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SIGN 130 • Brain injury rehabilitation in adults
A national clinical guideline
March 2013
Evidence
KEY TO EVIDENCE STATEMENTS AND GRADES OF RECOMMENDATIONS
LEVELS OF EVIDENCE
1++
High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias
1+
Well conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias
1-
Meta-analyses, systematic reviews, or RCTs with a high risk of bias
High quality systematic reviews of case control or cohort studies
2++
High
quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the
relationship is causal
2+
Well conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the
relationship is causal
2-
Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal
3
Non-analytic studies, eg case reports, case series
4
Expert opinion
GRADES OF RECOMMENDATION
Note: The grade of recommendation relates to the strength of the evidence on which the recommendation is based. It does not reflect the
clinical importance of the recommendation.
A
B
t least one meta-analysis, systematic review, or RCT rated as 1++,
A
and directly applicable to the target population; or
body of evidence consisting principally of studies rated as 1+,
A
directly applicable to the target population, and demonstrating overall consistency of results
A body of evidence including studies rated as 2++,
d
irectly applicable to the target population, and demonstrating overall consistency of results; or
Extrapolated evidence from studies rated as 1++ or 1+
C
A body of evidence including studies rated as 2+,
directly applicable to the target population and demonstrating overall consistency of results; or
Extrapolated evidence from studies rated as 2++
D
Evidence level 3 or 4; or
Extrapolated evidence from studies rated as 2+
GOOD PRACTICE POINTS

Recommended best practice based on the clinical experience of the guideline development group
NHS Evidence has accredited the process used by Scottish Intercollegiate Guidelines
Network to produce guidelines. Accreditation is valid for three years from 2009 and is
applicable to guidance produced using the processes described in SIGN 50: a guideline
developer’s handbook, 2008 edition (www.sign.ac.uk/guidelines/fulltext/50/index.
html). More information on accreditation can be viewed at
www.evidence.nhs.uk
Healthcare Improvement Scotland (HIS) is committed to equality and diversity and assesses all its publications for likely impact on the
six equality groups defined by age, disability, gender, race, religion/belief and sexual orientation.
SIGN guidelines are produced using a standard methodology that has been equality impact assessed to ensure that these equality
aims are addressed in every guideline. This methodology is set out in the current version of SIGN 50, our guideline manual, which
can be found at www.sign.ac.uk/guidelines/fulltext/50/index.html. The EQIA assessment of the manual can be seen at www.
sign.ac.uk/pdf/sign50eqia.pdf. The full report in paper form and/or alternative format is available on request from the Healthcare
Improvement Scotland Equality and Diversity Officer.
Every care is taken to ensure that this publication is correct in every detail at the time of publication. However, in the event of errors
or omissions corrections will be published in the web version of this document, which is the definitive version at all times. This version
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Scottish Intercollegiate Guidelines Network
Brain injury
rehabilitation in adults
A national clinical guideline
March 2013
Brain injury rehabilitation in adults
Scottish Intercollegiate Guidelines Network
Gyle Square, 1 South Gyle Crescent
Edinburgh EH12 9EBA
www.sign.ac.uk
First published March 2013
ISBN 978 1 905813 98 8
Citation text
Scottish Intercollegiate Guidelines Network (SIGN).
Brain injury rehabilitation in adults. Edinburgh: SIGN; 2013. (SIGN publication no. 130). [March 2013].
Available from URL: http://www.sign.ac.uk
SIGN consents to the photocopying of this guideline for the purpose
of implementation in NHSScotland.
Contents
Contents
1Introduction.............................................................................................................................................................1
1.1
The need for a guideline.............................................................................................................................................................1
1.2
Remit of the guideline.................................................................................................................................................................1
1.3
Definitions........................................................................................................................................................................................2
1.4
Methodological limitations inherent in rehabilitation literature.................................................................................4
1.5
Statement of intent.......................................................................................................................................................................6
2
Key recommendations...........................................................................................................................................8
2.1
Assessment and treatment of mild brain injury.................................................................................................................8
2.2
Cognitive rehabilitation..............................................................................................................................................................8
2.3
Service delivery..............................................................................................................................................................................8
3
Assessment and treatment of mild brain injury................................................................................................9
3.1
Epidemiology and definitions.................................................................................................................................9
3.2
Non-specific symptoms...............................................................................................................................................................10
3.3
Prognostic factors in adults.......................................................................................................................................................10
3.4
Treatment of mild traumatic brain injury.............................................................................................................................12
4
Physical rehabilitation and management..........................................................................................................14
4.1
Gait, balance and mobility.........................................................................................................................................................14
4.2
Spasticity and muscle tone........................................................................................................................................................16
4.3
Physical therapeutic interventions..........................................................................................................................................18
4.4
Continence problems..................................................................................................................................................................19
5
Cognitive rehabilitation.........................................................................................................................................20
5.1Introduction....................................................................................................................................................................................20
5.2
Self awareness and insight.........................................................................................................................................................20
5.3Memory.............................................................................................................................................................................................21
5.4Attention...........................................................................................................................................................................................21
5.5
Executive functioning..................................................................................................................................................................22
5.6
Visuospatial functioning.............................................................................................................................................................22
5.7
Emotional processing..................................................................................................................................................................22
5.8
Comprehensive/holistic treatment programmes..............................................................................................................22
6
Rehabilitation of behavioural and emotional disorders.................................................................................. 23
6.1
Challenging or aggressive behaviour....................................................................................................................................23
6.2
Depression and anxiety...............................................................................................................................................................24
7
Communication and swallowing..........................................................................................................................27
7.1
Managing communication problems....................................................................................................................................27
7.2
Assessing and managing dysphagia......................................................................................................................................30
7.3
Oral hygiene....................................................................................................................................................................................31
8
Vocational rehabilitation.......................................................................................................................................32
8.1
Benefits of returning to work....................................................................................................................................................32
Brain injury rehabilitation in adults
8.2
Vocational rehabilitation interventions.................................................................................................................................32
9
Management of the patient in the minimally conscious or vegetative state..............................................34
9.1Definitions........................................................................................................................................................................................34
9.2
Assessing changes in conscious level....................................................................................................................................35
9.3
Pharmacological therapy............................................................................................................................................................35
9.4
Non-pharmacological therapy.................................................................................................................................................36
9.5
Surgical interventions..................................................................................................................................................................37
10
Service delivery.......................................................................................................................................................38
10.1 Inpatient care..................................................................................................................................................................................38
10.2 Community rehabilitation..........................................................................................................................................................39
10.3Telemedicine...................................................................................................................................................................................41
10.4 Discharge planning.......................................................................................................................................................................42
11
Provision of information........................................................................................................................................45
11.1 Sources of further information.................................................................................................................................................45
11.2 Checklist for provision of information to patients.............................................................................................................47
12
Implementing the guideline.................................................................................................................................48
12.1 Implementation strategy............................................................................................................................................................48
12.2 Resource implications of key recommendations...............................................................................................................48
12.3 Auditing current practice...........................................................................................................................................................48
12.4Additional advice to NHSScotland from Healthcare Improvement Scotland and
the Scottish Medicines Consortium........................................................................................................................................49
13
The evidence base...................................................................................................................................................50
13.1 Systematic literature review......................................................................................................................................................50
13.2 Recommendations for research...............................................................................................................................................50
13.3 Review and updating...................................................................................................................................................................51
14
Development of the guideline..............................................................................................................................52
14.1 Introduction....................................................................................................................................................................................52
14.2 The guideline development group.........................................................................................................................................52
14.3 Acknowledgements......................................................................................................................................................................53
14.4 Consultation and peer review...................................................................................................................................................53
Abbreviations.......................................................................................................................................................................56
Annexes.................................................................................................................................................................................58
References............................................................................................................................................................................62
1 • Introduction
1Introduction
1.1the need for a guideline
Acquired brain injury (ABI) is a significant cause of morbidity and mortality in Scotland encompassing
damage to the brain’s physiology caused by an external force or pathophysical damage resulting from nondegenerative disease states (see section 1.3). It is estimated that more than 100 out of every 100,000 people
have a traumatic brain injury (TBI) that results in difficulties that persist beyond one year post injury.1 People
who have suffered a brain injury have a higher risk of death than people hospitalised for equal durations due
to other injuries or people from the general population. In a case control study which calculated mortality
rates following brain injury in Glasgow over a 13 year period, the death rate was more than twice that for
the general Scottish population (30.99 versus 13.85 per 1,000 per year).2 Traumatic brain injuries challenge
entire family/social systems and cause stress and disruption to normal life. The subsequent constellation
of difficulties experienced by the person with the injury and their family or carers can have a longer term
impact on their ability to return to their previous level of function and quality of life. This includes their ability
to attain, or retain, employment or education.
Access to appropriate and timely specialist assessment and rehabilitation can have a positive impact on
outcome. Historically, however, services in Scotland for this patient group have been variable. Rehabilitation
to manage brain injuries can be provided by individual professionals or specialised teams across a range of
settings from primary to tertiary care but a national strategy to coordinate this care has yet to be developed.
1.2
REMIT of the guideline
1.2.1overall objectives
While SIGN 110, Early management of patients with a head injury,3 focused on the management of the
patient in the first 72 hours following an acute injury, this SIGN guideline has been developed as a companion
document and covers the longer term rehabilitation of adults in the post-acute period. Other SIGN guidelines
will also assist practitioners in this area, eg SIGN 107, Diagnosis and management of headache in adults;4
SIGN 118, Management of patients with stroke: rehabilitation, prevention and management of complications
and discharge planning;5and SIGN 119, Management of patients with stroke: identification and management
of dysphagia.6
In some people with brain injuries there may be complications that impact on rehabilitation such as preexisting cognitive impairments or epilepsy. Cognisance should be taken of these issues, however their
presence does not preclude the affected individual from rehabilitation. Management of epilepsy is covered
in SIGN 70.7
The guideline will provide recommendations, where possible, about post-acute assessment for adults over
16 years of age with brain injuries and interventions for cognitive, communicative, emotional, behavioural
and physical rehabilitation. Furthermore, evidence will be presented on important questions relevant to
patient outcomes such as optimal models and settings of care, the benefits of discharge planning and the
applicability of telemedicine. While section 3 focuses specifically on the assessment and treatment of mild
traumatic brain injury, the remainder of the guideline is not limited to particular severities of injury.
Although this guideline focuses on the person with a brain injury, professionals working with this group
should be aware of the impact the injury and subsequent problems may have on the family and wider
social network, including children, siblings, partners and friends.8 Children and siblings of the person with
the TBI may experience physical, psychological and emotional upheaval. This can have long term effects on
relationships within the family unit as well as their own cognitive and emotional development (see sections
6.1.1 and 10.2.4).
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Brain injury rehabilitation in adults
While this guideline originally aimed to present recommendations for the management of adults and
children with brain injuries, after carrying out a systematic literature review it became clear that there was
not a sufficiently robust evidence base to support recommendations for the paediatric population. The
consequences of a brain injury in a child may be very different to those in adults. The injury may interfere
not only with daily functional activity, but also with important stages of physical and cognitive growth and
development. In addition, much of the available evidence in adults describes interventions which are tailored
for the specific individuals involved. The guideline development group therefore decided it was not reasonable
to extrapolate from the evidence for assessment and intervention in adults to a paediatric population.
