Doula Support cÉáàctÜàâÅ Weekend 3 ICA PEDIATRICS DIPLOMATE Sharon Vallone, DC, FICCP Jennifer Murphy DC DICCP PostPartumValloneMurphyDICCP Yr1Wknd 3 Doula Support • A doula makes sure the needs of the laboring woman's partner are met, allowing the partner to focus energy into becoming an effective, positive part of the birth process. A doula can create an atmosphere between partners that facilitates wonderful labor memories, adding to the superb care midwives provide by remaining close by while your midwife performs clinical tasks. • Advocating your choices during birth. • Your doula will be available after your baby is born to help you with breastfeeding, postpartum care, and basic infant care. PostPartumValloneMurphyDICCP Yr1Wknd 3 • Also, compared to national data, fewer doula mothers used epidural anesthesia and more initiated breastfeeding. The Robert Wood Johnson Foundation (RWJF) supported the project with a $327,196 grant awarded through its Local Initiative Funding Partners Program (LIFP), a national matching-grant program that seeks to stimulate innovative, community-based projects to improve the health and health care of underserved and vulnerable populations. Following the RWJF grant, Chicago Health Connection secured funding from other sources to replicate the project. As of December 2003, doula programs based on the Chicago model were under way in Atlanta, Albuquerque and Minneapolis as well as eight additional Illinois sites. • http://www.rwjf.org/portfolios/resources/grantsreport.jsp?filename= 029806.htm&iaid=144 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • She does not perform clinical activities; she is purely a labor educator during pregnancy and emotional support during childbirth.She stays with the family during labor and birth and her sole purpose is to provide support and encouragement, and to make sure all the laboring woman's physical and emotional needs are met. • Doulas work at hospital and home births. In hospitals, since there is normally no one on the payroll who stays with a woman throughout her entire labor and birth, doulas provide this service. Doulas are also known for their ability to advocate for a laboring woman's wishes at a hospital. At a homebirth doulas take on more of a labor-support role and less of an advocate role. PostPartumValloneMurphyDICCP Yr1Wknd 3 • Chicago Health Connection, a health education and advocacy organization, developed and implemented a four-year pilot project that used nonmedical birth assistants known as doulas to help low-income single teen mothers in high-risk Chicago neighborhoods. The doulas, who were recruited from the community and trained by project staff, provided information and emotional and physical support to the mothers from the last months of pregnancy through the first weeks postpartum and generally were present during labor and delivery. A researcher tracked outcome data for 259 women served by the project's three pilot sites in Chicago. Only 8.1 percent of the mothers with a doula present at birth had a cesarean section compared to 12.9 percent for Chicago teen mothers as a whole, the researcher found. PostPartumValloneMurphyDICCP Yr1Wknd 3 •Most doulas are certified by a doula organization, like Doulas of North America (DONA) or Association of Labor Assistance & Childbirth Educators (ALACE). They have gone through extensive training to learn everything there is to know about labor support and they have to be recertified every so many years. PostPartumValloneMurphyDICCP Yr1Wknd 3 What training have you had? (If she is certified, you may want to check with the certifying organization for performance references). What is your philosophy about childbirth and supporting women and their partners during labor? When do you try to join women in labor? May we meet with you to discuss our birth plans and the role you will play in supporting me (us) through childbirth? May we call you with questions or concerns before and after the birth? Will you meet with me (us) after the birth to review the labor and answer questions? Do you work with one or more backup doulas for times when you are not available? May we meet her/them? What is your fee, what does it include, when is it due and what are you refund policies? Can you provide references? (Be sure to check the references) OTHER RESEARCH REFERENCES • Berry, LM, "Realistic expectations of the labor coach." Journal of Obstetric, Gynecologic and Neonatal Nursing, Sept./Oct.: 354-55, 1988. • Bertsch, TD, Nagashima-Whalen, L, Dykeman, S. Kennel, JH, McGrath, S., "Labor Support by firsttime fathers: direct observations with comparisons to experienced doulas." Journal of Psychosomatics in Obstetrics and Gynaecology, 11:251-260, 1990. • Cogan R, Spinnato JA. "Social support during premature labor: effects on labor and the newborn, "Journal of Psychosomatics in Obstetrics and Gynaecology, 8:209-216,1988. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 OTHER RESEARCH REFERENCES OTHER RESEARCH REFERENCES • Gordon NP, Walton D, McAdam E, Derman J, Gallitero G, Garrett L. "Effects of providing hospitalbased doulas in health maintenance organization hospitals." Obstetrics & Gynecology, 93(3):422426, 1999. • Hodnett ED. "Support from caregivers during childbirth." (Cochrane Review) In the Cochrane Library, Issue 2. Oxford Update Software, 1998. Updated quarterly. • Hodnett ED, Osborn RW. "A randomised trial of the effects of monitrice support during labor: mothers' views two to four weeks postpartum," Birth, 16:177-183,1989. • Hodnett ED, Osborn RW. "Effects of continuous intrapartum professional support on childbirth outcomes," Research in Nursing Health, 12(5):289297,1989. • Hofmeyr GJ, Nikodem VC, Wolman WL, Chalmers BE, Kramer T. "Companionship to modify the clinical birth environment: effects on progress and perceptions of labour, and breastfeeding," British Journal of Obstetrics and Gynaecology, 98:756764, 1991. • Hommel F. "Natural childbirth: nurses in private practice as monitrices," American Journal of Nursing, 69:1446-50, 1969. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 OTHER RESEARCH REFERENCES OTHER RESEARCH REFERENCES • Kennell JH, Klaus MH, McGrath SK, Robertson S, Hinkley C. "Continuous emotional support during labor in a US hospital: a randomized controlled trial," Journal of American Medical Association, 265 (17): 2197-2201, 1991. • Kennell JH, McGrath SK "Labor support by a doula for middle-income couples; the effect on cesarean rates," Pediatric Res, 32:12A, 1993. • Kennell J H. "The effects of continuous emotional support for couples during labor," Presentation at the first international conference of Doulas of North America, Seattle, WA, July 22, 1994. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Klaus MH, Kennell JH, Robertson SS, Sosa R. "Effects of social support during parturition on maternal and infant morbidity," British Medical Journal, 293 (6547): 585-587, 1986. • Landry SH, McGrath SK, Kennell JH, Martin S, Steelman L, "The effects of doula support during labor on mother-infant interaction at 2 months," Pediatric Res, 43(4):Part 11, 13 A, 1998. • Langer A, Campero L, Garcia C, Reynoso S. "Effects of Psychosocial support during labour and childbirth on breast feeding, medical interventions, and mothers' wellbeing in a Mexican Public hospital: a randomised clinical trial." British Journal of Obstetrics and Gynaecology, 105:1056-1063, 1998. PostPartumValloneMurphyDICCP Yr1Wknd 3 OTHER RESEARCH REFERENCES • Martin S, Landry S, Steelman L, Kennell JH, McGrath S. "The effect of doula support during labor on mother-infant interaction at 2 months," Infant Behavior Development, 21:556, 1998. • McGrath SK, Kennell JH, "Induction of labor and doula support," Pediatric Res, 43(4):Part II, 14A, 1998. • Sosa R, Kennell JH, Klaus MH, Robertson S, Urrutia J. "The effect of a supportive companion on perinatal problems, length of labor, and mother-infant interaction," The New England Journal of Medicine, 303 (11): 597-600, 1980. • Wolman WL, Chalmers B, Hofmeyr J. Nikodem VC. "Postpartum depression and companionship in the clinical birth environment: a randomized, controlled study,' American Journal of Obstetrics and Gynecology, 168:1388-1393, 1993. