CARE OF RADIATION SKIN REACTIONS Definition Radiation skin reactions are a common side effect of radical ionizing radiation treatment. The pathophysiology of a radiation skin reaction is a combination of radiation injury and the subsequent inflammatory response and can occur at both the entrance and exit site of the irradiation. Ionizing radiation damages the mitotic ability of stem cells within the basal layer preventing the process of repopulation and weakening the integrity of the skin. Reactions are evident one to four weeks after beginning treatment and can persist for several weeks post treatment. Factors Contributing to the Severity of Radiation Skin Reactions Type of Radiation and Energy • • • Treatment Technique • Location of the Treatment Field Volume of Treated Tissue Dose, Time and Fractionation Parameters • Chemotherapeutic Agents Co-existing Chronic Illnesses Tobacco Use • Age • Nutritional Status • • • • • • A source of radiation used in cancer treatment is a linear accelerator. This high voltage machine generates ionizing radiation from electricity to deliver external beam radiation therapy in the form of photons or electrons Radiation treatments delivered by external beam vary in depth depending on the energy of the beam produced Photons penetrate more deeply with increasing energy and also partially spare the skin from the effect of radiation; while electrons have shallow depth and high skin dose There is evidence to suggest that specific treatment techniques such as Intensity Modulated Radiation Therapy (IMRT) are associated with a decreased severity of acute radiation skin reactions The radiation skin reaction may be more severe depending on the location of the treatment field i.e. sites where two skin surfaces are in contact such as the breast or buttocks The total volume of the area treated is considered when the dose is prescribed because larger areas of body surface will be irradiated which may result in increased skin toxicity Radiation treatments are prescribed in units of measurement known as Gy (Gray) or cGy (centiGray) with 1 Gy equaling 100 cGy In order to manage the toxicities associated with radiation therapy, the total dose is divided into multiple daily doses called fractions The effects of ionizing radiation therapy are enhanced by specific radiosensitizers such as doxorubicin, 5-fluorouracil and bleomycin Coexisting chronic illnesses such as anemia, diabetes mellitus and suppression of the immune system may contribute to the severity of the radiation skin reaction Smoking limits the oxygen carrying capacity of hemoglobin. Elevated carboxyhemoglobin levels have been associated with changes to the epithelium and increased platelet stickiness. Nicotine affects macrophage activity and reduces epithelialization Vasculoconnective damage caused by ionizing radiation, when combined with the degenerative changes to the epidermis and dermis, leads to an exacerbation of radiation skin reactions as age increases Malignancy alone can compromise nutritional status. Patients who are poorly nourished may be at risk for poor wound healing The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 1 of 17 Consequences Radiation skin reactions commonly progress from erythema to dry desquamation to moist desquamation and rarely to ulceration. Additionally, with current technology and treatment delivery, necrosis is now also a rare occurrence. Patients may complain of tenderness, discomfort, pain or burning in the treated skin. Some patients note a change in activities of daily living as a consequence of the skin reaction. General Skin Care Recommendations Washing: Patients should be encouraged to wash the irradiated skin daily using warm water and non perfumed soap. The use of wash cloths may cause friction and are therefore discouraged. The use of a soft towel to pat dry is recommended. Use of Deodorants: Patients may continue to use deodorants during radiation therapy. Other Skin Products: Patients are discouraged from using any perfumed products which may possess chemical irritants and induce discomfort. Products such as gels or creams should be applied at room temperature. Patients should be encouraged to use products advocated by the radiation department. Hair Removal: The use of an electric shaver is recommended and wax or other depilatory creams are discouraged. Patients are asked not to shave the axilla if it is within the treatment field. Swimming: Patients may continue to swim in chlorinated pools but should