1.2.2target users of the guideline
This guideline will be of interest to people who have a responsibility for the management of adults with
brain injuries in primary, secondary, tertiary or independent health care or the voluntary sector. This includes
specialists with an expertise in rehabilitation medicine, nurses, allied health professionals, neurologists,
clinical neuropsychologists, neuropsychiatrists, general practitioners and managers of rehabilitation services.
It will also be of interest to individuals with personal experience of brain injury, including patients and their
carers, members of the voluntary sector and those who are keen to develop research strategies in the area
of rehabilitation.
1.3definitions
1.3.1acquired brain injury
For the purposes of this guideline, the definition of acquired brain injury used is taken from the Scottish
Needs Assessment Programme report (2000):9
“ABI implies damage to the brain that was sudden in onset and occurred after birth and the neonatal period.
It is thus differentiated from birth injuries, congenital abnormalities and progressive or degenerative diseases
affecting the central nervous system.”
This definition permits the inclusion of open or closed traumatic head injuries, and non-traumatic causes,
such as vascular incidents (eg stroke), infection (eg meningitis), hypoxic injuries (eg cardiorespiratory arrest),
or toxic or metabolic insult (eg hypoglycaemia). Although stroke is included in this definition of ABI, specific
guidance on stroke rehabilitation can be found in SIGN 118.5 Where available, evidence from non-stroke ABI
populations has been used in this guideline. In some sections, however, it has been necessary to extrapolate
from mixed populations, including those with stroke (see section 1.4.3 for further discussion of the use of
evidence in this guideline).
1.3.2traumatic brain injury
Traumatic brain injury may be defined as a traumatically induced structural injury and/or physiological
disruption of brain function as a result of an external force that is indicated by new onset or worsening of
at least one of the following clinical signs, immediately following the event:
any period of loss of or a decreased level of consciousness
any loss of memory for events immediately before or after the injury
any alteration in mental state at the time of the injury (confusion, disorientation, slowed thinking, etc)
neurological deficits (weakness, loss of balance, change in vision, praxis, paresis/plegia, sensory loss,
aphasia, etc) that may or may not be transient, or
yy intracranial lesion.
yy
yy
yy
yy
2|
1 • Introduction
1.3.3brain injury severity
Long term prognosis in people with brain injuries correlates to different extents with various factors including
levels of consciousness, duration of post-traumatic amnesia, age, gender and pre-injury education and
employment. The most widely used index of injury severity is the Glasgow Coma Score (GCS) which classifies
injuries into mild, moderate or severe categories based on level of consciousness post injury (see Table 1). It
should be noted that severity of symptoms associated with an injury may not correlate perfectly with severity
of injury as defined by GCS, so that patients with a severe brain injury may experience many of the same
symptoms as patients with a mild injury, although these may be longer lasting or result in greater disability.
Table 1: Definition of mild, moderate and severe brain injury by GCS score
Degree of brain injury
GCS score
Mild
13-15
Moderate
9-12
Severe
8 or less
Throughout this guideline definitions of injury severity have been used which match those used in the
studies which support each section, therefore, there may be some variation between the characterisation
of the terms mild, moderate and severe between different sections.
1.3.4multidisciplinary and interdisciplinary working
In the evidence reviewed for this guideline, the terms multidisciplinary and interdisciplinary are often used
synonymously, although they are not consistently defined. They both imply a holistic approach to patient
care, maximising the resources (knowledge, experience, financial and physical) available to work towards
a common goal. However, multidisciplinary and interdisciplinary are methods of practice on a continuum
ranging from discipline-specific to transdisciplinary. Given the complexity of the cases with which practitioners
will be working, the guideline development group recommends that, in the majority of cases, the integrative
approaches of interdisciplinary practice across professions and sectors would most benefit patients and
their families. It is acknowledged that there are occasions when uni-disciplinary practice is required, but the
method of sharing information and goal setting will remain interdisciplinary.
1.3.5goal setting
Goal setting in brain injury rehabilitation is used by a range of professionals to maximise patient-centred and
therapy-focused goals. Ideally, the patient should be involved in the goal setting at all times and their family
or carers included at appropriate points. These goals can also be used to aid communication and to structure
planning and decision making. The goals set should be in context for the person involved and should be
reviewed and documented regularly. Engaging patients and families in goal setting increases the number of
goals set in a wider range of areas and in particular areas that are less common in global outcome measures.10
A range of tools may be used to assist in the assessment and subsequent setting of goals, for example
the Canadian Occupational Performance Measure,11 the Functional Independence Measure/Functional
Assessment Measure (FIM/FAM)12 or the Barthel Index.13
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Brain injury rehabilitation in adults
1.4methodological limitations inherent in rehabilitation literature
There are inherent difficulties in appraising the quality of rehabilitation studies by traditional evidence
based methods. This is particularly true of the complex, experience-based treatments that predominate in
rehabilitation over medically-oriented treatments such as pharmacotherapy and surgery.14 Interventions
that involve explicit teaching, behaviour change, and/or environmental manipulations cannot typically be
hidden from the patient or the therapist, thus the removal of bias by using standard blinding procedures,
such as placebo treatment, is not straightforward. Unlike medical treatments which may be aimed at specific
symptoms, rehabilitation interventions usually target multiple or complex outcomes at the levels of activity
and participation. Identification of a primary outcome for such treatments may be impossible and even
inappropriate. Goals associated with successful treatment will vary across participants, meaning that simple
outcome measures may not provide universal and objective metrics of improvement. Moreover, a highly
meaningful intervention may appear meaningless if the wrong outcome measure is selected. Rehabilitation
interventions are often delivered by members of multiple disciplines working synergistically, complicating
the application of quality appraisal standards that do not incorporate such factors.15
1.4.1
The choice of study design in rehabilitation research
Randomised controlled trials (RCTs) where patients are randomly assigned to at least two comparison groups
are best able to control for threats to the internal validity of studies and ensure pre-treatment equivalence of
experimental and control groups, strengthening the basis for statistical inference. Completing an RCT with
an adequate sample size, appropriate randomisation techniques to account for variability in the diagnostic
conditions and a combination of patient, service and/or system level outcome measures is difficult due to
competition for rehabilitation research funding and the individual nature of brain injuries.
There are also ethical constraints in using RCTs, particularly with severely affected patients for whom clinicians
believe there are no realistic alternative interventions to specialised care. Notably for conditions in which
multidisciplinary rehabilitation has become the standard of care without systematic evidence to support it
in practice, denying services randomly in order to conduct an RCT could be considered unethical.16
Few rehabilitation-focused, observational studies control for selection bias. A systematic review of
multidisciplinary rehabilitation services in post-acute care across a range of populations concluded that
adjusting for case mix when examining the influence of two or more interventions on an outcome does
not necessarily sufficiently reduce the selection bias associated with assignment to each intervention
group.16 Adjusting for the probability of receiving the treatment is essential in non-randomised studies of
the effectiveness of rehabilitation services.
The majority of studies published describing patients with brain injury use single-case design or are small
case series, reflecting the individual nature of rehabilitation interventions, the challenges of using more
complex designs and the relative simplicity of conducting single case studies. While RCTs may suffer from
problems with applicability of results or heterogeneity of included patients or wider population, “studies of
individuals and small case series can be optimal for exploring a new treatment, for titrating therapies, for
documenting a promising variation in behavioural therapies, for enhancing knowledge of generalisation of
treatment to a new group, and to enhance understanding of why some patients respond to a treatment of
known (average) effectiveness whereas others do not, that is, for extending results of an RCT.”14
The disadvantages associated with single case design studies are well reported. These include the difficulty in
drawing cause-and-effect conclusions (limited internal validity), possible biases when interpreting outcomes
due to observer bias and bias in data collection, and crucially, the problem of generalising findings from a
single individual to a group or wider population (limited external validity). While researchers can take steps
to attempt to limit the biases associated with this design there remain difficulties in assessing behaviours
which do not reverse back to baseline after withdrawal of treatment, indicating that the treatment may not
have been the key variable affecting change. Single case studies are usually ranked at the bottom of the
traditional hierarchy of evidence.17
4|
1 • Introduction
Functional therapies tend to be safe, and due to their context-dependent nature, their effectiveness may be
better examined using observational techniques which permit natural heterogeneity. Similarly, vocational
rehabilitation interventions by definition are contextual, depending on the nature of the specific job,
employment sector, country etc.
Meta-analysis can be undertaken only if the study populations, interventions, outcomes, and study designs
are agreed to be sufficiently consistent to allow pooling of data. This has tended to limit the use of the
technique to binary outcomes from RCTs. One systematic review notes that “while dichotomous data (for
example return to work) might reasonably be pooled, most outcome instruments which are commonly used
to assess activity and participation are in the form of ’long ordinal’ scales. There are significant concerns
about the validity of either treating these as continuous data or reducing them to binary outcomes. We
expected that there would be too much clinical heterogeneity among the studies, particularly with regard
to outcome measures (diversity of assessment tools, timing of measurements, presentation of results) to
make quantitative analysis possible.”18 Nevertheless, some authors have pooled data using a range of study
designs and making a range of assumptions about the quality of the data. In such cases, individual decisions
were made by the guideline development group about grading of these meta-analyses based on the volume
of included evidence with different study designs and attempts to maximise validity and reduce sources of
methodological bias.
1.4.2
Specific problems of brain injury populations
The evidence base in specific areas is small, for example in the management of challenging behaviour. Reasons
for this may be that staff are understandably not tolerant of aggression and fear entry into a trial will delay
treatment, the patients are not usually in a position to give informed consent, symptoms of agitation and
aggression fluctuate and the population of patients with ABI is very heterogeneous.19
Psychosocial, behavioural, exercise and/or educational interventions are fundamentally different from
pharmacological therapies as they are a function of the attention and activity of the individual rather
than the action of an external agent. Interventions tend to be multifactorial, context-dependent and vary
according to the motivations, values, thoughts and environmental situation of the patient. The conduct of
interpersonal therapeutic interventions can often depend on the development of a complex relationship
between patient and therapist, which can make distinguishing treatment efficacy from the characteristics
of those delivering it challenging.
The various challenges to conducting valid research which is sufficiently powered to establish clinical
effectiveness across a diverse population are outlined in the previous sections. These partially account for the
paucity of high quality evidence in the field of brain injury rehabilitation. It should be pointed out that, while
a lack of evidence is not synonymous with evidence for no clinical effect, in many cases the evidence base
to make firm recommendations either in support or contrary to an intervention is not available. While this
situation may be frustrating to therapists who have anecdotal daily demonstrations of effective rehabilitation
practices, it does not allow these to be recorded in an evidence based guideline which is reliant on objective,
repeatable measures of benefit.