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 fxáá|ÉÇ F cÉáà ctÜàâÅ Tw}âáà|Çz WâÜ|Çz WxÄ|äxÜç PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Adjust During Labor? Dig Deep in Technique • Optimum nerve supply – Cervix to dilate – Uterus to contact rhythmically and forcefully – Controls the hormones necessary to initiate and continue the labors process • Alignment of the pelvis ensures the maximum amount of room for the baby to exit. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Cranial Adjustments • Seated cervicals – Upper cervical work very dynamic in regulating or restarting contractions – Protect your wrists • Toggle • Activator technique • Logan basic performed while patient on all fours • Standing or seated thoracic adjustments • Sacral work—Buckling • Anteriority • Drop work – Toggle board • Flexion/Distraction – Side lying PostPartumValloneMurphyDICCP Yr1Wknd 3 Adjusting the laboring patient • Work with the mother and her contractions – Cannot get good motion fighting the contraction – Use contraction to your advantage Education of Labor • Don’t dehydrate – Causes baby heart rate to drop • Work in multiple positions – – – – Hard to work in hospital areas with monitoring equipment Better for mom to move around Water birth is very helpful Leaning on physioball or wall while decompressing L5/S1 • Educate dad or coach in massage techniques or sacral distraction if you can’t be there • Have coaches to assist – One for baby, one for mom • Stretches are very helpful • St. John’s Wort oil – Discuss pressure – Teach to protect from injury – Helps with pain in labor when rubbed on back or abdomen • Therapy ball can assist with labor and self adjusting – Ligaments are loose – Gravity to assist PostPartumValloneMurphyDICCP PostPartumValloneMurphyDICCP Yr1Wknd 3 Yr1Wknd 3 Other Care • Sciatica • Carpal Tunnel – Opposite uterine ligament • Cranio-sacral work – Unwinding abdomen – Unwinding cranials • Foot work – Myofascial release cÉáà ctÜàâÅ • Allergy – Apple cider vinegar – Concentrated cranberry juice _|yx „g{ÜxtàxÇ|Çz VÉÅÑÄ|vtà|ÉÇá • Muscle cramping – Myofascial release – BioFreeze – Acupressure/NIMMO PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Indications of Complications Umbilical Cord Prolapse • • • • • • • • • • Temp of 100.4 or higher Chills Nausea/vomiting Moderate to strong abdominal or back pain Increased pain, swelling, redness, or drainage from episiotomy or C-section incision Bleeding through more than one pad per hour Blood clots the size of a plum Extreme paleness Rapid, racing pulse • Foul smelling vaginal discharge • Chest pain • Increasing tenderness in the lower abdomen • Red, warm to touch, painful breasts • Burning on urination or blood in urine • Severe HA in forehead and behind eyes (extreme pain while sitting or standing) • Feeling depressed over 3 days • Severe weakness PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • • • • Occurs when the cord slips into the vagina after the membranes have ruptured, before the baby descends into the birth canal. Affects about 1 in 300 births. The baby can then put pressure on the cord as it passes through the cervix and vagina during labor and delivery, reducing or cutting off his oxygen supply. Can result in stillbirth unless the baby is delivered promptly--cesarean section. Babies who are delivered promptly are usually unharmed. The risk is increased if the baby is in a breech (foot-first) position or if baby is premature. In these cases, the baby’s presenting part (the foot or a smaller than-normal head) does not fill the pelvis and allows the cord to slip. More common – – – – The umbilical cord is too long Too much amniotic fluid When membranes are ruptured artificially to start/speed up labor. Vaginal twin deliveries (second twin most commonly affected) PostPartumValloneMurphyDICCP Yr1Wknd 3 • If a pregnant woman’s membranes rupture outside of the hospital, and she feels something in her vagina, she should have someone take her to the hospital immediately or call 911. • A health care provider may suspect that a woman in labor in the hospital has umbilical cord prolapse if her unborn baby develops heart rate abnormalities after the membranes have ruptured. The provider can confirm that the cord has prolapsed by doing a pelvic examination. • Emergency situation, and the provider will take steps to relieve pressure on the umbilical cord by lifting the presenting fetal part away from the cord while preparing the woman for prompt cesarean delivery. Occasionally, if a woman’s cervix is fully dilated, she may be able to deliver vaginally. • May occur late in pregnancy (>30 weeks) or in labor • As a result of tetanic contraction of the uterus during labor, the uterus may rupture • Most frequently seen if there is an excessive infusion rate of oxytocin resulting in hyperstimulation of the uterine muscle • Spontaneously occurs in1 in 1,900 deliveries • May occur as a result of blunt trauma to the abdomen in a motor vehicle accident • A predisposing factor may be a uterine scar from previous C section or removal of a fibroid tumor. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Amniotic Fluid Embolism Acute Inversion/Prolapse • 1/8000-80,000 pregnancies, but 10-80% fatal • Amniotic fluid entering the maternal circulation – Rent through the amnion and chorion – Open maternal veins – Pressure gradient sufficient to force the fluid into the venous circulation • Woman in vigorous labor develops – Severe dyspnea – Hypoxemia – Cardiac collapse • Woman either dies immediately or serious hemorrhage with severe coagulation defects • If woman survives, therapy is very unsuccessful – – – – – Ruptured Uterus Resusitation Oxygenation Mechanical ventilation Blood replacement Fibrinogen, heparin, fibrinolytic agents, and antifibrinolytic agents • “turning inside out” of the uterus in the third stage of labor. Consequence of strong traction on the umbilical cord that is attached to the placenta implanted in the fundus of the uterus. • Circulatory collapse and shock may follow • 1 in 20,000 pregnancies • Contributing factors – – – – Errors in maneuvers during delivery Tough cord that doesn’t break away from the placenta Fundal pressure Relaxed uterus and cervix • Treatment may be manual replacement or surgery PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Vaginal Prolapse Uterine Prolapse • Portion of the body of the uterus may protrude from the vulva during early months of pregnancy – 1st degree—Cervix remains in vagina – 2nd degree—Cervix is at or near introitus – 3rd degree—Most of uterus outside the vagina • Hard to conceive if full prolapse • Caused by weakness in pelvic floor including ms, ligaments and fascia • Must be fixed in early pregnancy – Uterus replaced and held into position – If pelvic floor weak, then bed rest – If the cervix persists outside the vulva and can’t be replaced—must terminate pregnancy PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Vagina is stretched so that when its front wall bulges (cystocele) or its back wall bulges (rectocele) during straining. • Upper posterior vaginal wall prolapse is nearly always associated with herniation of the pouch of Douglas, and, because this is likely to contain loops of bowel (enterocele). • Causes – Aging and the birthing process can be associated with the development of vaginal prolapse. • Treatment – Pessary in vagina – Surgery PostPartumValloneMurphyDICCP Yr1Wknd 3 Pyelonephritis • One of the most common medical complications of pregnancy and may occur postpartum (most frequently right sided) • Result of bacteria ascending from the bladder through the blood vessels and lymphatics. • S/S can be rather abrupt – – – – Bladder irritation Hematuria Fever, chills and aching pain in lumbar region Anorexia, nausea, and vomiting • Asymptomatic bacteriuria – Actively multiplying bacteria within the urinary tract w/o symptoms of a urinary infxn – Typically present at the time of the first prenatal visit – 25% will develop into acute symptomatic Puerperal Sepsis (Infxn) • Patients with a puerperal genital tract infection are susceptible to the development of septic shock, pelvic thrombophlebitis and pelvic abcess • Patients with retained placental