1 Curriculum Vitae – Rafael Grytz, PhD Curriculum Vitae revised April 15, 2015 Name Title Rafael Grytz, PhD Assistant Professor of Ophthalmology Date of Birth Citizenship December 8, 1976 Germany Affiliation University of Alabama at Birmingham Department of Ophthalmology 1670 University Blvd., VH 371 Birmingham, AL 35294 Email Web [email protected] uab.grytz.de, scholar.grytz.de Research Interests Our eyes are composed of living tissues, which are constantly remodeling in response to mechanical, chemical, and visual stimuli. In particular, the loadbearing collagenous structures of the eye can undergo substantial growth and remodeling during physiological and pathophysiological conditions. I seek to elucidate the biomechanical mechanisms that underlie growth and remodeling in ocular diseases. My laboratory is currently focused on establishing quantitative experimental methods and predictive computational simulation tools for growth and remodeling mechanisms in glaucoma, keratoconus and myopia. My laboratory’s goal is to provide computational simulation tools that support the development of new diagnostics and therapeutics in ocular diseases and conditions. Education Apr. 2009 – July 2010 Post-Doctoral Research Fellow Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, OR, USA Dec. 2008 Dr.-Ing. (Ph.D.), graduation with distinction Civil Engineering, Ruhr-University Bochum, Germany Thesis: Computational Modeling and Remodeling of Human Eye Tissues as Biomechanical Structures at Multiple Scales. Shaker Verlag, Aachen ISBN 978-3-8322-7958-5. Oct. 2002 Dipl.-Ing. (M.S.), graduation with distinction Civil Engineering, Ruhr-University Bochum, Germany Full Time Employment Dec. 2012 – present Assistant Professor, Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA Aug. 2010 – Nov. 2012 Research Associate, Bioengineering, Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, OR, USA Jan. 2003 – Mar. 2009 Teaching/Research Assistant, Institute for Structural Mechanics, Ruhr-University Bochum, Germany Curriculum Vitae – Rafael Grytz, PhD 2 Awards 2015 The Thomas R. Lee Award for Glaucoma Research given out by the BrightFocus Foundation ($100,000). 2012 ISER Travel Fellowship for Young Investigators granted by the International Society for Eye Research for the XX Biennial Meeting of the International Society for Eye Research (ISER), Berlin, Germany 2012 Travel grant granted by the US Association of Computational Mechanics (USACM) for the 10th World Congress on Computational Mechanics (WCCM2012), São Paulo, Brazil 2012 Travel grant granted by the “Deutsche Ophthalmologische Gesellschaft (DOG)” for the 110 th DOGCongress “One Ophthalmology”, Berlin, Germany 2010 Award of the “Gesellschaft der Freunde der Ruhr-Universität Bochum”, annual award for outstanding interdisciplinary research work granted by the Ruhr-University Research School (4,000€) 2009 “Deutscher Studienpreis”, 2nd prize, the annual nationwide award is given out by the KöberFoundation through the President of the German parliament and recognizes the best PhD dissertations in Germany for substantial and innovative research work with outstanding relevance for the society (3,000€) 2006 Travel grant granted by the German Research Council (DFG) for the CISM Summer School "Biomechanical Modeling at the Molecular, Cellular and Tissue Level" 2003 Travel grant granted by the German Research Council (DFG) for the CISM Summer School "Chemo-mechanical Coupling in Porous Media - Geomechanics and Biomechanics" 2003 “Preis an Studierende”, annual student of the year award recognizes the best diploma thesis at the Department of Civil Engineering, Ruhr-University