rinse afterwards and apply a moisturizing lotion. Patients experiencing a radiation skin reaction which has progressed beyond dry desquamation should avoid swimming. Heat and Cold: Patients are encouraged to avoid direct application of heat or cold to the irradiated area i.e. ice or electric heating pads. Band-Aids, Tape and Clothing: Rubbing, scratching and massaging the skin within the treatment area causes friction and should be discouraged. The use of Band-Aids or tape on the skin should also be avoided. Wearing loose fitting cotton clothing may avoid traumatic shearing and friction injuries. The use of a mild detergent to wash clothing is also recommended. Sun Exposure: Patients should be instructed to avoid direct sun exposure and cover the irradiated skin. The use of sunscreen products with at least SPF 30 are recommended for at least one year following treatment. Care of Malignant Wounds During Radiation Therapy Malignant wounds are the result of cancerous cells infiltrating the skin and its supporting blood and lymph vessels causing loss in vascularity leading to tissue death. The lesion may be a result of a primary cancer or a metastasis to the skin from a local tumour or from a tumour in a distant site. It may take the form of a cavity, an open area on the surface of the skin, skin nodules, or a nodular growth extending from the surface of the skin. A malignant wound may present with odour, exudate, bleeding, pruritis and pain and interfere with the patient’s quality of life. Treating the underlying cause of a malignant wound may involve surgery, radiation therapy, chemotherapy or hormone therapy. Managing symptoms such as bleeding, exudate and pain, reducing tumor size and promoting wound healing whenever possible can be additional aims of treatment. A reduction in the impact of symptoms may contribute to the overall comfort of the patient. The goal of radiation therapy is to reduce tumour size. As the tumour becomes smaller, a radiation skin reaction may develop on surrounding tissue and the patient may experience erythema, dry desquamation and moist desquamation. Skin care practices During Radiation Therapy: If the malignant lesion is encapsulated, skin care practices are the same as for patients with intact skin. However, if the lesion erupts (as a result of the inflammatory response associated with radiation therapy) skin care practices for open wounds should be initiated. The principles of moist wound healing should be applied from the beginning of treatment to promote patient comfort and create an optimal wound environment in the open lesion and in any radiation skin reaction in surrounding tissues. Applying products which absorb drainage is essential to avoid infection and promote comfort. Protecting the surrounding intact skin is a priority therefore observing the general skin care recommendations is required. http://www.bccancer.bc.ca/NR/rdonlyres/0A61B812-801E-4F1E-8375A89A8BD58377/51006/M30CareofMalignantWounds.pdf The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 2 of 17 Principle of Moist Healing Cell growth needs moisture and the principle aim of moist wound therapy is to create and maintain optimal moist conditions. Cells can grow, divide and migrate at an increased rate to optimize the formation of new tissue. During this phase of wound healing an aqueous medium with several nutrients and vitamins is essential for cell metabolism and growth. The wound exudate serves as a transport medium for a variety of bioactive molecules such as enzymes, growth factors and hormones. The different cells in the wound area communicate with each other via these mediators, making sure that the healing processes proceed in a coordinated manner. Wound exudate also provides the different cells of the immune system with ideal conditions to destroy invading pathogens such as bacteria, foreign bodies and necrotic tissues, diminishing the rate of infection. Moist wound treatment is known to prevent formation of a scab, allowing epithelial cells to spread horizontally outwards through the thin layer of wound exudate to rapidly close the wound. The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 3 of 17 Focused Health Assessment GENERAL ASSESSMENT SYMPTOM ASSESSMENT Contact Information Normal • • • • • Physician name oncologist, general practitioner (GP) Pharmacy (if applicable) name and contact information Home health care (if applicable) – name and contact information Consider Causative/Contributing Factors • • • • • • Cancer