components (placenta accreta) are subject to infection and morbidity • Following vaginal delivery, approximately 6-7% of women demonstrate febrile morbidity • Following C section, this number doubles • Antepartum factors – Anemia-Iron deficiency – Poor nutrition – Sexual intercourse-membrane rupture PostPartumValloneMurphyDICCP Yr1Wknd 3 Puerperal sepsis • S/S – – – – – – – Fever Uterine tenderness (day 2 or 3 postpartum) Chills Headache Malaise Anorexia Pallor, tachycardia and leukocytosis • The uterus is soft, large and tender • Lochia may be diminished or profuse and malodorous. PostPartumValloneMurphyDICCP Yr1Wknd 3 Infection • Account for 13.1% of all pregnancy-related deaths in US • Puerperal infection is presumed when the mother’s temperature rises to >= 38 degrees C (>=100.4 degrees F) on any two successive days after the first 24 hours postpartum and other causes are not apparent. • Infections directly related to delivery commonly affect the genital tract, occurring in the uterus or parametria. • Bladder and kidney infections also commonly occur soon after delivery • Other causes of fever, such as pelvic thrombophlebitis and breast infection, tend to occur after the 3rd day postpartum PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 HELLP Syndrome • Hemolysis—breakage of red blood cells • Elevated Liver Enzyme • Low Platelet Count • Complication of preeclampsia and eclampsia occurring in 25% of these pregnancies; can occur postpartum • Protein in urine, elevated blood pressure, and coma if hypoglycemic • Symptoms – – – – Malaise Nausea/vomiting Pain in upper abdomen Edema • Treatment – Management of blood clotting issues – Urgent delivery require if fetal growth restricted (34 wks+) • Complicated by Objectives • Recognize common and potentially lifethreatening postpartum complications – – – – – Postpartum hemorrhage Postpartum endometritis Peripartum cardiomyopathy Postpartum thyroiditis Postpartum depression • Direct the initial management of the ill postpartum patient • Know the appropriate threshold for consultation with specialist – Liver rupture, anemia, bleeding, and death PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Hemorrhage • Obstetrical emergency that can follow vaginal or cesarean delivery • Incidence – 3% of births • 3rd most common cause of maternal death in US • Definition – Excessive bleeding that makes the patient symptomatic (lightheaded, syncope) and/or results in signs of hypovolemia (hypotension, tachycardia, oliguria) PostPartumValloneMurphyDICCP Yr1Wknd 3 Hemorrhagic Shock • Hemorrhage is 28.8% of all pregnancy-related deaths in US • Blood loss greater than 500ml in vaginal birth and 1000ml in C-sec • Blood loss resulting in S/S of hemodynamic instability • Early PPH occurs w/in 24 hours of delivery • Late PPH occurs w/in 24 hours to 6 wks • 2-4% of all pregnancies in US PostPartumValloneMurphyDICCP Yr1Wknd 3 Morbidity & Mortality • Exposure to blood products • Need for surgical intervention • 13% of all maternal deaths deal with bleeding and 1/3 are PPH • Higher percentage among Asian and Hispanic population PostPartumValloneMurphyDICCP Yr1Wknd 3 • Which of the following is the most common cause of postpartum hemorrhage? – A. primigravida birth – B. retained placenta – C. uterine atony – D. uterine rupture – E. lacerations of the cervix PostPartumValloneMurphyDICCP Yr1Wknd 3 Causes of Postpartum Hemorrhage Four Ts Cause Approximate incidence (%) Tone Atonic uterus 70 Trauma Lacerations, hematomas, inversion, rupture 20 Tissue Retained tissue, invasive placenta 10 Thrombin Coagulopathies 1 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 Physical Assessment of PPH • Hx including family hx and medication check (hypertension & heart disease) • Bimanual palpation – Reveals bogginess – Atony – Uterine enlargement PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Hemorrhage • Risk Factors – – – – – – – Prolonged 3rd stage of labor Fibroids, placenta previa Previous PPH Overdistended uterus Episiotomy Use of magnesium sulfate, preeclampsia Induction or augmentation of labor • Not necessarily useful clinically as only about 10% of women with any of these risk factors develop atony and many without risk factors develop atony. PostPartumValloneMurphyDICCP Causes of PPH • • • • • • • Uterine atony Lacerations of cervix and/or vagina Retension of part or all of the placenta Disorders of coagulation and thrombocytopenia Trauma during delivery Uterine inversion Uterine rupture Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Risk Factors of PPH PPH - Management • Prolonged third stage of labor • Preeclampsia • Mediolateral episiotomy • Previous PPH • Multiple gestation • Arrest of descent • Maternal hypotension • Coagulation abnormalities • Lacerations of the cervix, vagina, and perineum • Asian or Hispanic ethnicity • Delivery with forceps or vacuum • Augmented labor • Nulliparity, Multiparity (20 fold increase in risk) & polyhydromnios • Swift execution of a sequence of interventions with prompt assessment of response • Initial steps – Fundal massage – O2 • transfuse blood products as needed – Examine genital tract, inspect placenta, observe clotting – Give uterotonic drugs PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Medications for PPH • Oxytocics (Oxytocin) – Produces rhythmic uterine contractions, can stimulate the gravid uterus and has vasopressive and antidiuretic effects • Ergonovine (Ergotrate Maleate) – Used to prevent and treat PPH due to uterine atony by producing firm contraction of the uterus within minutes • Methylergonovine (Methergine) – Works on smooth muscle causing a sustained tetanic uterotonic effect that reduces uterine bleeding and shortens the third stage of labor • Carboprost (Hemabate) – A prostoglandin the produces myometrial contractions that induces homeostasis • Misoprostol PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 Uterotonic Agents for PPH Drug Side Effects Contraind. Store Oxytocin (Pitocin) 10 units/ml Dilute 2040 units in 1 L NS 10 IU IM Dose Route Freq IV IM Continuous Infusion, 250 ml/hr Nausea, vomiting Water intox with prolonged IV use Hypersensitivity to the drug Room temp Carboprost (Hemabate) 15-methyl PG F2a 0.25 mg/ml 0.25 mg IM IMM Q 15-90 min not to exceed 8 doses Nausea, vomiting Diarrhea Fever/Chills HA Hypertension Bronchoconstriction Hypersensitivity to the drug Use with caution in patients with HTN or asthma Refrig Methylergonovine (Methergine) 0.2 mg/ml 0.2 mg IM Q 10 min x 2 Q 2 – 4 hrs Nausea, vomiting Hypertension, esp in pts with PIH or chronic HTN Hypotension Hypertension Preeclampsia Hypersensitivity to the drug Refrig Protect from light Misoprostol (Cytotec) 100 and 200 mcg tabs 600-1000 mcg PR Hypersensitivity to the drug Room temp Single dose Nausea, vomiting Shivering Fever PostPartumValloneMurphyDICCP Yr1Wknd Diarrhea 3 Management • Secondary steps – Will likely require regional or general anesthesia – Evaluate vagina and cervix for lacerations – Manually explore uterus • Treatment options – – – – Repair lacerations with running locked #0 absorbable suture Tamponade Arterial embolization Laparotomy PPH – Preventive Measures • correcting anemia prior to delivery • episiotomies only if necessary • active management of third stage • NNT to prevent 1 case of PPH = 12 • assess patient after completion of paperwork to detect slow steady bleeds • uterine vessel ligation • B-Lynch suture – Hysterectomy PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Endometritis PP Endometritis • Infection of the decidua (pregnancy endometrium) • Incidence – <3% after vaginal delivery – 10-50% after cesarean delivery • 5-15% after scheduled elective cesareans • Risk Factors – Prolonged labor, prolonged ROM, multiple vaginal exams, internal monitors, maternal DM, meconium, manual removal of placenta, low socioeconomic status • Polymicrobial, ascending infection – Mixture of aerobes and anaerobes from genital tract – BV and colonization with GBS increase likelihood of infection • Clinical manifestations (occur within 5 days pp) – – – – – Fever – most common sign Uterine tenderness Foul lochia Leukocytosis Bacteremia – in 10-20%, usually a single organism PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PP