1.4.3selection of evidence in this guideline
Evidence was identified in accordance with standard SIGN methodology, which matches the results of
systematic literature searches to a model for each key question that specifies the populations, interventions,
comparisons and outcomes (PICO) of interest to each question (see Annex 1). In this way, evidence which
included only individuals with brain injuries was identified and assessed for inclusion in the guideline. Due
to the paucity of direct evidence, the guideline development group also agreed to consider evidence which
included mixed populations of patients as long as they included some with brain injuries. Thus, for some
sections of the guideline, there is evidence cited which may include patients with other diagnoses, such as
stroke or multiple sclerosis.
|5
Brain injury rehabilitation in adults
While the volume of evidence available describing rehabilitation of patients following stroke far outnumbers
that in non-stroke brain injury, the guideline development group noted that these two etiologies are likely
to lead to different patterns of impairments that may be differentially receptive to rehabilitation during
treatment post injury. Therefore, it was decided not to use evidence in this guideline which described only
stroke patients in the absence of any other diagnoses.
1.5
Statement of intent
This guideline is not intended to be construed or to serve as a standard of care. Standards of care are
determined on the basis of all clinical data available for an individual case and are subject to change
as scientific knowledge and technology advance and patterns of care evolve. Adherence to guideline
recommendations will not ensure a successful outcome in every case, nor should they be construed as
including all proper methods of care or excluding other acceptable methods of care aimed at the same
results. The ultimate judgement must be made by the appropriate healthcare professional(s) responsible
for clinical decisions regarding a particular clinical procedure or treatment plan. This judgement should only
be arrived at following discussion of the options with the patient, covering the diagnostic and treatment
choices available. It is advised, however, that significant departures from the national guideline or any local
guidelines derived from it should be fully documented in the patient’s case notes at the time the relevant
decision is taken.
1.5.1prescribing oF licensed medicines outwith their marketing authorisation
Recommendations within this guideline are based on the best clinical evidence. Some recommendations
may be for medicines prescribed outwith the marketing authorisation (MA) also known as product licence.
This is known as ‘off label’ use.
Medicines may be prescribed off label in the following circumstances:
yy
yy
yy
yy
for an indication not specified within the marketing authorisation
for administration via a different route
for administration of a different dose
for a different patient population.
An unlicensed medicine is a medicine which does not have MA for medicinal use in humans.
Generally the off label use of medicines becomes necessary if the clinical need cannot be met by licensed
medicines within the marketing authorisation. Such use should be supported by appropriate evidence and
experience.20
“Prescribing medicines outside the conditions of their marketing authorisation alters (and probably increases)
the prescribers’ professional responsibility and potential liability”.20
The General Medical Council (GMC) recommends that when prescribing a medicine off-label, doctors should:
yy b
e satisfied that such use would better serve the patient’s needs than an authorised alternative (if one
exists)
yy be satisfied that there is sufficient evidence/experience of using the medicines to show its safety and
efficacy, seeking the necessary information from appropriate sources
yy record in the patient’s clinical notes the medicine prescribed and, when not following common practice,
the reasons for the choice
yy take responsibility for prescribing the medicine and for overseeing the patient’s care, including the
monitoring the effects of the medicine.
Non-medical prescribers should ensure that they are familiar with the legislative framework and their own
professional prescribing standards.
6|
1 • Introduction
Prior to any prescribing, the licensing status of a medication should be checked in the current version of the
British National Formulary (BNF).20 The prescriber must be competent, operate within the professional code
of ethics of their statutory bodies and the prescribing practices of their employers.21
1.5.2additional advice to nhsscotland from HEALTHCARE improvement scotland and the
scottish medicines consortium
Healthcare Improvement Scotland processes multiple technology appraisals (MTAs) for NHSScotland that
have been produced by the National Institute for Health and Clinical Excellence (NICE) in England and Wales.
The Scottish Medicines Consortium (SMC) provides advice to NHS Boards and their Area Drug and Therapeutics
Committees about the status of all newly licensed medicines and any major new indications for established
products.
SMC advice relevant to this guideline is summarised in section 12.4.
|7
Brain injury rehabilitation in adults
2
Key recommendations
The following recommendations were highlighted by the guideline development group as the key clinical
recommendations that should be prioritised for implementation. The grade of recommendation relates
to the strength of the supporting evidence on which the evidence is based. It does not reflect the clinical
importance of the recommendation.
2.1
Assessment and treatment of mild brain injury
B
Patients presenting with non-specific symptoms following mild traumatic brain injury should be
reassured that the symptoms are benign and likely to settle within three months.
2.2cognitive rehabilitation
D
Patients with memory impairment after TBI should be trained in the use of compensatory memory
strategies with a clear focus on improving everyday functioning rather than underlying memory
impairment.
yy For patients with mild-moderate memory impairment both external aids and internal strategies
(eg use of visual imagery) may be used.
yy For those with severe memory impairment external compensations with a clear focus on
functional activities is recommended.
DIn the post-acute setting interventions for cognitive deficits should be applied in the context
of a comprehensive/holistic neuropsychological rehabilitation programme. This would involve
an interdisciplinary team using a goal-focused programme which has the capacity to address
cognitive, emotional and behavioural difficulties with the aim of improving functioning in
meaningful everyday activities.
2.3service delivery
B
For optimal outcomes, higher intensity rehabilitation featuring early intervention should be
delivered by specialist multidisciplinary teams.
Planned discharge from inpatient rehabilitation to home for patients who have experienced an
D
ABI provides beneficial outcomes and should be an integrated part of treatment programmes.
8|
3 • Assessment and treatment of mild brain injury
3
Assessment and treatment of mild brain injury
This section describes the post-acute assessment of patients who later present to primary care services
complaining of ongoing symptoms in the aftermath of mild traumatic brain injury (MTBI).
3.1epidemiology and definitions
The incidence rate of mild brain injury varies substantially depending on the specific definition used and the
population studied. The point at which the minimum criteria are set for distinguishing between brain injury,
as opposed to a head injury in which the brain was unaffected, will have a significant effect on the incidence
rate as milder injuries are much more common. Worldwide, the incidence rates for MTBI are between 100300 per 100,000 population with mild injuries accounting for between 70-90% of all TBIs.22 Incidence figures
from Scotland are consistently at the upper end of this range.1, 23-25
The definition of what constitutes an MTBI varies. Differing criteria including measures of GCS, duration of
total loss of consciousness and duration of post-traumatic amnesia have been recommended and adopted in
different settings. Following comprehensive review of the scientific literature the World Health Organisation
(WHO) recommended the following definition:26
“Mild traumatic brain injury is an acute brain injury resulting from mechanical energy to the head from
external force. Operational criteria for clinical identification include:
2++
(i).One or more of the following: confusion or disorientation, loss of consciousness for 30 minutes or
less, post-traumatic amnesia for less than 24 hours, and/or other transient neurological abnormalities
such as focal signs, seizure, and intracranial lesion not requiring surgery;
AND
(ii). GCS score of 13-15 after 30 minutes post head injury or later upon presentation for health care. These
manifestations of MTBI must not be due to drugs, alcohol, medications, caused by other injuries
or treatment for other injuries (eg systemic injuries, facial injuries or intubation), caused by other
problems (eg psychological trauma, language barrier or coexisting medical conditions) or caused
by penetrating craniocerebral injury”.
Clinicians need to be aware that this imposes a categorical definition for convenience of clinical decision
making on a dimension of severity. Whilst the vast majority of injuries will be easily classified within this
definition there will be injuries which lie at the cusp of the definition which may require separate consideration
to the general guidance contained below; in particular, injuries where there is skull fracture, or substantive
haematoma (this is sometimes referred to as complicated mild brain injury), are not generally considered
as mild.
The description of acute assessment of severity is described within SIGN guideline 110.3 The criteria will
require to be applied retrospectively when reviewing patients after the acute phase. The assessment of posttraumatic amnesia can be made retrospectively but may, in some circumstances, be less reliable. Review of
emergency department (ED) records (or discharge letter) may be required, as may supplementary questions
about patients’ behaviour during any putative amnestic period; for example, to determine if they had shown
evidence of goal-directed behaviour that would indicate the presence of intact cognitive function, such as
managing to go to work.
B
The diagnosis of mild traumatic brain injury should be made according to WHO task force
operational criteria, subject to clinical judgement when complicating factors are present, eg skull
fracture, seizures, or a haematoma.
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Brain injury rehabilitation in adults
3.2non-specific symptoms
Almost all patients experiencing an MTBI will report any of a wide range of symptoms in the aftermath.
These typically consist of headache, fatigue, sleep disturbance, irritability, dizziness, subjective cognitive
impairments, sensitivity to light and noise, nausea and depersonalisation.
Such symptoms are non-specific in nature and occur at similar rates after other forms of physical trauma.
There is no consistent picture as to their causality. In particular, currently available evidence does not 2++
support neuronal damage as the main underlying mechanism but a range of other factors, including pain
and distress, may be involved.27
Such symptoms are often referred to as ‘post-concussional syndrome’ (PCS) and there are definitions for
this condition in the International Classification of Diseases (ICD-10) and Diagnostic and Statistical Manual
of Mental Disorders (DSM-IV). However, the definitions vary and causal implications of the term postconcussional syndrome are not supported by evidence as there is no specificity to the syndrome which
is found in a range of conditions including other physical trauma, chronic pain disorders, chronic fatigue
syndrome and mood disorders.
3.3
sing ‘post-concussional syndrome’ as a diagnostic term may imply a mechanism of neuronal damage
U
that is not supported by the available evidence. A wider formulation of all relevant factors to the
patient’s symptoms is more appropriate.
ProgNOSTIC FACTORS in adults
In the overwhelming majority of cases symptoms will remit within two to three months of injury.27 In a small
minority, symptoms may be more prolonged but in such cases the determinants of disability appear to be
2++
personal and social factors and not related to the brain injury. Litigation has been consistently identified as
a poor prognostic factor (see section 3.3.2).27 Recall bias is a common problem and pre-existing symptoms
may be subsequently misattributed to MTBI.27
3.3.1
NON-SPECIFIC SYMPTOMS
Persistent physical illness, prior neurological disease, prior head injuries, mood and anxiety disorders, being a
student, sustaining the injury in a motor vehicle accident and age over 40 years have been cited as predictive
++
of poor prognosis.1, 27 In general, the nature of the MTBI itself is not predictive of outcome except for those 2
3
MTBIs which are complicated or on the cusp of being graded as moderate (see section 3.3.2). A limited number
of studies in the elderly (aged over 70 years) suggest poorer outcome.27
B
Patients presenting with non-specific symptoms following mild traumatic brain injury should be
reassured that the symptoms are benign and likely to settle within three months.
3.3.2
onsideration should be given to alternate diagnostic explanations for ongoing symptoms post
C
MTBI, eg coincidental mood disorder or thyroid disease, and further investigation may be warranted.
Other secondary pathologies which are consequences of the original injury but not associated with,
or dependent on, any brain injury may occur in the context of a head injury, eg benign positional
paroxysmal vertigo, and should be treated accordingly.
