CURRICULUM VITAE SCOTT TILLEM Tillem CV page 1 Revised 04/2015
[email protected] B13 Kirtland Hall 2 Hillhouse Ave. New Haven, CT 06511 EDUCATION 2015 – Present Yale University; New Haven, Connecticut Ph.D. Candidate, Clinical Psychology 2009 – 2013 Case Western Reserve University; Cleveland, Ohio BA, Triple Major (Overall GPA: 3.88) Cognitive Science (GPA: 3.80) Psychology (GPA: 4.00) Sociology: Crime and Delinquency Concentration (GPA: 4.00) PROFESSIONAL EMPLOYMENT 2013-‐2015 Research Associate Clinical Sciences Division, Lieber Institute for Brain Development; Baltimore, Maryland Principle Investigator: Caroline Zink, Ph.D. Project: The Effects of Oxytocin and Vasopressin on the Neural Responses to Social Attention Cues Individuals suffering from a variety clinical disorders (most notably Autism Spectrum Disorder) display deficits, behavioral and neurological, in social cognition. Recently, the neuropeptides oxytocin and vasopressin have become of interest in the psychiatric literature as potential drug targets to treat some of these deficits in social cognition. Using data from a double-‐blind, within subject, fMRI drug study, we examined the effects of intranasally administered oxytocin and vasopressin on the neural response to social eye gaze cues in neurotypical controls. Eye gaze directionality serves as a probe for social attention, which is an important aspect of human social cognition. My responsibilities for this project included: Writing and editing MATLAB scripts for analysis of the behavioral and fMRI data Preprocessing the fMRI data using SPM8 and MATLAB scripts Performing first-‐ and second-‐level analyses on the fMRI data using SPM8 and MATLAB scripts • Extracting fMRI betas values from first-‐level general linear models and performing various behavioral and beta value analyses using SPSS • Reviewing the relevant literature • Interpreting the results from the group level behavioral and fMRI data analyses • Writing up the findings for publication as first author Project: Human Striatal Responses to Motivation vs. Reward Anticipation •
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Tillem CV page 2 Revised 04/2015
The deficits in motivation processing that are prominent in schizophrenia can be quite debilitating and make it difficult for individuals suffering from schizophrenia to function effectively in mainstream society. Unfortunately, the neurobiological basis of motivation is not well understood in neurotypical population which makes it difficult to find biologically-‐based treatments to address these motivational deficits in schizophrenic population. In an attempt to advance our understanding of neural circuitry involved motivation processing, this project utilized two novel variants of the Monetary Incentive Delay fMRI paradigm to determine the ventral striatum’s (a limbic structure which has a long association with reward-‐predicting cues) role in motivation, disentangled from reward processing (which is intact in schizophrenia). My responsibilities for this project included: •
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Writing and editing MATLAB scripts for analysis of the behavioral and fMRI data Preprocessing the fMRI data using SPM8 and MATLAB scripts Performing first and second-‐level analyses on the fMRI data using SPM8 and MATLAB scripts, including (but not limited to) parametric modulation analyses and regression analyses Reviewing the relevant literature Interpreting the results from the group level behavioral and fMRI data analyses Drafting the manuscript for publication as first author Drafting and presenting posters at the 2014 Organization for Human Brain Mapping conference and the 2014 Society for Neuroscience conference. Miscellaneous Lab Responsibilities Apart from the main projects I worked on in the lab, I was also involved in: •
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Training other lab members how to use MATLAB and SPM8 Assisting in the piloting of new fMRI paradigms at the scanner Spring 2012 Undergraduate Teaching Assistant Department of Cognitive Science, Case Western Reserve University; Cleveland, Ohio Professor: Anthony Jack, Ph.D. Class: COGS 102-‐ Introduction to Cognitive Neuroscience My responsibilities included: •
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2012-‐2013 Writing quizzes and exams Proctoring quizzes and exams Grading students quizzes, exams, presentations, and homework Gathering course materials and making them available for students Administering class when the professor was unavailable Being available to aid students in and outside the classroom as needed Undergraduate Research Assistant Department of Psychological Sciences, Case Western Reserve University; Cleveland, Ohio Neurodevelopment Research Lab Principle Investigator: Anastasia Dimitropoulos, Ph.D. Project: Facial Processing in Prader-‐Willi Syndrome Tillem CV page 3 Revised 04/2015