Endometritis PP Endometritis • Treatment • Workup – CBC – Blood cultures – Urine culture – DNA probe for GC/chlamydia – Imaging studies if no response to adequate abx in 48-72h • CT scan abd/pelvis • US abd/pelvis PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 – Broad spectrum IV abx • Clindamycin 900mg IV q8h and • Gentamicin 1.5mg/kg IV q8h – Treat until afebrile for 24-48h and clinically improved; oral therapy not necessary – Add ampicillin 2g IV q4h to regimen when not improving to cover resistant enterococci • Prevention – Abx prophylaxis for women undergoing C-section • Cefazolin 1-2g IV as single dose PostPartumValloneMurphyDICCP Yr1Wknd 3 Peripartum Cardiomyopathy • Rare cause of heart failure in late pregnancy or early puerperium • Definition Peripartum Cardiomyopathy • Incidence – 1:3000 to 1:4000 • Unknown etiology – Potential contributors: – Development of heart failure in last month of pregnancy or within 5 mos of delivery – No identifiable cause for the failure – No history of heart disease prior to the last month of pregnancy – Left ventricular systolic dysfunction • • • • • Hormones Inflammatory cytokines (TNF-alpha and IL-6) Myocarditis Abnormal immune response Genetic and/or environmental factors • LVEF <45% • • • • • • • • • • • • • • PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PPCM – Risk Factors PPCM - Diagnosis Age > 30 Multiparity Multiple fetuses Women of African descent History of PIH Maternal cocaine abuse Oral tocolytics with beta adrenergic agonists > 4 weeks • • • • • ECG CXR Echocardiogram Viral and bacterial cultures Cardiology referral – Cardiac catheterization – Endomyocardial biopsy PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PPCM - Treatment PPCM - Treatment Similar to treating other types of HF Digoxin Diuretics Vasodilator – hydralazine Beta blockers – beta-1 selective Class III antiarrhythmics Anticoagulation • IVIG showed increase in LVEF in small study • Heart transplantation – If conventional therapy not successful – Should avoid future pregnancy – heparin if pre-delivery (due to short half-life & reversibility), but may use Coumadin during 3rd trimester & postpartum, w/ INR goal of 2.0 to 2.5 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartum Thyroiditis • Inflamed thyroid gland of unknown cause – Can be hypo or hyperthyroid – 5-7% develop thyroid disease after giving birth • Risk Factors – Prior hx of thyroiditis – Hx of postpartum thyroiditis •A variant form of Hashimoto’s thyroiditis occurring within 1 year after parturition Postpartum Thyroiditis • Incidence – 3-16% of postpartum women – Up to 25% in women with Type 1 DM • Most have high serum levels of antiperoxidase Ab • Thyroid inflammation damages follicles Æ proteolysis of thyroglobulin Æ release of T3 + T4 Æ TSH suppression PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Thyroiditis Symptoms • Clinical manifestations – 20-30% • Hyperthyroidism 2-4 mos pp, lasting 2-8 wks, followed by hypothyroidism, lasting 2-8 wks, then recovery – 20-40% • Hyperthyroidism only – 40-50% • Hyperthyroid – – – – – – – • Hypothyroid Feeling warm Muscle weakness Feeling tremulous Anxiousness Rapid heartbeat Loss of concentration Weight loss • Hypothyroidism only, beginning 2-6 mos pp PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Thyroiditis • Symptoms and signs, when present, are mild – Hyperthyroidism • Anxiety, weakness, irritability, palpitations, tachycardia, tremor – Hypothyroidism – – – – Feeling tired Constipation Loss of memory Intolerance to cold weather – Muscle cramping – Weak feeling – Weight gain PostPartumValloneMurphyDICCP Yr1Wknd 3 PP Thyroiditis • Diagnosis (continued) – High or high normal T3 + T4, low TSH, low radioiodine uptake (hyper phase) – Low or low normal T4, high TSH (hypo phase) • 65-85% have high antithyroid Abs • Lack of energy, sluggishness, dry skin • Diagnosis – Small, diffuse, nontender goiter or normal exam PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PP Thyroiditis Treatments • Medical • Treatment – Most need no treatment unless have bothersome sx • Hyper: atenolol or propanolol – Avoid in nursing women • Hypo: levothyroxine 50-100 mcg qd for 8-12 wks, discontinue, re-eval in 4-6 wks • Educate patient on sx, increased risk of developing hypothyroidism or goiter, likely recurrence with subsequent pregnancies PostPartumValloneMurphyDICCP Yr1Wknd 3 • Naturopathic – Testing is exceptional poor • Must test – TSH – T4 – T3 – Hormone replacement therapy • Synthroid • Amor-thyroid—Better – Surgery – GLUTEN FREE DIET – SUPPLEMENTS – Iodine • Breast Cancer link – Selenium – Adrenal support – Fish Oil • Depression issues PostPartumValloneMurphyDICCP Yr1Wknd 3 Treatments fxáá|ÉÇ F cÉáà ctÜàâÅ • Acupuncture • Shiatsu • Herbs cÉáà ctÜàâÅ VÉÅÑÄ|vtà|ÉÇá PostPartumValloneMurphyDICCP Yr1Wknd 3 Phlebitis • Attacks a small vein close to the skin (superficial phlebitis) – More painful than life-threatening – May be affected by hormones making women more afflicted – 1 in 100 newly delivered moms due to hormone chxs • Symptoms – – – – Inflammation Swelling Tenderness Can feel the clot (painful, tender, hot lump under the skin • Treatment – May go away on their own in 2-4 weeks on own – Cold pack – Anti-inflam drug/anti-inflam homeopathy • Prevention – – – – Birth control pills increase chances of phlebitis Keep active—minimum 20 min walk 2-4X/wk Relax with you legs up Compression stockings PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Deep Vein Thrombosis • Complicated in pregnancy by diagnostic limitations and health risks of meds and 5X higher occurrence because pregnant • Severe form of phlebitis • Triad of risk factors – Hypercoaguability, stasis, and endothelial injury • Pregnancy considerations – Decreased flow velocity (1/3 at term) and increased vessel diameter – Venous statis related to compression of common iliac vein by the uterus • More common in left leg due to compression of the left iliac vein by crossing right iliac artery at its origin from the aorta PostPartumValloneMurphyDICCP Yr1Wknd 3 Deep Vein Thrombosis • Symptoms – Homan’s sign • Slight pain at back of the knee/calf when foot is dorsiflexed – Unexplained sharp leg pain in only one leg • Edema, leg tenderness, increased warmth, chx in coloration (red), venous distension • May have diffuse abdominal pain & dyspnea in pregnancy Diagnosis & Treatment • Contrast venography—Used when other tests are inconclusive, invasive • Duplex ultrasonography—For thrombosis above knee • Impedance plethysomography—Alternative to Duplex ultrasound, but less specific/sensative • MRI—Best for pelvic veins • Compression Ultrasonography—For pregnant patients • Initially Heparin given to thin blood (inter-venous) then changed to Warfin for months – May need compression support hose or undergo therapy for edema • Heparin must be stopped before delivery, then started again 48 hours after delivery for six weeks to three months • Warfarin is contraindicated because it is teratongenic and increases risk of maternal and fetal hemorrhage. • Side-effects – Bleeding & lower platelet counts (thrombocytopenia)—Heparin – Bleeding--Warfarin PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Phlebitis/DVT Prevention Pelvic Thrombophlebitis • Can occur within 30 minutes of being still—good to have mother moving and on her feet shortly after birth • If prolonged labor, passive motion of legs and walking excellent choices • All massage to be toward the heart PostPartumValloneMurphyDICCP Yr1Wknd 3 Thromboembolism • Accounts for 19.9% of all pregnancy-related deaths in US • Increased risks because increases in Cesarean/instrument assisted births, prescribed prolonged bed rest after delivery, multiparity, advanced maternal age and use of estrogens to suppress lactation • Risk of mortality outweighs fetal radiation risk PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • When the usual relative pelvic venous stasis is combined with a large inoculum of pathogenic anaerobic bacteria, a pelvic vein thrombophlebitis is likely to develop, usually on the right side of the pelvis. • The clinical picture of pelvic thrombophlebitis is characterized by a persistent spiking fever for 7 to 10 