research information Cholesterol Formula with Sytrinol TM Supports normal cholesterol levels Are you looking for a natural way to reduce moderately high levels of cholesterol without resorting to the ever-popular ‘statins’? Cholesterol Formula, combining plant sterols with Sytrinol has proven to be effective! Of course, diet and exercise are the building blocks of cardiovascular health, but even a heart-healthy diet may not bring down those numbers enough. The reason is simple: only 20% of our cholesterol actually comes from our diet, the other 80% is made in the liver. That’s why statin drugs have proved effective. They target one of the liver’s cholesterol producing mechanisms. Unfortunately, that same mechanism also produces coenzyme Q10 (CoQ10). The side-effect is that prolonged use of statin drugs cause severe deficiency of CoQ10, required for healthy muscle tissue (the heart is a muscle). It can also result in debilitating muscle deterioration. Combining plant sterols (SterolSource™) with Sytrinol provides a comprehensive formula that addresses all facets of dyslipidemia including high cholesterol, high LDL (low density lipoproteins, the “bad” cholesterol) and high triglycerides. This formula also contains a significant anti-inflammatory component as inflammation has been shown to be a risk factor for heart attack. This amazing natural heart health formula is ideal for anyone wishing to maintain a healthy lipid profile. Measured endpoints Total Cholesterol LDL Cholesterol Total Triglycerides HDL Cholesterol LDL/HDL Ratio Treatment group Sytrinol Sytrinol Sytrinol Sytrinol Sytrinol % Change (4 weeks) Study 1 Study 11 Study III -25%b -19%b -24%b nc -19%b -20%b -22%b -28%b 3% -24%b -25%b -23%b -29%b 4% -26%b Means + SEM Statistical analysis by ANOLVA plus post test by Dunnett’s method nc - no change from baseline b - significantly different within same group. P < 0.05 Why Plant Sterols? In 2000 the FDA allowed a label claim by the manufacturers of certain margarines and spreads that plant sterols reduce the risk of coronary heart disease. The FDA extended this claim for supplements containing sterols. These claims are based on numerous studies going back 50 years that show that plant sterols and stanols can effectively lower total and LDL cholesterol levels. Blood cholesterol levels are derived from two sources: endogenous synthesis (made by the body) and from animal products in our diet. Some of the endogenous cholesterol is released with bile into the intestine where it can be reabsorbed. “Phytosterol esters/sterols work by reducing absorption of both cholesterol sources, dietary cholesterol and The Dark Side of Statins Government guidelines have suggested that target LDL levels be reduced from the current 100 mg/dl to 70 mg/dl in patients considered to be high risk for heart attack or death from cardiovascular disease. Persons with only a moderate risk for heart attack are being encouraged to lower their cholesterol levels by 30 to 40%. Not surprisingly, the guidelines could dramatically increase the number of patients on statin drugs to as many as 50 million. In an embarrassing oversight, the same government panel drafting the guidelines failed to mention in its report that most of its panelists are linked to pharmaceutical companies that manufacture statin drugs. Six of the nine panelists had either received grants from or were paid consulting or speakers’ fees by the companies that make some of the most popular statins, including Pfizer’s Lipitor®, Bristol-Myers Squibb’s Pravachol®, Merck’s Mevacor®, and AstraZeneca’s Crestor®.” Life Extension Magazine November 2004. While statins have a clear benefit, they also can have adverse effects: • Liver problems and elevated liver function tests. • Interference with coenzyme Q10 production resulting in damaging deficiency. • Rhabdomyolysis (muscle pain and weakness), the breaking down of muscle tissue which can prove fatal. Between October 1997 and December 2000 statin drugs were linked to 72 fatal and 772 nonfatal cases. • Polyneuropathy (nerve damage) with chances of nerve damage 26 times higher than the normal population. • Brain and central nervous system functions (after prolonged use some patients suffered measurable decline in cognition). endogenous cholesterol. Phytosterol esters/sterols have chemical structures very similar to cholesterol and interfere with cholesterol absorption.” (Veris) This information is provided for educational purposes only, and is not intended for self-diagnosis or self-treatment of conditions that should be assessed and treated by your health care practitioner. While the information contained in this document has been carefully reviewed and reflects current clinical and scientific knowledge, it is subject to change. © All rights reserved – Natural Factors Nutritional Products Ltd. • Enquiries: [email protected] • 30555 •August 4, 2009 • Pg 1 of 2 Where Great Health Begins research information Cholesterol Formula with Sytrinol TM Plant sterols or phytosterols have been proven to lower cholesterol levels from 7 to 15%. In the ester form and in sufficient quantities, plant sterols and stanols can inhibit absorption of cholesterol in the small intestine by up to 50%, and lower LDL blood cholesterol by up to 14%. The most common plant sterols are sitosterol, campesterol and stigmasterol. What is Sytrinol? It’s well-known that drinking orange juice can reduce cholesterol. However, specific citrus flavonoids, particularly nobiletin (first isolated from orange peels) and the tangerine flavonoid tangeretin have been shown to reduce cholesterol