1. family and parenting
2. motherhood
3. pregnancy

INDEX
1. PLACENTA AND PLACENTAL EXTRACTS
4
Function
Active Ingredients of placenta
Pharmacological action
4
5
6
2. JAPAN BIO PRODUCTS
7
3. DRUGS
9
Laennec
Plamon/Curacen
9
17
4. COSMETICS
18
GHC Human Placenta
GHC Porcine Placenta
18
20
5. FOOD SUPPLEMENTS
23
Laennec P.O.
Tsuyan Rin
Placental Metabolizer
Laennec P.O. Porcine
Grace Hai
23
24
25
26
28
6. MESOTHERAPY PRODUCTS
29
Curacen Essence
Nanoneedles
30
31
7. ELECTROPORATION
34
JBP Placenta Solutions I and II
JBP Skin Poration
35
36
1
PLACENTA AND
PLACENTAL EXTRACTS
FUNCTION
Placenta allows the interface between the mother and the baby
providing not only nutrients and
oxygen but also performing
metabolic functions as excretion, breathing, digestion, secretion of hormones, and the provision of the immune system… to
make it difficult for the baby to
contract illnesses.
Placenta synthesizes and excretes Cell Growth Factors
which contribute to transform 2
cells in 60 trillion of cells after 9
months. Placenta contains vitamins, aminoacids, nucleic acids,
proteines, carbohidrates, enzymes, mucopolysaccharides,
lipid and fatty acids. Although
not all the components of placenta are currently identified.
FETAL
PLACENTA
?
UMBILICAL CORDS
AMNIOTIC FLUID
Transplantation of the stem
cells of umbilical blood
ORGAN FUNCTIONS:
• RESPIRATION
Lungs
• METABOLISM
Liver
• EXCRETORY EFFECTS
Kidney
• ENDOCRINE EFFECTS
Pituitary glands and ovaries
• IMMUNE EFFECTS
Spleen
AMNION
Amniotic membrane
transplant
• TranspoRation of nutrition. EMISSION OF EGESTA
ACTIVE INGREDIENTS OF PLACENTA
NUCLEIC
ACID
AMINO ACID
ALL KINDS OF
ACTIVATE
PEPTIDE
DNA, RNA and metabolic products (Uracil and Adenine, etc)
Essential amino acids including Leucine, Glycine, Valine, Threonine, Isoleucine
Others amino acids including Alanine, Arginine
Activate peptides wich work as key of medical action are
found so many times
VITAMIN
B1, B2, B6, B12, C, D, E, Niacin, etc
MINERAL
Ca, Na, K, P, Mg, Zn, Fe, etc
ENZYME
About 100 kinds of enzyme including ALK Phosphatase,
Acid Phosphatase, ADP
SACCHARID
GROW-UP
ELEMENT
Glucose, Galactose, numerous saccheride, Glicoprotein, etc
HGF, NGF, EGF, FGF, IGF, CSF, IL-1, IL-2, IL-3, IL-4,hCURF
and hCTRF, etc
Cytokines in charge of growth and differentiate T-Cells, B-Cells and macrophages.
GROWTH FACTORS AND CYTOKINES
• Always carry the genetic code of healthy cells
• Not acting as nutritional substances for cancer cells
• Placenta to control the ocurrence of cancer
Placenta has been used historically in the Asian medicine , but was in 1953 when Dr. Filatov
employed placenta for tissue therapy.
1950s placenta was licensed as a drug in Japan and currently is a famous product in the
Asiatic world.
PHARMACOLOGICAL ACTION
AUTONOMOUS
NERVOUS
SYSTEM
CONTROL
ENDOCRINE
HORMONE
CONTROL
IMPROVING
PHYSICAL
CONSTITUTION
VARIOUS MEDICINE ACTIONS OF PLACENTA
ANTIINFLAMMATION
ACTION
BLOOD
CIRCULATION AND
HEMATOGENESIS
EFFECT
WOUND
TREATMENT
ANEMIA
IMPROVEMENT
RECOVERY OF
TIREDNESS
LIVER
FUNCTIONAL
ENHACEMENT
AND DETOX
IMPROVEMENT
OF BASAL
METABOLISM
ANTI-OXIDANT
ACTION
ACTIVATION OF
THE IMMUNITY
SYSTEM
THE BEAUTY EFFECT OF PLACENTA INJECTION AND ANTI-AGING EFFECT
Human placenta extract includes various kinds of grow-up elements and nucleic acid including Uracil
and Tryptophan which has excellent effect of anti-oxidant action, so that it works for anti-aging effect
through whitening of skin. Human placenta extracts have demonstrated immunostimulant effect, cell
proliferation and moisturizing propertiens, along with differentation of cell, collagen generation.
