Help patients win the constipation battle Best practice in the prevention and treatment of constipation in adults under 65 years Authored by: Marianne Wallis, Shona McKenzie, Sheridan Guyatt, Jennifer Rayner, Fiona Ellem, Elizabeth Gass, Winsome St John and Roger Hughes. Based on a systematic review conducted by: Marianne Wallis, Elizabeth Gass, Ben Desbrow and Winsome St John. National Continence Management Strategy Department of Health and Ageing Commonwealth of Australia September 2003 About the Authors A/Prof. Marianne Wallis Chair, Clinical Nursing Research, a joint appointment between Griffith University and Gold Coast Health Service District Ms Shona McKenzie Continence Nurse Advisor Royal Brisbane Hospital Ms Sheridan Guyatt Physiotherapist Ms Jennifer Rayner Stomal Therapist Gold Coast Health Service District Ms Fiona Ellem Pharmacist Gold Coast Health Service District A/Prof. Elizabeth Gass School of Physiotherapy and Exercise Science Griffith University The production of these guidelines was funded by a grant obtained from the Australian Department of Health and Ageing, National Continence Management Strategy. Published by the Griffith University Research Centre for Clinical Practice Innovation PMB 50, Gold Coast Mail Centre, Queensland, 9726 or Parklands Drive, Southport, Queensland, 4215, Australia Copyright © 2003 Griffith University Research Centre for Clinical Practice Innovation The procedures described in these Clinical Guidelines must only be used by people who have appropriate expertise in the field to which the procedure relates. The applicability of any information must be established before relying on it. While care has been taken to ensure that these guidelines summarise available research and expert consensus, any loss, damage, cost, expense or liability suffered or incurred as a result of reliance on these procedures (whether arising in contract, negligence or otherwise) is, to the extent permitted by law, excluded. Dr Winsome St John School of Nursing Griffith University Mr Roger Hughes Nutrition Unit School of Health Science Griffith University Contents Prevention treatment chart 2 Management treatment chart 3 Guidelines for clinicians 4 Prevention of constipation in adults 8 • Diet and fluid intake 9 • Examples of fibre(soluble fibre) 11 • Exercise 12 • Effective bowel habits - bowel retraining 13 • Laxative therapy 15 Management of constipation in adults 16 Referral pathways • General practitioner 18 • Registered nurses: general and specialist 23 • Physiotherapist 24 • Dietitian 26 • Specialist medical services 27 References 28 Appendices 30 • Appendix 1 – Levels of evidence used in systematic review 30 • Appendix 2 – Assessment proforma, including food and fluids chart 31 • Appendix 3 – Investigations 34 • Appendix 4 – Bowel training instructions 35 1 Prevention Management If your middle-aged client complains of constipation or has any risk factors for constipation such as immobility, opioid ingestion or neurological damage Assess the following and reinforce healthy lifestyle Therapy for constipation in adults Reinforce good habits Refer for further assessment/treatment • Correct position for defaecation • 30 minutes of exercise daily • 8 glasses of water a day • 25-35g of fibre daily Dietary fibre and fluid intake 8 glasses of fluid a day, 25-35g/day of fibre. (See p. 10) Exercise Bowel habits Regular activity within ability – 30 minutes of walking most days of the week. (See p. 13) Use the urge following meals or first thing in the morning. Adopt the correct position. (See p. 14) Reassess in one to two weeks. If problem persists, assess compliance with lifestyle change and use three step plan. Step 1: Assess the degree of problem this is for the client – if not affecting functioning, reinforce lifestyle changes and refer client to a dietitian, nurse and/or physiotherapist. Step 2: If problem is affecting functioning to a small degree, suggest incremental introduction of laxative therapy under GP guidance and refer to a dietitian and/or physiotherapist. (See p. 15) Step 3: If affecting functioning severely, refer to GP for specialist physician referral and/or colonic transit studies. 2 Prevention & management General Practitioner Physiotherapist Dietitian Specialist Nurse Progressive introduction of laxatives (See p. 18) Exercise program Diet planning Massage Education Bowel habit training Lifestyle education Biofeedback Physician Investigations Pharmacotherapy Further referral Surgeon Prevention & management 3 The size of the problem Guidelines for clinicians Introduction These guidelines for clinicians are based on a systematic review of research literature that was conducted by a multidisciplinary team. The efficiency, effectiveness and/or appropriateness of five broad categories of interventions have been the subject of research studies focused on the prevention and treatment of constipation in adults. These categories are: • diet and fluid intake • exercise • drug treatments (laxatives) • behavioural training using biofeedback • surgical treatments. The quality of the evidence for all of these interventions is variable, and despite its prevalence, the literature indicates that the prevention and management of constipation in middle-aged adults is often not based on research and remains inconsistent in practice. These guidelines, which have been developed by a multi-disciplinary group of clinicians, focus on the overall weight of the evidence in order to provide as complete a guide as possible based on current knowledge. The criteria used to assess the level of evidence are presented in Appendix 1. In addition to the five areas of diet and fluid intake, exercise, drug treatments, behavioural training using biofeedback and surgical treatments, clinicians also use a number of other interventions. There is also much anecdotal evidence for the usefulness of comprehensive assessment, positioning and toileting behaviour training. While information on these strategies is included in these guidelines there is no research-based evidence for their efficacy and at best they are risk-free suggestions that may be of some clinical utility. Studies conducted in the United Kingdom (UK) and the United States of America (USA) suggest that the prevalence of constipation is between 2% and 10%, in the general population (Pettigrew et al., 1997; Tramonte et al., 1997) and up to 23% in older adults (Donald et al., 1985). It is also more common in women than men (Tramonte et al., 1997). One of the confounding issues when trying to examine the prevalence of constipation is the definition of the term. Some studies employ predetermined criteria, such as the Rome II definition (Thompson et al., 1999) (see Probert et al., 1995) while most others ask participants to either self-assess or report bowel movement frequency or frequency of straining at stool (see Heaton & Cripps, 1993; Thompson & Heaton, 1980). One study, completed in the UK, assessed symptoms using both the Rome criteria and respondents’ self-perception of constipation. The results were very similar with 8.5% of respondents indicating that they suffered from constipation and 8.2% of the same respondents having symptoms that fitted into the Rome definition of chronic constipation (Probert et al., 1995). Australian prevalence data for constipation