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WORLD JOURNAL OWorld
F PH A
RMAC
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AR
MACEUTICSciences
AL SCIENCES
Rajni
Journal
ofYPharmacy
and
Pharmaceutical
SJIF Impact Factor 5.210
Volume 4, Issue 05, 1548-1554.
Research Article
ISSN 2278 – 4357
FORMULATION AND STANDERIDIZATION OF PANCHASAKARA
CHURNA TO RECOVERY OF DIGESTIVE BALANCE
Rajni Haridas Sonone*
S.G.S.P.S. College of Pharmacy, District Akola-444002.
Article Received on
13 March 2015,
Revised on 04 April 2015,
Accepted on 25 April 2015
ABSTRACT
Most of the herbal drugs products have their own important placement
in the world. The traditional systems of medicine are effective but
there is need to improve them. A polyherbal ayurvedic formulation of
Panchasakara churna which is used mostly digestive problems,
*Correspondence for
Author
Constipation, pile, stomach pain a modify churna formulation contain
honey base. Panchasakara churna contain an ingredient of a Terminalia
Rajni Haridas Sonone
S.G.S.P.S. College of
chebula, Cassia angustifolia, Rock salt, Zingiber officinale and
Pharmacy, District Akola-
Foeniculum vulgare. Honey is a natural substance so that all the above
444002.
mention herbal preparation to be the best modify for vita and digestive
role in human being. It is authenticated an herbal drugs in house
preparation of formulation and raw material standardization of each drugs perform powder
microscopic by and a light microscope and physicochemical standardization performed.
KEYWORD: Panchasakara Churna, Standardization, Ash Value, Digestive Balance, Honey
Base, Phenolic and Flavonoid.
INTRODUCTION
The traditional system of medicine there is a health care is a most pivotal need to develop
them. Ayurvedic herbal product which play classic role, but there is need to improve them
self. Traditional system of ayurvedic herbal formulation the Panchasakara churna reported to
characterize by constipation stomach pain digestive problems and a abdominal disease. In the
ingredient of a Panchasakara churna formulation contain ginger, cassia angustifolia, terminal
chebula, Foeniculum vulgare and rock salt (Saindhava Lavana). In this research the part of
natural system of ayurveda contain modify churna honey base. In a reported study the
preparation of Panchasakara churna during to perform collection of raw material,
physiochemical standardization. Here respect to analyze them (Total ash, Acid insoluble ash,
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World Journal of Pharmacy and Pharmaceutical Sciences
Extractive value of Alcohol and water, foreign matter, moisture content, determination of
phenolic and flavonoid of an ingredient) (Nabavi SM, 2008).
MATERIAL AND METHOD
Plants material: Ayurvedic Advance churna honey base, contain cassia angustifolia and
Terminalia chebula (Kim TG, 2001) which is collected from in the Nagarjun Udyan of
Panjabrao Deshmukh Krushi Vidyapith Akola. Zingiber officinale and Foeniculum Vulgare
were collected from Pathkhed, Taluka Vadegao. Rock salt (Saindhava Lavana) was collected
from a local market at Amersing shop .The plants which is authenticated in the labortical
department of Botany Shri. Shivaji collage Akola. As per mention in Indian Pharmacopoeia
standard material and method has analyses to carry out. Panchsakra churna prepare as per in
Indian Pharmacopoeia but additional base is used as a Honey Bee in modify Panchsakra
churna.
Polyherbal formulation of Panchasakara churna determination of foreign matter, total ash,
acid insoluble ash (AOAC, 1990), Alcohol soluble extractive and water extractive, moister
content, determination of total phenolic content and flavonoid content of selective raw
material (Zheng W, 2001).
RESULT AND DISCUSSION
The present study records the highest yield in the case of Alcohol followed by water and
chloroform solvents used in succession [Graph.3 to Graph. 4] Water soluble extractive value
in Ginger: (L=41.80, H=64.80), Fennel (L=61.60, H=76.80), Hirda (L=51.20, H=67.20),
Senna (L=10.40, H=29.60) and Alcohol soluble extractive value in Ginger: (L=24.08,
H=60.80), Fennel (L=16.80, H=56.80), Hirda (L=4.80, H=11.20), Senna (L=1.60, H=18.40).
In the churna was taken and was examined microscopically to identify the various features
like phloem fibres, parenchyma, starch grain, endosperms, calcium oxalate crystals, oil
glands etc using various reagents [Graph. 1] The foreign matter reported as Foreign Matter in
Ginger: (L=0.80, H=0.95), Fennel (L=0.70, H=0.90), Hirda (L=1.04, H=1.08), Rock salt
(L=0.90, H=1.24), Senna (L=1.05, H=1.08).