Several are the medical procedures in which
placenta has been tested and demonstrated
positive results, as for
example in:
• Internal Medicine
– Viral and alcoholic
type hepatitis
– Cirrhosis
– Chronic pancreatitis
– Gastric ulcer
– Dyspepsia
– Duodenal ulcer
– Diabetes
– High blood pressure
– Lood blood pressue
It has to be mentioned the balanced role of placenta to
the body steady.
• Gynecology
– Menopausal disorders
– Algomenorrhea
– Irregular menses
– Lactation disorders
• Surgery
– Arthritis rheumatoides
– Arthrosis
– Neuralgic pain
– Back pain
• Urology
– Bladder enlargement
– Cystitis
2
JAPAN
BIO PRODUCTS
JBP, Japan Bio Products Co.,
Ltd., was established in 1956 as
specialized placenta company.
We have studied and manufactured pharmaceutical products and cosmetics based on
human placenta extract, and
our placenta injection market
share is about 80%.
We have studied human placenta applications for more
than 40 years.
Also, JBP manufactures and
sells the human placenta injection (Laennec) which was
approved for cirrhosis in Japan
since 1974.
JBP’s injection was being
used widely as a Japanese typical Placenta injection for more
than 30 years as well as there
were also no cases of serious
side effects.
PRODUCTS
3
DRUGS
LAENNEC
Laennec is the ethical drug manufactured with JBP’s unique
technologies for effective extraction of variety of growth factors, cytokines, and other physiologically active substances
from the human placenta. For instance, HGF (hepatocyte
growth factor) promotes the proliferation of hepatic parenchymal cells for recovery of a damaged liver. Our product safety
is ensured by the most rigid safety measures among existing
scientific standards.
Warning:
As the LAENNEC Injection is an ethical drug, JBP has never
sold it on Internet.
Each 2 ml ampoule of this product contains 112 mg of watersoluble substance of a product of enzymatic human placenta.
Content
Remarks
112 mg
Ingredient
extracted from
human placenta
Pepsin
Trace
Gastric glucosal
extract (pig)
Lactose
0,6 mg
-
pH Adjuster
qs
-
Ingredients
Active
ingredient
Inactive
ingredient
Water soluble
substance of
a product of
enzymatic
human placenta
PRODUCT DESCRIPTION
• This product is a light yellow-brown or yellow-brown clear liquid with a distinctive odor.
The pH level ranges from 5.5 to 6.5 and the osmotic pressure ratio (to physiological saline) is
approximately one.
INDICATIONS
• Improvement of hepatic function in chronic hepatic disease.
DOSAGE AND ADMINISTRATION
• The normal adult dose is a 2 ml subcutaneous or intramuscular injection once daily. According to symptoms, the dose can be increased to 2 or 3 times daily.
CAUTIONS FOR USE
1.
Careful Administration
LAENNEC should be administrated with care in patients predisposed to allergies.
2. Important Basic Cautions
This product is manufactured from the extract of human
placenta delivered full-term in
Japan. In order to screen each
donor, a complete medical
history, interviewing such as
a history of travel and serologic testing for viruses, bacteria
and infection are performed,
after nucleic-acid testing (NAT)
to meet with requirements for
HBV-DNA, HCV-RNA and HIV1-RNA is carried out. In addition, it has been confirmed that
high-pressure steam sterilization for 20 minutes at 121 °C
during the manufacturing process is effective in inactivating
10
various viruses such as HIV
etc. Furthermore, although in
the product test, the nucleicacid test meets with requirements for HBV-DNA, HCVRNA, HIV-1-RNA, HTLV-DNA,
and parvovirus B19-DNA, patients should be made aware
of the following points during
administration: To date, the
transmission of infection, such
as variant Creutzfeldt-Jakob
disease (vCJD), by administration of this product in Japan or
other countries has not been
reported. However, although
safety measures are taken to
prevent infection during the
manufacturing process, it is
theoretically impossible to fully eliminate the risks of infection transmission originating in
a human placenta used as raw
material. While safety measures during the manufacturing
process to prevent infection,
as well as confirmation of the
necessity of treatment for the
disease before administration are carried out, doctors
should explain to patients and
try to have them understand
that when human placenta is
used as the raw material of a
product, the risk of infection
cannot be fully ruled out.