is lacking (Koch & Hudson, 2000). Recently, the "Women’s Health Australia" (WHA) study, which surveys three different age group cohorts of women, has collected data on self-reports of constipation in a middle-aged cohort of approximately 14,000 women (WHA, 1997 – 2002). These data suggest that, in a general population, constipation is experienced often in 3.6% - 8.7% of women and that the prevalence increases with age (WHA, 1997 – 2002). The prevalence of constipation is much higher in certain groups, such as those with neurological problems and it is very common in those taking opioids especially those with a terminal illness (University of York, 2001). Constipation not only affects the quality of life of the sufferer (O’Keefe et al., 1995) but also has drug-related costs to individuals and to health services. In the UK it is estimated that £46million per year is spent on laxatives and that this exceeds the amount spent on hypnotics and anxiolytics (University of York, 2001). These best practice guidelines have been developed to target the prevention and management of constipation in adults aged between 40 and 65 years with no predisposing medical conditions. They are designed for use by members of a multidisciplinary healthcare team, including medical practitioners, pharmacists, physiotherapists, dietitians and nurses. 4 Guidelines for clinicians Guidelines for clinicians 5 Defining constipation The most commonly used definition in recent years is that developed by a multinational team of gastroenterologists called the Rome II criteria (Thompson et al., 1999). Rome II criteria for functional bowel disorders The diagnosis of a functional bowel disorder always presumes the absence of a structural or biochemical explanation of the symptoms. Functional constipation In the preceding 12 months, the person will have had, for at least 12 weeks, which do not need to be consecutive, of two or more of the following symptoms. 1. Straining > 1/4 of defaecations 2. Lumpy or hard stools > 1/4 of defaecations 3. Sensation of incomplete evacuation > 1/4 of defaecations 4. Sensation of anorectal obstruction or blockage > 1/4 of defaecations 5. Manual manoeuvres to facilitate > 1/4 of defaecations (eg digital evacuation, support of the pelvic floor) 6. < 3 defaecations per week. Risk factors for constipation The main risk factors associated with constipation in middle aged adults are • inadequate diet and fluid intake • reduced mobility and exercise • drug treatments associated with an increased risk of constipation • recent illness, surgery or lifestyle change • other medical conditions (physical and psychological) • increasing age. (University of York, 2001; Petticrew et al.,1997) Assessment There is no research-based evidence for the effectiveness of assessment in the overall management of constipation in middle-aged adults. There is, however, much evidence that treatment based on accurate assessment and interpretation of findings results in better client outcomes. Thus in order to determine the best course of action, when a client is either at risk of constipation or is experiencing on-going constipation, 6 Guidelines for clinicians it is advisable to have an accurate assessment of: • current symptoms experienced by patient • physical assessment – focusing on the abdomen and signs indicating hydration • medical history with particular emphasis on bowel function • bowel habits and toileting behaviour • diet and fluid intake • activity levels • drug treatments associated with an increased risk of constipation • recent illness, surgery or lifestyle change • other medical conditions (physical and psychological). It is important to allow the client to accurately describe signs and symptoms rather than to accept an interpretation of the signs and symptoms. Assessment guidelines Below are suggested assessment guidelines. Appendix 2 provides a proforma that may be copied for clinical use. • Presenting symptoms - as described by the client. • Duration of symptoms - as described by the client. • Previous management - and effect of these on bowel function. • Investigations – for example has the client undergone any bowel investigations? eg. colonoscopy, X-ray, defaecogram, ultrasound or manometry. (See Appendix 3) • Current medications – note especially medications with recognised constipating effect. e.g. antacids, anticholinergics, antidepressants, opioids, antihistamines, antihypertensives. • Medical / Surgical history - include gynaecological history in women. • Bowel habits – including frequency, consistency, urge, sensation of complete/incomplete emptying, bleeding, pain on defecation, abdominal pain and/or bloating. • Toileting behaviour – straining, sitting position, feet supported, manual assistance, time taken to empty. • Faecal incontinence – flatus, liquid, solids and/or mucous. • Diet / Fluid intake – ask patient to complete a 3 or 7 day fluid and food chart. • Physical activity / exercise - ask patient to describe type of exercise and frequency. • Physical assessment – palpation and auscultation of the abdomen and examination of skin flaccidity and eye pressures (signs of hydration). Send for medical / specialist review if: • sudden change in bowel habits • pain • bleeding • poor response to treatment, or • if further investigation is required. (See Appendix 3) Guidelines for clinicians 7 Prevention of constipation in adults If your middle-aged client complains of constipation or has any risk factors for constipation such as immobility, opioid ingestion or neurological damage Guidelines for prevention and management of constipation Prevention of constipation The algorithm on the facing page summarises key features of the approach to the prevention of constipation in people aged between 40 and 65 years. The evidence for the approach represented in the algorithm is presented in this section. Diet and fluid intake Assess the following and reinforce healthy lifestyle Dietary fibre and fluid intake 8 glasses of fluid a day, 25-35g/day of fibre. (See p. 10) Exercise Bowel habits Regular activity within ability – 30 minutes of walking most days of the week. (See p. 13) Use the urge following meals or first thing in the morning. Adopt the correct position. (See p. 14) There are very few well designed, double blind, crossover studies into the effect of increased intake (i.e. provide subjects with food) and assess the impact of dietary modification on bowel function. The systematic review revealed 12 studies that performed investigations using non-constipated subjects (i.e. prevention) and of these, six were designated properly designed randomised control trials (i.e. Level II). These six trials included a total of 187 subjects. There were eight experiments designed to compare different management strategies related to diet and only two of these were properly designed randomised controlled trials. These two trials included a total of 44 subjects. Reassess in one to two weeks. If problem persists, assess compliance with lifestyle change and move to the three step management plan. Step 1: Assess the degree of problem this is for the client – if not affecting functioning, reinforce lifestyle changes and refer client to a dietitian, nurse and/or physiotherapist. Step 2: If problem is affecting functioning to a small degree, suggest incremental introduction of laxative therapy under GP guidance and refer to a dietitian and/or physiotherapist. (See p. 15) Step 3: If affecting functioning severely, refer to GP for specialist physician referral. 