Bochum, Germany (500€) Memberships of Professional Organizations since 2013 UAB Vision Science Research Center (VSRC) since 2012 US Association of Computational Mechanics (USACM) since 2012 International Society for Eye Research (ISER) since 2011 American Society of Mechanical Engineering (ASME) since 2008 Association for Research in Vision and Ophthalmology (ARVO) since 2007 German Association for Computational Mechanics (GACM) Professional Activities present Active reviewer for international journals: Biomechanics and Modeling in Mechanobiology • Computer Methods in Biomechanics and Biomedical Engineering • Journal of Biomechanics • Journal of Biomechanical Engineering • Journal of the Mechanical Behavior of Biomedical Materials • Investigative Ophthalmology & Visual Science • Experimental Eye Research • Ophthalmic and Physiological Optics • Journal of The Royal Society Interface • Medical Engineering & Physics • Journal of the Mechanics and Physics of Solids • Mechanics of Materials • Theoretical Biology and Medical Modelling • Journal of Cataract & Refractive Surgery Curriculum Vitae – Rafael Grytz, PhD 3 July 2015 Minisymposium Organizer and Chair, Topics in Computational Biomechanics, 13th U.S. National Congress on Computational Mechanics (USCCM), San Diego, CA, USA. July 2014 Symposium Organizer and Chair, Biomechanics of the Eye, 7th World Congress of Biomechanics (WCB), Boston, MA. July 2014 Minisymposium Organizer and Chair, Growth and Remodeling of Living Tissues, 11th World Congress on Computational Mechanics (WCCM) – 5th European Conference on Computational Mechanics (ECCM) – 6th European Conference on Computational Fluid Dynamics (ECFD), Barcelona, Spain. 2013 Faculty Member, World Glaucoma Congress (WGC), Vancouver, Canada. 2013 Minisymposium Organizer, Biomechanics of Living Matter, 12th U.S. National Congress on Computational Mechanics (USCCM), Raleigh, NC, USA. 2012 Reviewer, Fight for Sight, PhD Studentship. July 2012 Minisymposium Organizer and Chair, Soft Tissue Elasticity Across Different Length Scales, 10 th World Congress on Computational Mechanics (WCCM), São Paulo, Brazil Aug. 2010 Session Co-Chair, Session on Biomechanical Test of the Soft Tissue, 6 th World Congress of Biomechanics (WCB), Singapore Feb. 2009 Minisymposium Organizer and Chair, Young Researchers’ Minisymposium on Computational modeling of biological tissues in physiological and pathophysiological conditions. 80 th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdańsk, Poland Sep. 2009 Minisymposium Organizer and Chair, Minisymposium on Biological Soft Tissues: Modelling and Simulation. 3nd German Association for Computational Mechanics Colloquium (GACM), Hanover, Germany Oct. 2007 Minisymposium Organizer and Chair, Minisymposium on Modeling Dissipative Effects in Soft Biological Tissues. 2nd German Association for Computational Mechanics Colloquium (GACM), Munich, Germany Sep. 2006 Participant, CISM-IUTAM Summer School, “Biomechanical modelling at the molecular, cellular and tissue levels", Udine, Italy June 2003 Participant, CISM-IUTAM Summer School, “Chemo-mechanical Coupling in Porous Media– Geomechanics and Biomechanics", Udine, Italy Invited Lectures July 2014 Computational Assessment of Collagen Remodeling in Myopia and Keratoconus. Department of Vision Sciences, Cardiff University, Cardiff, United Kingdom. July 2014 Collagen Sliding - A Potential Remodeling Mechanism in Myopia and Keratoconus. Department of Civil Engineering, Ruhr-University Bochum, Bochum, Germany. Feb. 2014 Computational Mechanics and Glaucoma. Department of Mathematical Sciences, Indiana University and Purdue University at Indianapolis, Indianapolis, Indiana Feb. 2013 Glaucoma and Growth and Remodeling Mechanisms in the Human Eye. