1. No category

FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
Metabolic and cellular function alterations in
dysfunctional myocardium and atherosclerotic
plaque. Neurohormonal signaling in the heart.
Myocardial blood flow, viability and function.
Imaging in heart failure and vascular disease..
1. Molecular Determinants of A-type lamin age
associated degeneration
2. Cardiogenomic Re-programming
Endocarditis, Valvualar disease, and
Echocardiography.
Diagnostic Cardiac Imaging.
Focus on evaluating and validating advanced
cardiac imaging techniques such as Cardiac CT
and Cardiac PET.
Heart Failure and Transplant.
Nuclear Cardiology and PET.
Electronic Health Records.
Pulmonary Hypertension.
Translational Cardiac Imaging and Physics.
Clinical research in obesity and the weight loss
process, as well as the genotype-phenotype
associations in obesity. History, Physical and
Laboratory parameters are available in SAS, Excel,
and Paradox on obese patients seeking treatment
both in the baseline state and through a standard
dietary challenge.
Heart Failure and Transplant.
Morbidity and mortality rounds and its role in
medical education of internal medicine residents
and quality assurance in cardiology.
1. Brain and the heart in hypertension and CHF.
2. Genetics of Salt Sensitive Hypertension.
Genetic etiology of cardiovascular disease, obesity
and dyslipidemia.
Atrial fibrillation and ventricular tachycardia –
pathophysiology and catheter ablation.
CARDIOLOGY
BEANLANDS, R.
Yes
Yes
BURGON, P.
No
Yes
CHAN, K-L.
Yes
No
CHOW, B.
Yes
No
DAVIES, R. A.
Yes
No
DEKEMP, R.
DENT, R.
Yes
Yes
Yes
No
HADDAD, H.
LAW, A.
Yes
Yes
No
No
LEENEN, F.
Yes
Yes
MCPHERSON, R.
No
Yes
NERY, P.
Yes
No
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
Molecular and Cellular Events involved in the
formation of primary atherosclerotic lesions, as well
as the process of in-stent restenosis.
Smoking Cessation, Physical Activity and Health,
Cardiac Rehabilitation, Health Policy,
Cardiovascular Disease Prevention.
Physical activity, smoking cessation, health
behavior change, cardiac rehabilitation and health
promotion.
Cardiac Imaging and Physiology.
Interventional cardiology.
Cardiac Outcomes Research.
Platelet Function.
Genetics of coronary artery disease risk.
Genetics of primary hypertension.
Transcription regulation of cardiac and muscle
gene expression.
Vascular biology; Regenerative medicine;
Pulmonary hypertension; Endothelial biology;
Angiogenesis; Stem/progenitor cells; Endothelial
factors. Translational research involving early
phase clinical trial of cell and gene-based
therapies.
Human molecular genetic of cardiovascular
diseases and the metabolic syndrome.
Physical activity, smoking cessation, health
behavior change, cardiac rehabilitation, health
promotion, mental health, quality of life.
Role of the brain Na pumps in the regulation of
blood pressure.
Improving image quality and diagnostic accuracy of
SPECT and PET cardiac imaging. Small-animal
cardiac SPECT.
CARDIOLOGY
O’BRIEN, E.
No
Yes
PIPE, A.
Yes
No
REID, R.
Yes
No
RUDDY, T.
SO, D.
Yes
Yes
Yes
No
STEWART, A.
Yes
Yes
STEWART, D.
Yes
Yes
TESSON, F.
No
Yes
TULLOCH, H.
Yes
No
VAN HUYSSE, J.
No
Yes
WELLS, R. G.
Yes
Yes
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
LABORATORY
RESEARCH
RESEARCH INTEREST
No
Prevalence of cardiovascular risk factors in the
community.
Outcome of training workshops on research writing
by young investigators in developing countries.
CLINICAL EPIDEMIOLOGY PROGRAM
ANDERSSON, N.
No
No
FERGUSSON, D.
Yes
No
GRIMSHAW, J.
Yes
No
Youth resilience.
AIDS prevention.
Large scale public health research at the Institute
of Population Health.
Perioperative transfusion and optimal transfusion
therapies and alternatives.
Methodologic Research: Focuses on clinical trial
design, analysis and ethics.