8 Prevention of constipation in adults Prevention of constipation in adults 9 All of the studies included in the systematic review showed that the intake of dietary fibre (especially bran), in a variety of forms (i.e. dietary intake, fibre suspensions and fibre tablets) improves bowel function (i.e. either stool frequency and/or weight or makes stools easier to pass). This highlights the importance that increasing dietary fibre (25-35g/day) has in preventing constipation. Table I The effects of differing sources of dietary fibre on bowel function indicate that insoluble fibres (eg. bran, rye) produce greater increases in stools (i.e. size and/or frequency) than soluble fibres (psyllium, partially hydrolysed gums) or resistant starches (legumes). This, however, does not take into consideration long-term compliance. A number of studies reviewed investigated differing methods to increase fibre intakes (Orr et al., 2000; Dettmar et al., 1998; Bass et al., 1988; Hamilton et al., 1988). It appears likely that convenience is a major factor in sustained high fibre intakes. See Table 1 on p. 11 for details of fibre content of common foods. Food Three studies investigated the effects of increasing fluid consumption on bowel habit (Chung et al., 1999; Anti et al., 1998; Ziegenhagen et al., 1991). The most recent of these studies was only performed over a very short period (9 days in total and only 4 days of increased fluid intake). They found no effect on bowel function following an increase in fluid intake. Anti et al., (1998) investigated subjects with constipation. They found that increasing subjects’ fluid intake (mineral water) to 1.5-2.0 litres/day enhanced the effects of a concurrently increased fibre intake. The third study, Ziegenhagen et al., (1991) was conducted on healthy subjects. Subjects showed no differences in response to a bran supplement with or without the addition of 600mls of additional fluid. The conflicting results indicated the possibility that, like fibre, fluid may affect the constipated individual differently than those without the condition. From these results it would seem reasonable to recommend to constipated clients that if they are going to increase their fibre intake it might be beneficial to raise their fluid intake to 2 litres per day. Recommendations for dietary fibre and fluid intake • Daily dietary fibre intake of 25-35 grams/day – Level II evidence. • This should be a combination of soluble and insoluble fibre - Level III evidence. • It is important that the client finds a way of taking the fibre that is convenient. The introduction of dietary fibre to prevent constipation is a long-term commitment and any strategy needs to be sustainable – Level III evidence. • Daily fluid intake of 1.5-2 litres (six to eight glasses of water) per day is recommended to prevent constipation – Level III evidence. 10 Prevention of constipation in adults Examples of fibre (soluble fibre) Those sources of fibre in bold are soluble fibre, those in black are insoluble fibre. Fibre (gram) Bread (1 slice) white wholemeal mixed grain 1.0 2.0 2.5 6.0 3.5 9.5 1.0 7.0 1.0 3.0 Bran/wheatgerm (1 tablespoon) oat wheat wheatgerm 2.0 2.0 1.0 Grains and Pastas (boiled – 1 cup) Barley Wholemeal pasta White rice Brown rice Fibre (gram) Fruit Breakfast cereals Muesli (1/2 cup) Rolled oats (1/2 cup raw) All bran (1/2 cup) Cornflakes (1 cup) Sultana Bran (1 cup) Special K (1 cup) Weetbix (2 biscuits) Food 7.0 10.0 1.5 3.0 Apple (1) Banana (1) Dates (1cup dried) Figs (5 dried) Kiwi fruit (2) Orange (1) Prunes (5) Pear (1) Sultanas (1 tablespoon) 3.0 3.0 10.0 11.0 5.0 2.5 3.0 4.0 1.0 Vegetables Beans, green (1/2 cup) Carrots (1/2 cup) Potato (1) Sweet corn (1 small cob) Tomato (1) 4.5 2.0 1.0 4.0 1.5 Legumes (1/2 cup) Baked beans Kidney beans Chickpea Lentil Split pea 6.5 6.0 4.5 3.5 3.5 Prevention of constipation in adults 11 Exercise Approximately 300 years ago it was said exercise "helps to throw down wind from the bowels … it also serves … as an evacuant, and a diversion by which artifices the humours are put into conditions of flying off without the danger of bringing on spasms" (Puch, 1794 cited in Sullivan, 1992). Unfortunately our lack of well-designed research studies means that we are not much further on than this in our knowledge today. Exercise is an anti-homeostatic stressor, with complex activation and interaction of many body systems and with adaptive consequences if performed repeatedly and at sufficient dosage. One of the consequences of exercise, particularly whole body exercise is activation of the autonomic nervous system. Of particular relevance is activation of the sympathetic nervous system in its role of redistributing blood away from non-exercising areas and towards exercising areas. The gastro-intestinal system is an area that is, typically, vaso-constricted during exercise, particularly if exercise is intense enough to elevate the heart rate above 100 b.min-1 (Rowell & Shepherd, 1996). Therefore most studies that have examined the role of exercise in preventing constipation have utilised light levels of aerobic exercise. Unfortunately, to date, there is no evidence that would allow us to judge how much exercise is enough and how much is too much, to have a positive influence on bowel function. It is likely, however, that strenuous and/or prolonged exercise can have negative effects on bowel function. A wide range of responses within study groups typifies research studies in the area of exercise and bowel function. Often differences are seen between responders and non-responders. This phenomenon is common in exercise studies and could simply be a reflection of methodological issues, such as small sample sizes. The responder/non-responder difference is usually masked by the statistical interpretation of the results, with the focus on mean scores. Koffler et al., (1992) used strength-training exercise and demonstrated a significantly accelerated whole body transit time (a valid estimate for constipation). This study may suggest strength training to be a mode of exercise of choice. Interestingly in this study all subjects showed the same trend. Complicating the impact of exercise on constipation are the linked co-factors of diet and fluid intake, individual differences in absorbing and metabolising food and fluids, colonic motility patterns, levels of physical fitness and levels of exercise undertaken, all of which may affect the material presented to the colon and its passage along the tract to the rectum. Given that there is no clear and consistent evidence-based prescription of exercise that can be offered for helping to prevent constipation, then it is best to look to The National Physical Activity Guidelines for Australians. These guidelines recommend a level of activity based on evidence that the specified level of activity or above is associated with general health benefits. 