days after delivery, despite antibiotic therapy PostPartumValloneMurphyDICCP Yr1Wknd 3 • Natural history of pulmonary embolism – Pulmonary emboli usually arise from the thrombi originating in the deep venous system of the lower extremities; however, rarely they may originate in the pelvic, renal, or upper extremity veins and the right heart chambers. – After traveling to the lung, large thrombi lodge at the bifurcation of the main pulmonary artery or the lobar branches and cause hemodynamic compromise. – Smaller thrombi continue traveling distally, occluding a smaller vessel in the lung periphery. These are more likely to produce pleuritic chest pain by initiating an inflammatory response adjacent to the parietal pleura. Most pulmonary emboli are multiple, and the lower lobes are involved more commonly than the upper lobes. PostPartumValloneMurphyDICCP Yr1Wknd 3 • Respiratory consequences • Respiratory consequences • Acute respiratory consequences of PE include increased alveolar dead space, pneumoconstriction, hypoxemia, and hyperventilation. • Later, 2 additional consequences may occur: regional loss of surfactant and pulmonary infarction. • Arterial hypoxemia is a frequent but not universal finding in patients with acute embolism. The mechanisms of hypoxemia include ventilationperfusion mismatch, intrapulmonary shunts, reduced cardiac output, and intracardiac shunt via patent foramen ovale. • Pulmonary infarction is an uncommon consequence because of the bronchial arterial collateral circulation. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 • Hemodynamic consequences • PE reduces the cross-sectional area of the pulmonary vascular bed, resulting in an increment in pulmonary vascular resistance, which, in turn, increases the right ventricular afterload. • If the afterload is increased severely, right ventricular failure may ensue. In addition, the humoral and reflex mechanisms contribute to the pulmonary arterial constriction. • Hemodynamic consequences • Prior poor cardiopulmonary status of the patient is an important factor leading to hemodynamic collapse. • Following the initiation of anticoagulant therapy, the resolution of emboli occurs rapidly during the first 2 weeks of therapy. • Significant long-term nonresolution of emboli causing pulmonary hypertension or cardiopulmonary symptoms is uncommon. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Symphysis pubis subluxation Osteitis Pubis • Pelvis makes a circle • Extreme pubic pain • Delivery knowledge – Know baby presentation – Labor tools used • Adjustment • Painful, non-infectious inflammatory condition involving the pubic bone, symphysis, and surrounding structures • S/S – – – – – Pain Waddling gait Low grade fever Elevated sedimentation rate Milk leukocytosis • X-ray – Sclerosis, rarefaction, and osteolytic chxs after 4 weeks – Doctor protection – Hand placement PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Treatment – Adjustment—pubic bone – Anti-inflams and bedrest PostPartumValloneMurphyDICCP Yr1Wknd 3 Coccygeal Subluxations Vs. Fx • Back labor hx • Falls • Birthing positioning – Think of mother’s weight on pelvis • Filum Terminale – Neurological considerations • Internal Adjustment • External Adjustment Meralgia Paresthetica • 4.3 in 10,000 complications with spinal anesthesia • Syndrome of pain and/or dyesthesia in the anterolateral thigh – – – – Dull ache Itching Numbness/tingling Burning • Can be caused when mother asked to pull knees back toward chest in hard labor – When prolonged damages femoral nerve – Epidural blocks pain receptors that indicate a problem • Entrapment mononeuropathy of lateral femoral cutaneous nerve (L2, L3) • Responds well to conservative tx but can re-occur – Spinal cord stimulator – Adjustments • Therapies • Surgery is performed with intractable pain that doesn’t respond to conservative care. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Obstetric Palsy Medical Intervention • Bilateral arm paralysis following a face presentation – Nerve roots affecting the deltoid, biceps, coracobrachialis, and brachioradialis • C5-C6—Erb’s Palsey • C6-C7—Klumpkey’s Palsey • C5-T1—Arm has marbled appearance due to vasomotor disturbances; may have Horner’s Syndrome • Risk factors – – – – – – Traumatic delivery (forceps, breech, transverse) In-utero ischemia Shoulder dystocia Maternal diabetes Large fetus Cephalo-pelvic distortion • Testing – Electromyography (EMG), Nerve conduction (NC), Spinal evoked potentials (SEP) , or Somato sensory evoked potentials (SSEP) • Surgical Intervention – Had been avoided, but with new anesthesia and microsurgery has revived interest – Designed to clear up ruptures, avulsions of plexus or isolated roots, grafting, or neuroma • Treatment – Adjustment of affected area – Traction and passive exercises PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 NEUROGENIC BLADDER • The normal function of the urinary bladder is to store and expel urine in a coordinated, controlled fashion. This coordinated activity is regulated by the central and peripheral nervous systems. Neurogenic bladder is a term applied to a malfunctioning urinary bladder due to neurologic dysfunction or insult emanating from internal or external trauma, disease, or injury. • Symptoms of neurogenic bladder range from detrusor underactivity to overactivity, depending on the site of neurologic insult. The urinary sphincter also may be affected, resulting in sphincter underactivity or overactivity and loss of coordination with bladder function. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 NEUROGENIC BLADDER • The somatic nervous system regulates the actions of the muscles under voluntary control. Examples of these muscles are the external urinary sphincter and the pelvic diaphragm. • The pudendal nerve originates from the nucleus of Onuf and regulates the voluntary actions of the external urinary sphincter and the pelvic diaphragm. Activation of the pudendal nerve causes contraction of the external sphincter and the pelvic floor muscles, which occurs with activities such as Kegel exercises. • Difficult or prolonged vaginal delivery may cause temporary neurapraxia of the pudendal nerve and cause stress urinary incontinence. • Conversely, suprasacral-infrapontine spinal cord trauma can cause overstimulation of the pudendal nerve that results in urinary retention. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • 1: Phys Ther. 1988 Jul;68(7):1082-6.Related Articles, Links Incidence of diastasis recti abdominis during the childbearing year. fxáá|ÉÇ FM cÉáà ctÜàâÅ Boissonnault JS, Blaschak MJ. Northwestern University Graduate School, Chicago, IL. This study was conducted to determine 1) the incidence of diastasis recti abdominis among women during the childbearing year and 2) the location of the condition along the linea alba. Clinicians have long noted its presence, prenatally and postnatally, but the magnitude of the problem is currently unknown. A cross-sectional design was used to test 71 primiparous women placed in one of five groups, based on placement within the childbearing year. A commonly accepted test for diastasis recti abdominis was performed. Palpation for diastasis recti abdominis at the linea alba was performed 4.5 cm above, 4.5 cm below, and at the umbilicus. Diastases were observed at all three places, but most often at the umbilicus. A significant relationship (p less than .05) was found between a woman's placement in her childbearing year and the presence or absence of the condition. Diastasis recti abdominis was observed initially in the women in the second trimester group. Its incidence peaked in the third trimester group; remained high in the women in the immediate postpartum group; and declined, but did not disappear, in the later postpartum group. These findings demonstrate the importance of testing for diastasis recti abdominis above, below, and at the umbilicus throughout and after the childbearing year. • cÉáà ctÜàâÅ WxÑÜxáá|ÉÇ PMID: 2968609 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2968 609&dopt=Abstract PostPartumValloneMurphyDICCP Yr1Wknd 3 • Which of the following statements about postpartum depression is true? – A. Postpartum depression often occurs 