Knowledge translation, quality and safety:
• Systematic reviews of interventions
• Rigorous evaluations of interventions
• Studies of barriers and facilitators to KT,
quality and safety
CRITICAL CARE
CARDINAL, P
Yes
No
HÉBERT, P.
HODDER, R.
Yes
Yes
No
No
KANJI, S.
Yes
No
KIM, J.
No
No
CARDIOLOGY
WIELGOSZ, A.
CLINICAL
RESEARCH
Yes
JONES, G.
Performance assessment of physicians and teams:
Simulation; Needs assessment
Transfusion and Critical Care Research
Mechanical ventilation ; ventilator-associated
pneumonia; ARDS; sepsis; translational research;
clinical trials
Carbon dioxide and acid base dynamics in shock
and resuscitation. The right ventricle and
pulmonary hypertension.
Atrial Fibrillation and Critical Care
Pharmacotherapy
Evaluation of performance in resuscitation of
critically ill patients. Evaluation of performance
using high-fidelity patient simulation
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
CRITICAL CARE
MCINTYRE, L.
Yes
Yes
PATEL, R.
Yes
No
Fluid resuscitation in septic shock and the organ
donor. Transfusion of blood products in the
critically ill. Use of Mesenchymal stromal cells in
sepsis.
Clinical Pharmacology and Therapeutics
Medical Education
DERMATOLOGY
GLASSMAN, S.
Yes
No
PIERSCIANOWSKI, T.
PRATT, M.
Yes
Yes
No
No
ENDOCRINOLOGY
BASAK, A.
KEELY, E.
No
Yes
Yes
No
LOCHNAN, H.
Yes
No
MALCOLM, J.
Yes
No
Psoriasis.
HIV and skin disease.
Drug eruptions.
Clinical research on various types of leg ulcers.
1) Allergen Content of Problem and Non Problem
Gloves
2) Filaggrin mutations and cell mediated allergic
contact sensitivity
3) Allergy to Dental materials
4) Paraphenylenediamine (hair dye) allergy and
HLA, also a ten year review of all PPD cases
5) Ten year Review of Corticosteroid allergy in the
NACDG Research group
6) Metal allergy to Orthopaedic and vascular
prostheses, stents and devices
Protein Chemistry, Proteases and their regulators
Quality improvement in diabetes care.
Diabetes in pregnancy.
See also: Medical Education
Clinical research related to diabetes management
and disorders of the thyroid.
See also: Medical Education
Clinical research related to health services in
diabetes care, quality of care in diabetes, exercise
in patients with type 1 diabetes, and diabetes in
pregnancy.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
ENDOCRINOLOGY
MBIKAY, M.
No
Yes
OOI, T. C.
Yes
Yes
SCOTT, F.
No
Yes
SORISKY, A.
No
Yes
ZHA, X.
No
Yes
Roles of secretory endoproteinases in metabolic
diseases, including obesity, diabetes,
atherosclerosis and infertility.
Pathophysiological studies in lipoprotein
metabolism.
Modification by dietary antigens of the gut immune
system and pancreas biology in pathogenesis of
type 1 diabetes.
Studies on adipose cells at the cellular and
molecular level.
Lipoprotein metabolism and cholesterol trafficking
at cellular level.
GASTROENTEROLOGY
HASSARD, P.
SHAW-STIFFEL, T.
Yes
No
SY, R.
Yes
No
GENERAL MEDICINE
CAMPBELL, C.
Yes
No
CHAN, J.
No
No
CONTRERAS, V.
Yes
No
FORSTER, A.
Yes
No
Clinical trial and case reports in IBD therapeutics,
general GI trials and case reports.
Viral Hepatitis B & C.
Cirrhosis and its complications.
Main interest in Inflammatory bowel disease.
Systematic review / meta-analyses and RCT in
general GI.
The role of electronic learning portfolios as a
formative evaluation tool in postgraduate medical
education. The role of Personal Learning Projects
in Postgraduate Education. The role of practice
audit tools as a formative evaluation tool focused
on resident performance in practice.
Perioperative assessment.
See also: Medical Education
Pulmonary hypertension, chronic thromboembolic
lung disease, right-sided heart function, pulmonary
vasodilators.
To evaluate and improve the safety and quality of
health care delivery.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
GENERAL MEDICINE
TOUCHIE, C.
No
No
TURNBULL, J.
VAN WALRAVEN, C.
Yes
Yes
No
No
WILLIAMS, J.