12 Prevention of constipation in adults These health benefits include reduced risk of coronary heart disease, hypertension, diabetes mellitus and colon cancer. There is also a reduced risk of premature mortality, reduced depression and anxiety, improved mood and an increased ability to perform daily tasks. Further, there is improved muscle strength, balance and co-ordination and an associated reduction in the risk of falling. Exercise also has recognised benefits for osteoporosis, arthritis, the immune system, a range of other chronic disease states (including incontinence and menstrual symptoms) and improved quality of life with ageing. Recommendations for exercise • The National Physical Activity Guidelines for Australians recommendation is 30 minutes of moderate intensity activity (such as walking) most days of the week – Level III evidence for effectiveness in preventing constipation. • A physiotherapist with a strong background in exercise can make individualised exercise prescriptions that will achieve specific desired goals for any one person. Referral to a physiotherapist may be beneficial for people who find it difficult to implement a change in exercise patterns – Level IV evidence. Effective bowel habits - bowel retraining Bowel retraining is a tool commonly used by physiotherapists and nurses to help their clients prevent constipation. There are no randomised controlled trials or well designed cohort studies that have been conducted to evaluate the effectiveness of bowel retraining. Thus the following material is presented as expert opinion only. Studies of human colonic activity tell us there are many mechanisms that assist in colon transit and normal defaecation (Bassotti et al., 1995). Some of these are under behavioural control and can be used to help develop effective bowel habits. There is an increase in colonic muscle activity associated with waking up and the urge to defaecate often follows this increase in motility. Gastro-colonic reflex also causes an increase in contractile activity in the bowel following food ingestion. This effect can last up to 3 hours (Bassotti et al., 1995). Normal defaecation begins with an urge to defaecate. The main receptors for this sensation are stretch receptors in the puborectalis muscle. Emptying is optimal when the urge is present as this indicates the rectum is full and the internal anal sphincter is relaxed. If defaecation is socially convenient the levator ani, puborectalis and external anal sphincter relax. This relaxation of the pelvic floor increases the anorectal angle. The anorectal angle is further straightened when the hips are flexed greater than 90 degrees as with squatting. Leaning forward enhances the effect of gravity on the rectal contents. When the rectum is empty and the increase in intra-abdominal pressure ceases the tonic activity in the pelvic floor muscles re-appears (Rasmussen, 1994). Prevention of constipation in adults 13 Straining to defaecate involves strongly contracting the abdominal wall inducing posterior pelvic tilt. This poor defaecation pattern results in excessive perineal descent and inadequate release of the anal outlet. Straining over an extended period can lead to long-term damage to pelvic nerves and muscles and soft tissues. Recommendations for toileting behaviour • The most effective time to empty the bowel is when the urge to defaecate is first experienced. First thing in the morning or following a meal are common times to get this urge. • Do not strain to empty the bowel. This will stretch down on the muscles supporting the pelvic area and not empty the bowel effectively. • For optimal muscle activation and effective use of gravity the correct position to sit on the toilet is to lean forward with feet supported so that the hips are flexed > 90 degrees; forearms resting on abducted thighs; back straight (maintaining a normal lumbar curve). Diagram of correct position Laxative therapy If a client has any of the risk factors for constipation it may be useful to utilise some laxatives to prevent the development of constipation. Evidence from four systematic reviews suggests that both fibre and laxatives modestly improve bowel movement frequency and decrease pain in adults with chronic constipation (Petticrew et al., 1997; Tramonte et al., 1997; University of York, 2001; Wallis et al., 2002). However, there is insufficient evidence to establish whether fibre is better than laxatives or which laxative (laxative class) is superior. It is not currently possible to determine the effectiveness of different types of laxatives (Petticrew et al., 1997; Tramonte et al., 1997; University of York, 2001; Wallis et al., 2002). The evidence from systematic reviews also indicates that constipation should be managed with a stepped-care approach. Increase dietary fibre, then introduce laxatives starting with the cheapest option first (Petticrew et al., 1997; University of York, 2001; Wallis et al., 2002). More research is required to determine the effectiveness of dietary change and the comparative effectiveness of bulk and non-bulk laxatives (Petticrew et al., 1997; Tramonte et al., 1997; University of York, 2001). In order to prevent constipation in patients with predisposing factors, for example, opioid medication usage, reduction in mobility due to illness, etc. it may be necessary to use bulk forming laxatives in the short term until normal patterns of bowel emptying can be resumed or lifestyle changes can be made. If this is the case patients need to be given advice about which agents to use and how to maximise the usefulness of the laxative. (See recommendations below.) Recommendations for bulking agents Bulking agents absorb water and expand to increase the bulk and moisture content of the bowel motion. The bowel is then stimulated by the presence of the bulky stool. Always drink a full glass of water with each dose, to allow the laxative to work properly and prevent intestinal blockage. 1. Elbows on knees Allow 1 to 3 days for this to work. 2. Lean forward 3. Feet on a stool Prevention of constipation Changes made to diet and/or fluid intake, exercise and bowel retraining need to be trialled for 2 – 4 weeks before moving on to further constipation-prevention strategies such as the administration of laxatives. Examples • Ispaghula husk (fybogel) • Psyllium (metamucil, agiofibe) • Sterculia (granocol, normacol plus) • Methylcellulose. Side effects include • Flatulence and abdominal cramps. NB A gradual increase in dose is advisable to avoid flatulence and distension. Level I evidence of effectiveness. 