3. Drug Interactions
When this product is directly
mixed with a strong base preparation of pH 8.5 or more, attenuation of pharmacological
activity has been reported.
No coadministration with this
product resulting in the enhancement or attenuation of
the pharmacological effect of
this product or concomitant
drugs, appearance of adverse
reactions, or aggravation of
disease has been reported.
4.
Adverse Reactions
Adverse reactions or patients
who were suspected to have
suffered adverse reactions
to this product were reported in a total of 10 (3.7%) of
the 273 patients selected for
safety evaluation in the clinical study performed during
implementation of reevaluation of the drug efficacy.
The most frequently observed adverse reactions were
injection site pain in 7 patients (2.6%), hypersensitivity (such as rash, fever, and
itching) in 1 patient (0.4%),
injection site indurations in
1 patient (0.4%), and gynaecomastia in 1 patient (0.4%).
The causal relationship between gynaecomastia and
this product is unknown.
• Clinically significant adverse reactions:
Shock (incidence unknown):
Since this product is a protein/ amino acid preparation
derived from human tissue,
this product may cause a
shock. If any signs of abnormality are observed, the drug
should be discontinued immediately, appropriate measures should be taken and
the condition should be monitored fully.
Use in the Elderly
From clinical data and present
use, no particular caution is
needed in the administration
of this product to the elderly.
However, since elderly patients often have reduced physiological function, it should
be administrated with care.
5.
Use during Pregnancy,
Delivery or Lactation
6.
In reproductive development
toxicity experiments on animals, including teratogenicity,
this product can be considered
not to have such toxicity.
7.
Pediatric use
The safety of this product in
premature infants, newborns,
infants, toddlers or children
has not been established due
to insufficient clinical data.
8.
Overdosage
Precautions for Use
Injection site
9.
In order to avoid any effect
on tissue or nerves, the
product should be injected
subcutaneously or intramuscularly taking the following
precautions:
• For the injection site, to avoid
nerve pathways, it should be
administrated with care.
• In the case of repeated injections, avoid injecting into
the same site by alternating
on the left and right side etc.
• If intense pain or regurgitation of blood is observed, the
needle should be removed
immediately, and injected
into a different site.
Opening the ampoule:
When opening the ampoule,
it is preferable to wipe the
part to be cut with an ethanol
sponge before opening it.
Overdosage of this product
and the resulting efficacy
or safety have not been established due to insufficient
clinical data.
11
PHARMACOKINETICS
• The bioactive ingredients of LAENNEC are extracted from human placenta, and the primary pharmacological effects of this product can not necessarily be attributed to a single
substance or ingredient. Therefore, evaluation of the pharmacokinetics (absorption, distribution, metabolism, and excretion) of this product has not been established.
CLINICAL STUDIES
1.
Double blind comparison to chronic hepatitis and hepatic cirrhosis1)
In a double-blind crossover study of 124 patients in Japan on the effects of this product
on chronic hepatitis and hepatic cirrhosis, administration of this product improved serum
transaminase (GOT, GPT) levels significantly (see figures below).
Efficacy to GOT
Units
110
GOT
100
90
A**
80
70
A*
60
50
40
** P < 0.01
30
* P < 0.05
A ; Laennec Administration
· Breadth ; Average ±1.645 S.E.
P ; Placebo Administration
s
√n
one- sided 95% confidence interval
20
before
2w
4w
6w
8w
after
+
12
Efficacy to GPT
Units
110
GPT
100
90
80
A*
70
60
A*
50
40
30
20
Gr. I
Subject
58
Gr. II
66
2w
Transitional
subjects
before
4w
6w
8w
after
A
58
P
57
A
50
P
48
66
P
62
A
56
P
52
A
13
Summary of drug-efficacy
[(A) Items having a tendence to decrease or increase significantly by Laennec]
Examination-Items
Before ~ 2w
2w ~ 4w
4w ~ 6w
6w ~ 8w
GOT
GPT
Al-P
TTT
ZTT
LHD
(cf)
T-chol
(cf) (I)
Summary of drug-efficacy
[(B) Items having a tendence to decrease or increase significantly by Placebo]
Examination-Items
Before ~ 2w
2w ~ 4w
4w ~ 6w
6w ~ 8w
Al-P
LHD
(cf)
A/G
Albumin
g Globulin
Significant under 1% level
Significant under 5% level
(I) To increase significanly. Nothing ist to decrease
(cf) To have a tendency inside of normal range
Calculated Logarithmically
Calculated by original-value
Method; t-Test (II) of the related samples
14
(I)
(I)
2. Action on HCV-RNA levels
3)
Twenty subjects of two-agent combination therapy only with Stronger Neo-Minophagen C
and Acelart were performed in the past and negativation neither of C100-3 antibody nor
HCV-RNA was admitted in them. In three-agent combination therapy with Laennec added,
two negative cases of serum HCV-RNA levels were admitted.