No
No
WILSON, K.
No
No
Will supervise interesting case reports
See also: Medical Education
Homelessness and Health
Study of effect of health interventions in routine
clinical practice.
Study of processes and outcomes of routine clinical
practice with a view to improve patient care.
Bioethics, research ethics, medical
professionalism, international bioethics.
Public health policy including blood safety,
vaccination policy and public health security.
GERIATRICS
AZAD, N.
Yes
No
BYSZEWSKI, A.
Yes
No
DALZIEL, W.
HING, M.
Yes
Yes
No
No
HEMATOLOGY
ALLAN, D.
Yes
Yes
Heart failure and cognitive assessment.
Gender health inequity.
Telehealth management of CHF.
Case reports on disclosure of dementia diagnosis
and unfitness to drive.
Medical Grand Rounds – designing an interactive
web based program for Royal College, Section 1
MOC.
Education, dementia, screening elderly
Driving issues in older persons. Atrial fibrillation
Endothelial Progenitor Cells (EPCs) and
regenerative capacity of hematopoietic grafts;
experimental BMT; and clinical studies in chronic
GVHD.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
HEMATOLOGY
ATKINS, H.
Yes
Yes
BENCE-BRUCKLER, I.
CARRIER, M.
Yes
Yes
No
No
FORGIE, M.
Yes
No
GONSALVES, C.
No
No
HUEBSCH, L.
Yes
No
RODGER, M.
Yes
Yes
SABLOFF, M.
Yes
No
SCARVELIS, D.
Yes
Yes
TINMOUTH, A.
Yes
No
Role of stem cells in recovery following myocardial
infarction and stroke, the use of viruses to treat
cancer cells and the role of bone marrow transplant
for the treatment of multiple sclerosis.
Lymphoma, clinical trials of therapies
Clinical Research in venous thromboembolic
disease and cancer, including cancer screening,
prevention and management.
Quality of life in chronically transfused patients.
Quality of life assessment tools.
Educational scholarship – needs assessment for
curriculum development.
Transplant registries and regenerative capacity of
hematopoietic grafts.
Diagnosis and treatment of DVT/PE. Management
of thrombophilia. Treatment of Thrombosis in
pregnancy and adverse events in pregnancy that
may be related to thrombophilia; pharmacokinetics
of low molecular weight heparins in renal failure;
perioperative anticoagulation bridging.
Leukemia and experimental stem cell transplant in
leukemia. Chronic lymphocytic leukemia and
experimental stem cell transplant in CLL. Follicular
lymphoma and stem cell transplant options in
follicular lymphoma.
Role of D-dimer in venous thromboembolic
disorders; diagnosis of pulmonary embolism and
evaluation of prognostic factors in pulmonary
embolism; acute treatment of venous
thromboembolic disorders.
Use of blood products for management of
coagulopathies, especially use of FFP; disorders of
hemostasis, clinical trials and laboratory evaluation
of; optimal transfusion therapies, alternatives and
knowledge translation of transfusion evidencebased data.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
HEMATOLOGY
VAN DER JAGT, R.
Yes
No
WELLS, P.
Yes
Yes
Clinical trials in leukemia, lymphoma, myeloma and
myelodysplasia
Clinical Research in venous thromboembolic
diseases, including diagnosis, treatment, etiology
and prevention.
Genome based studies, genetic association
studies.
Novel ways to monitor oral anticoagulants.
Knowledge translation of venous thromboembolism
treatments and diagnostic strategies.
INFECTIOUS DISEASES
ANGEL, J.
Yes
Yes
AUCLAIR, F.
BALFOUR, L.
Yes
Yes
No
No
BROOKS, J.
No
Yes
CAMERON, B.
Yes
Yes
COOPER, C.
Yes
No
CORACE, K.
Yes
No
Varied, several aspects of HIV research including
those related to host immune function-immunology
Clinical Reasoning.
HIV and HCV behavioral medicine, HIV medication
readiness and adherence, quality of life and
depression, Validating patient knowledge
measures and decision tools.
Investigating HIV drug resistance testing for
resource poor countries.
Dried blood spot specimen collection for HIV
diagnostics.
Cross-species retroviral transmission.
Sexually transmitted diseases, HIV/AIDS and
tuberculosis in developing countries and in
Canada.