14 Prevention of constipation in adults Prevention of constipation in adults 15 Management of constipation Management of constipation in adults If your middle-aged client complains of constipation or has any of the risk factors such as immobility, opioid ingestion or neurological damage and despite behavioural change continues to experience constipation, commence further assessment and treatment. Refer for further assessment/treatment • Correct position for defaecation • 30 minutes of exercise daily • 8 glasses of water a day • 25-35g of fibre daily If an otherwise healthy adult complains of on-going, bothersome constipation, a repeat assessment of presentation, symptoms and antecedents is generally considered good clinical practice (see Appendix 2). If, after reinforcing the good habits with respect to fibre intake, fluid intake, exercise levels and toileting behaviour indicated in the table below, there is no further improvement then treatment or referral will be necessary. Good habits Recommendations for dietary fibre and fluids Therapy for constipation in adults Reinforce good habits Refer to the algorithm on the facing page for stepwise approach for the management of constipation in people aged between 40 and 65 years. • Maintain a daily intake of 25-35g of fibre per day and a mixture of soluble and insoluble fibre. • Fluid intake of 1.5 –2 L per day. • Refer to prevention guidelines. Recommendations for exercise The National Physical Activity Guidelines for Australians recommendation is 30 minutes of moderate intensity activity (such as walking) most days of the week. Toileting habits General Practitioner Physiotherapist Dietician Specialist Nurse Progressive introduction of laxatives (See p. 18) Exercise program Diet planning Massage Education Bowel habit training Lifestyle education Biofeedback Attempt defaecation when the urge to defaecate is first experienced. Do not strain to empty the bowel. Sit on the toilet leaning forward with feet supported so that the hips are flexed > 90 degrees; forearms resting on abducted thighs; back straight (maintaining a normal lumbar curve). Referral pathways If the client continues to experience constipation or if the client finds it difficult to maintain lifestyle change it may be necessary to refer to one of the following clinicians. Physician Investigations Pharmacotherapy Further referral Surgeon 16 Management of constipation in adults Management of constipation in adults 17 General practitioner Table 2 The general practitioner can guide the client in a stepped approach to the introduction of laxatives should they be needed and can also refer clients with severe problems on to specialist gastroenterological medical services for assessment and treatment. Weekly cost of laxatives Class Preparation Laxatives are the most commonly prescribed pharmacological interventions for the treatment of constipation. Laxatives are associated with increases in bowel movement, frequency and improvements in the symptoms of constipation. Bulk forming laxatives Bran Isphaghula husk Psyllium Sterculia Key findings from systematic review Faecal softeners Liquid paraffin Docusate sodium Stimulant laxatives Bisocodyl Senna Examples as trade Trade name Name Cost per week at usual number of daily doses Side effects Effects ~$3.00 $4.67 $3.90 $4.20 Flatulence and abdominal cramps. Agarol Coloxyl $5.42 $2.24 None with short term use. $1.68 $1.12 $2.33 Abdominal cramps, flatulence, electrolyte imbalance (with prolonged use). Liquid paraffin Durolax Senokot Coloxyl and Senna Laxettes Agarol Osmotic Polyethylene Movicol $7.00 Flatulence, laxatives Glycol Lactulose Duphalac $12.40 intestinal cramping and diarrhoea. Laxative medications • Both fibre and laxatives modestly improve bowel movement frequency and decrease pain in adults with chronic constipation. • Insufficient evidence exists to establish whether fibre is better than laxatives or which laxative (laxative class) is superior. It was not possible to determine the effectiveness of different types of laxatives. • Bulk laxatives and osmotic laxatives are associated with increases in frequency and improvements in stool consistency and symptoms of constipation. A bulking agent in combination with a stimulant may be a useful combination. • Constipation should be managed with a stepped-care approach. Increase dietary fibre, and then introduce laxatives starting with the cheapest option first. (See Table 2) • More research is required to determine the effectiveness of dietary change and the comparative effectiveness of bulk and non-bulk laxatives. Fybogel Metamucil Normacol $5.44 $8.24 Recommendations for laxative prescription A stepped approach should be used in which bulking agents are introduced first, followed by either softening or stimulant laxatives with osmotic laxatives used if other laxatives fail or if side effects (such as flatulence) reduce adherence – Level I. Evidence There is no compelling evidence that one laxative is better than another so the cheapest alternative should be tried first. 18 Management of constipation in adults Management of constipation in adults 19 The stepped approach to laxative use in constipation There is no evidence to suggest that laxatives prevent constipation in middle-aged people. The information given on laxatives is for management of existing constipation using a stepped approach as suggested in the algorithm included in these guidelines. First changes to diet, fluid intake and exercise should be attempted. If this does not work laxatives should be introduced class by class. Laxatives are divided into four classes: bulking agents, faecal softeners, stimulant laxatives and osmotic laxatives. For the purpose of these guidelines suppositories and enemas are separated into a fifth class. NB Laxatives should not be taken within two hours of medication, because the desired effect of the other medication may be reduced. Bulking agents The evidence suggests that there is an improvement in bowel frequency with the use of bulk laxatives. Evidence from systematic reviews suggests that bulk laxatives are associated with an increase in frequency of one to two bowel motions per week compared to placebo. They also soften stools by increasing stool water content and one study found that bulk laxatives have a greater overall laxative efficacy in subjects with chronic idiopathic constipation. patients. Overall symptom improvement was greater with treatment of stool softeners but the effect compared to placebo did not reach statistical significance (Hyland & Foran, 1968). Recommendations for stool softeners Faecal softeners help liquid mix into the stool; this softens the stool and permits easier defaecation. These are best used to prevent straining or when hard stools are present. Allow 1 to 5 days for these to work. Liquid forms may be taken in milk or fruit juice to improve the flavour. Examples • Docusate sodium (Coloxyl) • Poloxalkol (Coloxyl drops) • Liquid paraffin (Parachoc, Agarol). Stimulants The systematic review did not reveal any consistent evidence that stimulant laxatives are more effective than non stimulant laxatives. However, they did produce a mean increase of 2.6 bowel movements per week. Recommendations for bulking agents Bulking agents absorb water and expand to increase the bulk and moisture content of the bowel motion. The bowel is then stimulated by the presence of the bulky stool. It is necessary to drink a full glass of water with each dose, to allow the laxative to work properly and prevent intestinal blockage. Allow 1 to 3 days for this to work. Examples • Ispaghula husk (Fybogel) • Psyllium (Metamucil, Agiofibe) • Sterculia (Granocol, Normacol plus) • Methylcellulose. Side effects include • Flatulence and abdominal cramps. Recommendations for stimulant laxatives Stimulant laxatives stimulate intestinal motility via an irritant effect. Stimulants may cause abdominal cramping. Prolonged use is not recommended. While there was level II to level III evidence that stimulant laxatives produced an increase in bowel movements, no consistent evidence was found that stimulant laxatives are more effective than non-stimulant laxatives. Allow 6 to 12 hours for these to work. Examples • Bisacodyl (Durolax, Bisalax) • Senna (Senokot, Coloxyl