COGNITIVE DEFICITS
In adults, evidence consistently suggests there are no MTBI-attributable cognitive deficits beyond three ++
2
months after injury. However, those with complicated MTBI, ie with associated skull fractures or intracranial 2+
lesions may have significant cognitive deficits.27, 28
10 |
3 • Assessment and treatment of mild brain injury
False positives on cognitive testing can be a problem. Effort tests have been developed for use in psychometric
examinations which evaluate whether a patient’s poor score on cognitive testing is likely to represent a
false positive due to poor effort. A number of such tests have been developed but no recommendation can 2++
be made on the superiority of one test over another. The British Psychological Society has discussed this in 4
greater detail.29 A systematic review, which identified seven studies using tools to assess malingering and
incomplete effort, showed that litigation was the only consistently identified poor prognostic factor.27 It is
not possible to distinguish between malingering and poor effort for valid reasons using such tests.
B
Referral for cognitive (psychometric) assessment is not routinely recommended after MTBI.
If a cognitive assessment has been conducted clinicians should be aware that false positives can
occur and that results may be unreliable in the absence of effort testing.
3.3.3mood and anxiety disorders
Cohort studies have consistently identified post-traumatic stress disorder (PTSD) and other psychiatric
disorders as contributing to the disability present in both military and civilian cohorts following reported
MTBI.30-35 These studies support the view that while an incident that causes an MTBI (eg motor vehicle 2++
accident or assault) may result in some short term symptoms, these usually resolve over time. It is argued 3
that such an incident, rather than the MTBI, is the main factor resulting in the development of longer term
PTSD symptoms. The evidence suggests that any resulting association between MTBI and PTSD symptoms
is therefore not causal.
C
As PTSD and other psychiatric disorders may contribute to the overall burden of symptoms in
some individuals following MTBI, particularly where problems persist for more than three months,
mental state should be routinely examined with an emphasis on symptoms of phobic avoidance,
traumatic re-experiencing phenomena (eg flashbacks and nightmares) and low mood.
3.3.4
NEUROLOGICAL DISORDERS
In a well conducted Scottish cohort study which followed up 549 patients admitted to hospital following a
head injury (two thirds of which had mild injury), pre-existing brain illness was present in 28% of patients, 3
30% had a previous head injury and 28% had physical limitations at time of injury.1
3.3.5
SUBSTANCE MISUSE
In the Scottish cohort study described in section 3.3.4, excessive alcohol consumption was a clinical problem
3
at the time of injury in 39% of patients.1 (SIGN 74, The management of harmful drinking and alcohol dependence 4
in primary care makes recommendations on screening and detection).36
D
Assessment and consideration of pre-existing health variables such as previous neurological
disorders and substance misuse should be carried out for all patients with MTBI.
3.3.6intracranial pathology
Delayed presentation of intracranial pathology is rare after MTBI. When such deterioration happens it normally ++
2
occurs within 24 hours of injury, deterioration after 21 days post injury is exceptionally rare (0.1% of cases).37
Nevertheless, MTBI is a very common occurrence and, in a very few patients, will be the result of a developing
neurological condition. For example, a developing brain tumour may cause loss of balance and predispose to
a fall. Clinicians should be vigilant to such alternative diagnoses because of the potentially serious implications
of missing them. New-onset focal neurological signs or deteriorating consciousness should be an indication
for further appropriate investigation.
B
Cranial imaging is not routinely recommended for the assessment of post-acute mild brain injury,
but should be considered in an atypical case.
| 11
Brain injury rehabilitation in adults
3.3.7
BLOOD MARKERS
One systematic review identified no evidence to support use of any specific blood chemistry markers as a ++
2
prognostic tool for the assessment of individuals with mild brain injury.27
3.4treatment of mild traumatic brain injury
No evidence was identified that uncomplicated symptoms should be treated differently in the MTBI population
from the general population. For example, SIGN guideline 107 makes recommendations on diagnosis and
management of headache in adults.4
3.4.1
Educational interventions
A systematic review did not find strong evidence that any non-surgical treatment has a clinically important
effect on symptoms or disability after MTBI.38 The review identified a small number of studies on early
intervention which provided some evidence that early, limited, educational intervention and providing 1++
reassurance about the lack of brain damage and the high probability of a good recovery, coupled with advice
and encouragement on gradual return to regular activities, reduce long term complaints. Routine provision
of intensive assessment and treatment is not additionally beneficial.
Another two systematic reviews which considered some of the same evidence noted that of 10 RCTs
identified concerning educational interventions, six showed no benefit and only three showed improvement
in symptoms. These trials were generally of poor quality and the authors note that the effectiveness of 1++
such interventions has been previously overstated. Nevertheless, non-randomised studies also included
in the reviews supported a potential benefit for information provision, reassurance and educational
approaches.39,40
CAll patients should be offered reassurance about the nature of their symptoms and advice on
gradual return to normal activities after uncomplicated mild traumatic brain injury.
3.4.2
Pharmacological interventions
One systematic review identified eight studies of pharmacological interventions in patients with MTBI.41 The
indications for pharmacotherapy were diverse including headache, cognitive dysfunction and post-MTBI
depression. Four involved amitryptyline and two included sertraline. Three of the four studies involving
amitriptyline showed either no benefit in the symptoms of patients with MTBI, or poorer performance than
patients without MTBI. In two studies patients without MTBI exhibited greater improvement of depressive
+
symptoms than patients with MTBI.42,43 In an evaluation of amitriptyline as a treatment for headaches 2
associated with depression 100% of patients in the depressed group without MTBI reported headache
improvement following four weeks of amitriptyline while none of the patients in the group with depression
and MTBI improved (p<0.001).44 Only one study found headache symptoms decreased substantially for
patients with MTBI treated with amitriptyline.45 In contrast, sertraline was associated with significant
improvement in depression, anger, aggression, functional disability, PCS and cognition in MTBI patients. It
should be noted that the studies reporting positive results in MTBI patients used a ‘pre-post’ design rather
than RCT and may therefore be overestimating the effectiveness.
C
3.4.3
Antidepressants may be considered for symptom relief after MTBI.
Psychological intERventions
A systematic review of psychological treatments found 10 studies of cognitive behavioural therapies (CBT),
including three RCTs. The studies, in general, were small and had short duration of follow up, so although 1++
robust conclusions could not be drawn the authors concluded there was some evidence that CBT may be
effective in the treatment of persistent symptoms (beyond three months duration) after MTBI.40
12 |
3 • Assessment and treatment of mild brain injury
Another systematic review identified nine studies which assessed the effects of neuropsychological
rehabilitation in patients with MTBI, although only two studies were RCTs.46 Interventions, methods and
evaluation tools varied in every study making it difficult to integrate results. The authors concluded that
the quantity and quality of evidence was too limited to allow specific recommendations to be formed on 1+
neuropsychological rehabilitation for patients with MTBI. The review identified five RCTs which demonstrated
the effectiveness of educational programmes for patients with MTBI and their family members in reducing or
preventing symptoms, but not necessarily improving neuropsychological function. The authors suggested
that educational programmes should start as soon as possible following injury, be simple precise and
adaptable to the individual and where possible, be presented in written form.
CReferral for cognitive behavioural therapy following MTBI may be considered in patients with
persistent symptoms who fail to respond to reassurance and encouragement from a general
practitioner after three months.
| 13
Brain injury rehabilitation in adults
4
Physical rehabilitation and management
Few data are available on the long term physical consequences of moderate to severe TBI. People who
have suffered a brain injury have a higher risk of death than people hospitalised for equal durations due to
other injuries or people from the general population2 and there is a high prevalence of residual disability
arising from brain injury.47 It has been reported that 90% of people with TBI admitted for rehabilitation
will experience one or more problems in the areas of physical functioning and community integration.48
Physical deficits such as altered muscle tone, impaired balance, impaired coordination, impaired sensation,
muscle weakness and impaired motor control impact on activity and participation. At two years post TBI
these problems reduce only slightly, with 84% and 77% still experiencing problems with physical function
and community integration respectively.48 However, rehabilitation can be effective in this population with
studies reporting a significant majority achieving independent ambulation at five months post severe TBI.49
4.1gait, balance and mobility
A key goal, both for people with TBI and members of the multidisciplinary rehabilitation team, will be the
recovery of mobility and there are a number of strategies used to address this goal. In general, there is a
paucity of research relating solely to the TBI population and therefore some recommendations have been
derived from evidence which included mixed diagnostic groups, such as stroke, multiple sclerosis, cerebral
palsy and other central nervous system (CNS) disorders.
4.1.1
Treadmill Training and Gait
Treadmill training (TT) is a form of task specific gait re-training that allows the patient to practise walking
at different speeds, at various inclines and with the potential for partial support of body weight by use of a
harness. While TT for people with neurological impairments has received considerable attention in the past
20 years, on a practical level it can be challenging and labour intensive to deliver this intervention.
No systematic reviews were found that solely looked at TT for people with TBI. Two systematic reviews which +
2
included heterogeneous populations showed that partial body weight supported TT gave no added benefit 3
over conventional gait training.50, 51
One small study investigated body weight supported TT compared to conventional gait training in people 1
with TBI and found that conventional training was more effective in improving gait symmetry than TT.52
A small RCT compared the Lokohelp electromechanical gait device to overground walking in 16 people
of whom 12 had a TBI.53 Both interventions resulted in improved gait ability and gait velocity. However, 1+
significantly fewer therapists were required with Lokohelp than for overground walking.
CPatients with TBI receiving gait training should not undergo treadmill training in preference to
conventional overground training.
4.1.2
Orthoses and gait
Orthoses may be off-the-shelf or custom made to improve ankle-foot alignment and other physical
impairments that have a negative impact on gait ability. Ankle foot orthoses (AFOs) are the most commonly
prescribed devices to improve gait for people with TBI.
A systematic review of studies in people with hemiplegia found that an AFO might result in immediate
kinematic and spatiotemporal improvements in gait (velocity, stride length, gait pattern and walking +
2
efficiency), but there was inconclusive evidence relating to the effects of AFO use on muscle activity.54 Two
of the included studies reported significant reductions in plantarflexion during swing phase and increased
dorsiflexion at heel strike. One study demonstrated less foot inversion at heel strike.
14 |
4 • Physical rehabilitation and management
4.1.3
Task-Specific and Repetitive Task Training
Task-specific training refers to interventions designed to improve specific tasks: these interventions may or
may not be intensive in nature. Repetitive task training is often used to describe an intervention that is both
task-specific and intensive and repetitive in nature.
A systematic review identified moderate evidence from one RCT (n=45) to support fine motor control
retraining, including functional tasks, resulting in improved fine motor coordination.50 The review also 1+
included a small RCT (n=22) which showed that sit-to-stand retraining improved the functional ability of
this task but had no effect on exercise capacity.
A small RCT found that repetitive task training using an electromechanical gait training device was beneficial +
1
for improving walking ability for people with TBI or stroke.53
A systematic review identified five studies of mixed quality that investigated the effects of intensity of
rehabilitation for people with TBI and found that there were medium term benefits in terms of improvement 1++
of functional skills for people receiving more intensive rehabilitation.55
BRepetitive task-oriented activities are recommended for improving functional ability, such as sitto-stand or fine motor control.
