SUSPECTED URINARY TRACT INFECTION (UTI) - NURSE PRACTITIONER SCOPE OF PRACTICE (SEE SUMMARY OF MANAGEMENT OF UNCOMPLICATED UTI IN ADULTS – PAGE 11) Practitioner Scope Outcomes Nurse Practitioner (NP) Symptoms suggestive of uncomplicated UTI. Clients not suitable for NP management include: Male with suspected UTI. Persons requiring parenteral antibiotics for management of UTI. Children under 16 years old. Co-existing medical condition requiring hospital admission or complex multiple co-morbidities (eg Diabetes and or Renal Failure). Particularly in age >65 years. Immuno-compromised person. o Evidence of impending septic shock (fever>38.5 C or hypotension or tachycardia) (1). Active Intravenous drug user. Suspected or confirmed penicillin immediate hypersensitivity reaction. Suspected or confirmed cephalosporin delayed or immediate hypersensitivity reaction. Pregnancy. Previously treated UTI not responsive to antibiotics. Known renal tract abnormalities (including long term indwelling catheter, ureteric stents obstructive uropathy, neurogenic bladder). Suspected Prostatitis. Signs and symptoms consistent with renal colic/calculi. Acute delirium. Social support structure inadequate for support of the client at home. Mental Health condition not stabilised on treatment (2). Identify clients suitable for Silver Chain Nurse Practitioner (NP). Medical Practitioner Management of clients not suitable for NP scope of practice (as per above). Identify client not suitable for NP and refer to Medical Governance Doctor of Silver Chain or Emergency Department (ED) of Western Australian Hospital. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. CC-NG-002 Review Date: 160410 Page 1 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner CLIENT ASSESSMENT Activity Presenting History Assessment Outcome Relevant past medical history including: Recent or present instrumentation: catheter, cystoscopy, urodynamics, and history of prostatic or other genitourinary disease. Allergy and immunization status (1). Medication usage (prescribed, over the counter and herbal/complimentary). Alcohol, cigarette and illicit drug use profile- ascertain if current intravenous drug user. Social and work related status. Onset and duration of symptoms. Sexual history. Treatment to date. Identify patients not suitable for NP and refer to Medical Governance Doctor of Silver Chain or ED of Western Australian Hospital. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Clinical Examination Conduct primary survey: Airway, breathing, circulation, disability, if evidence of potential system compromise exit clinical practice guideline (1). Conduct physical examination of genitourinary system include assessment of body temperature, heart rate, blood pressure and respiratory rate. Determine principal differential diagnosis is urinary tract infection; if findings inconsistent collaborate and if necessary refer to Medical Governance Dr of Silver Chain. Female clients with evidence of vaginal itch or discharge are recommended to undergo visual examination of external genitalia and vaginal examination (2). Male clients are recommended to undergo visual examination of external genitalia and digital rectal examination if an enlarged prostate is suspected (2). Clinical examination finding consistent with diagnosis of UTI. Ongoing care to be provided by NP. Identify patients not suitable for NP and refer to Medical Governance Doctor of Silver Chain or ED of Western Australian Hospital. Exit clinical practice guideline if evidence of abnormal primary survey. Male clients with evidence of prostatic hypertrophy and female clients with evidence of vaginitis will be referred to Medical Governance Doctor of Silver Chain. Clinical examination findings inconsistent with diagnosis of UTI will initiate collaboration with Medical Governance Doctor. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Pain Assessment Determine intensity of pain (refer to Symptom Assessment Scale Manual Entry Form HCS-FRM-054) and location, duration and characteristics of pain. Determines need and type of pain relief modalities required. Can guide the NP in determining alternative differential diagnosis. CC-NG-002 Review Date: 160410 Page 2 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner Activity Assessment Outcome Nausea and Vomiting Assessment Determine severity of nausea (refer to Symptom Assessment Scale Manual Entry Form HCS-FRM-054). Assess for precipitating factors, frequency and duration of nausea and vomiting. Determines need for antiemetics. Imaging Renal tract ultrasound (includes upper and lower tract - bladder). Plain abdominal x-ray. Renal status, obstruction, dilatation, bladder emptying capacity demonstrated. Abdominal x-ray will help to identify radioopaque renal tract calculi. Radiological identification of renal tract pathology will initiate referral to Medical Governance Doctor, joint management by Medical Governance Doctor and NP of Silver Chain may be deemed to be appropriate. Pathology Urine for microscopy, culture and sensitivity (MSU). Full blood picture and urea and electrolytes if evidence of pyelonephritis or client acutely unwell (3). Qualitative beta human chorionic gonadotropin (B HCG) if female and of child bearing years. Blood cultures if temperature >38.5, rigors or toxic clinical picture (3). Random plasma glucose level via finger prick (for client with known Diabetes Mellitus or high risk for Diabetes Mellitus). Macroscopic urinalysis (dipstick) (4). Gentamicin trough level if duration of therapy >3 days (5). Gentamicin dosing >3 days should be avoided because of risk of nephro and or oto-toxicity. Identify causative organisms and susceptibility of organisms to antibiotic treatment. Provide further evidence to suggest systemic inflammation. Identify any end organ involvement (renal). Assist in identification of undiagnosed or exacerbation of known Diabetes Mellitus. Macroscopic urinalysis results will provide further evidence for presence of UTI. Gentamicin level monitoring to identify potential drug toxicity. CC-NG-002 Review Date: 160410 Page 3 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner INTERPRETATION OF RESULTS AND MANAGEMENT DECISIONS Investigation Interpretation Outcomes Elevated Plasma Glucose Level Random plasma glucose level >8.0mmol/l in non diabetic client warrants further investigation for evidence of undiagnosed Diabetes Mellitus-referral to client’s General Practitioner for follow up (6). Loss of glycaemic control in a well controlled type 1 and 2 Diabetes Mellitus warrants collaboration with Medical Governance Doctor of Silver Chain and if deemed necessary transferred back to care of Medical Governance Doctor of Silver Chain or ED of WA public hospital. General Practitioner referral for further investigation of unrecognized hyperglycaemia. Collaboration with Medical Governance of Silver Chain re management of poor glycaemic control in known type 1 or 2 Diabetes Mellitus client. Transfer of care back to Medical Governance Doctor of Silver Chain or ED of WA public hospital. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Leucocytosis and Neutrophilia Leucocytosis and neutrophilia is a common finding in pyelonephritisabsence of, warrants consideration of alternative diagnosis and collaboration and possible referral to Medical Governance Doctor of Silver Chain (3). Alternative diagnosis considered. Initiates collaboration and possible referral to Medical Governance Doctor of Silver Chain. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Positive Urine Culture Identification of organism will guide Practitioner in antibiotic therapy. Evidence of atypical or multi-resistant organism will initiate collaboration and possible referral to Infectious Diseases Specialist. Identification of positive blood cultures requires collaboration and possible referral to Infectious Diseases Specialist. Antibiotic regime adjusted to reflect susceptibility results. Atypical or multi-resistant organism initiates collaboration and possible referral to Infectious Diseases Specialist. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Positive blood cultures initiates collaboration and possible referral to Infectious Diseases Specialist. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Deranged Renal Function Tests Biochemical evidence of acute deterioration in renal function tests (serum creatinine >110micromol/L) necessitates collaboration and possible referral with Medical Governance Doctor of Silver Chain to reconsider severity of UTI or alternative diagnosis (3). Abnormal renal function initiates collaboration and possible referral to Medical Governance Doctor of Silver Chain. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. CC-NG-002 Review Date: 160410 Page 4 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner Investigation Interpretation Outcomes Positive Macroscopic Result (dipstick) Presence of blood, nitrites or leucocytes strengthens diagnosis of UTI (4). Presence of microscopic or macroscopic haematuria in male client warrants collaboration and referral to Medical Governance Doctor of Silver Chain (2). Assists in diagnosis of UTI. Presence of haematuria in male initiates collaboration and referral to Medical Governance Doctor of Silver Chain. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Elevated Gentamicin Trough Level Elevated trough level warrants dose readjustment (5). Potential drug toxicity will be identified and treated. CLIENT SUPPORT Topic Action Outcomes Certificates Absence from work certificates will be provided as appropriate. Workers compensation and Motor Vehicle Insurance Trust certificates will be provided as appropriate. Referral letters. Correspondence with client’s GP. Follow Up Review in 3 days. Follow up pathology results. Persistent fever and or loin pain warrants further investigation: MSU, renal tract ultrasound and collaboration/referral with Medical Governance Dr of Silver Chain. Client Education Hygiene and prevention strategies. The client will demonstrate an understanding of strategies to reduce the risk of UTI. Referrals Health Care Practitioners for issues that lie outside NP Scope of Practice. Issues that lie outside NP Scope of Practice will be referred onto appropriate Health Care Practitioners. CC-NG-002 Review Date: 160410 Page 5 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner PHARMACOLOGY INFORMATION Drug Group General Information Drug Formulary Outcomes Client will be educated re medication usage, potential adverse effects and course of action to take in event of adverse effect. Anaphylaxis will be managed as per Silver Chain policy FP4-OA (33) Anaphylaxis emergency management in the home. Client will use the medication in an effective and safe manner. Prescribing NP will be informed of significant adverse effects of medication. Analgesia Mild pain (unscheduled-S2) (7&8) Adults and children > 12yrs old: Paracetamol PO 0.5 to 1.0g 4-6hrly not to exceed 4g in 24 hours. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Analgesia requirements determined by ongoing assessment of pain. Analgesia Moderate Pain (S2-S4) (7&8) ADD to paracetamol if still in pain Adults: Ibuprofen: PO 200-400mg TDS or QID up to maximum dose of 2400mg per 24 hours. If pain poorly managed with above regime or client not suitable for non steroidal anti-inflammatory drugs add Panadeine Forte (in lieu of paracetamol): 1-2 tablets,4-6 hourly, maximum of 8 tablets in 24 hours (only suitable for adults). If non steroidal anti-inflammatory drugs and Panadeine forte not suitable or pain poorly controlled refer back to Medical Governance Doctor of Silver Chain. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Use ibuprofen with caution in clients with evidence of renal impairment and in the elderly. Analgesia requirements determined by ongoing assessment of pain. Severe pain warrants consideration of severity of UTI or alternative differential diagnosis. Inadequate pain relief initiates referral to Medical Governance Doctor of Silver Chain. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. CC-NG-002 Review Date: 160410 Page 6 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner Drug Group Drug Formulary Outcomes Antiemetics S4 (8&9) Ondansetron 4-8 mg IV/IM/subling or PO BD. Metoclopramide Adult (>20yrs old) Total daily dose should not normally exceed 0.5 mg/kg. Give orally, IV or IM as needed. >60 kg, 10 mg 3 times daily. 30–59 kg, 5 mg 3 times daily. Generally a dose of 5mg TDS is better tolerated due to less adverse effects of drowsiness. Adult: Oral, initially 20 mg, then 10 mg 2 hours later; if still needed, Prochlorperazine PO: 5–10 mg tds, IM/IV: 12.5 mg every 8 hours as needed, .Rectal: 25 mg followed by oral medication (if possible) 6 hours later. Enteric administration route will be the route of choice- a parental route will be utilized if the enteric route is unsuitable. Uncontrolled nausea and vomiting warrants collaboration and possible referral to Medical Governance Doctor of Silver Chain for further assessment and management. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Referral to Medical Governance Doctor of Silver Chain for poorly controlled nausea and vomiting. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. Antibiotics S4 (5&8) Antibiotic therapy as per drug formulary below. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Collaboration with Infectious Diseases Specialist or Medical Governance Doctor of Silver Chain for patient showing no improvement after ~ 72 hours of antibiotics or worsening illness severity. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. CC-NG-002 Review Date: 160410 Page 7 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner ANTIBIOTIC DRUG FORMULARY Indication (2,5&8) Drug (2,5&8) UTI in Women Mild lower UTI in non-pregnant woman Mild lower UTI as an alternative to Trimethoprim in non-pregnant woman Mild lower UTI as an alternative to Trimethoprim or Cephalexin in nonpregnant woman Mild lower UTI as an alternative to Trimethoprim, Cephalexin and Amoxycillan+clavulanate in non-pregnant woman If resistance to above drugs is present or if the organism is identified as Pseudomonas aeruginosa in non-pregnant woman UTI in Men Mild UTI men Mild UTI as an alternative to Trimethoprin Mild UTI as an alternative to Trimethoprim or Cephalexin Mild UTI as an alternative to Trimethoprim, Cephalexin, Amoxycillan+clavulanate Men and Women Mild acute pyelonephritis (low grade, fever and no nausea or vomiting) Mild acute pyelonephritis (low grade, fever and no nausea or vomiting) as an alternative Cephalexin Mild acute pyelonephritis (low grade, fever and no nausea or vomiting) as an alternative to Cephalexin or Amoxycillan+clavulanate Mild acute pyelonephritis (low grade, fever and no nausea or vomiting) as an alternative Cephalexin or Amoxycillan+clavulanate or Trimethoprim Mild acute pyelonephritis (low grade fever and no nausea or vomiting) and if resistance to above drugs is present or if the organism is identified as Pseudomonas aeruginosa As an alternative to Norfloxacin in mild acute pyelonephritis (low grade, fever and no nausea or vomiting) and if resistance to above drugs is present or if the organism is identified as Pseudomonas aeruginosa CC-NG-002 Dosage Duration of Drug Therapy Trimethoprim Cephalexin Amoxycillan + clavulanate 300mg PO daily 500mg PO BD 500+125mg PO BD 3 days 5 days 5 days Nitrofurantoin 50mg PO QID 5 days Norfloxacin 400mg PO BD 3 days Trimethoprim Cephalexin Amoxycillan+clavulanate Nitrofurantoin 300mg PO daily 500mg PO BD 500+125mg PO BD 50mg PO QID 14 days 14 days 14 days 14 days Cephalexin 500mg PO 6-hourly Amoxycillan+clavulanate 875+125mg PO BD Trimethoprim 300mg daily PO Trimethoprim+ sulfamethoxazole Norfloxacin 160+800mg PO BD 10 days for women, 14 days for men 10 days for women, 14 days for men 10 days for women, 14 days for men 10 days for women, 14 days for men 10 days for women, 14 days for men Ciprofloxacin 500mg PO BD Review Date: 160410 400mg PO BD 10 days for women, 14 days for men Page 8 of 11 Suspected Urinary Tract Infection (UTI) - Nurse Practitioner Drug Group Drug Formulary Outcomes Adrenaline S3 (8,10&11) Indicated for use in patients experiencing anaphylaxis. Dosage-for adults and children >12yrs old with spontaneous circulation: 300ug (epipen) or 500ug (adrenaline 1:1000) IM-lateral thigh repeated every 5 minutes if inadequate resolution of symptoms. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Cetirizine S2 (8,10&11) Indicated for use in patients experiencing cutaneous changes only associated with drug hypersensitivity reaction. Dosage for adults and children> 12 years old: 10mg daily. Route: Oral. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Sodium Chloride 0.9% IV fluid (8,10,11&12) Unscheduled Indicated for use in patients with evidence of hypovolaemia due to hypovolaemic or septic shock or anaphylaxis. Route: IV. Dosage for adult (18yrs or older) 250-1000ml STAT. Dosage for children (<18yrs old) 20ml/Kg STAT. Client prescribed medication appropriate to known adverse drug reactions, current medications and medical history. Oxygen Therapy Oxygen therapy will be guided by measured oxygen saturation levels (SaO2). Patients with no history/evidence of chronic lung disease aim for SaO2 > 94%. Oxygen delivery device will be either nasal prongs or face mask. Patients with history of chronic lung disease aim for Sao2 via oxygen delivery device equivalent to baseline SaO2 (if known) otherwise aim for SaO2 >90%. Authorization for use of oxygen therapy to seek to maintain SaO2 > 90%. Transferral of care to Medical Governance Doctor of Silver Chain or ED of WA public hospital. Joint management by Medical Governance Doctor of