and Senna, Nulax, Prune and Senna, Laxettes with Senna, Bioglan, Agiolax) • Phenolpthalein (Figsen, Laxettes, Veracolate) • Liquid paraffin (Parachoc, Agarol) • Castor oil (not recommended). NB A gradual increase in dose is advisable to avoid flatulence and distension. Faecal softeners There are very few studies that compare stool softeners to placebo. One randomised controlled trial examined the role of stool softeners in preventing constipation in elderly nursing home 20 Management of constipation in adults Side effects include • Abdominal cramps • Flatulence • Electrolyte imbalance (with prolonged use). Management of constipation in adults 21 Osmotic laxatives Registered nurses: general and specialist Laxatives with an osmotic effect appear to be consistently associated with significant improvements in frequency, consistency, straining and pain compared to placebo (University of York, 2001). Nursing is a profession that is skilled in providing primary care, health education and health promotion. Nurses can provide ongoing client education about normal function, diet, exercise, medications, procedures and therapies. They have particular skills in assisting clients to manage their health conditions and therapies within their own particular circumstances, capabilities and contexts. Recommendations for osmotic laxatives Osmotic laxatives encourage bowel movements by drawing water into the bowel, hydrating and softening the stool. Allow 2 to 48 hours for this to work. Registered nurses are registered health care professionals with university degree qualifications. Specialist nurses have postgraduate and/or specialist qualifications in ostomy and/or continence nursing. Each dose should be taken in or with a full glass of water or fruit juice. A more rapid effect will be achieved if the dose is taken on an empty stomach, with a full glass of liquid or more. Accessing nursing services Examples • Sorbitol 70% (Sorbilax) • Lactulose (Duphalac, Actilax) • Magnesium salt (Epsom salts) • Movicol (Polyethylene Glycol - PEG). Nursing services can be accessed via a local private or public hospital, home visiting nursing services and community health services such as a community health centre. Side effects include • Flatulence • Intestinal cramping • Diarrhoea • Magnesium and phosphate containing preparations should be used with caution or avoided in patients with renal insufficiency, cardiac disease, electrolyte imbalances and in patients on diuretic therapy. Suppositories and enemas There is no evidence that suppositories or enemas have any long-term effect on constipation or the patterns of bowel emptying. They are only appropriate for distal faecal impaction. Recommendations for suppositories and enemas Allow 15 to 30 minutes for these to work. Examples • Bisacodyl (Durolax) • Combination products (Microlax, Travad) • Glycerine • Docusate sodium (Rectalad). 22 Management of constipation in adults Management of constipation in adults 23 Physiotherapist Physiotherapy is a profession with specialised skills in assessment of muscle dysfunction and muscle retraining and activation. In the case of obstructed defaecation the process involves assessing muscle dysfunction and retraining the abdominal and pelvic floor muscle timing and activation. Australian physiotherapists are registered health care professionals with university degree qualifications. Physiotherapists who are members of the Australian Physiotherapy Association (APA) are expected to undertake continuing professional development programs. Some physiotherapists have specialist expertise in continence management. The Continence Foundation of Australia (CFA) can provide details of these physiotherapists. The overall management of the physiotherapy client involves: • assessment of motor behaviour and physical condition, • analysis and identification of the client’s problems, • development of a treatment program, • management of the treatment or training program, and • evaluation of progress and modification of treatment if necessary. Bowel retraining and biofeedback inpatient environment. However, most studies demonstrate that provision in an outpatient setting, or an outpatient setting supplemented with home therapy can be just as effective. Biofeedback is an expensive therapy in terms of personnel and equipment and is not readily available to the general public in many centres. The simplest form of biofeedback is that provided by a physiotherapist using basic muscle re-education and positioning as a form of muscle retraining. Other biofeedback treatment strategies that have been developed include intrarectal balloon training, intra-anal electromyography (EMG), perianal EMG or some combination of these strategies. These treatments can be conducted in in-patient settings or the patient may be taught to use the particular strategy (more common with EMG) and will then practice the biofeedback at home. Accessing a physiotherapist To access the services of physiotherapists clients can contact their local public or private hospital or community health centre. Physiotherapists in private practice can be located • through the local Yellow Pages • via the website of the Australian Physiotherapy Association www.physiotherapy.asn.au • by calling the CFA on 1800 33 00 66. Effective bowel habits used to prevent constipation may also be effective in the management of constipation, however, there is no research-based evidence to support this contention. Bowel training and the use of the correct position may be useful as well as muscle retraining / biofeedback (see Appendix 4). Biofeedback is used to train the puborectalis muscles of the pelvic floor to relax at defaecation. In the case of difficulty in emptying the bowel or obstructed defaecation it involves retraining the striated muscles used in opening and emptying the bowel. It is theorised that some patients have paradoxical contraction or non-relaxation of the pubrectalis muscle at defaecation and that this leads to anismus and constipation. Not all constipation is a result of these disorders of the anorectum, rather these patients are a sub-group with obstructed defaecation. Biofeedback is not an effective treatment of all forms of constipation. Biofeedback can be used to teach patients to recognize and consciously influence the anal sphincter mechanism. Generally very positive results have been reported for biofeedback. However, many studies were poorly designed, retrospective, had no randomisation, limited control of extraneous variables, and had small samples. It is also not certain which groups benefit most from biofeedback. There is also little account taken of the impact of concurrent factors in the success of biofeedback, such as education, support, etc. Originally biofeedback was carried out in an 24 Management of constipation in adults Management of constipation in adults 25 Dietitian Specialist medical services Dietitians are health professionals who have specialised knowledge related to human nutrition and specialised communication skills designed to help people attain and maintain health. Dietitians translate scientific information related to food, nutrition and mealtime behaviours into practical advice about how to modify a diet to achieve healthy outcomes. As experts in food and nutrition advice dietitians