4.1.4
Physical fitness training
Regular fitness training is a relatively recent addition to the therapies available for people with TBI. While
physical fitness training can be regarded as safe and acceptable, historically some therapists may have
avoided this form of intervention for fear of inducing unwanted negative effects relating to muscle tone and
spasticity. Three systematic reviews provide evidence for physical fitness training in TBI patients.
One systematic review identified six RCTs investigating fitness training mostly in patients with TBI meeting
their quality criteria. These studies included 303 patients but were clinically diverse with regard to the 1++
interventions, time post injury and the outcome measures used. Only one study showed an improvement
in fitness. No meaningful improvements in any other motor parameter were noted.56
Another systematic review of 14 studies included four exclusively in patients with TBI. Benefits in cardiovascular
fitness following fitness or aerobic training for people with moderate-severe TBI were noted. However, these 1++
benefits did not translate to improved activity or participation levels. A reduction in depression was also
noted.55
A third systematic review identified eight studies investigating the effects of aerobic training on aerobic
capacity post TBI and reported that all studies identified at least one positive outcome.51 An RCT included
3
in this review (n=157) compared a 12 week exercise programme against a 12 week relaxation programme
and demonstrated a significant increase in work rate by the exercise group. This increase in work rate did
not translate to improved functional ability.
Benefits of fitness training have not shown specific effects on impairments of motor function or spasticity
but it has been suggested that regular fitness training, of a sufficient intensity will improve some of the
common physical and psychosocial sequalae of TBI.56, 57
4.1.5
Virtual Reality Training
Virtual reality training is an emerging area in rehabilitation enhanced by the development and popularity
of commercially available, interactive computer gaming devices. As such, there is limited evidence relating
to this therapy.
A systematic review conducted mostly in stroke patients found that there was insufficient robust evidence
3
to support virtual reality interventions in acquired brain injury rehabilitation.58
One study (n=20) included a small number of people with TBI and found that both conventional balance
retraining and balance retraining incorporating the use of a WiiTM Balance Board showed improvements over 1time with no significant differences between the groups.
| 15
Brain injury rehabilitation in adults
4.1.6walking aids
No evidence was identified relating to use of walking aids and recovery of mobility post TBI. Similar to
guidance for people with stroke in SIGN 118,5 it is suggested that individual patients with TBI may benefit from
using a walking aid. If walking aids improve confidence, gait efficiency, balance, functional independence,
and safety, they could provide a cost-effective intervention. However, walking aids may have adverse effects
on gait pattern, safety and the achievement of independent walking (without an aid). At present there is
insufficient evidence to assess the size of these potential impacts.
Walking aids should be considered only after a full assessment of the potential benefits and harms
of the walking aid in relation to the individual patient’s physical status and cognitive ability.
4.2spasticity and muscle tone
Data regarding the prevalence of spasticity post TBI are limited, however incidence rates of up to 75% in
people with severe TBI have been reported.59
There are other motor disorders associated with TBI ranging from non-specific walking and balancing
difficulties through to severe problems affecting cerebellar or extra-pyramidal pathways. Spasticity does not
always require treatment, for example some patients with lower limb spasticity develop adaptive gait patterns
which rely upon spasticity for postural stability. When it is a problem, spasticity in TBI can be both severe
and difficult to manage, requiring multifocal interventions arising from multidisciplinary collaboration.
In TBI spasticity has similar pathophysiology to that found in certain diseases which cause the upper motor
neurone syndrome, such as stroke. It is less similar to that found in spinal cord diseases and in multiple
sclerosis. Cognitive considerations also impact on physical therapy treatments. These differences are reflected
in the individualised approach to the patient’s problems.
The multidisciplinary team in spasticity management will include input from nursing, physiotherapy,
occupational therapy, orthotists, pharmacy and surgical and medical staff and many patients will receive
multiple treatment modalities. Control of pain and review of posture and seating are vital first considerations
in spasticity management. Further details are contained in the British Society of Rehabilitation Medicine
guideline for specialised wheelchair seating.60
4.2.1
Splints, Casts, Stretches and Orthoses
Splints are generally fashioned from plastic or metal and are removable. Casts encase a limb and are made of
resin or plaster. Both casts and splints, together with regular passive stretching are employed in management
of spasticity and in the mitigation of resulting deformities.
Five systematic reviews of different stretching treatments were identified.50,55,61-63 The quality of reviews
was good, however the quality of the studies examined in these reviews was highly variable as were the 1++
interventions and target populations. The evidence shows that whilst clinically significant improvements are 2+
made in short term outcome measures at some joints using each of these types of treatment these benefits 3
are quickly lost once treatment is discontinued.
Further evidence has reinforced that beneficial effects of physical rehabilitation interventions for spasticity
are often not preserved in the medium or long term. One trial (n=26) showed that casting reduced elbow
flexion contracture by an average of 22 degrees (95% confidence interval (CI) 13 to 31 degrees; p<0.001) 1+
compared with the positioning (control) group. One day later this effect had decreased to 11 degrees (95%
CI, 0 to 21 degrees; p=0.052). The effect had almost completely disappeared at the four-week follow up
(mean 2 degrees, 95% CI -13 to 17 degrees; p=0.782).64
16 |
4 • Physical rehabilitation and management
One further RCT (n=35) compared two interventions, lower leg casting plus injections with either saline or
botulinum toxin, to controls receiving usual care.65 Casting with or without botulinum neurotoxin therapy
1+
(BoNT) was more effective in reducing spasticity and plantigrade contracture at the ankle than usual care
alone. Outcomes were assessed immediately at the end of the period of treatment but long term outcomes
were not reported.
1++
3
Hand splinting has been reported to be ineffective.50, 55
CCasts, splints and passive stretching may be considered in cases where contracture and deformity
are progressive.
4.2.2
Botulinum Neurotoxin Therapy
Botulinum neurotoxin therapy is a widely adopted treatment for focal spasticity. Most of the evidence to
support its use derives from before and after studies in various populations, including patients with TBI.
Whether the improvements in joint position or spasticity scores seen are clinically important or cost effective
have not been addressed in clinical trials. Much use remains outwith the product licence and is customised
in a multidisciplinary team (MDT) setting to the needs of the individual.
One RCT (n=15) reported gait improvement following treatment of elbow flexion deformities in TBI patients.66
The BoNT group demonstrated a statistically significant increase in walking velocity after treatment (p=0.037) +
1
and mean modified Ashworth score was significantly reduced from 2.6 before treatment to 1.4 after treatment
(p=0.00003).
One RCT randomised 40 patients with brain injury or stroke to receive either rehabilitative motor therapy
alone (control) or motor therapy plus BoNT (intervention).67 Fugl-Mayer Assessment scores (measuring physical
ability) were higher in the intervention group at one and three months post injection (mean ±standard 1deviation) (23.36±10.69 and 35.36±11.36) than the control group (20.55±10.22 and 30.33±10.96; p<0.01)
Modified Ashworth, and Barthel scores also improved following BoNT. Some of the details of the conduct
of this study were not described.
In one RCT (n=60) where most of the participants were stroke patients BoNT was safer and more effective +
1
than tizanidine in reducing tone and deformity in wrist spasticity.68
B
BoNT may be considered to reduce tone and deformity in patients with focal spasticity.
oNT should be used in a multidisciplinary setting with physiotherapist/occupational therapist and
B
orthotic inputs where appropriate.
A multiagency national guideline on the appropriate use of botulinum toxin in the management of spasticity
in adults provides further details on many aspects of BoNT.59
4.2.3
Oral anti-spasticity medication
Oral agents used to treat spasticity in patients with brain injury include medications which act centrally
(baclofen, tizanidine, and benzodiazepines) and a medication which acts on muscle, dantrolene.
One RCT (n=17) showed tizanidine was more effective than placebo in treating both upper limb and lower +
1
limb spasticity in patients with ABI.69
A before and after comparison reported that baclofen was effective in reducing lower limb spasticity but
3
not upper limb spasticity in patients with brain injury (n=35).70
The BNF notes that baclofen should be used with caution in the following groups: patients with psychiatric
illness, Parkinson’s disease, cerebrovascular disease, respiratory impairment, epilepsy, history of peptic ulcer
(avoid oral route in active peptic ulceration), diabetes, hypertonic bladder sphincter and the elderly. Tizanidine
should be used with caution in the elderly and in those where there is concomitant administration of drugs
that prolong QT interval. The BNF also suggests liver function is monitored monthly for first four months
and, beyond this, in those who develop unexplained nausea, anorexia or fatigue.20
| 17
Brain injury rehabilitation in adults
Adverse effects noted in both drugs include drowsiness, dizziness, dry mouth, gastrointestinal disturbances
and hypotension.20 The efficacy and dosing schedules for these drugs vary unpredictably from patient to
patient.
D
4.2.4
Oral baclofen or tizanidine may be considered for treatment of spasticity.
Electrical Stimulation and Functional Electrical Stimulation
Functional electrical stimulation is a technique to correct for muscular imbalance at a joint by stimulating,
and thereby strengthening the weaker of the opposing muscle groups. No evidence regarding the use of
functional electrical stimulation interventions in patients with brain injuries was identified. There is weak 3
evidence that electrical stimulation may be effective for decreasing lower extremity spasticity for up to 24
hours.50
4.2.5Surgery
Surgical intervention is generally a last resort in spasticity management. Techniques developed from
orthopaedic surgical work on patients with cerebral palsy are sometimes applied in TBI. Only one relevant 3
case series was identified comparing two tendon transfer procedures for ankle spasticity which showed
decrease in the use of ambulatory aids and improvement in ambulatory status following both procedures.71
4.2.6
Other interventions
One case series of patients with ABI and muscle hypertonia (n=28) showed an inconclusive effect of intrathecal
baclofen on range of motion of lower extremities.72 No evidence was identified for specific occupational
therapy interventions for the reduction in spasticity. Further research into therapy modalities is required.
4.3physical therapeutic interventions
A significant proportion of patients who sustain a TBI are left with physical function problems. It is therefore
important to establish whether any therapeutic interventions are effective in regaining physical function
in these patients.
4.3.1
Upper limb function
There are limited studies which address the effect of upper limb recovery following TBI. One RCT assigned
patients with ABI to either experimental (five one-hour sessions of individualised task-specific motor therapy
in addition to 30 minutes of usual motor control therapy to shoulder and elbow five times per week) or
control (10 minutes of individualised task specific motor therapy three times a week plus 30 minutes of
+
usual motor control therapy). Hand and overall arm function of all participants improved over the six-week 1
period, however there was not a clear benefit from providing additional hand therapy.73
A systematic review found insufficient evidence to support or refute the effectiveness of any one specific
rehabilitation intervention to improve upper limb function.74 No evidence directly related to brain injury
was identified concerning the effect of constraint induced therapy on measurable components of physical
function.
4.3.2
General therapeutic interventions
A Cochrane review investigated music therapy delivered using a number of different therapeutic
interventions.75 It suggested that rhythmic auditory stimulation may be beneficial in improving elements of 1++
gait, although the relevant trials were carried out on a stroke population. Further RCTs need to be undertaken
before recommendations for clinical practice can be made.