Agenda designed to evaluate the clinical,
biochemical, virologic, immunologic, and
pharmacokinetic intereactions between HIV, HCV,
and the medications used to treat these chronic
infections.
Hep C / HIV treatment readiness and adherence,
mental health, Hep C / HIV stigma, health risk
behaviour change, psychometric scale validation,
statistical methods.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
INFECTIOUS DISEASES
CORRALES-MEDINA, V.
Yes
No
GARBER, G.
Yes
Yes
LAPORTE, C.
Yes
Yes
LEE, C.
Yes
Yes
MACPHERSON, P.
Yes
Yes
MCCARTHY, A.
Yes
No
ROSE, G.
Yes
No
ROTH, V.
No
No
SAGINUR, R.
Yes
No
SINGHAL, N.
Yes
No
Cardiovascular complications in patients with
community acquired pneumonia. The role of
infection in the triggering of acute coronary
syndromes.
Hand hygiene. Strategies to improve resident and
staff compliance. Sepsis pathogenesis.
Pathogenesis of Trichomonas
Clinical Pharmacology in HIV, pharmacokinetics,
drug levels, drug interactions
Investigating the molecular mechanisms of heme
acquisition in pathogenic bacteria.
Basic Science: Immune dysregulation and
cytokine signaling in HIV infection.
Clinical: Treatment of HIV and other sexually
transmitted infections.
Infectious in compromised hosts, vaccine efficacy,
antimalarial drugs, and compliance with travel
medicine recommendations.
Decision aid development and utilization.
Influenza vaccine uptake in health care providers.
Malaria prevention choices in travelers.
Global Health Curriculum development.
Infection control and hospital epidemiology.
Complicated skin and soft tissue infections.
Diabetic foot infections.
Use of electronic and administrative data sources.
Hospital Epidemiology and Infection Control,
including surveillance and control of hospitalacquired infections, hand hygiene, antibiotic
resistance and emergency preparedness.
Infections of prosthetic devices.
Research ethics: web-based education; ethics of
multicentre trials; governance; consent issues.
Micronutrients in HIV.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
INFECTIOUS DISEASES
SUH, K.
Yes
No
WONG, T.
Yes
No
Hospital epidemiology/infection control, nosocomial
infections, abx resistant organisms, antimicrobial
use.
HIV, STI, hep C, TB, Aboriginal, street youth,
immigrant, IDU, MSM, emergency preparedness,
pandemic influenza.
MEDICAL EDUCATION
CHAN, J.
No
No
Evaluations / OSCE.
Technology in Medical Education.
See also: General Internal Medicine
DOJEIJI, S.
No
No
DUDEK, N.
Yes
No
HUMPHREY, S.
Yes
No
KEELY, E.
Yes
No
LOCHNAN, H.
Yes
No
PEREIRA, J.
Yes
No
PUGH, D.
No
No
Written, verbal and team based communication
skills.
See also: Physical Medicine and Rehabilitation
Clinical performance evaluation
See also: Physical Medicine and Rehabilitation
Procedural skills- how to best assess and teach,
Students as OSCE examiners, OSCE related such
as how to establish pass/fail scores, can a trained
observer replace a physician examiner? The use of
patient partners in teaching the MSK exam.
See also: Rheumatology
Written Communication
See also: Endocrinology
Student and resident learning, professionalism and
networking.
See also: Endocrinology
Instructional technologies, distributed learning and
the use of OSCEs in evaluation, particularly in
palliative care.
See also: Palliative Care
Technical Skills Assessment.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
MEDICAL EDUCATION
TOUCHIE, C.
No
No
VARPIO, L.
Yes
No
Procedural Skills, Examination Development:
Written assessments, Clinical-decision making,
performance examinations, communication skills
and CanMED roles. Other studies related to
medical education can be considered.
See also: General Medicine
Medical Education, communications, use of
information and computer technologies (ICTs) in
clinical settings, inter-professional collaboration
and education.
MOLECULAR CELLULAR
ANDRADE, M.
No
Yes
KOTHARY, R.
No
Yes
LEE, H.
No
Yes
PARISSENTI, A.
Yes
Yes
PICKETTS, D.
No
Yes
Bioinformatics, genomics, proteomics, data mining,
text mining.
Our long-term goals are to understand the
mechanisms which maintain/alter muscle and
nervous system integrity, and in so doing acquire
the information base to alleviate the pathology of
neuromuscular diseases like Spinal Muscular
Atrophy.