diagnosis (site) Cancer treatment: date of last treatment/s, concurrent treatments, volume of tissue treated, technique, type of radiation and energy, location of treatment field, volume of tissue treated, dose, time and fractionation Co-morbidities Nutritional status Tobacco use Recent lab or diagnostic reports What is the condition of your skin normally? What are your normal hygiene practices? Onset • When did the changes in your skin begin? Provoking / Palliating • What makes it feel better or worse? Quality (in the last 24 hours) • • Do you have any pain, redness, dry or scaling skin, blisters or drainage? Do you have any swelling? Severity / Other Symptoms • • Since your last visit, how would you rate the discomfort associated with the skin reaction? between 0-10? What is it now? At worst? At best? On average? Have you been experiencing any other symptoms: fever, discharge, bleeding PHYSICAL ASSESSMENT Vital Signs • Include temperature, pulse, respiratory rate and blood pressure Frequency – as clinically indicated Physical Assessment Assess skin condition • Location • Colour • Size • Wound base (if present) • Discomfort • Drainage (if present) • Signs of infection Treatment • • • When was your last cancer treatment (radiation or chemotherapy)? How have you been managing the radiation skin reaction? (cream, ointments, dressings) Are you currently using any medications? How effective are they? Any side effects? Understanding / Impact on You • Is your skin reaction and treatment impacting your • • activities of daily living (ADL)? Do you require any support to (family, home care nursing) complete your skin care routine? Are you having any difficulty sleeping, eating, drinking? Value • What is your comfort goal or acceptable level for this symptom? The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 4 of 17 DERMATITIS GRADING SCALE Adapted NCI CTCAE (Version 3.0) GRADE 0 (Normal) Normal GRADE 1 (Mild) Faint erythema or dry desquamation GRADE 2 (Moderate) GRADE 3 (Severe) GRADE 4 Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema Moist desquamation other than skin folds and creases; bleeding induced by minor trauma or abrasion Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site GRADE 0 – GRADE 1 NON – URGENT Support, teaching, & follow-up as clinically indicated Clinical Presentation Erythema • Pink to dusky colouration • May be accompanied by mild edema • Burning, itching and mild discomfort Dry desquamation • Partial loss of the epidermal basal cells • Dryness, itching, scaling, flaking and peeling • Hyperpigmentation Brisk Erythema Reaction Assessment Promote Cleanliness Promote Comfort Reduce Inflammation Dry Desquamation Assessment to include: • Location • Size of area • Colour • Discomfort (burning, itching, pulling, tenderness) – erythema • Discomfort (dryness, itching, scaling, flaking, peeling) – dry desquamation • Use non-perfumed soap. Bathe using warm water and palm of hand to gently wash affected skin. Rinse well and pat dry with a soft towel • Wash hair using warm water and mild, non-medicated shampoo such as baby shampoo • Patients receiving RT for perineal/rectal cancer, should use a sitz bath daily beginning at the start of treatment • Apply hydrophilic (water based) body lotions or creams on affected area. Gently apply with clean hand twice a day. Do not rub skin • Avoid petroleum jelly based products • Avoid irritant products containing alcohol, perfumes, or additives and products containing Alpha Hydroxy Acids (AHA) • Normal saline compresses up to 4 times daily • Alleviate pruritus and inflammation. Corticosteroid creams may be used sparingly as ordered by the physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 5 of 17 GRADE 0 – GRADE 1 – Continued… NON – URGENT Support, teaching, & follow-up as clinically indicated Prevent Trauma to the Treatment Area • • • • • • Follow-Up Possible Referrals and Resources • • • • • For facial and underarm shaving, use an electric razor Recommend loose, non-binding, breathable clothing such as cotton Protect skin from direct sunlight and wind exposure by wearing a wide brimmed hat and protective clothing Remove wet swimwear, shower and apply moisturizer after swimming in pools and lakes Avoid extremes of heat and cold, including hot tubs, heating pads and ice packs Avoid adhesive tape. Extend dressing out of treatment area and adhere to intact skin with paper tape. Secure dressing with cling gauze, net tubing or under clothing Patients to be assessed at