An RCT on motor imagery effectiveness came to no conclusion about the effectiveness of this intervention
10
due to low levels of compliance of both patients and therapists.76
There is no clear evidence that any specific therapeutic interventions in patients with TBI, other than those
involving task-specific and repetitive task training (see section 4.1.3) or for managing spasticity (see section
4.2) improve measurable components of physical function.
18 |
4 • Physical rehabilitation and management
4.4continence problems
Urinary and faecal incontinence are frequently reported following neurological illness or injury and specifically
following a brain injury.77 Up to 62% of patients will have urinary incontinence issues at admission, reducing
to 18% at six months post injury.78 The frequency of faecal incontinence can be correlated to increase in
severity of a brain injury.79 Urinary disturbances are also associated with a poor overall function following
TBI, including impaired cognitive function.80,81
A Cochrane review of management of incontinence and constipation in adults with neurological diseases
reported that there was insufficient evidence to make any recommendation on the management of
1++
neurogenic bowel function.82 The review noted that, in the absence of a robust evidence base, bowel
management protocols will continue to be developed empirically using an individualised and patientcentred approach.
One very small non-comparative study (n=3) reported that voiding dysfunction can be a significant problem
following brain injury, but that it carried a good prognosis and resolves spontaneously. Treatment with 3
anticholinergics may be required in the acute phase.83
A prospective study of 20 patients with moderate or severe TBI reported that motor difficulties are more
frequent in patients with urodynamic abnormalities. The study noted that while only two patients reported
3
lower tract symptoms when screened using a questionnaire, urodynamic evaluation revealed abnormalities
in 55% of the patients. Subtle dysfunction may not be clinically evident but can be picked up on urodynamic
evaluation and may have short and long term implications.80
Further advice on the care and treatment of people with a neurological condition and urinary incontinence
can be found in NICE clinical guideline 148: urinary incontinence in neurological disease.84 It is not possible based on the evidence reviewed to make a specific recommendation for treatment of
incontinence in patients with brain injuries. However, the suggestion in studies of the influence of cognitive
impairment and incontinence would suggest that an individualised approach including behavioural
management strategies could influence a positive outcome.
F ull assessment of bladder and bowel function should be undertaken over a period of days following
admission. The physical, cognitive and emotional function of the patient should be considered and
the multidisciplinary team should be involved to plan an individualised approach.
| 19
Brain injury rehabilitation in adults
5
Cognitive rehabilitation
5.1introduction
Prevalence of cognitive dysfunction following ABI varies due to the heterogeneous nature of the studies
which report it. However, it is widely recognised that disorders of cognitive functioning resulting from brain
injury are very common and have significant long term consequences.85 Cognitive dysfunction includes
impairments in memory, attention and concentration, executive functioning (eg planning, problem solving
and self regulation), language and perception (using visual information to understand the world). Cognitive
impairment, together with disorders of mood, emotion and behaviour, is considered to be one of the most
important factors affecting a person’s ability to participate in rehabilitation, function effectively in everyday
life and return to participation in meaningful activities including work, social and leisure activities.86-88
5.1.1
Approaches to cognitive rehabilitation
A number of different strategies for the rehabilitation of cognitive impairments exist. These can be divided
into two main approaches – compensatory and restitution approaches. Compensatory approaches refer to
interventions that aim to improve functioning in everyday life by provision of some form of aid or strategy
that compensates for a deficit but does not aim to restore normal operation of the cognitive process. These
include ‘external’ aids such as diaries or electronic reminding devices or ‘internal’ strategies such as using
visual memory to compensate for a deficient verbal memory. Restitution approaches aim to restore normal
functioning, often through repetitive practice of cognitive tasks (including computerised cognitive training
packages).
Although this section addresses evidence relating to interventions for specific cognitive impairments (eg
memory, attention, executive functioning and perception), it should be noted that most interventions are not
carried out in isolation but rather in the context of a broader rehabilitation programme that also addresses
mood, emotion and behaviour (see section 6) and is focused on enabling individuals with ABI to return to
participation in meaningful activities.
There is a considerable body of evidence relating to the effectiveness of cognitive rehabilitation interventions
after brain injury including meta-analyses, systematic reviews and RCTs. Although the methodological
quality of at least some of the meta-analyses and systematic reviews is good, the quality of many of the
studies included within the reviews is reported to be poor, with only a very limited number of high quality
studies on which to base recommendations. Most of the systematic reviews have examined evidence for
interventions in relation to a number of specific cognitive domains (eg memory, attention, perception and
executive functioning), and although the overall volume of evidence is large, within each domain the volume
of evidence is small and the quality very variable.
In relation to adults with brain injury, one meta-analysis and two well conducted systematic reviews that
examine studies on interventions for a broad range of cognitive domains conclude that there is evidence for
the effectiveness of cognitive rehabilitation interventions in at least some domains of cognition.89,90,91 In most
domains, the evidence suggests that the most effective interventions are those that focus on provision of
cognitive strategies or external aids that compensate for a cognitive impairment in order to improve everyday
functioning. Those interventions that aim to reduce levels of impairment are less effective.
5.2self awareness and insight
Lack of self awareness or insight is characterised by an inability to recognise difficulties following an acquired
brain injury.90 There is ongoing debate about what the concept refers to and the degree to which it impacts
on rehabilitation and everyday functioning. Numerous explanations have supported the idea that poor self
awareness is not a unitary construct but is complex involving interacting neurocognitive, psychological and
social factors.
20 |
5 • Cognitive rehabilitation
It has been argued that there are various forms of awareness including intellectual, emergent and anticipatory.91
Unfortunately, this complexity and lack of consensus means that the term is often misunderstood and
many interventions have arguably developed out of a perceived clinical need with inadequate theoretical
grounding.92 In clinical contexts a variety of treatment approaches have been suggested, including behavioural
interventions, direct feedback, game formats, group work, structured experiments, and psychotherapy.
Despite the importance afforded this area in clinical practice, there is a very limited body of evidence
examining the effectiveness of treatment interventions, with few systematic reviews or RCTs available. A
systematic review revealed mixed findings concerning the association between awareness of deficits and
rehabilitation outcome following brain injury (four supporting studies, six with partial support and two that 1+
did not support the association). It concluded, however, that awareness deficits represent a probable barrier to 1
the client’s own goals or personally valued outcomes.93 An RCT reported that an awareness training protocol
embedded within the practice of instrumental activities of daily living significantly but selectively improved
self awareness as well as functional performance.94 The need for a larger study with more treatment sessions
was emphasised by the authors.
There is insufficient evidence available to support recommendations relating to the rehabilitation of poor
insight or self awareness.
5.3memory
There is evidence to support the use of compensatory approaches including memory strategy training
1+
and electronic aids (such as NeuroPage, personal digital assistants).95-97 There is no substantial evidence
3
that repetitive practice improves memory impairment. There is some evidence that cognitive approaches, 4
including errorless learning, may be effective in relation to learning specific information.95, 98
DPatients with memory impairment after TBI should be trained in the use of compensatory memory
strategies with a clear focus on improving everyday functioning rather than underlying memory
impairment.
yy For patients with mild-moderate memory impairment both external aids and internal strategies
(eg use of visual imagery) may be used.
yy For those with severe memory impairment external compensations with a clear focus on
functional activities is recommended.
B
Learning techniques that reduce the likelihood of errors being made during the learning of specific
information should be considered for people with moderate-severe memory impairment.
5.4attention
In relation to attention, there is evidence that impairment focused training (eg computerised attention
training) may produce small beneficial effects in the post-acute phase after TBI,97 although evidence for 2++
generalisation of these effects is weak.89,95,99 However, larger effects are found when interventions focus on 3
training-specific functional skills that make demands on attention through repetitive practice, or teaching 4
strategies that compensate for attention impairments in everyday tasks.
C
Patients with attention impairment in the post-acute phase after TBI should be given strategy
training relating to the management of attention problems in personally relevant functional
situations.
| 21
Brain injury rehabilitation in adults
5.5executive functioning
Two systematic reviews85,100 and two additional RCTs101,102 address the efficacy of interventions for executive
deficits in relation to executive functioning. All four studies show that treatment approaches based on
training patients in meta-cognitive strategies (eg training in problem solving, goal management and strategic ++
1
reasoning) are effective at improving performance in practical or functional settings. Such interventions do 1+
not necessarily restore completely normal executive functioning, but nevertheless do improve functioning 3
in everyday contexts or on tests that reflect well the demands associated with everyday problem solving,
multitasking and goal management.
B
Patients with TBI and deficits in executive functioning should be trained in meta-cognitive strategies
relating to the management of difficulties with planning, problem solving and goal management
in personally relevant functional situations.
5.6visuospatial functioning
The available evidence on visual perception related mainly to patients with stroke and almost all of the
evidence relates to the treatment of unilateral visual neglect. Evidence relating to treatment of other forms
of visuospatial deficits is limited. (SIGN 118 discusses the management of visuospatial functioning in patients
following a stroke).5
5.7emotional processing
There is limited evidence on the treatment of emotional perception deficits in ABI. Two good quality RCTs
indicate that participants significantly improved in judging basic emotional stimuli when it was presented
in a naturalistic format (video vignettes) and in making social inferences on the basis of speaker demeanour,
but small numbers of participants limit the conclusions that can be drawn.103,104 There is insufficient evidence
to recommend use of strategies to improve emotional processing.
5.8
Comprehensive/holistic Treatment Programmes
Treatment of cognitive impairment is not usually undertaken in isolation. One approach to rehabilitation
after brain injury is comprehensive/holistic neuropsychological rehabilitation. This refers to programmes that
aim to simultaneously address cognitive, emotional and behavioural difficulties in the context of a focus on
returning to participation in meaningful activities. One systematic review concluded that there was sufficient
evidence to recommend the use of comprehensive-holistic neuropsychological rehabilitation during post- 3
acute rehabilitation to minimise the impact of moderate or severe traumatic brain injury.97 A limitation of
studies of such programmes is that it is not possible to identify the specific components that lead to positive
change and improvement. However, it does appear that such programmes, which have in part an explicit
focus on addressing cognitive impairment, do improve functioning after brain injury.
D
22 |
In the post-acute setting interventions for cognitive deficits should be applied in the context
of a comprehensive/holistic neuropsychological rehabilitation programme. This would involve
an interdisciplinary team using a goal-focused programme which has the capacity to address
cognitive, emotional and behavioural difficulties with the aim of improving functioning in
meaningful everyday activities.
6 • Rehabilitation of behavioural and emotional disorders
6
Rehabilitation of behavioural and emotional
disorders
6.1challenging or agGressive behaviour
Challenging behaviours are frequent neurobehavioural sequelae of a brain injury. Behavioural disturbance
may include inappropriate vocalisation, intolerance of medical management or equipment, directed or diffuse
aggressive, disinhibited or sexualised behaviour. Agitated patients may resist direct care, be disruptive or
pose a physical risk to themselves, family and staff. Reported prevalence ranges from 10-96% of patients
with estimates varying according to the exact definition used and the setting studied. All studies recognise
that it is a major burden on care givers.