PHARMACOLOGY
Stimulatory effects of
hepatic reproduction 4), 5)
1.
After 70% of livers in healthy
rats was resected, time comparisons of liver weight to
the control groups resulted
in significant stimulation of
hepatic reproduction in the
Laennec groups.
2. Stimulatory
effects of
cellular DNA synthesis4)
Compared to control groups,
in vivo experimental system
using primary culture rat hepatocytes, the DNA-synthesis
accelerator activity was observed in 2 μL/ml-administrated groups. That accelerator
activity was equivalent to 10
pM of rHGF. The liver tissue
in vivo experimental system
using rats with acute hepatitis
by ANIT was stained and the
result of evaluation of the rate
of hepatocyte nucleus in DNA
synthesis period showed significant accelerator of DNA
synthesis compared to the
control groups.
3. Inhibitory effects of ex-
perimental liver injury
4), 6)
Compared to control groups,
in vivo experimental system
using rats with acute hepatitis by ANIT, the liver cytosolic
enzymes in serum (GPT, ALP,
LAP and g-GTP) and the bilirubin levels significantly degreased in the Laennec groups.
In addition, compared to
control groups, in vivo experimental system using rats
with acute hepatitis and chronic hepatitis by CCI4, the liver
cytosolic enzymes in serum
(GPT, GOT) significantly degreased and histopathologically improved liver disorder
in the Laennec groups.
4. Anti-fatty liver action
7)
A 5-day subcutaneous injection of 1.2 ml/kg of this
product in rats suffering from
acute hepatic disorder with
CCI4 resulted in a significant
decrease in hepatic weight
to body weight as compared
with the control groups. Furthermore, total hepatic lipids
and total hepatic cholesterol
decreased significantly in the
3.6 ml/kg dose groups, and
hepatohistological findings
to support such results were
seen and the body weight
was realized.
After pretreatment of acute
hepatic disorder with CCI4,
there were no significant differences with regards to
biochemical findings between the control groups and
when 5-day repeated, subcutaneous administration of
1.2 ml/kg of this product was
performed. However, in the
3.6-ml/kg dose groups, maintenance of lobular structure was better than the control
groups with regards to hepatohistological findings.
5.
Absorption accelerated
activity on interstitial connective tissue8)
This product exhibited inhibitory action of fibroplasias
in rat liver due to 12-week
repeated administration of
CCI4, and it was confirmed
histologically that once multiplied, interstitial connective
tissues were absorbed.
15
PHYSICOCHEMISTRY
• This product is human-placental extract, and contains various biological active substances. However, the active ingredients of this agent cannot be specified as a single substance
or several sorts of substances.
PRECAUTIONS FOR HANDLING*
• This product corresponds to a specialized biological product. Therefore, when this product is administrated, the product name, manufacturing No., date of administration (or
prescription), name and address of patients should be reported and stored for at least 20
years in accordance with the order issued by the Japanese Ministry of Health, Labour and
Welfare. This product should be used with attention to the point that the indication of this
product is “improvement of hepatic function in chronic liver disease.”
PACKAGING
• 2 ml 50 ampoules
REFERENCES
1) Ueda H. et al.: Kanzo (Liver), vol.15, 162, 1974
2) Taniguchi H. et al.: data on file in Japan Bio Products Co. Ltd., 1985-1991
3) Takami T.: Kiso to Rinsho, vol.30, 3549, 1996
4) Liu K. et al.: Yakuri to Rinsho, vol.5, 2187, 1995
5) Sakamoto K. et al.: Journal of Tokyo Medical University, vol.33, 271, 1975
6) Nakayama S. et al.: Folia Pharmacologica Japonica, vol.94, 289, 1989
7) Sakamoto K. et al.: Journal of Tokyo Medical University, vol.31, 829, 1973
16
PLAMON
Is not yet available in Europe. Indicated for climateric disorders, Plamon is for intramuscular and subcutaneous administration.
CURACEN
Indicated for rejuvenation, anti-aging, whitering and antiwrinkle. Curacen is for subcutaneous injection and can be
reforced by Curacen Essence. Curacen is not available in
Europe yet.