each visit. If symptoms are not resolved, provide further information regarding recommended strategies - Instruct patient/family to call back if radiation skin reaction worsens - Arrange for nurse initiated telephone follow–up Document assessment, intervention and patient care plan Communicate with health care team as appropriate Registered Nurse Physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 6 of 17 GRADE 2 – GRADE 3 URGENT: Requires medical attention within 24 hours Clinical Presentation Moist Desquamation • Sloughing of the epidermis and exposure of the dermal layer • Blister or vesicle formation • Serous drainage • Pain Moist Desquamation Reaction Assessment Assessment to include: • Location - Moist areas - Dry areas • Size of area • Wound base: granular tissue, eschar or necrotic tissue • Exudate - Type - Amount - Odour • Discomfort (burning, itching, pulling, tenderness) • Signs of clinical infection - fever - foul odour - purulent drainage - pain and swelling extending outside of radiation area Promote Cleanliness • • ● Maintain Principles of Moist Healing • • • • ● • Manage Pain Prevention of Infection • • • • • Cleanse with warm or room temperature normal saline Apply normal saline compresses up to 4 times daily Patients receiving RT for perineal/rectal cancer, should use a sitz bath daily beginning at the start of treatment Can use a moisture retentive protective barrier ointment after each saline soak Consider the use of hydrogels Use a non-adherent dressing Use absorbent dressings over non-adherent dressings. Change as drainage warrants Control drainage. Consider using hydrocolloid dressings Cover open areas to protect nerve endings. To significantly decrease burning and tenderness use non-adherent or low adherent dressings Assess pain at each appointment (Link to Pain SMG) Administer analgesics as ordered by the physician Regularly assess for signs of infection Culture wound if infection suspected Apply antibacterial/antifungal products as ordered by the physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 7 of 17 GRADE 2 – GRADE 3 – Continued… URGENT: Requires medical attention within 24 hours Prevent Trauma to the Treatment Area • • • • • • Follow-Up • Possible Referrals and Resources • • • • For facial and underarm shaving, use an electric razor Recommend loose, non-binding clothing Protect skin from direct sunlight and wind exposure Discontinue swimming in pools and lakes Avoid extremes of heat and cold, including hot tubs Avoid adhesive tape. Extend dressing out of treatment area and adhere to intact skin with paper tape. Other products include cling gauze and net tubing under clothing Patients to be assessed at each visit. If symptoms are not resolved, provide further information regarding recommended strategies - Instruct patient/family to call back if radiation skin reaction worsens - Arrange for nurse initiated telephone follow–up Document assessment, intervention and patient care plan Communicate with health care team as appropriate Registered Nurse Physician GRADE 4 EMERGENT: Requires IMMEDIATE medical attention Clinical Presentation Reaction Assessment Promote Cleanliness • Rarely occurs • Skin necrosis or ulceration of full thickness dermis • May have spontaneous bleeding from the site • Pain Assessment to include: • Location - Moist areas - Dry areas • Size of area • Wound base: granular tissue, eschar or necrotic tissue • Exudate - Type - Amount - Odour • Discomfort (burning, itching, pulling, tenderness) • Signs of clinical infection - fever - foul odour - purulent drainage - pain and swelling extending outside of radiation area • Cleanse with warm or room temperature normal saline • Apply normal saline compresses up to 4 times daily (or as required) The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 8 of 17 GRADE 4 – Continued… EMERGENT: Requires IMMEDIATE medical attention Maintain Principles of Moist Healing Prevent Trauma Manage Pain Prevention of Infection Follow-Up Possible Referrals and Resources • • • • • • • • • • • • • • • • • • • • Maintain a moist environment for healing Use a non-adherent dressing Layer dressings as appropriate. If dressings overlap, apply the dressing with the longest wear time first. Label dressings with date May require debridement Use a non-adherent dressing Secure products with appropriate secondary dressing Avoid adhesive tape. Extend dressing out of treatment area and adhere to intact skin with paper tape. Other products include cling gauze and net