Agitated behaviour in brain injured patients may not be the result of their brain injury in itself but reflect
other factors including:
yy
yy
yy
yy
yy
yy
premorbid personality
drug/alcohol intoxication and withdrawal
mood disorder, phobic anxiety and emotional adjustment
pain
urinary retention
constipation.
6.1.1
fter acquired brain injury medically remediable causes of agitation should be excluded before
A
therapies are started. Therapies should take account not just of the nature of the brain injury but the
characteristics of the individual affected and the potential adverse effects of treatment.
Non-pharmacological interventions
A wide range of non-pharmacological interventions has been used with adults presenting with challenging
behaviours following ABI, including specifically tailored contingency management procedures based in
operant learning theory; positive behaviour interventions focusing on proactive prevention of maladaptive
behaviours through supportive work with the individual and environmental modifications; CBT; music
therapy; and comprehensive neurobehavioural rehabilitation programmes. In many cases elements of
different therapeutic models are combined in order to devise a multimodal treatment programme suited
to the needs of the individual.
Contingency management and positive behaviour interventions
Two systematic reviews identified 98 studies which adopted contingency management procedures (CMP),
positive behaviour interventions (PBI) or a combination of both.105,106 This evidence included only three
RCTs while the remaining studies were individual case reports or case series. Two trials adopted a combined 3
treatment approach with samples of patients with acquired brain injury of mixed causes but failed to find
a substantial improvement for the treatment sample relative to the control groups. The uncontrolled case
series showed inconsistent results in terms of treatment effect.
Comprehensive neurobehavioural rehabilitation programmes
A systematic review reported one study of patients with ABI of mixed causes (n=76) who presented
with persisting aggressive behaviour and were unable to live independently.107 The cohort underwent a
programme of social and neurobehavioural rehabilitation for a mean duration of 14 months. The intervention 2+
was supported by non-professional therapy care assistants, however the intensity of input and make up
of the rehabilitation team was not specified. Positive outcomes were reported in terms of improved living
arrangements, hours of care required and employment. These effects were maintained at follow up (mean=2.8
years).
| 23
Brain injury rehabilitation in adults
Cognitive behavioural therapy
A systematic review identified three observational studies which adopted CBT to treat challenging
behaviours.105 No substantive treatment effects were reported across these studies. There is insufficient 3
evidence to recommend cognitive behavioural therapy as a treatment for challenging behaviour.
Music therapy
A systematic review of music therapy following acquired brain injury highlighted one study (n=22) which
demonstrated a positive effect of listening to live and taped music on levels of agitation.75 The authors ++
1
concluded that there was insufficient evidence to support the use of music therapy for improving agitation
following ABI.
6.1.2
T he family and key members of the affected individual’s social network should be provided with
education about appropriate management of behaviour and emotion.
Pharmacological interventions
One systematic review included six RCTs evaluating propranolol and pindolol, methylphenidate or
amantadine.19 There was some evidence that the beta-blockers propranolol and pindolol can reduce aggressive
behaviour. The studies used very large doses, although no significant adverse effects were reported and ++
1
clinical experience suggests this is not usually a problem. It was notable that there were no included trials
reporting the use of antipsychotics or anticonvulsants. The authors concluded that there was insufficient
evidence on which to make firm recommendations regarding the use of these treatments, although betablockers had the best evidence for efficacy.
B or pindolol may be considered as a first line treatment option for moderate levels of
agitation/aggression.
rug treatments should be individually tailored and commenced in very low doses. The patient’s
D
progress should be monitored with surveillance for possible adverse effects.
6.2depression and anxiety
The emotional impact of brain injury can be profound. For many people, a process of emotional adjustment
to changed circumstances is required. Rates of disorders of emotion are high after brain injury. Although
estimates of the prevalence of depression and anxiety have varied widely, findings have indicated that rates of
mood disorder are typically considerably higher than in non-brain-injured populations and may occur at any
stage after a head injury.108 For some people, low mood or anxiety are transient and part of the adjustment
process. For others, symptoms may persist to the extent that they can be classified as a formal mood disorder.
Levels of disability a year after a head injury are significantly related to psychological disorders rather than
physical impairment (see section 3.2).86 There is therefore a compelling need to treat depression and anxiety
after brain injury. However, overall there is a limited body of evidence relating to the treatment of depression
and anxiety following TBI.
An important issue to consider in relation to TBI is injury severity. Although there is a broad range of severity
represented in the evidence considered, the majority of studies include participants with mild-moderate
injury. This limits the generalisability of the evidence and any recommendations, such that conclusions may
be less applicable to people with more severe injury.
Another difficulty commonly reported is emotional lability. This is the tendency for a person’s emotion to be
quick to change and to be more extreme than usual and is associated with poor self regulation of emotion.
No evidence was identified that specifically addressed the treatment of emotional lability in patients with ABI.
The literature that is relevant to the treatment of mood disorder after brain injury is varied in the extent to
which mood disorder is the primary focus of an intervention or a primary outcome measure. For example,
mood management interventions are common components of comprehensive or holistic neuropsychological
rehabilitation programmes. This presents a difficulty in relation to reviewing the evidence as the precise
24 |
6 • Rehabilitation of behavioural and emotional disorders
relationship between specific components of a comprehensive programme and outcomes are difficult to
determine. In some studies mood may not be the primary focus of an intervention programme, but may
improve as part of a rehabilitation programme that is addressing the factors that are contributing to the
development or maintenance of a mood disorder. For example, someone who is depressed as a result of
inability to return to work may be supported through a vocational rehabilitation programme to gain some
form of employment, with an associated improvement in mood. So while the therapeutic intervention was
not a traditional treatment for mood disorder (pharmacological or psychotherapy), improvement in mood
is a secondary outcome.
6.2.1depression
A survey of 666 people after TBI reported that 27% of the participants reported five or more symptoms of
depression.109 Another large single cohort study found higher rates in a sample of 559 participants followed
for up to a year post injury. They found that 53.1% of their sample met criteria for depression at some point
in the year after injury, almost eight times the rate in the general population who did not have a brain injury.
At any one point in time around 20-30% of participants were depressed.108
Pharmacological interventions
A systematic review of 13 studies (n=301) of pharmacological agents to treat depression in patients following
TBI identified only small studies which varied widely in design, diagnostic and outcome assessment, severity
of brain injury, and time post injury. The authors concluded that there was insufficient evidence on which
+
to base strong recommendations.15 However, based on weak evidence and expert opinion, the use of 1
3
sertraline in clinical practice was suggested. One RCT with 99 participants found evidence that prophylactic
administration of sertraline reduced the incidence of depression in the first year after a head injury, but
overall rates of depression were lower than usual, and no conclusions can be drawn regarding who benefits
most from the intervention.110
The evidence relating to the pharmacological treatment of depression after brain injury is inconclusive and
no specific recommendation can be made. A systematic review showed that antidepressant treatment is
more effective than placebo in treating depression in the context of a wide range of neurological conditions
including stroke, Parkinson’s disease, epilepsy, multiple sclerosis and brain injury, although this review which 1++
included 20 RCTs only involved one study with patients who had suffered brain injury. Of eight adverse
effects reported to be associated with antidepressant use only dry mouth was statistically more common
in intervention groups than controls (odds ratio 2.41, 95% CI 1.32 to 4.40).111
Psychological interventions
A systematic review of interventions in patients following TBI included eight studies, most of which were
uncontrolled, and which involved widely different treatment models. Although all studies included both
pre- and post-treatment measures of depressive symptoms (an inclusion criterion for this review), none
of them were designed specifically to evaluate treatments for depression. The authors concluded that no
recommendations regarding psychological interventions could be made. They noted that depression was 3
improved in the context of multimodal interventions and that cognitive behavioural interventions appeared
to have the best preliminary evidence, but in the absence of clear evidence relating to the specific individual
elements which might impact on depressive symptoms among these complex treatments, many of which
were deliberately multifaceted and not directly targeted at depression originally, no specific recommendations
could be made.15
Three RCTs of telephone counselling interventions reported different findings. One study of people after
admission to an ED found no significant benefit of the telephone intervention (five phone calls over a 12-week
period) in terms of psychological symptoms at six months.112 By contrast, another trial reported significant 1+
++
benefit in people with more severe injury who received seven calls over nine months when followed up at 1
one year.113 A third, multicentre, study found no effect of a scheduled telephone intervention over either
one or two years although this study did not separate data on depression and anxiety.11
| 25
Brain injury rehabilitation in adults
One non-randomised controlled trial of 20 participants found a strong effect on measures of distress including
depression, anxiety and stress from a CBT intervention delivered either via a group (n=5) or by telephone (n=5)
when compared with an education control also delivered either via a group (n=5) or telephone (n=5).115 The
interventions were delivered over nine weeks, followed by a one month follow up. The CBT intervention is 2+
described as being an individually tailored intervention taking into account participants’ cognitive impairment.
However, the lack of randomisation and very small sample size in each subgroup limits the conclusions that
can be drawn from this study.
The evidence relating to the psychotherapeutic treatment of depression after head injury is inconclusive
and therefore no specific recommendation can be made. General guidance is available in SIGN 114 on the
non-pharmaceutical management of depression in adults.116
6.2.2anxiety
A Cochrane review noted that anxiety symptoms occurred following TBI with a frequency ranging from
18% to 60%.117 Studies examining specific anxiety disorders have found that in people with brain injury,
24% to 27% were diagnosed with generalised anxiety disorder and 4% to 6% with panic disorder.118,119 An
observational study found that 27.1% of patients who sustained a severe TBI had developed post-traumatic
stress disorder at six months after the injury.120
Pharmacological interventions
No evidence was identified on the use of pharmacological interventions to reduce anxiety in patients with
brain injuries.
Psychological interventions
One Cochrane review identified three trials meeting initial review inclusion criteria, of which two (with a total
of 44 participants) were of good quality.117 It concluded that there was some evidence to support CBT for the
++
treatment of acute stress disorder following TBI and for the use of CBT combined with neurorehabilitation 1
to alleviate anxiety symptoms following mild-moderate TBI.
One RCT evaluated an ‘information plus writing’ intervention (three 20 minute sessions writing about thoughts
and feelings in relation to the accident) for acute stress disorder after TBI, but found that it was no more 1++
effective than information alone.121
A non-randomised controlled study found a strong effect on measures of distress including depression,
anxiety and stress from a CBT intervention.115 However, the lack of randomisation and very small sample size 2+
in each subgroup limits the conclusions that can be drawn from this study.
BCognitive behavioural therapy should be considered for the treatment of acute stress disorder
following mild TBI.
BCognitive behavioural therapy should be considered for the treatment of anxiety symptoms
following mild to moderate TBI, as part of a broader neurorehabilitation programme.
26 |
7 • Communication and swallowing
7
Communication and swallowing
7.1managing communication problems
7.1.1Introduction
There is limited evidence describing the efficacy of specific communication interventions post TBI, and the
methodological quality of the studies is generally poor with little replication of relevant studies. Most studies
have not exclusively included patients with TBI. Many have targeted the more general population of ABI, with
frequent reference to stroke. The presence of cognitive impairments in conjunction with communication
impairments in people with TBI means that interventions described as being successful in the stroke
population may not successfully transfer (or be assumed to transfer) to the TBI or non-stroke ABI population.