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 4 Curriculum Vitae – Rafael Grytz, PhD Feb. 2013 Computational Biomechanics - A Chance for Vision Science. Department of Vision Science, University of Alabama at Birmingham, Birmingham, Alabama Aug. 2012 Biomechanical Mechanisms in Glaucoma – a Chance for Computational Multi-Scale Mechanics. Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama July 2012 Loss of Scleral Compliance during Aging. Ruhr-University Bochum, Bochum, Germany June 2011 Advanced Computational Analysis in Ophthalmology Research, Growth and Remodeling of the Lamina Cribrosa in Early Glaucoma. University of Pittsburgh, Pittsburgh, Pennsylvania May 2011 Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Computational Growth and Remodeling Simulation. Ruhr-University Bochum, Bochum, Germany Oct. 2010 Glaucoma and Computational Multi-Scale Modeling of the Human Eye. Mechanics and Computation Seminar, Stanford University, Stanford, California Aug. 2010 Computational Multi-Scale Modeling and Remodeling of Biomechanical Structures of the Human Eye. In Silico Medicine Seminar, Osaka University, Osaka, Japan Oct. 2008 Numerische Mehrskalenmodellierung der Kollagenarchitektur und dessen Umformung im menschlichen Auge (engl. Numerical Multi-Scale Modeling of the Collagen Architecture and its Remodeling in Human Eyes). Mechanics Colloquium and Seminar, Technical University of Braunschweig, Braunschweig, Germany Sep. 2008 Computational Modeling and remodeling of Human Eye Tissues as Biomechanical Structures at Multiple Scales. DEI Research Seminar, Devers Eye Institute, Portland, Oregon Book chapter All works are listed in the reversed order of their times of appearance. ٭Corresponding author 1. R. Grytz٭, G. Meschke, JB. Jonas and JC. Downs (in press) Glaucoma and Structure-Based Mechanics of the Lamina Cribrosa at Multiple Scales. In: GS. Kassab and MS. Sacks (Eds.), Structure Based Mechanics of Tissues and Organs: A Tribute to Yoram Lanir. 2. JC. Downs*, R. Grytz, CF. Burgoyne (2014) Mechanical Strain and Restructuring of the Optic Nerve Head. In: TM. Shaarawy, MB. Sherwood, RA. Hitchings, JG. Crowston (Eds.), Glaucoma, Second Edition. Refereed Journal Papers 1. R. Grytz and JT. Siegwart (2015) Changing Material Properties of the Tree Shrew Sclera during Minus Lens Compensation and Recovery. Investigative Ophthalmology & Visual Science, 56, pp. 2065–2078. 2. R. Grytz, MA. Fazio, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs* (2014) Age- and Racerelated Differences in Human Scleral Material Properties. Investigative Ophthalmology & Visual Science, 55, pp. 8163–8172. 3. MA. Fazio, R. Grytz, JS. Morrison, L. Bruno, CA. Girkin and JC. Downs* (2014). Human Scleral Structural Stiffness Increases More Rapidly with Age in Donors of African Descent Compared to Donors of European Descent. Investigative Ophthalmology & Visual Science, 55, pp. 7189–7198. 4. MA. Fazio, R. Grytz, JS. Morrison, L. Bruno, S. Gardiner, CA. Girkin and JC. Downs* (2014). Age-related changes in human peripapillary scleral strain. Biomechanics and Modeling in Mechanobiology, 13, pp. 551– 563. 5. R. Grytz, MA. Fazio, MJA. Girard, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs* (2014) Material Properties of the Posterior Human Sclera. Journal of the Mechanical Behavior of Biomedical Materials, 29, pp. 602–617. 5 Curriculum Vitae – Rafael Grytz, PhD 6. R. Grytz ٭and JC. Downs (2013) A Forward Incremental Prestressing Method with Application to Inverse Parameter Estimations from Scleral Inflation Tests. Computer Methods in Biomechanics and Biomedical Engineering, 16, pp. 768-780. 