Silver Chain and NP may be deemed to be appropriate. CC-NG-002 Review Date: 160410 Page 9 of 11 Suspected Urinary Tract Infection (UTI) Nurse Practitioner PURPOSE: Summary of Management of Uncomplicated UTI in Adults (excluding pregnant females by HATH Nurse Practitioner) SCOPE: PROCESS Obtain patient history: Dysuria, frequency Suprapubic/flank pain Fever Antibiotic allergies Conduct physical assessment Conduct Urine dipstick analysis: Leucocyte Nitrites Consider differential diagnosis: (Collaborate with Medical Governance Doctor as need arises) Renal Colic/Calculi Male: Prostatitis Epididyorchitis Urethritis Female: Pelvic Inflammatory Disease Vaginitis Conduct Investigations: MSU for MC&S. If pyelonephritis suspected: U&E, FBP, BC If pregnancy suspected: beta-HCG Suitable for NP HATH: Cystitis Mild uncomplicated Pyelonephritis Determine if suitable for NP HATH management No Yes Unsuitable for NP HATH: Evidence of complicated UTI Severe illness: Male with UTI Parental antibiotics required Pregnancy Acute onset Delirium Temp> 38.50C Hypotension Oliguria Renal tract abnormality: IDC/SPC/ureteric stent insitu, Obstruction, neurogenic bladder Renal failure Presence of unstable comorbiditity (eg diabetes, decompensated heart failure) Suitable for oral antibiotics? Yes Commence oral Trimethoprim 300mg daily or amoxycillin 500mg+clavulanate acid 125mg BD. 14 days for males 5 days for females uncomplicated cystitis or 10 days for pyelonephritis. No Refer to Medical Governance Doctor or Emergency Department Referral to Medical Governance Doctor or Emergency Department Review in 2 days with MSU result (CC: GP) Further investigations by GP for all male UTIs and females with recurrent/complicated UTI MAC-CPG-002 Review Date: 070210 Page 10 of 11 Suspected Urinary Tract Infection (UTI) Nurse Practitioner REFERENCES 1 Lee F. Clinical practice guideline and protocol urinart tract infection [Online]. 2007 Aug [cited 2009 Feb 28]; Available from: URL:http://www.ocno.health.wa.gov.au/practitioner/docs/urology_continence/NPCG_UTI.pdf 2 Scottish Intercollegiate Guideline Network. Management of suspected bacterial urinary tract infection in adults; A national clinical guideline. [Online] 2006 [cited 2009 Mar 9]; Available from: http://www.sign.ac.uk/pdf/sign88.pdf. 3 Nicolle L. Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis. Urol Clin N Am [serial online] 2008 Feb [cited 2009 Feb 24]; 35:1-12. Avalable from: URL: http://www.mdconsult.com.rplibresources.health.wa.gov.au/das/article/body/1250392653/jorg=journal&source=MI&sp=20186587&sid=814689937/N/620000/s0094014307000894.pdf?SEQN O=1&issn=0094-0143 4 St John A, Boyd J, Lowes A, Price C. The use of urinary dipstick tests to exclude urinary tract infection-a systematic review of the literature. Am J Clin Pathol 2006;126: 428-436. 5 eTG complete 2008. Urinary tract infections.Therapeutic Guidelines limited. [Online]. 2008 Nov [cited 2009 Feb 24]. Available from: URL:http://etg.tg.com.au.rplibresources.health.wa.gov.au/ip/ 6 Australian Centre for Diabetes Strategies Prince of Wales Hospital, Sydney. National Evidence Based Guidelines for the management of type 2 diabetes mellitus. [Online]. 2001 updated 2005 [cited 2009 Feb 22]; Available from: National Health and Medical Research Council http://www.nhmrc.gov.au.rplibresources.health.wa.gov.au/PUBLICATIONS/synopses/_files/di9.pdf 7 eTG complete 2008. Analgesics.Therapeutic Guidelines limited. [Online]. 2008 Nov [cited 2009 Feb 24]. Available from: URL:http://etg.tg.com.au.rplibresources.health.wa.gov.au/ip/ 8 Australian Medicines Handbook. [Online]. 2009 Jan [cited 2009 Feb 22]. Available from: URL: http://www.amh.net.au.rplibresources.health.wa.gov.au/online/view.php?page=index.html 9 eTG complete 2008. Nausea and vomiting.Therapeutic Guidelines limited. [Online]. 2008 Nov [cited 2009 Feb 24]. Available from: URL:http://etg.tg.com.au.rplibresources.health.wa.gov.au/ip/ 10 Australian Resuscitation Council. Cardiopulmonary resuscitation for advanced life support providers. Melbourne : Australian Resuscitation Council, 2007. 11 Working group of the Resuscitation Council (UK). Emergency treatment of anaphylactic reactionsguidelines for healthcare providers. Resus 2008 77: 473-483. 12 Burridge N, editor. Australian Injectable Drugs Handbook-The Society of Hospital Pharmacists of th Australia. 4 ed. Melbourne: SHPA Publications. 2008. 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