1. Cell cycle, PI3K-Akt signal pathway and
chromosome replication.
2. Tumor radiosensitivity
3. Drug discovery from natural and synthetic
compounds
4. We use molecular, cellular, genomic, proteomic,
and high throughput screening technologies
Mechanisms of resistance to anthracyclines and
taxanes in human breast cancer.
Identification of biomarkers for monitoring or
predicting drug resistance and drug
response/toxicity in breast cancer patients.
Understanding the role of chromatin remodeling
proteins in the pathogenesis of X-linked intellectual
disability disorders and neural development.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
MOLECULAR CELLULAR
RUDNICKI, M.
No
Yes
SUTHERLAND, L.
No
Yes
Molecular genetic approaches to determine the
function and roles played by regulatory genes
acting in pathways that regulate cellular
proliferation and differentiation of stern cells.
Research into the role of the putative tumour
suppressor, RBM5, and its homologue, RBM10, in
lung and breast cancer.
NEPHROLOGY
AKBARI, A.
Yes
No
BIYANI, M.
Yes
No
BURNS, K.
Yes
Yes
The role of Angiotensin and its peptide degradation
fragments in progressive renal disease.
Translational studies on use of vascular
progenitors in acute kidney injury.
DAVIS, J.
Yes
No
Progressive renal insufficiency (CKD stage 4) and
quality assurance.
EDWARDS, C.
Yes
No
Cardiovascular disease in patients with chronic
kidney disease.
FAIRHEAD, T.
No
Yes
The role of T cells in allo- and autoimmunity in the
context of kidney disease.
HEBERT, R. L.
No
Yes
Role of intrarenal prostaglandins in diabetic
nephropathy, in vitro tubular microperfusion.
Improving care of patients who develop Pregnancy
induced hypertension and early detection of renal
failure.
Peritoneal dialysis clinical research
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
NEPHROLOGY
HIREMATH, S.
Yes
No
HOAR, S.
Yes
No
-Clinical research in outcomes related to Vascular
access in hemodialysis patients. Contrast-Induced
Acute Kidney Injury and Sudden Death in
hemodialysis patients.
-Methodology used including systematic reviews
and meta-analysis, decision analysis and survival
analysis.
Research in Medical Education
KARPINSKI, J.
Yes
No
Research in Medical Education
KENNEDY, C.
No
Yes
Mechanisms of proteinuria, and prostaglandin
function in the glomerulus, animal models of CKD
KNOLL, G.
Yes
No
LAVOIE, S.
Yes
No
Clinical aspects of kidney transplantation.
Clinical research involving dialysis patients and/or
with general nephrological problems.
Systematic reviews in Nephrology.
Measurement of kidney function.
Peritoneal dialysis clinical research
MAGNER, P.
Yes
No
Hemodialysis, vascular access, and management
of chronic kidney disease.
McCORMICK, B.
Yes
No
Management of complications in peritoneal dialysis
patients, including blood pressure and fluid
management control.
RUZICKA, M.
Yes
No
Role of Sympathetic Nerve Activation in
Hypertension, Hypertension management in CKD
TOUYZ, R.
Yes
Yes
The pathophysiology and molecular mechanisms of
hypertension and vascular disease, using animal
models and human subjects.
ZIMMERMAN, D.
Yes
No
Research in Hemodialysis, Hemofiltration and
Cardiovascular Disease
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
NEUROLOGY
ALBERT, P.
No
Yes
Clinical genetics and characterization of gene
involved in mental illness and mental retardation.
BENNETT, S.
No
Yes
BERGERON, R.
No
Yes
BULMAN, D.
No
Yes
BUSSIERE, M.
Yes
No
CHEN, H. H.
No
Yes
COLAVITA, A.
No
Yes
FIGEYS, D.
No
Yes
Dr. Bennett is a cell biologist and neuroscientist
whose expertise is in molecular mechanisms of cell
death and intercellular communication. The overall
goal of Dr. Bennett’s research is to better
understand basic molecular mechanisms of
neurodegeneration and neuroegeneration.
Function of the NMDA receptor in the central
nervous system, schizophrenia and dementia.
Identification of genes responsible for inherited
disorders.