7. MA. Fazio, R. Grytz, L. Bruno, MJA. Girard, S. Gardiner, CA. Girkin and JC. Downs* (2012). Regional variations in mechanical strain in the posterior human sclera. Investigative Ophthalmology & Visual Science, 53, pp. 5326–5333. 8. R. Grytz٭, CA. Girkin, V. Libertiaux and JC. Downs (2012) Perspectives on Biomechanical Growth and Remodeling Mechanisms in Glaucoma. Mechanics Research Communications, invited for special issue: “Recent Advances on the Biomechanics of Growth and Remodeling”, 42, pp. 92–106. 9. R. Grytz٭, IA. Sigal, JW. Ruberti, G. Meschke and JC. Downs (2012) Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Motivated Growth and Remodeling Approach. Mechanics of Materials, invited for special issue: “Evolving Microstructures and Anisotropies in Engineering Materials and Biological Tissues”, 44, pp. 99–109. 10. R. Grytz٭, G. Meschke and JB. Jonas (2010) The collagen fibril architecture in the lamina cribrosa and peripapillary sclera predicted by a computational remodeling approach. Biomechanics and Modeling in Mechanobiology, 10, pp. 371–382. 11. R. Grytz ٭and G. Meschke (2010) A Computational Remodeling Approach to Predict the Physiological Architecture of the Collagen Fibril Network in Corneo-Scleral Shells. Biomechanics and Modeling in Mechanobiology, 9, pp. 225–235. 12. R. Grytz ٭and G. Meschke (2009) Constitutive Modeling of Crimped Collagen Fibrils in Soft Tissues. Journal of the Mechanical Behavior of Biomedical Materials, 2, pp. 522–533. 13. R. Grytz ٭and G. Meschke (2008) Consistent micro-macro transitions at large objective strains in curvilinear convective coordinates. International Journal for Numerical Methods in Engineering 73, pp. 805–824. 14. Y. Başar and R. Grytz( ٭2004) Incompressibility at Large Strains and Finite-Element Implementation. Acta Mechanica 168, pp. 75–101. Conference Proceedings / Presentations (presenter underlined if not RG) 1. R. Grytz, JT. Siegwart, TT. Norton (2014) Changing Material Properties of the Tree Shrew Sclera during Minus Lens Compensation and Recovery. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Orlando, Florida. 2. MA. Fazio, JS. Morris, R. Grytz, L. Bruno, CA. Girkin and JC. Downs (2014) Age and Racial Differences in Mechanical Energy Absorption in the Posterior Human Sclera. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Orlando, Florida. 3. R. Grytz, M. Koster, S. Hayes, C. Boote, JW. Ruberti, G. Meschke, KM. Meek (2014) Multi-scale modeling of keratoconus progression based on anisotropic sliding and degradation of collagen fibrils. 7th World Congress on Biomechanics (WCB), Boston, MA. 4. MA. Fazio, JS. Morris, R. Grytz, L. Bruno, CA. Girkin and JC. Downs (2014) Variation of the Mechanical Energy Density of the Posterior Human Sclera with Age and Race. 7th World Congress on Biomechanics (WCB), Boston, MA. 5. JC. Downs, MA. Fazio, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, R. Grytz (2014) Age- and Racerelated Differences in Scleral Material Properties. 7th World Congress on Biomechanics (WCB), Boston, MA. 6. R. Grytz, JT. Siegwart, TT. Norton (2014) Changing Hyperelastic Properties of the Tree Shrew Sclera during Visually-Guided Remodeling. 11th World Congress on Computational Mechanics (WCCM) – 5th 6 Curriculum Vitae – Rafael Grytz, PhD European Conference on Computational Mechanics (ECCM) – 6th European Conference on Computational Fluid Dynamics (ECFD), Barcelona, Spain. 