Technical information GPS Safety Summary Acetone cyanohydrin Substance name Acetone cyanohydrin General statement Acetone cyanohydrin is an intermediate and used as a building block for chemical synthesis. Consumer risk and exposure is very unlikely as this substance is manufactured and handled in industrial settings. The environmental effects, ecotoxicology and toxicology information available for this chemical is provided based on studies and/or a reliable evaluation of its hazardous properties. See Health and Environmental Effects. This chemical should not enter surface water, groundwater water and soil. See Risk Management Recommendations. Chemical identity Name Acetone cyanohydrin Brand names VISIOMER® ACH Chemical name (IUPAC) 2-hydroxy-2-methylpropanenitrile CAS number 75-86-5 EC number 200-909-4 Synonyms 2-cyanopropan-2-ol Evonik Industries Industries AG | GPS Safety Summary Acetone cyanohydrin | December 2011 | Version 2 | page 1/6 Uses and application Acetone cyanohydrin is used primarily as an intermediate component in the manufacture of other chemicals. Physical/chemical properies Acetone cyanohydrin is a clear to yellow, pungent liquid. The liquid density is 0.93 g/cm3 which is lower than that of water and a vapor pressure at <0.3 hPa. Based on the boiling point and the flash point, Acetone cyanohydrin is not classified as flammable. Property Value Molecular weight 85.11 g/mol Water solubility Miscible in water Density 0.93 g/cm3 (20 °C) Vapor pressure < 0.3 hPa (20 °C) Explosive Properties Explosion limits 2.2 % (V) and 12 % (V) Melting / Boiling point -19 °C / 120 °C (1013 hPa) Self-ignition temperature 540 °C Flashpoint 75 °C Health and environmental effects Consumer Consumer risk and exposure is very unlikely as this substance is manufactured and handled in industrial settings. Worker Based on available data, Acetone cyanohydrin is fatal if swallowed, inhaled or absorbed through the skin. Standard tests show no evidence that Acetone cyanohydrin is mutagenic or genotoxic. Data shows no evidence that Acetone cyanohydrin is a reproductive or developmental toxin. Evonik Industries Industries AG | GPS Safety Summary Acetone cyanohydrin | December 2011 | Version 2 | page 2/6 Health effects Effect Assessment Result Acute toxicity (oral, dermal Fatal if swallowed, inhaled or absorbed and inhalation) through the skin. Affects the Central Nervous System. Eye / Skin irritation No data available. Avoid contact with the substance. Sensitization No data available. Avoid contact with the substance. Toxicity after repeated No evidence of toxicity upon repeated exposure exposure. Genotoxicity / Mutagenicity No evidence of mutagenic / genotoxic effects Carcinogenicity No data available. Toxicity for reproduction No evidence of reproductive or developmental effects. Environmental effects Based on available data, Acetone cyanohydrin is very toxic to aquatic life with long lasting effects. It is readily biodegradable. However, in waste water treatment plants toxic concentrations have to be avoided in order to ensure the proper function of the plant. There is no evidence that the substance would bioaccumulate. Environmental effects Effect Assessment Result Aquatic toxicity Very toxic to water organisms with long lasting effects. Fate and Behavior Result Biodegradation Readily biodegradable Bioaccumulation potential No potential for bioaccumulation PBT / vPvB conclusion Not considered to be either PBT or vPvB Evonik Industries Industries AG | GPS Safety Summary Version 2 | page 3/6 Acetone cyanohydrin | December 2011 | Exposure Human health Consumers will not come in contact with this chemical as it is manufactured in a closed process which also minimizes employee exposure potential. Personnel exposure to this chemical in the manufacturing facilities is low because the process, storage and handling operations are enclosed. Normal industrial practices assure limited workplace exposures. These practices include handling with good ventilation. When containers and tanks are cleaned, residues are captured and treated. All workers are trained in the properties and safe practices of using chemicals including using personal protective clothing. Environment Direct use by consumers is not intended since there are no known consumer uses for this chemical. The manufacture is a closed and automated process and no exposure to the environment are intended. Any exposures will generally be lower than concern levels. Any waste containing residual ACH has to be disposed in accordance with local, state and federal laws. Risk management recommendations