Recent genetics literature has suggested that individuals with the maternal uniparental disomy subtype of Prader-‐Willi Syndrome display some genetic similarities with a small but significant percent of individuals diagnosed with idiopathic autism. This fact resulted in a large scale project evaluating autistic symptomology in patients with Prader-‐Willi Syndrome. An earlier part of this project established that populations with Prader-‐Willi Syndrome exhibited similar behavioral deficits in facial processing to those found in Autism Spectrum Disorder. The goal of this study was to extend those findings by determining whether individuals with Prader-‐Willi Syndrome display an atypical neural response to facial processing, similar to that found in Autism Spectrum Disorder. This was achieved by running individuals with Prader-‐Willi Syndrome, Autism Spectrum Disorder, and neurotypical controls through a commonly used fMRI face localizer paradigm contrasting blocks of face pictures with blocks of house pictures. My responsibilities for this project included: •
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Reviewing the relevant literature Analyzing and interpreting the group level fMRI data using Brain Voyager, including within group contrasts, between group contrasts, and ANOVA interaction effects Extracting beta values from the fMRI data using Brain Voyager Analyzing and interpreting demographic data, various neuropsychological measures (e.g. SRS, Benton, and VABS), and beta values from the fMRI data using SPSS Drafting sections of the manuscript for publication as second author Drafting and presenting a poster at the 2013 Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities Miscellaneous Lab Responsibilities Apart from my work on the Facial Processing in Prader-‐Willi Syndrome project, I was also involved in: •
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2010-‐2013 Training other lab members how to use Brain Voyager and SPSS Completing literature searches on various clinical populations of interest for the lab Undergraduate Research Assistant Department of Cognitive Science, Case Western Reserve University; Cleveland, Ohio Brain Mind and Consciousness Lab Principle Investigator: Anthony Jack, Ph.D. Project: Meta-‐Analysis and Functional Annotation The function of the default mode network and its relationship with the task-‐positive network has recently been of particular interest in the neuroimaging literature, for both clinical populations and cognitive neuroscience in general. One of the more recent theories suggests that the default mode network is responsible for social and emotional processing, and that it displays an antagonistic relationship with the task positive network which is primarily involved in processes related to reasoning about the physical world/environment. The goal of this project was to use data from previous fMRI studies of various processes previously associated with the default mode network to evaluate this theory and see how it compares to other theories about the default mode network. This was completed by performing various Activation Likelihood Estimation (ALE) based meta-‐analyses on data taken from 299 fMRI papers examining various social, emotional, Tillem CV page 4 Revised 04/2015
mnemonic, and action related processes, and comparing those ALE results against the antagonistic networks the lab previously found in a resting-‐state functional connectivity analysis. My responsibilities for this project included: •
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Performing various literature searches and initial data collection Developing the data categorization system Training lab members in the use for the data categorization system Reading and categorizing the data from over 150 neuroimaging articles Compiling, organizing, and maintaining the project database Generating the ALE maps using GingerALE Analyzing and interpreting the results from the ALE maps using Caret Drafting the manuscript for the publication as first author Drafting and presenting posters at the 2013 Association for the Psychological Sciences Annual Convention and at Case Western Reserve University’s Spring 2012 SOURCE Symposium and Poster Session Miscellaneous Lab Responsibilities Apart from my work on the Meta-‐Analysis and Functional Annotation project, I was also involved in: •