9 to 12 months after delivery. – B. Social support has little impact on the development of postpartum depression. – C. Those with obstetric complications are at increased risk. – D. Those affected are at increased risk for postpartum depression with subsequent pregnancies – E. Patients who have postpartum depression have no higher risk of developing depression in later years when compared to the general population. PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Depression • Most common complication – Occurs in 13% (1 in 8) of women after pregnancy – Recurs in 1 in 4 with prior depression – Often begins within 4 weeks after delivery but may begin later • Multifactorial etiology – Rapid decline in hormones, genetic susceptibility, life stressors • Risk Factors – Prior h/o depression, family h/o mood disorders, stressful life events PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Depression Depression • Pattern of sx are similar to other episodes of depression – Depressed mood, anxiety, loss of appetite, sleep disturbance, fatigue, guilt, decreased concentration – Must be present most of the day nearly every day for 2 wks • Not a separate dx from depression in DSM-IV; “postpartum onset specifier” is used for mood d/o within 4 wks pp • Screening – Edinburgh Postnatal Depression Scale – + screen with score >/= 10 – r/o anemia and thyroid disease PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • One in eight new mothers experience various degrees of postpartum depression • May occur gradually but can take a year to appear • Hormonal changes affect the neurotransmitters – 15-20% of pregnant women experience depression • Cause low birth weight • Cause preterm delivery – 15% of these are severe • Cause constriction of blood vessels • High cortisol levels • Life stressors – Financial – Work – Social • Supposed to be happy – Family • Feelings will flux moment to moment PostPartumValloneMurphyDICCP Yr1Wknd 3 Perinatal Mood Disorders • • • • • • • “Baby Blues” Depression/Anxiety Obsessive-Compulsive Disorder Panic Disorder Psychosis Postpartum Psychiatric Illness Post-traumatic Stress Disorder Baby Blues • 80% of mothers • Onset w/in first week postpartum • Symptoms up to three weeks and resolve on their own – – – – – – Mood instability Weepiness Sadness Anxiety Lack of concentration Feeling of dependency PostPartumValloneMurphyDICCP Yr1Wknd 3 Depression/Anxiety • 15-20% of moms • Onset is usually gradual • Symptoms – – – – – – – – – – – – – Excessive worry or anxiety Irritable or short temper Feeling overwhelmed Hard to make decisions Sad mood, guilt, phobias Hopelessness Sleep problems (too much or too little) Physical symptoms w/o apparent cause Discomfort around baby or lack of feelings for baby Loss of focus or concentration Loss of interest, pleasure Decreased libido Change in appetite • Risk Factors – 50-80% risk if prior postpartum depression – Depression or anxiety during pregnancy – Personal or family hx of depression – Abrupt weaning – Social isolation/poor support – PMS or PMDD (premenstrual dysphoric disorder) – Mood changes with birth control or fertility meds – Thyroid dysfunction • Treatment – Psychotherapy – Antidepressants – Support groups – Rapid hormonal changes – Physical/emotional stress of birthing – Physical discomforts – Emotional letdown – Awareness and anxiety about new responsibility – Fatigue & sleep deprivation – Disappointments • Birth • Spousal support • Nursing PostPartumValloneMurphyDICCP Yr1Wknd 3 Obsessive-Compulsive Disorder • 3-5% of new mothers • Symptoms – – – – Intrusive, repetitive and persistent thoughts or mental pictures Thoughts about hurting in killing the baby Sense of horror and disgust Behaviors to reduce anxiety • Hiding knives, guns – Counting, checking, cleaning or other repetitive behaviors • Risk Factors – Personal/family history of obsessive-compulsive disorder • Treatment – Therapy – Antidepressants – Support groups PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Panic Disorder Psychosis • 10% postpartum women • Symptoms – – – – – – – – • Causes Episodes of extreme anxiety Shortness of breath, chest pain, sensations of choking/smothering Hot/cold flashes, trembling, palpitations, numbness or tingling Restlessness, agitation or irritability Fear of going crazy, doom, or dying Panic attacks w/ no trigger Excessive worry or fear Want to run away • Risk Factors – Personal history of panic/anxiety disorder – Thyroid dysfunction • Treatment • • • • 1-2 per thousand Onset 2-3 days postpartum 5% suicide and 4% infanticide rate Symptoms – – – – • Visual/auditory hallucinations Delusional thinking Delirium and/or mania Parnoia Risk factors – Personal or family hx of psychosis, bipolar disorder, or schizophrenia – Previous postpartum psychotic/bipolar episode • 1 in 3 will have another episode with pregnancy • Treatment – Hospitalization – Medication – Support group – Medications – Stress Management PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Postpartum Psychiatric Illness/Posttraumatic Stress Disorder • No data on prevalence or onset • Symptoms – Recurrent nightmares – Extreme anxiety – Reliving past traumatic events • Risk Factors – Past traumatic events (Abuse) Etiology of Depression/Anxiety • • • • • Nutrient deficiency Blood sugar instability “Stress” Medications Alcohol, caffeine, recreational drugs • Situational Factors • Medical conditions (cancer, heart disease, RA, MS, Chronic pain, anemia) • Hormonal/endocrine • Allergies • Toxins/Heavy Metals • Treatment – Postpartum doula – Therapy PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Comprehensive Approach Comprehensive Approach • Evaluate the patient and rule out underlying causes of disorder • Anemia – Fe deficiency vs. B12/folate • Nutritional Deficiency • Adrenal • Thyroid – Postpartum thyroiditis prevalence is 5-10% of all women – Can present as post partum depression – Onset generally first 2-4 mos. post partum – High cortisol, low DHEA PostPartumValloneMurphyDICCP Yr1Wknd 3 Treatment Consideration • Evaluate the underlying causes to target the most effective treatment • Choose least invasive treatment option • Monitor nursing baby for potential side effects of any treatment given to mother orally (pharmacologic effects of herbs as important as medications) PostPartumValloneMurphyDICCP Yr1Wknd 3 Diet • Goal: stabilize blood sugar – Hydration needs to be adequate • Especially in a nursing mother – Three meals and 2-3 snacks – Protein with each meal and snack – Avoid refined sugar, flour and processed foods – Chromium • Effective for “atypical depression” PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Fish Oil • Maternal DHA status declines in the second trimester associated with high demand for fetal brain development • Omega 3 fatty acids may be protective for high risk pregnancy outcomes • DHA supplementation may enhance language development in breast fed infants • Fish Oil • EPA improves symptoms of depressed patients already treated with antidepressants • Double blind placebo controlled study • 20 patients given 1g EPA bid • Significant reduction in HAM-D score seen in 4 weeks • No side effects • Nemets, B, et.al. Addition of Omega 3 Fatty Acid to Maintenance for Recurrent Unipolar Depressive Disorder, Ann Psychiatry, March 2002;159;477-479 PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Omega 3 Fatty Acids Estrogen Successful treatment of major depression during pregnancy and following delivery with omega-3 polyunsaturated fatty acids • • • After two weeks of treatment, 19 of the women experienced a clinical recovery as defined by a score <7 on the Montgomery-Asberg Depression Rating Scale (MADRS). Omega-3 polyunsaturated fatty acids health benefits – Support the optimal neurological development of the fetus and infant (Birch et al., 2000; Willatts and Forsyth, 2000). – Risk of preterm labor is reduced in women who consume omega-3 fatty acids during pregnancy (Olsen and Secher, 2002). – Support the optimal neurological development of the fetus and infant (Birch et al., 2000; Willatts and Forsyth, 2000). • Estrogen – In a double-blind study of 61 women with major depression that began three months postpartum, transdermal estrogen (as 17 ß-estradiol 