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Innovative treatment for acneic skin
Disease overview
Acne is a skin
disorder, due to
many intrinsic
factors
Acne affects 80%
of adolescents &
20% of adults
Acne improves
mainly upon
reaching
adulthood
20% of Acne
consultations are
with
Dermatologists
Main consequences of
acne are:
Abnormal desquamation
(comedogenesis)
Ø Excessive sebum
production
Ø Proliferation and
inflammation (caused by
Propioni bacterium)
Ø Follicular reactivity
Ø Heredity
Disease overview: causes
Acne is the result from a combination of 3 successive factors
Hypo-seborrhea
Bacterial proliferation/
inflammation
Hereditary
factors
Secondary
causes
are
Stress,
overwork,
anxiety
Medications
Hyper- keratinization,
that means thickening
of the epidermis and
obstruction of the pores
Disease overview: classification
Acne is the disease of filo sebaceous follicles unit
On the face(forehead,
nose & chin)
Chest area
Mild, with open
and closed
Hereditary
comedones,
factors
some pustules
and papules
The
Secondary Moderate, with
comedones
condition
causes
with more
is
are
frequent paclassified pules
Severe , with
comedones,
Medications
papules,
nodular
abscesses
Back & shoulders
Disease overview: type of lesions
Retentional lesions
(i.e. Accumulation of sebum and
obstruction of the pores)
Inflammatory lesion
Scarring
Blackheads (open comedones)
Whiteheads (closed comedones)
Pustules (white spots)
Papules (red spots)
Nodules (Large cysts)
Disease overview: Cook system classification
0
2
4
6
8
Need not to
be perfect; 3
small
comedones
and /or
papules are
permitted, if
they are
scattered
Very few
pustules, up
to 3 dozen
papules and
/or
comedones;
no big or
prominent
lesions;
lesions are
hardly visible
from 2,5 m
away
Between
grades 2 and
6.
Red lesions
and
inflammation
are present to
a significant
degree.
Worthy of
treatment
Numerous
comedones,
but no
inflammation
or
inflammatory
lesions,
numerous
pustules,
lesions, easily
recognized at
2,5m, some
pustules may
be quite large
(1-2 cm)
Conglobated,
sinus or cystic
type acne or
highly
inflammatory
acne covering
most of the
yellow
pustules
extend to
neck and chin
Current Treatment
Key objectives in the
treatment of Acne
Resolution of
inflammation
Regulation of
sebum production
Elimination of non
inflammatory lesions
The choice of treatment
depends on type and
severity of Acne
Topical treatments
for mild and
moderate Acne
Systemic treatments
for severe Acne or
resistance to topical
treatments
Current treatment
Acne Treatment:
retinoid topical or
systemic treatment
+
special
formulated
hygiene
+
special
formulated
skincare
Market need:
to have a special formulated line of
hygienic products, that covers skin
hygiene and skincare for all different
types of Acne and all different
types of skin
Current treatment Management:
topical treatment
Topical retinoid:
Keratolytic agents
Tretinoin
and
Isotretinoin
Adapalene
Anti-inflammatory and
Keratolytic agent
Benzoyl
peroxide
Local antibiotics:
Anti-inflammatory
Erythromycin
4%
Due to this
multi
component
Clindamycin disease, an
appropriate
1%
combination
anti acne
therapy is
Treatment generally associated
chosen
with an active hydrating cream
in order to minimize induced dryness
and to improve compliance
Current treatment Management:
oral treatment
Hormone therapy
(women only)
Cyproterone
acetate:
anti
androgenic
action
Zinc
(gluconate)
Anti
inflammatory
action
Antibiotic
therapy
Cyclines
Isotretinoin
Severe
nodulocystic
Acne
Macrolides
Acne resistant to treatments
used in traditional therapies
(oral antibiotics > 3 months
+ topical)
Current disease Management:
dermocosmetic
Skin hygiene is soap free
Products
Gently
cleansing of
the face
which:
is gentle
to the skin
Skincare
Products
has a
physiological
pH
Skincare
products
which:
has a non
greasy
texture
is enriched
with active
keratolytic,
sebo-regulating,
anti
inflammatory,
antibacterial
agents and
have a
mattifying
effect
Acne Kit: Product description
Aknekit represents a
complete daily
management of signs
and symptoms of
light to moderate
Acne
The Aknekit is an
original and
exclusive concept
based on a
unique combination
of ingredients
Combination of 3
products
Day
treatment,
available in
30ml tube
Cleanser,
available in
100ml bottle
Night treatment,
available in 30ml
tube
Step 1 : Cleanser
Non-aggressive cleansing
Prevents dehydration of the skin
Soothes
Purifies with an exfoliating effect
Leaves a feeling of freshness
To be used in the skincare
routine morning and night
Based on Salycilic acid, Glycolic acid and Urea Peroxide, it has an exfoliating
action; its ingredients penetrate deep within the pores to reduce the formation
of sebum and attack the formation of skin imperfections.