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2010-‐2012 Entering and maintaining data for various lab projects Consenting participants for various lab projects Assisting in participant recruitment for various lab projects Assisted in the collection of fMRI data for multiple lab studies at the scanner Undergraduate Research Assistant Department of Psychological Sciences, Case Western Reserve University; Cleveland, Ohio Relationships, Emotion and Family Lab Principle Investigator: Arin Connell, Ph.D. My responsibilities in this lab included: •
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Performing clinical/diagnostic interviews for depression on adolescences and their parents Collecting data for various lab projects utilizing EEG/ERP and other physiological recording equipment (e.g. respiration rate, heart rate, electro-‐dermal response, and startle-‐blink response) Cleaning EEG/ERP data and other physiological recording data Collecting observation data from dyadic interactions about family life between a parent and his or her adolescent child Entering survey data into SPSS Spring 2010; Undergraduate Research Assistant 2011-‐2012 Department of Psychological Sciences, Case Western Reserve University; Cleveland, Ohio Principle Investigator: Jennifer Butler, Ph.D. My responsibilities in this lab included: •
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Developing and refining multiple experimental paradigms and scripts meant to examine negative self-‐directed emotions and risk taking behavior Recruiting, scheduling, consenting, and running participants though experimental paradigms utilizing an autobiographical recall task Organizing study finances Entering, analyzing, and interpreting data for multiple studies using SPSS Performing literature searches for various lab projects HONORS AND AWARDS 2013 2013 2013 2012 Magna Cum Laude; Case Western Reserve University The Award in Cognition and Culture; Department of Cognitive Science, Case Western Reserve University Laraine Masters Glidden Undergraduate Student Award; Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities First Place Presentation at SOURCE Symposium Poster Presentation, Social Sciences Category; Case Western Reserve University Deans High Honor Roll; Case Western Reserve University 2010-‐2012 SKILLS AND QUALIFICATIONS Computer Skills • Extensive experience with Windows XP, Windows Vista, and Windows 7 • Familiar with Unix • Expertise with Microsoft Excel, Microsoft Powerpoint, Microsoft Word, and SPSS • Proficiency with MATLAB • Experience using GingerALE for meta-‐analyses of neuroimaging data • Experience processing, examining, and analyzing fMRI data using SPM8, Caret (version 5), and Brain Voyager Miscellaneous Skills •
CPR certified PROFESSIONAL SOCIETY MEMBERSHIPS 2014 Society for Neuroscience 2013 Association for Psychological Sciences POSTER PRESENTIONATIONS 2014 Tillem, S., Pepe, L., Weinberger, D. & Zink, C. Human Striatal Responses to Reward Void of Motivation, and Motivation Void of Reward. 44th Annual Society for Neuroscience Meeting Poster Presentation. 2014 Tillem, S., Pepe, L., Weinberger, D. & Zink, C. Reward vs Motivation: Striatal Responses to Reward Cues Presented after a Target. 20th Annual Organization for Human Brain Mapping Conference Poster Presentation. 2013 Tillem, S. & Jack, A. Social Brain Meta-‐Analysis: Regional Specialization and Relationship to Anti-‐Correlated Networks. 25th Annual Association for Psychological Science Convention Poster Presentation. 2013 2012 Tillem CV page 6 Revised 04/2015
Tillem, S. & Dimitropoulos, A. Functional Differences between Prader-‐Willi Syndrome, Autism Spectrum Disorder, and Neurotypical Controls During an fMRI based Facial Processing Task. 46th Annual Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities Poster Presentation. Tillem, S. & Jack, A. The Social Brain: An ALE Based Meta-‐Analysis of Social Cognition in the Brain. Source Symposium Poster Presentation. PUBLICATIONS Research Articles: 1)
Tillem, S., Gozzi, M., Dashow, E., Thurm, A., Swedo S. & Zink, C. (In Preparation). The Effects of Intranasal Oxytocin and Vasopressin on the Human Neural Responses to Social and Nonsocial Attention Orienting Cues. 2)
Tillem, S., Pepe, L., Weinberger, D. & Zink, C. (In Preparation). Human Striatal Responses to Reward Void of Motivation, and Motivation Void of Reward. 3)
Dimitropoulos, A. & Tillem, S. (In Preparation). Altered Face Processing in Prader-‐Willi Syndrome: A Direct Comparison to Autism and Neurotypical Controls. 4)
Tillem, S. & Jack, A. (In Preparation). Meta-‐analysis of social, emotional and memory related processes and their relationship to antagonistic neural networks.