200 µg/day) led to a rapid improvement in mood (Gregoire et al., 1996). – Second study, 23 women with major depression that occurred in the six months following delivery took sublingual estrogen (as micronized 17 ß-estradiol, mean dose=4.8 mg/day after the first week) (Ahokas et al., 2001). – Inadequate levels of omega-3 fatty acids have been associated with depression, including postpartum depression (Hibbeln, 1998; Horrobin and Bennett, 1999; Peet and Horrobin, 2002; Peet et al., 1998), and these fatty acids (e.g., 1 g/day to 4 g/day ethyl eicosapentaenoate) – Used to potentiate the effects of antidepressant medications (Nemets et al., 2002; Peet and Horrobin, 2002). The health benefits following delivery. – In infant formula can improve infant cognitive development and visual acuity (Birch et al., 2000; Willatts and Forsyth, 2000). – Positive mood effects • • Estrogen appeals to patients because it is a naturally occurring substance. Estrogen levels precipitously decline following delivery – Estrogen deficiency underlies postpartum depression, but has not been conclusively linked to low levels of estrogen or any other hormone (Hendrick et al., 1998). • Risks – Endometrial hyperplasia – Thromboembolism – Diminishes the production of breast milk in nursing mothers. • Not highly recommended PostPartumValloneMurphyDICCP Yr1Wknd 3 Progesterone PostPartumValloneMurphyDICCP Yr1Wknd 3 Nutrients • B12 – cottage cheese, liver, oysters, swiss cheese • Progesterone levels are low post partum • Women with post partum depression are more sensitive to the w/drawal of steroid hormones. • Not evaluated in a clinical trial • Natural progesterone is metabolized into allopregnanolone, a neuroactive steroid that enhances aminobutyric acid (GABA) in the central nervous system, producing anxiolytic and hypnotic effects (Rupprecht and Holsboer, 1999). • Synthetic progestogens do not help postpartum depression and may, on the contrary, exacerbate the symptoms (Lawrie et al., 2000). – Not metabolized into GABA-ergic neuroactive steroids. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Folate – Brewer’s yeast, rice germ, walnuts, soy beans, almonds, broccoli • Zinc • Copper • Pyridoxine (B6) – Whole grains • Thiamine (B1) – Brewer’s yeast, wheat germ, soybeans, sunflower seeds • Magnesium – Tofu, legumes, seeds, nuts, whole grains, green leafy vegetables PostPartumValloneMurphyDICCP Yr1Wknd 3 SAMe • Naturally occurring molecule found in all body tissue • Plays a role in over 100 biochemical rxns • Rapidly relieves depressive symptoms (12 wks) • Increases activity of serotonin, dopamine, and norepinephrine • Peak plasma concentration 3-5 hours after ingestion • Half life 100 minutes • Readily crosses the blood brain barrier • Efficacy comparable to tricyclic antidepressants for major depression SAMe – Caution/Side Effects • Side effects can include flatulence, nausea, diarrhea, anorexia – Watch breastfeeding baby carefully • Can induce mania in bipolar disorder • Drug interacctinos – Additive effect with SSRI’s PostPartumValloneMurphyDICCP Yr1Wknd 3 5-Hydroxytryptophan PostPartumValloneMurphyDICCP Yr1Wknd 3 Other Considerations • Skullcap : – • Precursor to serotonin from the amino acid, tryptophan • 5-HTP readily crosses the BBB • Excellent safety Profile • Effective for mild, moderate, and severe depression-comparable to SSRI’s • Side effects minimal – – – – • • • • • • Tones and nourishes the nervous system Used with serious mental exhaustion, depression and prolonged sickness Aids in calming tension and stress Improve sleep patterns Side effects Dizziness Confusion Twitching Palpitations – nausea Abdominal upset Abnormal skin coloring Sun sensitivity PostPartumValloneMurphyDICCP Yr1Wknd 3 Helps enzymes generate energy Promotes nerve function Promotes glucose transport Side effects • • • • Appetite loss Breathing problems Headaches Unusual tiredness Low Vitamin B1 (Thiamine) – Reduces depressive moods Relieves anxiety Depresses central nervous system Antibacterial to heal wounds Side effects • • • – – – – • St. John’s Wort (Klamath Weed)* – – – – – Low manganese – – – – – Normal function of nervous system, muscle and heart Promotes normal growth and development Replaces deficiencies from pregnancy and breastfeeding Reduces depression Reduces fatigue Side effects • • • Skin rash or itching Swelling in face Wheezing PostPartumValloneMurphyDICCP Yr1Wknd 3 Other Considerations Herbal Ideas • Recipe for bath-herbs in my files OTHERS: Gotu Kola, Ginseng, Kelp, Black Cohosh, Capsicum, Valerian, Mistletoe, Ginger, Hops, Wood Betony *WARNING: many herbs contraindicated if mother is breastfeeding – – – – – – 1 C Sea salt 1 Large clove of fresh garlic 1 Ounce of uva ursi 1-2 Ounces of comfrey 1/2-1 Ounce of shepherd's purse Boil large pot of water.. Add herbs, and simmer 30 minutes to an hour. Strain. Add sea salt and pureed garlic.. • Garlic and sea salt-- antiseptic. • Uva ursi -- healing for female organs. • Comfrey -- soothing and is said to aid healing by causing the edges of wounds to grow together. • Shepherd's purse, -- preventing and controlling heavy bleeding. • Another recipe – 2 hands full of Comfrey – 1 handful salt tied into a clean sock – Simmer in water, throw sock and tea into the tub…adde a dropper of St Johns Wort oil and Arnica oil to the water…Great for soreness PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Alternatives Recommendations Alternatives Recommendations • Support – – – – Communicate your needs Ask for help with the demands of caring for a newborn baby. Consider hiring a doula Consider pumping for the nighttime feedings and have your partner do at least some of the nighttime feedings so you can sleep. – Ask for help with housekeeping and preparing meals. Many people who no longer have young children feel honored to be asked to care for the baby for short periods of time. • Exercise • Promote sleep – Inadequate sleep can make depression worse. – Release inflammation and heat – Restore balance & energy • Meditation – Encourages rest – Restores inner balance and peace PostPartumValloneMurphyDICCP Yr1Wknd 3 Continued… Adjusting for Depression Eating a well balanced diet Regularly scheduled meals Decreasing refined sugar, caffeine, alcohol, and chocolate may help. REMOVE FOOD ALLERGENS!!! Use of calcium, and B vitamins (B6) may also decrease symptoms. • Spend time with others • Make time to do what you enjoy • Give yourself a break – – Being with others is a way to gain perspective • Consider joining a support group for new mothers – Lose ability to enjoy themselves – Continue doing pleasurable activities even if you don't feel like it. – Getting better takes time. Be realistic about the demands and expectations you make on yourself. • • Identify the main sources of stress in your life • Find the most effective way to cope with those • Identify stressors that you are putting on yourself (trying to be "perfect", doing too much). • Set priorities and let unnecessary tasks wait. PostPartumValloneMurphyDICCP Yr1Wknd 3 Dietary changes – – – – – – Learning to deal more effectively with stress may reduce depression. • Acupuncture – Releasing the body's mood-elevating compounds – Reducing the depression hormone in the blood, providing perspective on life, providing a feeling of accomplishment, enhancing self-esteem, and increasing levels of (a found to be key in the development of depression). – As little as 10 minutes a day has been found to have beneficial effects. • • Stress Management Negative influences • CRANIALS • C1 • Spinal tracts – Lumbars • Sympathetic vs. Parasympathetic • Endorphins – Acupuncture PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Did We Know Better? fxáá|ÉÇ FM cÉáà ctÜàâÅ [|áàÉÜç Éy UÜxtáàyxxw|Çz PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 • Breastfeeding has been going on since mammals existed on earth. • The ancient Greek and Roman medical writings from Hippocrates, Soranus, and especially Galen included infant health and feeding to some extent in their broader treatises on health. • These beliefs were carried into the Middle Ages by the Arabian School (Rhazes, Avicenna and Averroes) and picked up in the Renaissance medical writers (Bagellardus, Metlinger, Roesslin, Phayer, Muffet, and de Vallambert) PostPartumValloneMurphyDICCP Yr1Wknd 3 Did We Know Better? • Presumably these beliefs spread in the same way as the humoral ("hot-cold") theory of disease causation through much of Asia and the Middle East, via the Moors to Spain, and via the Spanish conquerors to Latin America. • These beliefs received a wider audience in Europe with the advent of printing and the use of vernacular languages in the fifteenth and sixteenth centuries. They may lay behind the remarkable similarity of many "traditional" beliefs about infant feeding found throughout the world today. Did They Know…. • Breastfeeding duration – An average duration of 3-4 years among "primitive" peoples (although some breast fed much less than this). – Hawaiians were said to breast feed for five years – Eskimos for about seven years – Breastfeeding continued for three years or longer in 15 of 45 "primitive" cultures for which he could find clear data • Two years in 16 of them • 18 months in 13 of them • 6 months in one culture. PostPartumValloneMurphyDICCP Yr1Wknd 3 Did They Know…. PostPartumValloneMurphyDICCP Yr1Wknd 3 • Issues in lactation management • The late 1400's suggesting that it was normal to breast feed for only about one year in Germany. • In Italy in 1583, women gave pap by the third month and stopped breastfeeding by the 13th month. • During the 1800s, sustained breastfeeding seems to have been considered harmful. • In 1842, a physician writing in Lancet about epilepsy which developed in a child who happened to have been breast fed for three years, concluded, "The worst symptoms of debility at last attended this monstrous proceeding. • By 1900, it was considered immoral in Tyrol. – India—The discarding of colostrum and use of honey and clarified butter to evacuate the meconium and the delaying of breastfeeding until the fifth day was practised in the second century BC. – The Old Testament (Isaiah 7:15) refers to curds and honey to be given to the son born of a virgin "until He knows how to reject the evil and choose the good." – The colostrum taboo was carried into the seventeenth century English and French pediatric literature via ancient Greek and Roman sources . – Ettmuller in 1699 (5) and Smith (6), however, recommended that colostrum be given. • Galactagogues, and various devises to increase breast milk production have long been common in many cultures – Going back to around 1550 BC prompting speculation that failure of the let-down reflex may have commonly occurred, perhaps as a result of "fears of bewitchment or guilt over non-observance of taboos, especially of a sexual nature." PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 History of Artificial Feeding • Issues in lactation management • Rhazes in the tenth century set a precedent for many writers over the years, claiming that many ailments are caused by "overfeeding". – This has led many to insist that the mother must discipline the child not to take the breast too many times or for too long a period each time or at regular intervals. – One of the first books on infant feeding was written by Guillemeau and translated in 1612 into English. It recommended regimented discipline of the child. – Followed up on by Pernell in the second English pediatric textbook in 1653--Let not the child suck so often, nor so long – The German Ettmuller's "Practice of Physic was translated into English in 1699--Nothing is more apt to disorder the child than suckling it too often – Cadogan recommended four feeds per 24 hours for infants – Smith who, in 1792, published the first mothercraft manual--four hourly feeds be followed by about one month of age, since frequent suckling stimulated lactation. • Feeding vessels dating from about 2000 BC have been found in Egypt. – A mother holding a very modern-looking nursing bottle in one hand and a stick, presumably to mix the food – Clay feeding vessels were found in graves with infants from the first to fifth centuries AD in Rome. • • "Hand rearing" was criticized already by Soranus of Epheses, a Roman physician of the second century AD who chided those foolish people who begin artificial feeding too early. Records from foundling homes in England and France show that the vast majority who were artificially fed died. – Sir Hans Sloan wrote that the mortality of suckled infants in Britain in 1660 was 19%; for dry nursed infants it was 54%. – In Rouen, France data from the two-year period 1763-5 showed that of 132 foundlings fed diluted cow s milk, with pap, soup and cider added at three months, only five survived. – In 1753, the governor of the Vasa District in Sweden received permission for the King to fine those mothers who did not breast feed. • Bottle feeding began to work somewhat better as technology for evaporating and canning milk (reducing its curd tension and sterilizing it) was developed in the mid nineteenth century. – Pediatricians became commercially involved in artificial feeding in Paris in 1903. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 And Now…. • It was noted in the 1970’s that formula fed babies had higher death rate due to malnutrition and recurrent infectious diseases • In 1990’s breastfeeding was assoc with decreased death rates due to URI and diarrhea – – – – Bacterial contamination in water Bacterial contamination in bottles Recurrent episodes of infectious gastroenteritis Watered down by those in poverty to make last longer Going Against Design? • Body is designed for it – Anatomically – Neurologically • Hormonally • Emotionally • Countries that utilize breastfeeding and midwifery have better infant mortality rates • Only in 20th century we think we can do it better – Modified mammalian milk (cow formula) – Unmodified mammalian milk (cause metabolic problems in infant) – Grain/legume based beverages (soy formula or gruel) – Wet nurse PostPartumValloneMurphyDICCP Yr1Wknd 3 Composition of human breast milk • • • Lactose (carbohydrates) Contain whey protein, casein proteins, and non-protein nitrogen Infants have softer, less foul smelling stools…ideal for GI tract – Bacteria in GI tract only found in breastfed babies • • • Composition varies based on time of day (longer you feed the higher the fat content) Odor and taste of breast milk changes to help child adapt to different tastes Vitamin K and D (may need to be supplemented after birth) • Minerals – Sodium, Potassium, Calcium, Magnesium, Iron, Zinc, Copper, Selenium, Chromium, Manganese, Molybdemun, and Nickel – Poor in Iron • Anti-infective properties – – – – – – – – – – – Immunoglobulins IgA, IgM, IgG Complement Chemotactic factors Lactoferrin Lysozyme Lactobacillis Bifidus growth factor Cytokines Macrophages T & B Cell Lymphcytes Plasma & Neutrophils Interleukins PostPartumValloneMurphyDICCP Yr1Wknd 3 Hormones of Breastfeeding • Prolactin – Produced by the adenohypophysis (ant pit) and released into the circulation – Produces milk – Controlled by the dopaminergic system – It takes several minutes of sucking to cause prolactin secretion – Inhibits ovulation • Oxytocin – Produced by the neurohypophysis (post pit) – Suckling stimulates the neurohypophysis to produce and release oxytocin intermittently – Produce milk let down – Causes uterine contractions Others for production: Insulin, Cortisol, Thyroid hormone, Parathyroid Hormone, Parathyroid hormone-related protein, and human growth hormone. PostPartumValloneMurphyDICCP Yr1Wknd 3 PostPartumValloneMurphyDICCPYr1Wk nd 3 PostPartumValloneMurphyDICCP Yr1Wknd 3 Changes in Composition • Birth to three days • 4-10 days – Colostrum—thick, yellowish milk • Increased Ca, K, Proteins, Fat-soluable vitamins, mineral, and antibodies – Intermediate between colostrum and mature milk – Volume increases • 10-termination of breastfeeding – Energy—750 kcal/liter – Lipids (Mom’s diet doesn’t affect fat amount, just type) • Triacyl-glycerols • Phospholipids • Fatty acids – Casein—lower concentration than cow’s milk – Whey • • • • • Alphs-lactalbumen Lactoferrin Lyzozyme Albumen Immunoglobulins – Nonprotein Nitrogen—Used in amino acid synthesis – Lactose • Major carbohydrate in breast milk – Galactose – Glucose PostPartumValloneMurphyDICCP Yr1Wknd 3
© Copyright 2024