‘Principles of Mitochondrial Biology, Metabolism and Bioenergetics in health and disease’ – MiP Spring, London 2015
A workshop to be held at University College London, April 20th-24th
th
Monday April 20
CHAIR:
Gyorgy Szabadkai
9:30-10.30
10.30-11.00
st
Tuesday April 21
nd
Wednesday April 22
CHAIR:
CHAIR:
Josef Kittler
Nick Lane
Opening Guest lecture
Mitochondrial trafficking, fission
Basic principles of free radical
and fusion.
biology
rd
Thursday April 23
th
Friday April 24
CHAIR
Shamima Rahman
Metabolomics and human
disease
CHAIR
Sean Davidson
Disordered mitochondrial
quality control and
neurodegenerative disease
Barry Halliwell (Singapore)
Josef Kittler (UCL)
Christian Frezza (Cambridge)
Helene Plun Favreau (IoN)
Measuring ROS I: EPR
Maintenance of mtDNA
Mitochondria and Cancer
Johann Klare (Osnabrück)
Ian Holt (NIMR)
Gyorgy Szabadkai (UCL)
Mitochondria in cardiac
ischaemia and reperfusion
injury
Andrew Hall (UCL)
COFFEE&POSTERS
Measuring ROS II: fluorescence Can Mathematical Modelling
give us new insights into
mitochondrial biology
REGISTRATION OPENS
Andrey Abramov (UCL)
Nick Jones (Imperial)
STUDENT HUB, ANATOMY
BUILDING. ENTRANCE ON
GOWER STREET
Principles of respirometry
Autophagy/mitophagy in health
12.00-12.30
and disease
11.30-12.00
Erich Gnaiger (Innsbruck)
Michelangelo Campanella
(RVC)
Exploring mitochondrial
dysfunction in
neuroinflammation
Nuclear mutations of
mitochondrial proteins and
disease
Kenneth Smith (IoN UCL)
Shamima Rahman (ICH,
UCL)
GRADUATE TALKS
mTOR and NAD homeostasis
Johannes Ehinger (Lund)
as therapeutic targets for
Cell-permeable mitochondrial treating mitochondrial disease
complex II substrates – a new
compound class for treatment Matt Kaeberlin (UW Seattle)
of complex I-linked
mitochondrial disease
Gaia Gherardi (Padova)
The Mitochondrial Calcium
Uniporter controls skeletal
muscle trophism in vivo
GRADUATE TALKS
GRADUATE TALKS
Tito Cali (Padova)
Iain Johnston (Imperial)
Complementable green
Stochastic modelling, Bayesian
fluorescent protein based
inference, and new in vivo
sensors of organelle proximity measurements elucidate the
debated mtDNA bottleneck
Ina Pettersen (Bergen)
mechanism
Metabolic adjustments after
Rubén Quintana Cabrera
reversible induction of
(Padova)
mitochondrial biogenesis via
AMPK/NRF1 in HeLa cells
Cristae remodeling by Opa1
modulates mitochondrial
bioenergetics by promoting
ATPase dimerization and
activity
12.30-1.00
CLOSE OF COURSE
POSTER PRESENTATIONS
LUNCH&POSTERS
2.00-2.15
Opening. Orientation
Close
DEMONSTRATIONS
DEMONSTRATIONS
Welcome and course
overview
Michael Duchen (UCL),
Erich Gnaiger (MiP,
Innsbruck)
PARALLEL SESSIONS IN AV HILL:
SPONSOR PRESENTATIONS FROM
ZEISS; BMG LABTECH,
SEAHORSE
2:15
3.15-4:00
At the beginning:
mitochondria and the origins
of life
Nick Lane (UCL)
Mitochondria and calcium
signalling in health and
disease.
Michael Duchen (UCL)
DISCUSSION
FOCUS GROUPS
WITH ABCAM (G40).

EPR/ESR spectroscopy

UV/visible and FTIR Spectroscopy

Respirometry: OROBOROS Oxygraph O2K

Extracellular flux analysis: Seahorse Bioscience

High throughput imaging solutions: Molecular Devices

Luminescent probes: aequorin and luciferase

Confocal imaging (x5)

Luxcel Assays: Metabolism and mitochondrial function
TEA/COFFEE
4.30-5.30
6.00
Chemiosmotic coupling;
structures and mechanisms
of the respiratory enzymes.
Peter Rich (UCL)
WELCOME MIXER/ DRINKS
NIBBLES IN THE GRANT MUSEUM
Oxidative stress and human
disease.
Mike Murphy
(MRC MBU Cambridge)
FREE EVENING
Clinical approaches to
mitochondrial Disease
Massimo Zeviani
(MRC MBU Cambridge)
COURSE DINNER (BY BOAT ON
THE THAMES)
Michael Duchen &
Gyorgy Szabadkai
Mitochondria, telomeres and
ageing
Joao Passos (Newcastle)
FREE EVENING