provide individual or family counselling, health policy advice and consultancy services to industry groups. For clients who have severe constipation, bleeding from the rectum or signs of bowel obstruction, referral by the general practitioner to a specialist gastrointestinal physician will be necessary. These physicians, who specialise in gastrointestinal disease, will be able to investigate the aetiology and contributing factors to severe bowel dysfunction. Once investigations have suggested a diagnosis of severe rectal dysfunction the physician may refer the client to a colorectal surgeon. The Dietitians Association of Australia (DAA) oversees the Accredited Practising Dietitians (APD) program. APDs have gained a qualification in an accredited university course, undertake ongoing professional development and commit to uphold the DAA Code of Professional Conduct. Colorectal surgeons have skills in surgical techniques designed to correct mechanical bowel dysfunction that contributes to constipation and also in the use of biofeedback. A consultation with a dietitian will generally include a dietary assessment, nutritional assessment and education regarding the most appropriate dietary modification for the individual. Further consultations may be necessary to monitor progress and to provide support and encouragement to the individual. Dietitians may work in a public health facility or in private practice. They may have consultation rooms in public and private hospitals, nursing homes, community health centres or private practice centres. Accessing a dietitian To access the services of dietitians clients can contact their local public or private hospital or community health centre. Dietitians in private practice can be located: • through the local Yellow Pages • via the website of the Dietitians Association of Australia www.daa.asn.au • by calling the APD Hotline on 1800 812 942. The results of systematic reviews (Knowles et al., 1999; Wallis et al., 2003) indicate that failure of a prolonged trial of laxatives, fibre and exercise may mean that treatment of slow transit constipation with either total colectomy or ileorectal anastomosis is required. There is level III evidence that this treatment will effectively treat the constipation (Wallis et al., 2003). However, the other symptoms of bloating and flatulence may remain (Locke et al., 2000). Recommendations for surgical treatment of constipation Surgical treatment of constipation should only be considered when a prolonged trial of diet modification, increased exercise, laxatives and biofeedback have been unsuccessful. If surgical treatment is pursued the following should be noted. • Careful diagnosis of the underlying cause of the chronic constipation is imperative and selection of patients for surgical treatments is one of the most important factors in the success of the procedure. • Paradoxical puborectalis contraction and descending perineum syndrome should probably not be treated with current surgical techniques. • Total colectomy with ileorectal anastomosis may be useful for slow transit constipation and a reversible stoma formation may have merit for some patients. • The continent colonic conduit is a procedure that may be of use in helping patients with severe chronic constipation manage their condition more successfully. Level I evidence for the above recommendations. Accessing a specialist physician or surgeon A referral from a general practitioner is always required before a specialist medical service can be accessed. 26 Management of constipation in adults Management of constipation in adults 27 References Rowell, L. G., & Shepherd, J. T. (Eds.). (1996). Exercise: regulation and integration of multiple systems. New York: Published for the American Physiological Society by Oxford University Press. Sullivan, S.N. (1992). Overcoming runner's diarrhoea. Physician & Sportsmedicine, 20(10), 63-64, 66-68. Anti, M., Pignataro, G., Armuzzi, A., Valenti, A., Lascone, E., Marmo, R., Lamazza, A., Pretaroli, A. R., Pace, V., Leo, P., Castelli, A., & Gasbarrini, G. (1998). Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepato Gastroenterology, 45(21), 727-732. Bassotti, G., Germani, U., & Morelli, A. (1995) Human colonic motility: physiological aspects. International Journal of Colorectal Disease, 10(3),173-180. Chung, B. D., Parekh, U., & Sellin, J. H. (1999). Effect of increased fluid intake on stool output in normal healthy volunteers. Journal of Clinical Gastroenterology, 28(1), 29-32. Donald, I.P., Smith, R.G., Cruikshank, J.G., Elton, R.A., & Stoddart, M.E. (1985). A study of constipation in the elderly living at home. Gerontology, 31, 112-118. Heaton, K. W., & Cripps, H. A. (1993). Straining at stool and laxative taking in an English population. Digestive Diseases and Sciences, 38(6), 1004-1008. Koch, T., & Hudson, S. (2000). Older people and laxative use: literature review and pilot study report. Journal of Clinical Nursing, 9(4), 516-525. Koffler, K. H., Menkes, A., Redmond, R. A., Whitehead, W. E., Pratley, R. E., & Hurley, B. F. (1992). Strength training accelerates gastrointestinal transit in middle-aged and older men. Medicine and Science in Sports and Exercise, 24(4), 415-419. Locke, G. R., 3rd, Pemberton, J. H., & Phillips, S. F. (2000). AGA technical review on constipation. Gastroenterology, 119(6), 1766-1778. Markwell, S., & Sapsford, R. (1995). Physiotherapy management of obstructed defaecation. Australian Journal of Physiotherapy, 41(4), 279-283. O’Keefe, E. A., Talley, N. J., Zinsmeister, A. R., & Jacobsen, S. J. (1995). Bowel disorders impair functional status and quality of life in the elderly: a population based study. Journal of Gerontological and Biological Science in Medical Science, 50(4), M184-189. Thompson, W. G., & Heaton, K.W. (1980). Functional bowel disorders in apparently healthy people. Gastroenterology, 79, 283-288. Thompson, W. G., Longstreth, G. F., Drossman, D. A., & Heaton, K. W. (1999). Functional bowel disorders and functional abdominal pain. Gut, 45(Suppl II), 1143-1147. Tramonte, S. M., Brand, M. B., Mulrow, C. D., Amato, M. G., O'Keefe, M. E., & Ramirez, G. (1997). The treatment of chronic constipation in adults. A systematic review. Journal of General Internal Medicine, 12(1), 15-24. University of York. (2001). Effectiveness of laxatives in adults. Effective Health Care, 7(1), 1-12. Womens’ Health Australia (1997a). Data book for the baseline survey of the Australian Longitudinal Study on Women’s Health, Young cohort, 18-23 years. (2nd ed.). The Research Institute for Gender and Health, University of Newcastle. Womens’ Health Australia (1997b). Data book for the baseline survey of the Australian Longitudinal Study on Women’s Health, Mid age cohort, 45-50 years. (2nd ed.). The Research Institute for Gender and Health, University of Newcastle. Womens’ Health Australia (1997c). Data book for the baseline survey of the Australian Longitudinal Study on Women’s Health, Older cohort, 70-75 years. (2nd ed.). The Research Institute for Gender and Health, University of Newcastle. Womens’ Health Australia (2002a). Data book for the 2000 Phase 2 survey of the young cohort (22-27 years). Australian Longitudinal Study on Women’s Health. The Research Institute for Gender and Health, University of Newcastle. Womens’ Health Australia (2002b). Data book for the 1998 Phase 2 survey of the mid age cohort (47-52 years). Australian Longitudinal Study on Women’s Health. The Research Institute for Gender and Health, University of Newcastle. Petticrew, M., Watt, I., & Sheldon, T. (1997). Systematic review of the effectiveness of laxatives in the elderly. Health Technology Assessment, 1(13). Womens’ Health Australia (2002c). Data book for the 1999 Phase 2 survey of the older cohort (73-78 years). Australian Longitudinal Study on Women’s Health. The Research Institute for Gender and Health, University of Newcastle. Probert, C. S., Emmett, P.M., & Heaton, K.W. (1995). Some determinants of whole-gut transit time: a population based study. QJM Monthly Journal of the Association of Physicians, 88, 311-315. Ziegenhagen, D. J., Tewinkel, G., Kruis, W., & Herrmann, F. (1991). Adding more fluid to wheat bran has no significant effects on intestinal functions of healthy subjects. Journal of Clinical Gastroenterology, 13(5), 525-530. Rasmussen, O. O. (1994). Anorectal function. Diseases of the Colon & Rectum, 37(4), 386-403. 