17
4
COSMETICS
: : GHC HUMAN PLACENTA
WHITENING SOAP
Based on JBP Placental Extract which has anti-oxidant and
whitening effect, works on increase in fibroblast growth factor
and repairs skin cells by growth factor. Provides moisture and
brightness while effectively washes up excess sebum and dirt
on your skin without stiff feeling. Gentle to sensitive skin.
LOTION
JBP Placental Extract suppresses the generation of the melanin pigment and gives your skin brightness. While collagen,
hyaluronic acid, and elastin produced by the activated fibroblast growth factor make your skin elastic. GHC Lotion protects your skin, effective to whitening, damage by U.V. stress,
dryness, and aging.
ESSENTIAL SHIELD
JBP Placental Extract in this serum neutralizes active oxygen
by its antioxidant effect. Ceramide and hyaluronic acid provides moisture, protects your skin against skin trouble. Dipotassium glycyrrhizinate has anti-inflammatory effect, protects
your skin against aging.
18
GHC HUMAN PLACENTA
ESSENCE
GHC Essence is in the highest concentration of JBP Placental
Extract among GHC cosmetics, gives your skin firmness and
moisture working with hyaluronic acid and collagen, suitable
to intensive care for pigmentation, wrinkles, and saggings.
g-FORCE
Mortierelle oil (=g-Linolenic acid) in the emulsion normalizes turnovers and products healthy skin, protects your skin
against dullness, pigmentation, and wrinkle arose from hormone imbalance particular to women. While it keeps moisturizing substances of GHC cosmetics by coating your skin
surface with bergamot oil.
REPAIRING CREAM
This is the water-soluble cream with JBP Placental Extract
which supports collagen generation, cell proliferation and
reproduction. RNA, ceramide, and squalane helps turnover
and moisturising. Suitable to pigmentation, wrinkles, and
dryness, gives you firm skin.
PLACENTAL MASK WITH CoQ10
This hydro-gel mask gives your tired skin moisture, elasticity
and smoothness. JBP Placental Extract helps activation of
skin cells, makes your skin whitened by inhibition of generation of the melanin pigment. CoQ10 works for pigmentation,
wrinkle, and saggings. Tartaric acid has astringent effect lead
your skin to be smooth.
19
GHC PORCINE PLACENTA
: : GHC PORCINE PLACENTA
GHC BRIGHTENING SOAP
(facial soap)
Provides moisture and brightness whenever you use. You
can feel dullness-free, clear skin.
This placental soap makes your skin soft and moist as well as
removing excess sebum and dirt effectively. Gentle and kind
to sensitive skin.
GHC UV PROTECTOR (sunscreen)
Protects your skin from UVA / UVB with SPF50 & PA+++
while conditioning your skin with placental extract.
Gentle to your skin, free from ultraviolet light absorbers, artificial color, fragance, alcohol, and parabens. With placental
extract to help shields your skin from dryness and other damages. Applicable to entire body at any occasion and to all
ages. Water proof formula. Good for makeup base too.
GHC ESSENTIAL SHIELD (serum)
Soothing serum for clear skin.
Excessive active oxygen is a major enemy of the skin.
This placental serum neutralizes active oxygen and restores and protects damaged skin. It gently heals skin and
makes it clear.
20
GHC PORCINE PLACENTA
GHC LOTION (skin lotion)
Deep moisturizing after facial cleansing produces moist,
fresh skin.
Placental extract combined with the moisturizing ingredients
of hyaluronic acid, ceramide, and polyglutamic acid. This lotion protects your skin from stress, and drying, and effective
for whitening and anti-aging.
GHC REPAIRING CREAM (cream)
Directly works on cell to produce fresh, firm skin.
This placental cream works directly on weakened cell and
promotes the regeneration of the cells. Placenta helps the
production of collagen for firm skin.
GHC g-FORCE (milky lotion)
Finishing milky lotion wraps around the face with moisture veil.
This milky lotion solves skin problems caused by hormone
imbalance peculiar to women. The moisture veil keeps active
ingredients information in the skin as well as prevents your
skin from external irritation.
GHC PLACENTAL MASK WITH COQ10
(facial mask)
Moisturizing and whitening special care.
Hydro gel used for this mask containing placental extract, CoQ10,
and many other moisturizing ingredients. The serum in the mask gives brightness, moisture, and elasticity to your skin.
21
GHC PORCINE PLACENTA
GHC ESSENCE (intensive serum)
Placental extract penetrates into the skin cells slowly
but steadily.
High concentration of placental extract combined with collagen, hyaluronic acid, and ceramide, which give firmness and
moisture to your skin. This product provides intensive care for
annoying blotches, wrinkles, and sagging.
