closing Remarks:
George Hara, Chairman of the Board, Alliance Forum Foundation
17:30–19:00
Cocktail Reception
8
Program (Friday, November 7, 2014)
Day 2 - Morning: Friday, November 7
8:30–9:00
Complimentary Continental Breakfast
Master of Ceremonies
Yoriko Kishimoto, former Mayor of Palo Alto,
Board Director, Midpeninsula Regional Open Space District
9:00–9:10
Welcome:
Susumu Kaminaga, Concil member, Alliance Forum Foundation
Yoshio Yamawaki, Deputy Director-General, Research Promotion Bureau,
Ministry of Education, Culture, Sports, Science and Technology (MEXT)
DEVELOPMENTS IN REGENERATIVE MEDICINE 2014
Session V
Eye and Retina
Session Chair: Henry Klassen
9:10–10:50
Special Speech:
“Transplantation of iPS-derived Retinal Cells”
Masayo Takahashi, MD, PhD,
Project Leader, Laboratory for Retinal Regeneration Research, RIKEN
Presentations:
"Embryonic Stem Cell-derived RPE for the treatment of Age-Related Macular
Degeneration: The California Project to Cure Blindness"
David Hinton, MD, Gavin S. Herbert Professor in Retinal Research, Professor of
Pathology, Neurological Surgery and Ophthalmology, Keck School of Medicine,
University of Southern California
“Human Neural Stem Cells: Potential Application for Dry Age-related Macular
Degeneration”
Ann Tsukamoto, PhD, Executive Vice President, Scientific and Strategic Alliances,
StemCells, Inc.
“Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa”
Henry Klassen, MD, PhD, Associate Professor and Director,
Stem Cell & Retinal Regeneration Program, Ophthalmology, School of Medicine,
University of California, Irvine
10:50–11:05
Coffee Break
Master of Ceremonies
Tasha A. Yorozu, Attorney at Law, Yorozu Law Group
11:05–11:20
Company Showcase:
“What It Takes to Bring the World's First iPSC-based Replacement Therapy for Patients
Globally”
Hardy T S Kagimoto, MD, President and CEO, Healios KK
9
Program (Friday, November 7, 2014)
Session VI
Cardiovascular
Session Chair: Deepak Srivastava
11:20-12:30
Special Speech:
“Regenerative Therapy for Severe Heart Failure Patients”
Yoshiki Sawa, MD, PhD, Professor, Department of Cardiovascular Surgery, Graduate
School of Medicine, Osaka University
Presentations:
“Cardiac Reprogramming for Regenerative Medicine”
Deepak Srivastava, MD, Director and Senior Investigator, Gladstone Institute of
Cardiovascular Disease; Director, Roddenberry Center for Stem Cell Biology and Medicine;
Professor, Departments of Pediatrics and Biochemistry & Biophysics, University of
California, San Francisco; Wilma and Adeline Pirag Distinguished Professor in Pediatric
Developmental Cardiology, University of California, San Francisco
“Cardiac iPSCs for Disease Modeling and Drug Discovery”
Joseph C. Wu, MD, PhD, Director, Stanford Cardiovascular Institute,
Professor, Dept of Medicine/Cardiology & Radiology, Stanford University School of Medicine
12:30–13:30
Complimentary Lunch in Fischer Banquet Room (1 st Floor)
Day 2 - Afternoon: Friday, November 7, 2014
A PROMISE OF LIFE SCIENCE REVOLUTION
13:30–13:35
13:35-14:05
Introduction of Mahendra Rao: Ken-ichi Arai, MD, PhD, Professor Emeritus and former
Dean of the Institute of Medical Science, The University of Tokyo (IMSUT), Founder &
Chairman, SBI Biotech, Co., Ltd.
Keynote Speech:
“Moving iPSC to the Clinic–Issues and Solutions”
Mahendra Rao, MD, PhD, Vice-president of Regenerative Medicine, New York Stem Cell
Foundation and former Director, NIH Center for Regenerative Medicine
10
Program (Friday, November 7, 2014)
Session VII
Stem Cells and Translational Research
Session Chair: Ken-ichi Arai
14:05–14:55
Remarks:
Ken-ichi Arai, MD, PhD, Professor Emeritus and former Dean of the Institute of Medical
Science, The University of Tokyo (IMSUT), Founder & Chairman, SBI Biotech, Co., Ltd.
Presentations:
Shigetaka Asano, MD, PhD, Professor Emeritus, School of Science and Engineering,
Waseda Univsersity and The Institute of Medical Science, The Tokyo University (IMSUT)
Leonore A. Herzenberg, PhD, Professor, Genetics Department, Stanford University
Antonio (Tony) Lee, PhD, CEO and Managing Director, MEDIPOST America, Inc.
14:55–15:15
Company Presentations:
SanBio, Inc., Keita Mori, MBA, Co-CEO, Chairman, Co-founder
Nihon Unisys, Ltd., Masao Watase, Business Development Manager
15:15–15:30
Coffee Break
Session VIII
The Future of Regenerative Medicine: Five, Ten Years from Now
Session Chair: Regis Kelly
15:30–16:40
Presentations:
“The Stem Cell in Context”
Regis Kelly, PhD, Director, QB3, University of California, San Francisco
“Molecular Elucidation and Engineering of Stem Cell Microenvironments for Therapeutic
Application”
David Schaffer, PhD, Director of Stem Cell Center, University of California, Berkeley
“The Future Promise of Insights and Applications Provided by Studying Regenerative Medicine”
Thea Tlsty, PhD,
Director of the Center for Translational Research in the Molecular Genetics of Cancer,
University of California, San Francisco
16:40–17:00
Concluding Remark:
Mr. George Hara, Chairman of the Board, Alliance Forum Foundation
17:00–18:00
Cocktail Reception
11