7. R. Grytz, MA. Fazio, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs (2013) Racial Differences in the Ageing Human Sclera. In Proceedings of the ASME 2013 Summer Bioengineering Conference (SBC), Sunriver, Oregon, USA. 8. MA. Fazio, R. Grytz, J. Morris, L. Bruno, CA. Girkin, JC. Downs (2013) Age-Related Changes in the NonLinear Mechanical Strain Response of Human Peripapillary Sclera. In Proceedings of the ASME 2013 Summer Bioengineering Conference (SBC), Sunriver, Oregon, USA. 9. R. Grytz (2013) Biomechanical Mechanisms of Scleral and Laminar Remodeling. Invited faculty lecture at the 5th World Glaucoma Congress (WGC), Vancouver, Canada. 10. R. Grytz, MA. Fazio, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs (2013) Age- and RaceDependent Material Properties of the Human Sclera. 12th U.S. National Congress on Computational Mechanics (USNCCM), Raleigh, North Carolina. 11. M. Koster, C. Boote, KM. Meek, PG. Fowler, CA. Girkin, G. Meschke, R. Grytz (2013) Inter- and IntraLamellar Slippage of Collagen Fibrils as a Potential Mechanism of Keratoconus Progression. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington. 12. R. Grytz (2013) Computational Modeling of Keratoconus Progression. Annual Clinical and Research Symposium by UAB Department of Ophthalmology, Birmingham, Alabama. 13. V. Libertiaux, R. Grytz, J. Reynaud, CA. Girkin, JC. Downs (2013) Laminar Beam Orientation and Connective Tissue Volume Fraction in Three-dimensionally (3D) Reconstructed Optic Nerve Heads (ONH) from Human Donor Eyes. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington. 14. R. Grytz, MA. Fazio, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs (2013) Racial Differences in Human Scleral Material Properties. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington. 15. MA. Fazio, R. Grytz, L. Bruno, JS. Morris, CA. Girkin, JC. Downs (2013) Racial Differences in Mechanical Strain in the Posterior Human Sclera. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington. 16. R. Grytz, IA. Sigal, JW. Ruberti, JC. Downs (2012) Growth and Remodeling of the Lamina Cribrosa in Early Glaucoma – A Computational Study, invited minisymposium talk. XX Biennial Meeting of the International Society for Eye Research (ISER), Berlin, Germany. 17. R. Grytz, MA. Fazio, MJ. Girard, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs (2012) Loss of Scleral Elasticity during Aging. 10th World Congress on computational Mechanics (WCCM), São Paulo, Brazil. 18. R. Grytz (2012) „Biomechanische Veränderungen der Lamina cribrosa – Computersimulationen in der Glaukomforschung“, invited minisymposium talk. 110th DOG Congress “One Ophthalmology“, Berlin, Germany. 19. R. Grytz (2012) Biomechanical Implications of Remodeling in the Sclera and Lamina Cribrosa, invited minisymposium talk. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 20. R. Grytz, MA. Fazio, MJ. Girard, V. Libertiaux, L. Bruno, S. Gardiner, CA. Girkin, JC. Downs (2012) Loss of Elasticity in the Aging Human Sclera. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 21. V. Libertiaux, R. Grytz, J. Reynaud, CF. Burgoyne, CA. Girkin, JC. Downs (2012) Laminar Beam Orientation Surrounding Acquired Pits of the Optic Nerve (APON) in Three-dimensionally (3D) Reconstructed Human 7 Curriculum Vitae – Rafael Grytz, PhD Donor Eyes. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 22. MA. Fazio, R. Grytz, L. Bruno, MJ. Girard, CA. Girkin, A. Poggialini, JC. Downs (2012) Regional Variations in Mechanical Strain in the Posterior Human Sclera. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 23. R. Grytz, IA. Sigal, JW. Ruberti, JC. Downs (2011) Microstructure Motivated Growth and Remodeling of the Lamina Cribrosa in Early Glaucoma. In Proceedings of the ASME 2011 Summer Bioengineering Conference (SBC2011), Farmington, Pennsylvania, USA. 24. R. Grytz, IA. Sigal, JW. Ruberti, JC. Downs (2011) A Microstructure Motivated Growth and Remodeling Approach to Predict Lamina Cribrosa Thickening in Early Glaucoma. ASME Applied Mechanics and Materials Conference (McMAT 2011), Chicago, Illinois. 25. R. Grytz, IA. Sigal, JW. Ruberti, JC. Downs (2011) Lamina Cribrosa Thickening in Early Glaucoma is Predicted by a Biomechanically-Driven Growth and Remodeling Approach. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 26. MA. Fazio, L. Bruno, R. Grytz, CA. Girkin, JC. Downs (2011) Analysis of Experimental IOP-induced Scleral Deformations at the Sub-Micrometer Scale Using Electronic Speckle Interferometry. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 27. R. Grytz, MJA. Girard, M. Fazio and JC. Downs (2010) Inverse Numerical Estimation of Eye-Specific Intrinsic Material Properties and Local Collagen Architecture from Scleral Inflation Tests. 6 th World Congress on Biomechanics (WCB), Singapore. 28. MA. Fazio, R. Grytz, MJA. Girard and JC. Downs (2010) Anisotropic, Nonlinear Biomechanical Behavior of Human Posterior Sclera. 6th World Congress on Biomechanics (WCB), Singapore. 29. R. Grytz, G. Meschke and JC. Downs (2010) Stress-Based Adaptation and Stretch-Based Optimization Approaches to Estimate the Local Collagen Architecture in Ocular Tissues. 9th World Congress on computational Mechanics (WCCM), Sydney, Australia. 30. R. Grytz, MJA. Girard, M. Fazio, CF. Burgoyne and J.C. Downs (2010) Biomechanical Implications of Agerelated Alterations in Scleral Collagen Fibril Crimp. Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 31. R. Grytz and G. Meschke (2009). Glaucoma and Computational Two-Scale Modeling and Remodeling of the Optic Nerve Head. In Proceedings of the 7th EUROMECH Solid Mechanics Conference (ESMC2009), pp. 313–314, Lisbon, Portugal. 32. R. Grytz and G. Meschke (2009). Multiscale Modeling and Computational Remodeling of the Human Eye Tissue. In: K. Gürlebeck and C. Könke (eds.), Proceedings of the 18th International Conference on the Application of Computer Science and Mathematics in Architecture and Civil Engineering, Weimar, Germany. 33. R. Grytz, G. Meschke and Jost B. Jonas (2009) A Mathematical Approach to Predict the Local Microarchitecture of the Lamina Cribrosa (LC) and Peripapillary Sclera (PPS). Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida. 34. R. Grytz and G. Meschke (2009) Glaucoma and Numerical Modeling and Remodeling of the Lamina Cribrosa at Multiple Scales. X International Conference on Computational Plasticity (COMPLAS), Barcelona, Spain. 35. R. Grytz and G. Meschke (2009) Computational modeling and remodeling of the collagen architecture in human eye tissues. 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM 2009), Gdańsk, Poland. 36. R. Grytz and G. Meschke (2008). Computational Micro-Macro Transitions at Large Strains for Curvilinear Physical Directions. In Proceedings in Applied Mathematics and Mechanics 7, pp. 4080009–4080010. 8 Curriculum Vitae – Rafael Grytz, PhD 37. R. Grytz and G. Meschke (2008). Microstructure-Oriented Modeling and Computational Remodeling of the Collagen Network in Corneo-Scleral Shells. In: J. Eberhardsteiner, C. Hellmich, H. Mang, and J. Périaux (eds.), Proceedings of ECCOMAS Multidisciplinary Jubilee Symposium 2008, 14, pp. 155–168, Springer Netherlands. 38. R. Grytz and G. Meschke (2008) Computational Remodeling of the Crimped Collagen Fibril Architecture in Corneal and Scleral Tissue. In Proceedings of the 8th World Congress on Computational Mechanics (WCCM), Venice, Italy. 