GHC PROTOCOL
FOR DAY
SOAP
TONIC
g-FORCE
UV PROTECTOR
FOR NIGHT
SOAP
TONIC
g-FORCE
ESPECIAL CARE
Every 2 weeks
MASK
ESSENTIAL SHIELDS (Serum)
Once a month
ESSENCE (Intensive Serum)
22
REPAIRING CREAM
5
FOOD
SUPLEMENTS
LAENNEC P.O.
Human placental supplement extracted by the same technology and safety protocol as Laennec injection.
Designed the same efficacy and availability as two capsules
equivalent to one ampoule of Laennec injection.
ANTI-AGING AND DERMATOLOGICAL EFFECTS
• Whitening and moisture retention
• Cell proliferation and reproduction
• Promoting self-adjustment/medication of immune and hormonal system
• Extracellular matrix generation
• Blood circulation promotion, etc…
COMPONENTS IN JBP PLACENTAL EXTRACT
• Growth factors and cytokines: central element of placenta, demonstrating medicinal effects
• Aminoacid: essence of life
• Protein
• Carbohydrates: energy source
• Vitamin
• Nucleic acid and nucleobases
• Lipid and fatty acid
• Mucopolysaccharides: element to connect cells, works to suppress inflammation
• Mineral
• Enzyme
23
PRESENTATION
• 100 caps of 350 mg/ box
ADMINISTRATION
• 2 Capsules after dinner
TSUYAN RIN
This drink with a taste of bilberry contains JBP Placental
Extract, together with collagen, chondroitin, elastin, and
L-proline to maintain supple skin, vitamin C, ceramides, and
astaxanthin for light, radiant skin. Each ingredient promotes
beauty from the inside. For beautiful lustrous skin.
INGREDIENTS PER BOTTLE
24
Active
ingredient
Amount
Function
Porcine Placenta
Extract
8g
FGF (fibroblast growth factor) promotes the
production of collagen, elastin and
chondroitin in the dermis
Collagen
1g
Lack of collagen results in sags
and wrinkles
Vitamin
150 mg
Promotes collagen synthesis.
Helps lightening of skin
Chondroitin
100 mg
Makes skin soft, smooth and moist
Elastin
30 mg
Maintenance of skin resistant
Active
ingredient
Amount
Function
L- proline
21 mg
Component of collagen. Raw material
to built collagen fibers
Ceramide
10 mg
Fill the intracellular spaces to maintain
skin moisture
Astaxanthin
5 mg
Antioxidant properties. Maintain skin in good
condition and prevents rough skin,
wrinkles and spots.
PRESENTATION
• 10 bottles of 50 ml per box
ADMINISTRATION
• 1 bottle a day
PLACENTA METABOLIZER
Placental Metabolizer is the “functional supplement,” prescribing JBP Placental Extract with CoQ10, Carnitine, and
Vitamin-B1, the ideal combination for toning and designing
your body metabolism. Specially recommended for body fitness and anti-aging, and for athletes.
25
INGREDIENTS PER CAPSULE
Active
ingredient
Amount
Function
Porcine Placenta
Extract
280 mg
Keeps body metabolism
Coenzyme Q10
30 mg
For cell´s energy producing
L- Carnitine
50 mg
Component for fat-burning
Vitamin B1
8,3 mg
Helps energy production from carbohydrates.
Keeps skin and mucosa healthy
PRESENTATION
• 60 Caps of 350 mg per box
ADMINISTRATION
• 2-3 Capsules a day
LAENNEC P.O. PORCINE
A capsule contains 350mg of 100% JBP placental extract
(porcine), applying the same extraction method of Laennec
injection, our ethical product extracted from human placenta, to the Japanese domestic porcine placenta. You will realize the benefit of pure placental extract without any additives
or any other ingredients.
26
INGREDIENTS PER CAPSULE
Active
ingredient
Amount
Function
Porcine Placenta
Extract
350 mg
Keeps body metabolism
PRESENTATION
• 100 Caps of 350 mg per box
ADMINISTRATION
• 3-6 Caps a day. Free from additives.
RECOMENDED FOR:
• Maintain physiological functions and hormone balance.
• Adjust autonomous nervous system
• Improves metabolism and blood circulation
• Promotes recovery from fatigue
• Enhances immunity and resistance
• Helps synthesis of collagen
• Suppresses the generation of melanin pigment
• Keeps and produces healthy skin
• Neutralizes active enzymes and prevent oxidation
• Supports liver function.