Step 2 : Day treatment
Hydrates the skin with no oily effect
Clinically proven
Non photosensitizing, can be used also during summer period
No side effect
Leaves a feeling of freshness
Perfume free
The presence of Hyaluronic acid gives an hydrating action and favors a filmforming action.
The Hydrogen peroxide is well know in bibliography as an anti-bacterial agent
Step 3 : Night treatment
Synergic action of Ratania extract, Glycolic acid & Kojic acid
Regulates sebum production
Perfume free
Dermatologically tested
Exfoliating action thanks to Glycolic and Kojic acid
Limits bacterial proliferation and inflammation
Ratania extract has been frequently used in oral products as anti-bacterial
agent: it is useful in oily skin and in presence of blackheads
Competitors : USA
Product
Composition
Company
Proactiv
Cleanser with Benzoyl
peroxide+ revitalizing toner
with Glycolic acid+ repairing
treatment with Benzoyl
peroxide
Guthy Renker
Complete acne therapy
system
Cleanser with Salicylic acid+
lotion with Benzoyl peroxide+
oil free SPF15 lotion with
botanical complex
Neutrogena
Cleanser with Benzoyl
peroxide+ moisturizer+ clearing
spot treatment
J&J
Yes
Clarifying cleanser with
salicylic acid+ exfoliating gel
with Hydrogen peroxide+ skin
lotion with algae extract+ &
Arnica+ acne spot treatment
with Sulfur+ clarifying mask
Murad
Yes
Clean & clear advantage
acne control
Acne introductory kit
Acne complex kit
Acne repair kit
Outer peace acne relief kit
Clinicals
Yes
Price
$ 29,95
Yes
$ 24,99
Not available
$ 29,95
Clarifying cleanser with
salicylic acid+ exfoliating gel
with Hydrogen peroxide+ skin
lotion with algae extract+ &
Arnica+ acne spot treatment
with Sulfur
Murad
Yes
Drying lotion with Salicylic
acid+ drying cream with Sulfur,
Titanium dioxide and
Beeswax+ buffering lotion with
Niacinamide
Mario Badescu
No
Foaming cleanser+ acne spot
relief+ acne relief lotion + acne
relief pads
Aveda
Yes
$ 60,00
$ 46,00
$ 129,50
Competitors : Italy
Product
Composition
Company
Clinicals
3 step system antiblemish solutions
clear skin system
Anti-blemish solutions
cleansing foam 50ml
+ anti-blemish
solutions clarifying
lotion 100ml + antiblemish solutions
cleaning moisturizer
30ml
Clinique
Not available
Kit acne speciale
brufoli
Cleansing gel 200ml
+ intensive treatment
30ml+ purifying
cream 50ml
Tabiano
Not available
€ 26,00
Cream with Salicylic
acid & Azelaic acid+
vial with Salicylic
acid, Azelaic acid &
Glycolic acid
Cosmeceutica mirata
Not available
€ 59,40
Regular cream with
Salicylic acid &
Azelaic acid+
balancing cream with
Azelaic acid &
Mandelic acid+ calm
cream with Vit B3 &
teat tree oil+
modulating cream
with Chamomile &
Glycerrethic acid
Neoglis
Not available
Kit pelle con acne
Kit Neos acne
Price
€ 39,60
Not available
Clinicals : Study in Italy
Multicenter, randomized, controlled
3 centers in Italy
Ø
Rome, Istituto san Gallicano, Prof. Berardesca
Ø
Milan, Prof. Veraldi
Ø
Catania, Clinica dermatologica , Prof. Micali
Evaluation of the efficacy of Akne kit versus Proactiv
120 patients affected by mild to moderate acne
Duration of the study : 8 weeks +
evaluation at 15 days, 4 and 8 weeks
Evaluation based on :
Ø GAGS (Global Acne Grading System)
Ø Cosmetic acceptability by the patients
Ø Efficacy and safety by the doctors and the patients
Presentation/Publications :
Ø Acne e rosacea day, Milan , September 2013
Ø Dermo-venerologia days, Catania, February 2014
Ø AAD Denver, USA, March 2014
Packaging presentation
[email protected]
www.aknekit.com