Human health When using chemicals make sure that there is adequate ventilation. Always use appropriate chemical resistant gloves to protect your hands and skin and always wear eye protection such as chemical goggles. Exposure to the chemical demands a special treatment (appropriate antidotes, e.g. polyethylene glycol-400) by doctor on call without delay (hydrogen cyanide poisoning). Do not eat, drink and smoke where chemicals are handled, processed or stored. All releases that may include the substance must be directed to a wastewater treatment plant that removes the substance from the final releases to the receiving water. Releases to air are not expected and therefore no specific recommendations are required. Waste containing hazardous levels of the substance must be disposed of in accordance with the regulations after consultation of the competent local authorities and the disposal company in a suitable and licensed facility. Regulatory information/classification and labeling ACH is listed in various national chemical inventories as an existing substance. As it is a high production volume chemical (HPV) it occurs on many national regulatory programs including the OECD (Organization for Economic Co-operation and Development) Screening Inventory Dataset (SIDS) and has been recently registered under the EU REACH program. ACH is not a Substance of Very High Concern (SVHC). Evonik Industries Industries AG | GPS Safety Summary Version 2 | page 4/6 Acetone cyanohydrin | December 2011 | GHSGHS-Classification ACH is classified as follows: GHSGHS-Classification Statutory basis Acetone cyanohydrin UN-GHS Ver. 4 (2011) Acute toxicity (oral) Hazard category 2 Acute toxicity (dermal) Hazard category 1 Acute toxicity (inhalation) Hazard category 1 Specific Target Organ Toxicity Hazard category 1 - Single exposure (neurotoxic effects) Hazardous to the aquatic Hazard category 1 environment – Acute Hazard Chronic water hazard Hazard category 1 GHSGHS-Labeling ACH is labeled as follows: GHSGHS-Labeling Statutory basis Acetone cyanohydrin UN-GHS Ver. 4 (2011) Symbol(s) Signal word Danger Hazard statement H300: Fatal if swallowed. H310: Fatal in contact with skin. H330: Fatal if inhaled. H370: Causes damage to organs. H410: Very toxic to aquatic life with long lasting effects. Precautionary statements: Precautionary statements and more information about ACH can be found on the Safety Data Sheet. Evonik Industries Industries AG | GPS Safety Summary Version 2 | page 5/6 Acetone cyanohydrin | December 2011 | This GPS Safety Summary is based on Evonik´s present knowledge and experience as of the date of issue. However, it implies no liability or other legal responsibility on the part of Evonik, including with regards to existing third party intellectual property rights, especially patent rights. In no event shall Evonik be responsible for damages of any nature whatsoever resulting from the use of or reliance upon the information herein or the chemical to which that information refers. In particular, no warranty, whether express or implied, or guarantee in the legal sense is intended or implied by Evonik. This GPS Safety Summary is only intended to provide general information about the chemical referred to herein but not any in-depth health and safety information. The information in this GPS Safety Summary is supplied on the condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. This GPS Safety Summary does not supersede or replace required regulatory and/or legal communication documents. Performance of the chemical described herein should be verified by testing which should be carried out only by qualified experts. Evonik reserves the right to make any changes to this GPS Safety Summary in accordance with technological progress or further developments. Reference to trade names used by other companies is neither a recommendation, nor does it imply, that similar products could not be used. December 2011 Glossary Acute toxicity harmful effects after a single exposure Biodegradable breakdown of materials by a physiological environment Bioaccumulation accumulation of substances in the environment Carcinogenicity effects causing cancer Chronic toxicity harmful effects after repeated exposures GHS Global Harmonized System on Classification and Labelling Mutagenicity effects that change genes Reprotoxicity combining teratogenicity, embryotoxicity and harmful effects on fertility Sensitising allergenic Teratogenic effects on fetal morphology Contact information within company Email address EU [email protected] Email address USA [email protected]