tubing under clothing Cover open areas to protect nerve endings Use non-adherent or low adherent dressings Assess pain at each appointment (Link to Pain SMG) Administer analgesics as ordered by the physician Regularly assess for signs of infection Culture wound if infection suspected Apply antibacterial/antifungal products as ordered by the physician Patients to be re-assessed at each visit Instruct patient/family to contact the Health Care Professional if the skin reaction worsens Document assessment, intervention, and patient care plan Communicate with health care team as appropriate Registered Nurse Physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 9 of 17 Potential Post-Radiation Skin Reaction Late Reactions Definition Clinical Presentation Reaction Assessment Maintain Skin Flexibility Prevent Injury • • Skin reactions occurring six or more months after completion of radiation therapy The clinical presentation and the degree of late reaction vary. Patient care will be individualized and based on the degree of severity. • Pigmentation changes • Permanent hair loss • Telangectasia • Fibrous changes • Atrophy • Ulceration Assessment to include: • Location - Moist areas - Dry areas • Size of area • Wound base: granular tissue, eschar or necrotic tissue • Exudate - Type - Amount - Odour • Discomfort (burning, itching, pulling, tenderness) • Signs of clinical infection - fever - foul odour - purulent drainage - pain and swelling extending outside of radiation area • Apply hydrophilic (water based) body lotions or creams on affected area. Gently apply with clean hand twice a day. Do not rub skin • Follow-Up • • • • • • Possible Referrals and Resources • • • • Manage Pain Prevention of Infection Avoid excessive sun exposure. Wear protective clothing. Sunblocking creams or lotions with minimum SPF 30 recommended at all times Assess pain at each appointment (Link to Pain SMG) Administer analgesics as ordered by the physician Regularly assess for signs of infection Culture wound if infection suspected Apply antibacterial/antifungal products as ordered by the physician Patients to be assessed at each visit. If symptoms are not resolved, provide further information regarding recommended strategies - Instruct patient/family to call back if radiation skin reaction worsens - Arrange for nurse initiated telephone follow–up Document assessment, intervention and patient care plan Communicate with health care team as appropriate Registered Nurse Physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 10 of 17 Potential Post-Radiation Skin Reaction Recall Phenomenon Definition Clinical Presentation Reaction Assessment Promote Cleanliness Maintain Principles of Moist Healing Manage Pain Prevention of Infection Follow-Up Possible Referrals and Resources • Recall phenomenon occurs when skin reactions manifest very rapidly within a previously treated radiation field, following the administration of chemotherapy drugs • Symptoms of moist desquamation • Rapid onset and progression Assessment to include: • Location - Moist areas - Dry areas • Size of area • Wound base: granular tissue, eschar or necrotic tissue • Exudate - Type - Amount - Odour • Discomfort (burning, itching, pulling, tenderness) • Signs of clinical infection - fever - foul odour - purulent drainage - pain and swelling extending outside of radiation area • Cleanse with warm or room temperature normal saline • Apply normal saline compresses up to 4 times daily • Patients receiving RT for perineal/rectal cancer, should use a sitz bath daily beginning at the start of treatment • Can use a moisture retentive protective barrier ointment after each saline soak • Consider the use of hydrogels • Use an non-adherent dressing • Use absorbent dressings over low-adherent dressings. Change as drainage warrants • Control drainage. Consider using hydrocolloid dressings • Cover open areas to protect nerve endings • Use non-adherent or low adherent dressings • Assess pain at each appointment (Link to Pain SMG) • Administer analgesics as ordered by the physician • Regularly assess for signs of infection • Culture wound if infection suspected • Apply antibacterial/antifungal products as ordered by the physician • Patients to be assessed at each visit. If symptoms are not resolved, provide further information regarding recommended strategies - Instruct patient/family to call back if radiation skin reaction worsens - Arrange for nurse initiated telephone follow–up • Document assessment, intervention