27
GRACE HAI
Grace Hai has been developed to solve the skin troubles
caused by the internal problems such as digestive organ
disorders, unbalanced hormone secretion, immunodeficiency, fatigue and aging.
INGREDIENTS PER CAPSULE
Active
ingredient
Amount
Function
Porcine Placenta
Extract
140 mg
Growth factor and citokynes to maintain
physiological functions and hormone balance
and improve skin conditions
Gamma Linolenic
Acid
244 mg
Maintaining autonomic nerves and hormone
balance as well as revitalizing metabolism
Royal Jelly
30 mg
Rich in proteins, vitamin A,B,C,D,E, minerals,
enzymes and other nutrients
10 mg
Component of the cell membranes, brain,
nerve tissue and other organs
6 mg
Antioxidant
Lecithin
Vitamin E
PRESENTATION
• 100 Caps of 450 mg per box
ADMINISTRATION
• 3-4 Capsules a day. Free of additives.
28
6
MESOTHERAPY
PRODUCTS
The use of placenta in Mesotherapy treatments is not new.
The treatment employ injection of placenta containing essential nutrients of skin as vitamin, mineral, uracil, etc,…,
to part of face and neck. Basically this treatment is applied
periodically, and shows significant effect for skin’s anti-aging
and elastance. Also, it effects on atopic/allergic disease and
alopecia as well.
: : Wrinkles/whithening
Fibroblast growth factor (FGF) contained in placenta productes collagen, elastin and hyaluronic acid, and makes moisturizing/elastin skin
by eliminates active oxygen. Also it promotes
cell division in basal layer of skin to activate
turnover, then leads to excretion of melanin.
This action mechanism gives an excellent
effect on whitening of skin.
: : Depilation
Placenta maintains the hormone secretion
normally. Also it helps the blood circulation of
scalp and improves the condition of hair root
with good nutritional status, so that this action
mechanism stimulates cell division to promote
the hair growth.
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: : Atopy/Allergy
Placenta acts to prevent the excretion of histamine, and has effect on making normal immune
system and proliferation of skin cell. Therefore,
Mesoplacenta treatments combine with dietotherapy can improve atopic/allergic symptoms.
CURACEN ESSENCE
Curacen Essence is formulated base on human placental extract. This placental extract is obtained as a low molecular
weight extract which allow to be used not only for mesotherapy but also in electroporation and iontophoresis procedures.
This new formulation allows an immediate cell reactivation
along with a nice whitening and improvement of skin glow.
The quick reaction and cellular activation can be expected
from shallow layers of the skin for its small molecules.
PRESENTATION
• 2 ml ampoule JBP Placenta extract (as soluble substance 100 mg). Box of 10 ampoules.
ADMINISTRATION
• Apply to skin with mesotherapy, ionotophoresis or electroporation.
INDICATION
• Anti-aging, Whitening, Anti-wrinkle
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STORAGE CONDITION
• Store under room temperature.
SHELF LIFE
• 24 months from mfg. date
JBP NANONEEDLE
JBP Nanoneedle was born from the voices of doctors and
patients. The integrations of craftsmanship and technology has created this ultra-thin needle to lessen patient discomfort during needling and to realize minimal hemorrhage
and swelling.
The pain and bleeding are successfully reduced during
needling by an ultra-thin walled needle which lessens friction resistances by a special process of Micron Sharpness.
It makes possible to inject high viscosity solutions with extra fine needles.