28 References References 29 Appendices Appendix 2 Assessment proforma Assessment guidelines for constipation management Presenting symptoms Appendix 1 Levels of evidence used in systematic review The levels of evidence referred to throughout these guidelines relate to those used for the systematic review referred to in these guidelines. The level of evidence represented by the articles was assessed by two independent assessors using criteria based on the National Health and Medical Research Council’s (2000) criteria described in "A Guide to the Development, Implementation and Evaluation of Clinical Practice Guidelines". These levels are Level I Evidence obtained from a systematic review or meta-analysis of all relevant randomised controlled trials. Level II Evidence obtained from at least one properly designed randomised controlled trial. Level III - 1 Evidence obtained from well-designed pseudo-randomised controlled trials (alternate allocation or some other method). - 2 Evidence obtained from comparative studies with concurrent controls and allocation not randomised (cohort studies), case control studies or interrupted time series design with a parallel control group. - 3 Evidence obtained from comparative studies with historical control, two or more single arm studies or interrupted time series design without a parallel control group. Level IV Evidence obtained from case series (either post-test or pre-test and post-test), opinions of respected authorities, descriptive studies or reports of expert committees. ➔ Presenting symptoms (as described by the client) Duration of these symptoms Previous management and effect of these on bowel function Investigations (has the client undergone any bowel investigations eg. colonoscopy, X-ray, defaecogram, ultrasound, manometry) Current medications (use * to denote recognised constipating effect eg. Antacids; anticholinergics; antidepressants; opioids; antihistamines; antihypertensives) Medical / Surgical history (include gynaecological history in women) Bowel Habits ➔ Frequency (normal is between 3/day and 3/week) ➔ Consistency ➔ Urge normal loose/watery reduced ➔ Sensation of complete emptying 30 Appendices soft formed lumpy hard no urge always mostly sometimes never Appendices ?????????? 31 Bleeding Pain no no Food and Fluids Chart yes – when? yes – when? (If Yes to bleeding and pain – further investigation necessary) Date Straining always mostly sometimes never Sitting position leaning forward leaning back upright Feet supported no yes Manual assistance digital evacuation support pelvic floor /perineam Time taken to empty ➔ Faecal incontinence flatus liquid Morning Lunch Afternoon Dinner Evening solids FOOD ➔ Emptying pattern – • • • • • Breakfast yes – when? FLUID no mucous (Severe constipation / faecal impaction is a frequent cause of FI – further investigation is recommended) FOOD ➔ Abdominal discomfort / bloating Refer to fluids / food chart for fibre and fluid content of diet. Ask client to complete for a minimum of 3 days. (See next page). whole body or endurance or muscle groups strength FLUID Sessions per week Length of each session Intensity not out of breath out of breath out of breath and sweating ➔ Physical assessment FOOD Type (mainly) FOOD ➔ Physical activity / exercise FLUID ➔ Diet / Fluid intake Send for medical / specialist review if Sudden change in bowel habits Pain Bleeding Poor response to treatment Reassess using ➔ points, 4 – 6 weeks after initiation of management program. Refer to initial assessment for comparison. 32 Appendices FLUID Assess hydration and abdomen for masses and abnormal bowel sounds. Record all food and drinks consumed over a ___ day period. This record will help to determine if your diet lacks certain fibre types and / or fluids. Please also note if any foods seem to improve or worsen your symptoms of constipation. ?????????? Appendices 33 Appendix 3 Investigations Appendix 4 Bowel training instructions Investigations Uses Digital anal examination Assessing structural abnormalities and / or impacted faeces. Plain X-ray Assessing impaction of the large bowel. Endoscopy Visualisation of internal gastrointestinal tract to check for abnormalities, inflammation, neoplastic changes. First adopt ‘The Correct Sitting Position’. (See diagram p. 14). - This sitting position facilitates optimal muscle action for defaecation: feet supported, forearms resting comfortably on thighs and the back straight with the normal lumbar curve. Defaecating proctogram Assessing adequacy of rectal emptying, perianal descent, anorectal angle, rectal prolapse/rectocele. RELAX the tummy and back passage. (Levator ani, puborectalis and external anal sphincter relax increasing the Anorectal angle) Endo-anal ultrasound Assessing integrity of anal sphincter (can also assess via MRI). Ano-rectal manometry Assessing sphincter muscle functions - sensation of distension, resting and squeeze pressures, effectiveness of ano-rectal inhibitory reflex. BULGE the tummy muscles forward and feel the waist WIDEN. (Increases intra-abdominal pressure (IAP) using contraction of external obliques followed by internal obliques, transversus abdominus and diaphragm) Colonic transit studies Radio-opaque markers record faecal matter transit through colon. EMG Electromyography. Instructions to help the client adopt the correct action to empty the bowel HOLD this position while the bowel opens. REPEAT ➔ RELAX ➔ BULGE forward & WIDEN at the waist ➔ HOLD and REPEAT until empty. Do not strain down at the back passage. (Straining recruits rectus abdominus and co-activates the pelvic floor and posteriorly tilts the pelvis) This emptying process should take no longer than 1 minute. To finish, tighten in and up at the back passage. (Contracts the pelvic floor) This emptying pattern increases intra-abdominal pressure while correctly coordinating the ano-rectal muscles for effective defaecation (Markwell & Sapsford, 1995). General pelvic floor strengthening exercises are also encouraged to improve support of the rectum and muscle awareness. 34 ????????? Appendices Appendices ?????????? 35 CRICOS Provider Number 00233E Funded by the National Continence Management Strategy
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