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Vol 16 No.6 February-March 2015
Iranian Journal of Endocrinology and Metabolism / 460
Original Article
Effect of Nigella Sativa Oil Extract on Lipid Profiles in Type 2
Diabetic Patients: A Randomized, Double Blind, Placebocontrolled Clinical Trial
Hadi S1, Mirmiran P2, Hosseinpour-Niazi S2, Hedayati M3, Azizi F4
1Department
of Nutrition and Diet Therapy, Faculty of Nutrition Sciences and Food Technology, National Nutrition
and Food Technology Research Institute, & 2Nutrition and Endocrine Research Center, & 3Cellular and Molecular
Research Center, & 4Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti
University of Medical Sciences, Tehran, I.R. Iran
e-mail: [email protected]
Received: 14/09/2014 Accepted: 03/12/2014
Abstract
Introduction: Improvement of lipid abnormalities are important in the prevention of diabetes
complications. The study aimed to determine the effect of nigella sativa oil extract oil on blood lipid
abnormalities in patients with type 2 diabetes. Materials and Methods: In this double blind
randomized clinical trial, 43 men and women with type 2 diabetes who were randomized to the
intervention (n=23) and placebo (n=20) groups were studied and compared. The intervention group
received 2 capsules daily, (500 mg extract of Black Seed Oil) while the control group took 2
capsules (500 mg, placebo daily) for 8 weeks, respectively. Lipid profiles were measured at the
beginning and end of the intervention. Result: Mean age and body mass index of participants was
53.7±6.0 y and 28.6±5.4 kg/m2, respectively. At the end of the eighth week, the concentrations of
serum triglycerides, LDL cholesterol, total cholesterol and LDL to HDL cholesterol of the
intervention group were compared to the placebo group, and a significant reduction (P<0.05) was
found. However concentrations of HDL cholesterol and total cholesterol to HDL cholesterol ratio, at
the of the end eighth week in the intervention group and the control group showed no significant
difference. Conclusion: Black Seed Oil extract improves lipid profiles in type 2 diabetic patients.
Keywords: Type 2 diabetes, Nigella sativa, Timokinon, Lipid profile