Medical and interventional treatments for idiopathic
intracranial hypertension, carotid stenting,
interventional treatments for stroke, predictors of
outcome of coma after cardiac surgery.
Dr. Chen studies molecular mechanisms involved
in neuronal differentiation and development with
the goal of devising strategies to treat stroke.
Dr. Colavita’s research focuses on discerning the
genetic and molecular mechanisms involved in
axon branch formation and outgrowth, using C.
elegans as a model. The process of axon
outgrowth is essential to brain recovery.
Dr. Figeys’ research efforts are focused on 1)
mapping protein-protein interactions of proteins
relevant to human diseases; 2) validating the roles
that some of these proteins play in human
diseases; and 3) the development of novel
technological approaches.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
NEUROLOGY
FREEDMAN, M. S.
Yes
Yes
GRIMES, D.
Yes
Yes
HAKIM, A.
Yes
Yes
HOGAN, M.
Yes
Yes
LOY-ENGLISH, I.
Yes
No
MACLEAN, H.
MCILRAITH, D.
MENDIS, T.
Yes
Yes
Yes
No
No
No
MORRIS, C.
No
Yes
Clinical and basic research in the field of Multiple
Sclerosis. Clinical research includes numerous
industry supported trials of new agents as well as
investigator driven trials of stem cell
transplantation. Laboratory research examines the
mechanisms of immune-mediated damage to the
CNS.
Exploring the role of genes that cause or contribute
to the development of abnormal movements.
Including Parkinson’s disease.
Dr. Hakim’s research has focused on what
happens in the brain after a stroke and has led to
important insights into potential approaches to
prevent and repair stroke damage. He also led the
creation of the Canadian Stroke Network and the
Centre for Stroke Recovery, as well as the
development of the Canadian Stroke Strategy,
which promotes an integrated approach to stroke
prevention, care and recovery.
Use of non-invasive imaging methods (CT and
MRI) to study the metabolic and functional
consequences of acute ischemic stroke and
recovery from ischemic brain injury.
Clinical research in Alzheimer disease and other
dementias, including clinical trials, genotypephenotype associations, the effect of vascular risk
factors on AD, psychosocial effects and imaging.
Clinical research in Multiple Sclerosis.
Medical Education
Clinical trials in Parkinson’s Disease.
Clinical trials in Alzheimer disease and other
dementias.
The Bilayer Mechanics of voltage-Gated Channels.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
NEUROLOGY
NGSEE, J.
No
Yes
PARK, D.
No
Yes
RENAUD, L.
No
Yes
SCHLOSSMACHER, M.
Yes
Yes
SHARMA, M.
Yes
No
SITWELL, L.
SLACK, R.
Yes
No
No
Yes
STOTTS, G.
THOMPSON, C.
Yes
No
No
Yes
My research focuses on defects in vesicle
trafficking and protein sorting that underlie
neurodegenerative diseases such as ALS,
Huntington’s and Parkinson’s Disease.
Dr. Park’s primary research interest is the study of
how death-signaling molecules interact to regulate
the death process occurring in neurodegenerative
conditions including stroke and Parkinson’s
disease.
Dr. Renaud is an expert in cellular
neurophysiology. He is particularly interested in
the study of neurotransmission in the brain and
spinal cord.
Diagnostic approaches and basic science aspects
of Parkinson disease-linked genes.
Dr. Sharma leads the Heart & Stroke Foundation
Centre for Stroke Recovery Granulocyte-Colony
Stimulating Factor in Ischemic Stroke Trial (GIST)
project and has been developing
pharmacoeconomic models of stroke and stroke
care in Ontario.
Clinical trials in headache.
Dr. Slack has extensive expertise in the
identification of molecular mechanisms that
regulate pluripotent cell self-renewal, progenitor
numbers and neurogenesis (the development of
new neuronal cells). Her research may facilitate
the regeneration of brain cells after acute injury.
Clinical stroke research and imaging.
Dr. Thompson has expertise in laboratory models
of preconditioning against stroke and in the
assessment of cognitive and motor recovery from
stroke. He has developed ways to use cultured
cells to reveal molecular mechanisms involved in
the induction of ischemic tolerance in the brain by
preconditioning.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
NEUROLOGY
TIBERI, M.
TSAI, E.
No
Yes
Yes
Yes
WALKER, L.
Yes
No
Molecular basis of dopamine receptor regulation.