In the formulation was prepared in accordance with the Ayurveda Panchasakara churna Ash
values are present (total ash and acid insoluble ash) in [Graph 2] Total ash value in Ginger
(L=0.2, H=0.22), Fennel (L=0.05, H=0.15), Hirda (L=0.1, H=0.40), Senna (L=0.09, H=0.15)
and water soluble and Alcohol soluble extractive values are given in [Graph 3] Water soluble
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extractive value in Ginger (L=41.80, H=64.80), Fennel (L=61.60, H=76.80), Hirda (L=51.20,
H=67.20), Senna (L=10.40, H=29.60) [Graph 4] Alcohol soluble extractive value in Ginger
(L=24.08, H=60.80), Fennel (L=16.80, H=56.80), Hirda (L=4.80, H=11.20), Senna (L=1.60,
H=18.40). The ash values of the samples were carried out based on the method as described
by the World Health Organisation (WHO) guidelines for medicinal plant materials.
The physicochemical organoleptic formulations are given in [Graph 1 to Graph 4] if
estimation of other churna compares to this studies the active constitute content in very
effective than other formulations. The standard plot for moisture content is given in [Graph 5]
Moisture content value in Ginger (L=51.01, H=51.87), Fennel (L=52.08, H=53.07), Hirda
(L=50.58, H=51.42), Senna (L=55.08, H=55.92). In liner standard stand the anti digestive
content was found to be highest in Panchsakra churna Ayurvedic Pharmacy Formulation.
Absorbance of Standard value at 765 nm in [Graph 6] Linear value Sample 1 (549, 603, 678),
Sample 2 (463, 495, 608), Sample 3 (530, 594, 665) in its [Graph 6.1] shows phenolic value
of Ginger at 765 nm Sample 1(0.777, 0.719, 0.377), [Graph 6.2] shows value of Hirda
sample 1(0.515,0.377,0.307). Absorbance of Slandered value at 415 nm in [Graph 7] Liner
value Sample 1 (549, 603, 678), Sample 2 (463, 495, 608), Sample 3 (530, 594, 665) in its
[Graph 7.1] shows flavonoid value of Ginger at 765 nm Sample 1(0.777, 0.719, 0.377),
[Graph 7.2] shows value of Hirda sample 1(0.515,0.377,0.307) The phytochemical evaluation
for various phytoconstituents in resulted fractions of Ayurveda Panchasakara churna were
marked as very well quality based on the intensity of the colored reaction product of the test
compared to control in each case (Table-2 and Figures 2 to 7).
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ADVANCE CHURNA FORMULATION CONTENT HONEY BASE
Graph 1. Foreign Matter of various Herbal
Preparation
Graph. 2. Total Ash value in percentage for
Herbal Preparation
Graph. 3. Water soluble Extractive value in
percentage for Herbal Preparation
Graph. 4. Alcohol soluble Extractive value
in percentage for Herbal Preparation
Graph.5. Moisture content in percentage for Herbal Preparation.
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Graph. 6. (Phenolic content test) Absorbance standard at 765 nm value in percentage for
Herbal Preparation
Graph. 6.1. (Phenolic content test)
Absorbance of sample (Ginger) at 765 nm
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Graph. 6.2. (Phenolic content test) Absorbance
of sample (Hirda) at 765 nm
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Graph. 7. (Flavonoid content test) Absorbance standard at 415nm value in percentage
for Herbal Preparation
Graph. 7.1. (Flavonoid content test)
Absorbance of sample (Hirda) at 415nm
Graph. 7.2. (Flavonoid content test)
Absorbance of sample (Ginger) at 415nm
*Notes: L=Lowest, H=Highest, Series 1=sample=1, Series 2= Sample=2, Series 3=
Sample=3
CONCLUSIONS
The reported modify study of each ingredient were passable for on an panchasakara churna
formulation and as a standardization, all these content extractive value, ash value, moisture
content so that these stander which capable for a ayurvedic polyherbal formulation and
standardization. So that all over test perform after the churna formulation it less beneficial to
patient, but whenever it given with modify honey base formulation it give best reporting
result to certified in this research. Finally this invention conclude that this modify honey base
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churna is best for all over to human being for most of the stomach related Abdominal and
digestive problems. While all the formulations were established for reported ingredients were
genuine and passed the human beneficial.
ACKNOWLEDGEMENT
Authors are grateful to the Head of Pharmacognosy Dr. Dhirendra Sanghai, S.G.S.P.S.
College of Pharmacy District Akola for providing necessary facilities to carry out the present
research work.
REFERENCES
1. Kim TG, Kang SY, Jung KK, Kang JH, Lee E, Han HM and Kim SH. Antiviral activities
of extracts isolated from Terminalia chebula Retz., Sanguisorba officinalis L., Rubus
coreanus Miq and Rheum palmatum L. against hepatitis B virus, Phytotherapy research,
2001; 15(8): 718-720.
2. AOAC,. Methods of Analysis: 15th Ed. Washington, DC: Association of Official
Analytical Chemists, 1990.
3. Zheng, W and Wang, S. Antioxidant activity and phenolic composition in selected herbs.
Journal of Agricultural and Food Chemistry, 2001; 49: 5165-5170.
4. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Hamidinia and Bekhradnia AR,
Determination of antioxidant activity, phenol and flavonoids content of Parrotia persica
Mey. Pharmacology online, 2008; 2: 560-7.
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