NANONEEDLE ULTRA-THIN WALL SERIES
34G Ultra-thin wall
Outer diameter 0.20 mm
Inner diameter 0.10 mm
5/16” mm (8mm)
100 pcs/ box
33G Ultra-thin wall
Outer diameter 0.26 mm
Inner diameter 0.16 mm
1/ 2” (13mm)
100 pcs/ box
30G Ultra-thin wall
Outer diameter 0.30 mm
Inner diameter 0.20 mm
1/2” (13 mm)
100 pcs/ box
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APLICATIONS
• Mesotherapy
• Placenta injection
• Botox injection
• Collagen injection
• Hyaluronic acid injection
• Local anesthetics
FEATURES OF JBP NANONEEDLE
ULTRA-THIN WALLED
• LESS PAIN & SWELLING
• LITTLE BLEEDING
EXTRA FINE
• INVISIBLE INJECTION MARKS
• INJECTABLE FOR HIGH
VISCOSITY SOLUTION
MICRO POLISHING
TECHNOLOGY
(Micron Sharpness)
COMPARISON OF INNER AND OUTER DIAMETERS BEETWEEN JBP NANONEEDLE
AND CONVENTIONAL NEEDLE
CONVENTIONAL NEEDLE
33G
0.10 mm
0.26 mm
32
larger inner
diameter
same outer
diameter
JBP NANONEEDLE
33G
JBP NANONEEDLE
30G
0.16 mm
0.20 mm
0.26 mm
0.30 mm
CONVENTIONAL NEEDLE
30G
larger inner
diameter
same outer
diameter
0.15 mm
0.30 mm
Conventional needle
JBP Nanoneedle
Gauge
Outer Diameter
Inner Diameter
Outer Diameter
Inner Diameter
34G
0.20 mm
0.10 mm
-
-
33G
0.26 mm
0.16 mm
0.26 mm
0.10 mm
30G
0.30 mm
0.20 mm
0.30 mm
0.15 mm
JBP NANONEEDLE
CONVENTIONAL NEEDLE
COMPARISON OF INJECTION MARKS BEETWEEN JBP NANONEEDLE AND
CONVENTIONAL NEEDLE
FIRST REACTION
JBP NANONEEDLE
(34G)
6 HOURS LATER
CONVENTIONAL
NEEDLE (30G)
JBP NANONEEDLE
(34G)
CONVENTIONAL
NEEDLE (30G)
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7
ELECTROPORATION
Japan Bio Products has developed a new concept in electroporation with “JBP Electorporation” and “JBP Placental Solution I-II”.
Electroporation increase the transcutaneous absortion of molecules with pharmacological and trophic activity. It allows to use
mesotherapy in a non-invasive manner.
Peter Agree and Roderick Mackinnor were prized with the Nobel
in chemistry in 2003 due to their results in electroporation. This
procedure is based in the principle of obtaining a variable transmembrane potential (0,5-1,5V) after applying an electrical pulse.
After 8 minutes the opening of electorpores appears. This process lasting depends of the wavelength generated and vary from
seconds to several minutes.
The electropore or water channel sized obtained is large between 1-2 microns.
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JBP PLACENTAL SOLUTION I-II
JBP Placental Solution I-II are 100% pure placental extracts
(porcine) free from preservatives and additives, developed
especially for skin treatments by JBP Skin Poration.
LOW MOLECULES: EASY TO PENETRATE INTO SKIN
WHITENING EFFECTS
ANTI-OXIDATION
JBP Placental Solution I
4ml x 5 bottles
HIGH MOLECULES: PENETRATION INTO DERMIS
PRODUCTION OF PROCOLLAGEN
SKIN REJUVENATION
JBP Placental Solution II
4ml x 5 bottles
JBP Placental Solutions I and II can be used for iontophoretic/ ultrasonic skin treatments.
For external use only. Each bottle is one time only use after opening. Use the solution immediately after opening the bottle and dispose the leftovers because no preservatives and additives
are contained.
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JBP SKIN PORATION
The JBP Skin Poration is an electroporation hybrid beauty
device which combine the electroporation technique with ultrasonic cleansing and microcurrent in 1 unit.
Electroporation is a system with dramatically low voltage/low
current and new waveforms to open skin pores to provide
the active ingredient to the inner layers of the skin.
JBP Skin Poration provides a maximum reduction of electric
stimuli to the epidermides without metal elution from the probe. The cleansing probe is made of titanium.
Microcurrent function are switchable continuous and intermittent modes which allows better nutrient diffusion/infiltration and lifting effects. Particular advantage is the 2,2 Kg
compact size.
JBP Skin Poration is supplied with cleansing and face probes. Hair and body probes are available separately.
Japan Bio Products ensures with this new electroporation
device that big molecules or pools of molecules like placenta
extracts, hyaluronic acid, DMAE, vitamin C and others penentrate the cells.
HYBRID BEAUTY DEVICE INCORPORATING 3 FUNCTION UN 1 UNIT
ULTRASONIC CLEANSING
SKIN PORATION
PATTING & FINISHING
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FEATURES
2 .Safety
3 .Multifuntional
• A systems with low voltage/ low current and news
waveforms.
• Titanium is used for the sonic probes and all points on
skin poration probes.
• Maximum reduction of electric stimuli to the epidermides
and high skin poration effects.
• No elution of metals from
the probes.
• One unit can perform three
functions; ultrasonic cleansing, skin poration and patting & finishing.
1.
Avanced Technology
4 . Various
Optional Probes
for Body and Hair Treatments.
ATTACHED PROBES
Sonic for Face & Body
For Face
OPTIONAL PROBES
For Body
For Fine Points
Hair Sonic
For Hair
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