Spinal cord repair, spinal cord imaging,
tractography, magnetic resonance imaging.
Cognition in multiple sclerosIs and stroke.
Relationship to structural and functional imaging.
Change in cognition over time.
NUCLEAR MEDICINE
LEUNG, E.
Management of thyroid cancer. Improving skeletal,
pulmonary, and tumour scintigraphy with
SPECT/CT. FDG PET/CT in cardiac sarcoidosis.
Radioisotope therapy of bone metastases.
WASSENAAR, R.
Yes
No
ZENG, W.
Yes
No
ONCOLOGY
ASMIS, T.
Yes
No
BIRNBOIM, H. C.
No
Yes
CLEMONS, M.
Yes
Yes
SPECT, SPECT/CT, and PET/CT image analysis
and physics.
Molecular imaging with PET/CT and SPECT/CT.
Gastrointestinal Malignancies: Adjuvant and
metastatic treatment, clinical trials, treatment of the
elderly and patients with co-morbidity, translational
research, retrospective chart reviews.
Sarcoma: Prognostic factors, adjuvant and
metastatic therapy, guideline development, GISTS
(GI stromal tumors).
Colorectal cancer: translational research into
prognostic and predictive markers of toxicity and
response.
Breast Cancer: locally advanced and metastatic.
Clinical and lab projects looking at strategies to
improve individualized patient care through an
increased knowledge of the metastatic process.
Biomarker studies.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
ONCOLOGY
CRIPPS, C
Yes
Yes
DENT, S.
Yes
Yes
GOSS, G.
Yes
Yes
JONKER, D.
Yes
Yes
LORIMER, I.
No
Yes
REAUME, N.
Yes
No
SONG, X.
Yes
No
Gastrointestinal Cancer – Phase II and III trials,
education
Breast Cancer: adjuvant and metastatic breast
cancer, investigative drug development trials.
Special interest in locally advanced and
inflammatory breast cancer, chemotherapy and
trastuzumab-induced cardiotoxicity, aromatase
inhibitor toxicities, and patient knowledge transfer.
Lung cancer: NSCLC and SCLC, adjuvant and
metastatic treatment, treatment in the elderly and
poor prognosis patients, research on prognostic
and predictive factors in various lung cancers,
retrospective chart reviews.
New drug development: early phase clinical trials;
anti EGFR pathway and anti-angiogenesis therapy.
Translational research: Molecular markers of
NSCLC and SCLC.
GI malignancies: guideline development,
development of therapeutics, translational research
(prognostic and predictive markers of toxicity and
response).
Brain and breast cancer, the epidermal growth
factor receptor and experimental therapeutics for
cancer.
Clinical trials of novel agents in lung and
enitourinary cancers. Evaluation levels of
evidence and its translation into practice. Health
Services research (economic analysis). Outcomes
research of standardized treatment protocol
implementation.
Clinical research in Breast and Skin Cancer
management, focusing on survivorship issues.
Research in medical education and knowledge
translation.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
ONCOLOGY
VERMA, S.
Yes
Yes
WHEATLEY-PRICE, P.
Yes
Yes
Breast cancer: high risk, prevention, prognostic
factors, adjuvant and metastatic therapy, biologic
predictive molecular markers, decision making and
support, economic evaluations ( cost –
effectiveness analysis) , access to therapy and
guideline development; Survivorship and coping
strategies after breast cancer.
Melanoma: Immunotherapy, guideline
development; Biology and outcomes of ocular
melanoma.
Sarcoma: prognostic factors, adjuvant and
metastatic therapy, molecular markers, decision
making and support, access to therapy and
guideline development; GISTS(GI Stromal
Tumors).
Lung cancer: NSCLC, SCLC and mesothelioma.
Adjuvant and metastatic treatment, clinical trials,
outcomes in clinical subgroups, retrospective chart
reviews
Lung cancer: Communication skills in advanced
cancer
Breast cancer: Adjuvant and metastatic
treatment, clinical trials, outcomes in clinical
subgroups, retrospective chart reviews
PALLIATIVE CARE
ALLARD, P.
Yes
No
Delirium assessment, management and outcomes
in palliative care settings
BHIMJI, K.
BUSH, S. H.
Yes
Yes
No
No
CHAN, R.
Yes
No
Palliation of end-stage heart disease
Delirium (assessment and management, and
impact).