39. R. Grytz, S. Jox, F. Nagel, G. Meschke (2008). Microstructure-oriented multi-phase characterization of biological and engineering materials and structures. ECCOMAS Multidisciplinary Jubilee Symposium, Vienna, Austria. 40. R. Grytz and G. Meschke (2007) An incompressible finite shell element with crimped collagen fibers for numerical analyses of the human eye. Modeling of Heterogeneous Material with Application in Construction and Biomedical Engineering, Prague, Czech Republic. 41. R. Grytz and G. Meschke (2007) Computational Micro-Macro Transitions at Large Strains for Curvilinear Physical Directions. 6th International Congress on Industrial and Applied Mathematics (ICIAM07), Zurich, Switzerland. 42. R. Grytz and G. Meschke (2007) Computational Micro-Macro Transitions at Large Strains for Curvilinear Physical Directions. 2nd GACM Colloquium on Computational Mechanics, Munich, Germany. 43. R. Grytz and G. Meschke (2006). Computational Homogenization in Multi-Scale Shell Analysis at Large Strains. In Proceedings of the 3rd European Conference on Computational Mechanics (ECCM 2006), Lisbon, Portugal, Springer, DOI:10.1007/1-4020-5370-3 592. 44. R. Grytz and G. Meschke (2005) Computational Homogenization Analysis at Large Strains in Curvilinear Convective Coordinates. 1st GACM Colloquium on Computational Mechanics, Bochum, Germany. Consulting Report 1. G. Meschke, R. Grytz and M. Gofmann (2005). ’Grundlagen der statischen Berechnung und Bemessung von Sandwich-Linern für die Sanierung geschädigter Abwasserschächte’ (engl. ’Computational Sizing of Sandwich Liners to Stabilize Damaged Sewage Hoppers’), by order of the Institute for Underground Infrastructure, Bochum, Germany. Master Thesis Supervision 1. Con Nguyen, ’Das Auge als biomechanische Struktur: Finite-Elemente Modellierung’ (engl. ’The Human Eye as Biomechanical Structure: Finite-Element Modeling’), Department of Civil Engineering and Computational Engineering, Ruhr-University Bochum, 2007. 2. Philippe Jäger, ’Parallelisierung von Mehrskalen-Analysen im Rahmen der nichtlinearen Finite-ElementeMethode’ (engl. ’Parallelization of Multi-Scale Finite Element Analyses’), Department of Civil Engineering and Computational Engineering, Ruhr-University Bochum, 2005. 3. Christine Teck, ’Minimalflächen – Formfindung und Optimierung von Membranen’ (engl. ’Minimal Surfaces– Form Finding and Optimization of Membranes’), Department of Civil Engineering and Computational Engineering, Ruhr-University Bochum, 2004. 9 Curriculum Vitae – Rafael Grytz, PhD Teaching Experience Class Lecture on “Growth and Remodeling Mechanisms in the Eye”, BME 435/535 – Tissue Engineering, Department of Biomedical Engineering, University of Alabama at Birmingham Semester WS 2014/15 2. Lecture on “Ocular Biomechanics and Related Posterior Pole Pathologies II”, VIS 745 - Biology and pathology of the Posterior Segment, Department of Vision Sciences, University of Alabama at Birmingham WS 2012/13 WS 2013/14 WS 2014/15 3. Teaching Assistant, ’Matritzenmethoden der Stabstatik’ (engl. ’Computational methods in Structural Mechanics of Beams’), Department of Civil Engineering, RuhrUniversity Bochum SS 2003 SS 2004 SS 2005 SS 2006 SS 2007 SS 2008 4. Teaching Assistant, ’Baustatik III’ (engl. ’Adv. Structural Mechanics’), Department of Civil Engineering, Ruhr-University Bochum WS 2003/04 WS 2004/05 WS 2005/06 WS 2006/07 WS 2007/08 WS 2008/09 5. School Project Coordinator, ’Von Windkanälen, Brücken und Häusern’ (engl. ’About Wind Tunnels, Bridges and Buildings’), School Project at the “Alfried Krupp Schülerlabor“, Ruhr-University Bochum throughout 2003 – 2009 1.
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