and triglycerides, lower inflammation and reduce apopiloprotein B3. Sytrinol is a patented proprietary formula derived from these natural citrus and palm fruit extracts. It inhibits the enzymes responsible for increasing the liver’s cholesterol and triglyceride production. Three of its complementary mechanisms of action in the body that deliver the cardiac health benefits are: • Polymethoxylated flavones (PMFs) decrease apolipoprotein B, a structural protein needed for endogenous synthesis of LDL cholesterol. “Apolipoprotein B particles enable cholesterol to penetrate and lodge in vascular walls, an important step in initiating the formation of atherosclerotic plaque.” (English) • PMFs (tangeretin and nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triglycerides. • Palm tocotrienols inhibit HMG CoA reductase, a liver enzyme responsible for endogenous synthesis of cholesterol. Sytrinol also provides powerful antioxidant with anti-inflammatory properties that support a healthy cardiac system. Backed by Research Clinical results have demonstrated that Sytrinol can improve total cholesterol levels up to 30%, LDL cholesterol levels up to 27% and triglyceride levels up to 34% within four to twelve weeks. Additionally, clinical trials have demonstrated that Sytrinol can have a positive impact on apolipoprotein (also known as apoprotein) B and apolipoprotein A1 levels as well as playing a significant role as an anti-inflammatory. Sytrinol can do all this without the negative side-effects associated with pharmaceutical drugs. Sytrinol and Sterols – Positive Synergy The Cholesterol Formula provides 200 mg of SterolSource plant sterols (standardized to >95% total sterols) combined with 75 mg of Sytrinol phytosterol, a patented formula derived from natural citrus and palm fruit extracts (standardized to >30% polymethoxylated flavones and tocotrienols). Together, SterolSource and Sytrinol have a greater biological impact than each component individually. In the digestive tract this formula inhibits the absorption of cholesterol from foods consumed and reduces cholesterol reabsorption (liver and gall bladder bile is 90% cholesterol, much of which is reabsorbed back into the bloodstream from the digestive tract). In the liver this combination reduces the amount of cholesterol made by inhibiting the enzymes that produce cholesterol. What you can expect from the Cholesterol Formula It may lower total cholesterol and “bad” LDL cholesterol and may help maintain (and even slightly increase) levels of the “good” HDL. Components in the Cholesterol Formula have been shown to significantly lower triglyceride levels and may reduce inflammation of the heart and blood vessels with none of the side-effects associated with statins. Dosage Two capsules 2 times daily or as directed by a health care practitioner. Best when used as part of a diet low in saturated fats, trans fatty acids and cholesterol. Safety This remarkable combination is very safe for long-term use. Sytrinol is not diet specific and has no known sideeffects. The Cholesterol Formula can enhance the performance of cholesterol lowering drugs such as the statins, and can be used along with natural cholesterol lowering supplements such as policosanol, niacin or garlic. Children: There is no appropriate use at the present time. Pregnancy and Lactation: Since the effects of the Cholesterol Formula have not been sufficiently evaluated, it should not be used during those times. Pre-existing heart conditions: Use this formula under the direction of their health care practitioner. Do not stop taking any prescription medications that lower cholesterol unless directed by a health care practitioner. Beta sitolsterolemia: People with this rare genetic condition called should not use any supplements containing plant sterols. Anticancer drugs: People on some drugs such as vinblastine should use products containing Sytrinol with caution as it can increase the uptake of the drug as flavones of orange juice are inhibitors of P-glycoprotein. Drug-nutrient interactions: Other than the above, the Cholesterol Formula can be safely used with other medications, including cholesterol-lowering medications. Unlike grapefruit, this formula does not seem to interfere with the P450 3A4 pathway through which 60% of all drugs are metabolized, so is less likely to have any drug-nutrient interactions. Lowering cholesterol naturally and safely is no longer out of reach. Serious side-effects no longer need to be a concern. The Cholesterol Formula with Sytrinol can be your solution. Key References English J., “Novel dietary supplement shows dramatic effects in lowering cholesterol, LDL, and triglycerides,” Life Extension; November, 2004 FDA, “FDA authorizes new coronary heart disease health claim for plant sterol and plant stanol ester,” FDA Talk Paper; September 5, 2000 Kurowska, E.M., et al., “Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin,” Lipids, Feb, 39 (2): 143-51; 2004 Plant sterol esters/sterols may reduce the risk of heart disease, VERIS Research Information Service; November 2003 This information is provided for educational purposes only, and is not intended for self-diagnosis or self-treatment of conditions that should be assessed and treated by your health care practitioner. While the information contained in this document has been carefully reviewed and reflects current clinical and scientific knowledge, it is subject to change. © All rights reserved – Natural Factors Nutritional Products Ltd. • Enquiries: [email protected] • 30555 • August 4, 2009 • Pg 2 of 2 Where Great Health Begins