Palliative care education (undergraduate and
postgraduate).
Clinical Practice Guideline Development
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
PALLIATIVE CARE
CHASEN, M.
Yes
No
FITZGIBBON, E.
HALL, P.
HARTWICK, M.
Yes
Yes
No
No
No
No
•
•
•
•
•
•
LAWLOR, P.
Yes
No
PEREIRA, J.
Yes
No
TUCKER, T.
Yes
No
PHYSICAL MEDICINE & REHABILITATION
ACHARYA, M.
Yes
No
DOJEIJI, S.
No
No
DUDEK, N.
Yes
No
FINESTONE, H.
Yes
No
GREENE-FINESTONE, L.
No
No
Palliative Rehabilitation
Cancer Anorexia and Cachexia
Cancer Survivorship
Complex Cancer Pain Management
Interprofessional learning & practice
Communication Skills in the Critical Care
Setting/ICU
• Assessment of Cancer Pain, Delirium,
Methadone
• Palliative Care
• Management of delirium in palliative care
• The consultation role
• Medical Education
Palliative care education (postgrad):
the experience of caring and the care given
Cultural differences in dealing with disabilities.
Secondary risk reduction of strokes by treating
hyperhomocysteinemia.
Aphasic depression rating scale: application and
evaluation.
Medical Education with a focus on written, verbal
and team based communication skills.
See also: Medical Education
Amputee rehabilitation. Dermatological problems
in amputees.
See also: Medical education
1) Driving and stroke issues- how does a stroke
affect ablity to drive. 2) MSKL injury and pain and
how psycho-social issues affect recovery. 3) Use of
Virtual Reality techniques to improve motor
performance in stroke patients.
Driving and stroke issues.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
LABORATORY
RESEARCH
RESEARCH INTEREST
PHYSICAL MEDICINE & REHABILITATION
MARSHALL, S.
Yes
No
TRUDEL, G.
No
Yes
Driving and Disability.
Brain Injury Rehabilitation.
Effects of immobility, anemia of immobility, fat
accumulation in the bone marrow in muscle,
tendonopathy.
REHABILITATION
RESEARCH
LEMAIRE, E.
Yes
Yes
WILSON, K.
Yes
No
RESPIROLOGY
AARON, S.
Yes
Yes
ALVAREZ, G.
Yes
No
AMJADI, K.
Yes
Yes
HODDER, R.
Yes
No
LEECH, J.
Yes
No
MCKIM, D.
Yes
No
CLINICAL
RESEARCH
Mobility and assistive devices (primarily prosthetics
and orthotics). Motion analysis. Telehealth and
e-learning applications. Using Internet-based
communication technology to accomplish clinical
tasks.
Chronic pain; psychosocial aspects of chronic
illness and disability; palliative and end-of-life care.
COPD, Cystic Fibrosis, Microbiology, Clinical
Epidemiology, Clinical Trials.
Tuberculosis, Mycobacteria other than TB, HIV,
developing countries, clinical trials.
Management of malignant pleural effusion.
Endoscopic interventions for complications of
thoracic malignancies.
COPD; asthma: pulmonary fibrosis; clinical trials;
translational research.
Sleep-disordered breathing, narcolepsy housing
and indoor air pollution.
Long Term Non-invasive ventilation, Quality of Life
in Neuromuscular patients, Airway Clearance in
Neuromuscular Disease among others. One project
that needs to be done immediately is to review the
Ottawa Hospital’s experience with ventilated
patients outside the ICU.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA
NAME
CLINICAL
RESEARCH
LABORATORY
RESEARCH
RESEARCH INTEREST
RESPIROLOGY
PAKHALE, S.
Yes
Yes
Asthma, COPD, CF, clinical epidemiology, social
determinants, cohort studies
RHEUMATOLOGY
HUMPHREY, S.
Yes
No
Case reports in Rheumatology
See also: Medical Education
KARSH, J.
Yes
No
Inflammatory arthritis and clinical trials.
SMITH, D.
Yes
No
Clinical trials related to Systemic Lupus
Erythematosus and Scleroderma.
TUGWELL, P.
Yes
No
Clinical Trials in musculoskeletal disease; quality of
life studies; caregiver quality of life; Cochrane and
Campbell collaboration systematic reviews of
interventions in musculoskeletal conditions;
interventions that reduce inequities; international
health knowledge translation.