Product Profile Maxalac® Dry Cow Intramammary Antibiotic Maxalac D.C. contains the broad spectrum, and long acting antibacterial cephalonium. The high potency of cephalonium delivers excellent cure rates of existing infections. In the later part of the dry period the intrinsic low solubility of cephalonium means the release of drug slows, providing prolonged activity and prevention of new infections developing prior to the start of the next lactation. Cure of existing infections The high levels of antibiotic present in the initial dry period give effective concentrations to target pathogens that are often deep in the udder tissue. Cephalonium has consistently shown good cure rates in clinical trials1,2,3,4,5,6. Maxalac DC showed excellent overall cure for important mastitis pathogens which was similar to Cepravin® DC7. Prevention of new infections over the dry period. This is a major objective of dry cow therapy, with particular focus on S. uberis which, in Australia, is responsible for the vast majority of cases of clinical mastitis8.Cephalonium treatment has been associated with faster formation of the keratin plug in the teat end2. This in conjunction with the prolonged antibiotic effect has been shown to give a major reduction in the incidence of mastitis due to S. uberis during the dry period2. Prevention of new infections over the dry period with cephalonium treatment has been shown to: - Reduce clinical mastitis cases during the dry period and around calving. - Reduce clinical mastitis cases in early lactation. - Reduce somatic cell counts (SCC) in the subsequent lactation. Withholding period Meat - 21 days Milk - Do not use in lactating cows or within 49 days before calving. - After calving, milk taken from treated dry cows must NOT be used for human consumption or processing for 96 hours (8 milkings). - If any cow calves less than 49 days after treatment, milk must NOT be used for human consumption or processing until the milk tests negative to a recognized antibiotic residue test. Consult the prescribing veterinarian or your local co-operative to discuss the testing processes. w w w. j u r o x . c o m . a u Jurox Pty Limited, 85 Gardiner Street Rutherford NSW 2320. Customer Service: 1800 023 312 ABN 56 000 932 230. ® Registered trademark of Jurox Pty Ltd. A U S T R A L I A’ S ANIMAL H E A LT H COMPANY Dry Cow Therapy ADMINISTRATION GUIDELINES oo Allow plenty of time to treat animals. Allow each operator an hour to treat 20 cows. Treat cows in manageable mobs. oo Ensure all operators are trained adequately in the treatment procedure and supervised well. oo Use dry cow antibiotics only at the cows’ last milking for the current lactation. Using dry cow antibiotics after the cow is dried off carries a higher risk of residue violation after calving. oo Watch for and do NOT treat glands that have already dried off (e.g. 3-titters) as there is an increased risk of residue violation. oo Record cow number, treatment and date for every cow. oo Mark each cow clearly so that she won’t be accidentally milked if she jumps a fence or the wrong mob is bought in. oo Treat every quarter of each cow with a full tube of the selected dry cow treatment. oo Vigorously rub the teat end for 10-15 seconds (or until the swab comes away clean) with a teat wipe or cotton wool dampened in 70% alcohol. Wipe any excess alcohol off the teat-end. oo Partial insertion (no more than 3 mm into the teat canal) of the syringe nozzle reduces teat canal damage and the risk of carrying bacteria into the udder. oo Spray or dip all teats with a freshly prepared sanitiser (teat spray) within 1 minute after insertion. oo Put cows into a clean paddock after drying off i.e. avoid effluent or recently grazed paddocks. oo Don’t bring cows near the milking shed for at least 7 days after drying-off as this can cause milk let down and elimination of the antibiotic that has been instilled. Check for Clinical Mastitis after drying off. Dry cows should be checked regularly (each week) for visible udder changes during the dry period. If quarters look swollen, bring the cow in and check her manually. Do not remove milk or secretion from normal quarters. If suspicious, treat as a clinical case using lactating cow intramammary treatments (do not use dry cow therapy at this stage). 1 Buddle BM & Cooper MG (1980) Dry-cow therapy for Staphylococcus aureus mastitis. New Zealand Veterinary Journal 2 Williamson JH, Woolford MW, Day AM (1995) The prophylactic effect of a dry-cow antibiotic against Streptococcus uberis. New Zealand Veterinary Journal 3 Shephard RW, Burman S, Marcun P (2004) A comparative field trial of cephalonium and cloxacillin for dry cow therapy for mastitis in Australian dairy cows. Australian Veterinary Journal. 4 Bradley AJ, Breen JE, Payne B, Williams P, Green MJ (2010) The use of a cephalonium containing dry cow therapy and an internal teat sealant, both alone and in combination. J. Dairy Sci. 5 McDougall S. (2010) A randomised, non-inferiority trial of a new cephalonium dry-cow therapy. New Zealand Veterinary Journal 6 Bryan MA, Heuer C, Emslie FR. (2011) The comparative efficacy of two long-acting dry-cow cephalonium products in curing and preventing intramammary infections. New Zealand Veterinary Journal. 7 Jurox data on file. 8 Charman N, Dyson R, Hodge A, Robertson N and Chaplin S (2012). A survey of mastitis pathogens in the South-Eastern Australian dairy industry. Proc. Countdown Symposium, 2012. Maxalac is a registered trademark of Jurox Pty Ltd. Cepravin is a registered trademark of Schering-Plough Animal Health. w w w. j u r o x . c o m . a u Jurox Pty Limited, 85 Gardiner Street Rutherford NSW 2320. Customer Service: 1800 023 312 ABN 56 000 932 230. ® Registered trademark of Jurox Pty Ltd. A U S T R A L I A’ S ANIMAL H E A LT H COMPANY