and patient care plan • Communicate with health care team as appropriate • Registered Nurse • Physician The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 11 of 17 Treatment Procedures Application of Topical Products Moisturizing Products Corticosteroid Creams • Instruct the patient to gently apply a thin layer of water soluble moisturizing ointment or cream using their clean hand 2 to 4 times daily to the skin in the treatment area • • • A prescription for hydrocortisone cream is required Do not use hydrocortisone if a skin infection is suspected as it may mask signs of infection and increasing severity of the radiation skin reaction Do not use hydrocortisone on a long-term basis as it may cause problems resulting from reduced blood flow to the skin Instruct patient to gently apply a very thin layer of hydrocortisone cream using their clean hand as prescribed by the physician Instruct patient to apply to skin in the treatment area until discomfort decreases and to wash hands after application Discontinue use of hydrocortisone if there is any exudate from the affected area • • Instruct patient to apply a thin layer of (water soluble) barrier cream to the treatment area Non-adhesive dressings may be applied, depending on the location of the skin reaction • • • Barrier Creams Normal Saline Compresses Indications Contraindication Procedure Note • • • • • • • • • • • • To reduce discomfort due to inflammation or skin irritation To cleanse open areas To loosen dressings Increased discomfort during procedure Moisten gauze with warm or room temperature saline solution Wring out excess moisture (ensure that gauze will not dry out and adhere to open area) Apply moist gauze to open areas for 10-15 minutes. Cover compress with abdominal pad or disposable under-pad to retain warmth and moisture Remove gauze and gently irrigate wound with normal saline if required to remove any debris Gently dry surrounding skin Apply dressing/other treatments as indicated Repeat up to 4 times daily or as required Continuous moist saline compresses may be indicated for short term use (24-48hrs.) for a necrotic or heavily exudative wound. It is critical that the compress is replaced frequently enough that it does not dry out and adhere to the area. Moist gauze is applied only to the wound area to avoid maceration of intact skin Sitz Baths Purpose • Indications • • • • • • • • • • • • Contraindication Procedure Perineal hygiene is the primary reason for using a sitz bath during/post RT when the area is tender and inflamed Use at onset of treatment for comfort and cleanliness Use at any time for any skin reaction in the perineal/peri-rectal area Discomfort with defecation Continuous discomfort due to perineal inflammation, hemorrhoids, radiation-induced diarrhea Discomfort during procedure Water should be warm (40-43°C) Hot water can cause increased drying of skin Warm water will increase vasoconstriction and may decrease the itching Do not add bath oils or other products to water A hand held shower with a gentle spray or bathtub may be appropriate alternatives Maximum 10-15 minutes, repeat up to 4 times daily and/or after each bowel movement Gently pat area dry with a soft towel or expose area to room air The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 12 of 17 Silver Sulfadiazine Cream (antibacterial) Purpose Indications Contraindications Procedure • • • • • • • • • • • • • To reduce risk of infection To reduce discomfort To maintain moist healing environment To reduce adherence of dressings The treatment and prophylaxis of infection in open wounds (moist desquamation) Allergy to sulfa Should not be used for patients with history of severe renal or hepatic disease or during pregnancy Gently cleanse wound area with normal saline if area is small and dressing is easily removed Cleanse with tap water (sink, bathtub, shower or sitz bath) if area is large, difficult to cleanse or adherence of dressing is a problem It is important to gently remove all residual cream from previous applications (saline compresses may be required) Apply a thin layer of cream to area of affected skin only Apply appropriate secondary dressing Change dressing at least once daily Hydrogels Hydrogel is a sterile wound gel for helping create or maintain a moist environment. Some hydrogels provide absorption, desloughing and debriding capacities to necrotic and fibrotic tissue. Hydrogel sheets are cross-linked polymer gels in sheet form Purpose Indications Contraindication Procedure • • • • • • • • • • • • • To increase comfort (cooling effect on skin) To increase moisture content To absorb small amounts of exudate Moist desquamation with minimal exudate Not advised for infected wounds Moderate to heavily exudating wounds Areas that need to be kept dry Cleanse area with normal saline soaks or sitz baths Pat dry surrounding skin Either apply a thin layer of hydrogel directly onto the area of moist desquamation or apply with a tongue depressor Cover with non-adhesive dressing (may be secured by clothing if patient is ambulatory) May be used in combination with transparent films, foams, hydrocolloids or other nonadherents Reapply at least daily and always following normal saline soaks/sitz baths Hydrocolloid Dressings Hydrocolloids are occlusive and adhesive water dressing which combine absorbent colloidal material with adhesive elastomeres to manage light to moderate amount of wound exudate. Most hydrocolloids react with wound exudate to form a gel-like covering which protect the wound bed and maintain a moist wound environment Purpose Indications Contraindication Procedure • • • • Maintain moist wound bed To increase comfort Support autolytic debridement by keeping wound exudate in contact with necrotic tissue Moist desquamation with moderate exudate • • • • • • • Not advised for infected wounds Heavily exudating wounds Cleanse area with normal saline soaks or sitz baths Pat dry surrounding skin Choose a dressing that extends beyond the wound Remove backing and apply to wound Change dressing as required depending on causative factors, contributing factors and amount of exudate The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 13 of 17 Bibliography Aistars, J., (2006). The Validity of Skin Care Protocols Followed by Women With Breast Cancer Receiving External Radiation. Clinical Journal of Oncology Nursing. 10 (4), pp. 487-492. Archambeau, J., Pezner, R., & Wasserman, T., (1995). Pathophysiology of irradiated skin and breast. International Journal of Radiation Oncology, Biology, & Physics. 31, pp.1171-1185. Atiyeh, B., Ioannovich, J., Al-Amm & El-Musa, K., (2002). Management of Acute and Chronic Open Wounds: The Importance of Moist Environment in Optimal Wound Healing. Current Pharmaceutical Biotechnology. 3, pp.179-195. Atiyeh, B., Costagliola, M., Hayek, S., & Dibo, S., (2007). Effect of silver on burn wound infection control and healing: review of the literature. Burns. 33 (2), pp. 139-148. Babin, E., Sigston, E., Hitier, M., Dehesdin, D., Marie, J., & Choussy, O., (2008). Quality of life in head and neck cancer patients: predictive factors, functional and psychosocial outcome. European Archives of Otorhinolaryngology. 265, pp.265270. Bentzen, S.M., & Overgaard, J., (1994). Patient to patient variability in the expression of radiation induced normal tissue injury. Seminars in Radiation Oncology. 4, pp.69-80. Bolderston, A., (2003). Skin Care Recommendations during Radiotherapy: A Survey of Canadian Practice. The Canadian Journal of Medical Radiation Therapy. 34 (1), pp.3-11. Bolderston, A., Lloyd, N., Wong, L., & Robb-Blenderman, L., (2006). The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. 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Date of Print: Revised July 18, 2012 Contributing Authors: Anne Hughes, Regional Professional Practice Leader, Nursing Alison Mitchell, Radiation Therapy Educator VIC June Bianchini, Assessment Module Leader CSI Frankie Goodwin, Assessment Module Leader Normita Guidote RN Rachelle Gunderson RN Ann Hulstyn RN Susan Kishore RT Krista Kuncewicz RT Sheri Lomas RT Gillian Long, Radiation Educator AC Heather Montgomery RN Dawn Robertson RN Jenny Soo, Radiation Educator VC Stacey Tanaka RN Victoria van le Leest RT Wendy Vanhoerden RN Tara Volpatti RT Dr. Frances Wong, Radiation Oncologist FVC Karen Yendley RT Reviewed By: British Columbia Cancer Agency Radiation Therapy Skin Care Committee Dr. Hosam Kader, Radiation Oncologist VIC Dr. Jonn Wu, Radiation Oncologist FVC BCCA Nursing Practice Committee The information contained in these documents is a statement of consensus of BC Cancer Agency professionals regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these documents is expected to use independent medical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use of these documents is at your own risk and is subject to BC Cancer Agency's terms of use, available at www.bccancer.bc.ca/legal.htm. Page 17 of 17
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