Research into the effectiveness of interventions in this area is made difficult because of the heterogeneous
nature of the patient group. They present with diverse combinations of communication disorders, generally
with additional cognitive, behavioural and physical deficits. Treatment approaches therefore need to be
individually tailored to each patient’s pattern of disorder, and this reduces the possibilities for carrying out
RCTs. In addition, treatments in ABI are often given as an integrated package, with blurring of professional
roles across the rehabilitation team. Studies of efficacy are further complicated by the difficulty in identifying
the relative contributions of different members of the team.
7.1.2Definitions
Traumatic brain injury may result in a variety of communication impairments of varying degrees of severity.
These include:
dysarthria - a group of motor speech impairments affecting clarity of speech, voice quality and volume and
overall speech intelligibility
dysphasia/aphasia - these two terms are now generally used interchangeably to refer to an acquired
multimodal language disorder which can affect someone’s ability to comprehend auditory and written
language and to talk or write. It may or may not coexist with cognitive deficits including visuoperceptual
problems
cognitive-communication disorder, social communication disorder, pragmatic impairments, right
hemisphere language disorder - these terms (which are not interchangeable but denote different disorders)
refer to various impairments of communication affecting language use and discourse, producing a variety
of symptoms, such as reduced use of facial expression, poor eye contact, reduced turn-taking, verbosity/
taciturnity, poor listening skills, reduced relevance, and so on. These impairments may or may not coexist
with aphasic symptoms, and affect the ability to converse successfully.
motor aprosodia - a neurological condition characterized by the inability of a person to properly convey
emotional prosody by means of the pitch, stress and rhythm functions of normal speech production.
7.1.3problems with language or functional communication
Several systematic reviews and one meta-analysis suggest language deficits and/or functional communication
deficits can be remedied.
One review presents findings which largely apply to patients with stroke (40 studies in total, of which eight
included patients with TBI). The authors summarise that there is substantial evidence to support cognitivelinguistic therapies for language deficits following left hemisphere stroke.85 Specifically, group treatment
has been shown to be effective in remediating language deficits, a greater intensity of treatment produces
3
improved communication skills, interventions for specific language impairments such as acquired dyslexia
are effective (but the nature of the interventions was not described), and computer therapy provides a useful
adjunct to face-to-face (FTF) treatment by a therapist. The authors recognise a compelling need for more
studies to evaluate treatments of pragmatic communication problems in TBI.
| 27
Brain injury rehabilitation in adults
A non-systematic, but comprehensive, review covered studies of stroke as well as TBI. It showed that although
few good quality RCTs have been carried out in the area of aphasia rehabilitation, there is considerable
evidence from lower grade studies indicating the probable effectiveness of aphasia rehabilitation (of various 4
kinds).95 In particular, it is commented that massed therapy (a large amount of therapy over a short period
of time) is superior to smaller amounts of therapy over a longer period of time. However, it comments that
there is a need for further studies to provide more evidence.
A third review covered stroke and other forms of non-traumatic brain injury, as well as studies where the
cause of injury was not described (21 studies; 52% of the subjects had TBI and 35% had non-traumatic brain
injury). It excluded studies of interventions for speech and writing. It reported only three studies which it
considered to have positive outcomes with a conclusive level of certainty, but the nature of the brain injuries 2+
of the participants in the studies was not clear so it is not possible to say if the outcomes are relevant to
TBI.122 The studies are said to demonstrate positive outcomes of the following interventions: graphic and
conversational partner support to improve successful conversational exchanges in aphasia; the use of
computer based therapy to improve the complexity of utterances in aphasia; the use of a verbal prompting
hierarchy to improve naming. These studies collectively included only 12 study participants.
One meta-analysis attempted to separate out the treatment effect sizes in studies of TBI versus studies of
stroke, and concluded that at best there was only weak evidence in favour of effective language rehabilitation
after TBI, partly because only four studies of language treatment after TBI were identified, and one of those 2++
had a negative effect size (the control group did better than the treatment group).89 The authors found a smallmedium language treatment effect in stroke. They note that the evidence is weakened by the dominance in
the literature of studies using single group pre-post designs, as opposed to stronger study designs.
Almost all of the evidence above relates to stroke rather than TBI. Only one study noted weak evidence in
favour of language rehabilitation after TBI. One further non-comparative study suggested that aphasic patients
with TBI can make the same functional and cognitive gains as non-aphasic patients, but over a longer time
span.123 This study did not detail any of the therapeutic techniques used. A survey suggested that adults
with TBI who are introduced to augmentative and alternative communication generally find it acceptable
and use it for extended periods of time, but this was a non-experimental study.124
7.1.4intonation and prosody problems
Intonation refers to variations of pitch in speech. Prosody refers to the use of rhythm, stress and intonation in
spoken output. A systematic review, an RCT and a non-comparative study provide evidence that intonation/
prosody problems can be remediated.51,125,126 Treatments researched were a song-singing programme, an +
2
imitative programme and a cognitive-linguistic treatment. The systematic review reported evidence that a 2
pitch biofeedback and expression modelling intervention is beneficial to a patient with motor aprosodia,
improving affective prosody. In the RCT, only one of the 14 subjects had a TBI, all the other subjects had
stroke which limits the generalisability of the study.
7.1.5social communication problems
A systematic review, an RCT and a non-comparative study suggest social communication deficits can be
improved through group treatment. The systematic review identified evidence that conversation group
2+
therapy has a beneficial effect on pragmatic and quality of life concerns in patients with ABI.51 The RCT +
1
excluded the most typical patients with TBI and there was a risk of bias with some of the outcome measures.127 3
The non-comparative study was limited by the lack of a control group, a small number of participants and
a 43% dropout at six months.128
28 |
7 • Communication and swallowing
7.1.6
Training communication partners
A systematic review and an RCT suggest that training communication partners to improve communication
with people after ABI is beneficial.51,129 Two of the studies related to stroke. In the study focusing exclusively
on TBI, there was only a small number of participants. The systematic review suggested that interventions 2+
+
that focus on training the communication partners of individuals with severe ABI were effective. It also 1
showed communication strategies used by those who work with individuals who have sustained an ABI are
effective in improving communication exchanges.51
7.1.7dysarthria
Six studies focus on the treatment of dysarthria in adult patients, one Cochrane review, 130 three other
systematic reviews51,131,132 and two non-comparative studies.133,134 The Cochrane review identified no
appropriate studies. Two of the reviews did not allow conclusions to be drawn regarding patients with TBI
because they took as their topic the diagnosis of stable dysarthria, as opposed to any single aetiology.131,132
This body of evidence provides some evidence of the benefits of Lee Silverman Voice Treatment (LSVT)
(an intensive programme of voice exercises which aims to improve loudness, quality and variation, and
promotes self-monitoring) but otherwise no conclusive evidence for the management of dysarthria in patients
following brain injury. One of the systematic reviews identified studies which suggested that combination 2+
treatment incorporating LSVT-type exercises, direct respiration treatment, and physiotherapy exercises has 3
a mild and inconsistent effect on outcome. Three further studies indicated that LSVT has some potential in
treating dysarthria in individuals with ABI.51 Further research using a control group is needed. This review
also identified evidence that external pacing techniques (eg metronome, pacing board) are effective in
increasing intelligibility through rate reduction outcomes in patients with ABI.
One non-comparative study investigated the use of LSVT for improving dysarthria in seven patients with
TBI and three with stroke. It assessed patients at baseline, after treatment and at six months follow up but
did not compare LSVT with another treatment. Positive results were described, but there were limitations
in study design including a lack of treatment comparison.133 The authors assumed stability of the patients’ 3
dysarthria simply because the participants were six months or more post onset, but did not test this with
initial assessment. Several of the outcome measures required judgements made by the participants, their
carers and their therapists, introducing an element of bias. There were only seven participants with TBI.
A further case series explored the suitability for and benefits of commencing individualised dysarthria
treatment for people with TBI whilst in later post-traumatic amnesia (PTA).134 The authors report on two cases
and state that PTA did not preclude the provision of therapy but certain neurobehavioural characteristics
affected the quality of the therapy. They report improvement in the dysarthria over the period of intervention 3
(which extended from later PTA until emergence from PTA), but note that as parameters other than those
included in therapy also improved, the improvement could be due to spontaneous recovery rather than
the therapy itself.
Although this treatment approach looks promising, there are few studies and small numbers of participants.
In addition, LSVT requires a specially trained therapist and very intensive input which may not be realistic
for some clinicians.
7.1.8
Other interventions
A systematic review identified evidence which suggested that some patients with severe head injuries
may improve their ability to communicate yes/no responses after undergoing consistent training and
environmental enrichments.51 This review also identified evidence which suggested that pragmatic
interventions including role playing improves a variety of social communication skills as well as self concept +
2
and self confidence in social communications, and evidence which suggested that peer-group training of
pragmatic language skills may benefit individuals with communication deficits following brain injury. For
patients in minimally responsive states, there was evidence that structured intervention does have a positive
effect on an individual’s ability to communicate.
| 29
Brain injury rehabilitation in adults
Expert opinion and uncontrolled case series suggest value in interventions designed to improve 3
4
communication disorders post TBI.85,135-139
The low quality of evidence should not be interpreted to mean that intervention in this area has no clinical
value. However, it is not possible on the basis of this body of evidence to make recommendations about
specific interventions for communication deficits post TBI. There remains a pressing need to design and
implement methodologically sound and well powered research studies in this field.
DPatients with communication deficits post TBI should be referred to speech and language therapy
for assessment and management of their communication impairments.
7.2assessing and managing dysphagia
Dysphagia refers to a difficulty with swallowing, and estimates of its incidence post ABI vary from 25% to
78%.51 SIGN guideline 119 contains recommendations for the assessment and management of patients with
dysphagia following stroke.6
7.2.1assessment
Dysphagia is generally assessed by speech and language therapists using a combination of bedside and
instrumental approaches. The two most widely used instrumental assessments are videofluoroscopy
and Fibreoptic Endoscopic Evaluation of Swallowing (FEES). Instrumental assessment allows diagnosis of
pharyngeal stage swallowing problems including aspiration. It therefore allows more informed decision
making about feeding and therapy, whilst helping to avoid the risk of silent aspiration, compared with bedside
assessment alone. Potentially, individuals may progress more quickly following instrumental assessment
because of the ability to identify the intactness or otherwise of the pharyngeal swallow. However, there are
resource implications in relation to the availability of videofluoroscopy and FEES and the ability to carry out
the assessments in patients with acute brain injury and those in low arousal states. Additionally, patients
are exposed to radiation in videofluoroscopy and FEES is an invasive procedure.
There is little evidence comparing outcomes following instrumental assessment versus bedside assessment
in patients post TBI. One small non-comparative study suggests that FEES is an objective and sensitive tool
that can be used to evaluate dysphagia in patients with acute TBI,140 and another small retrospective case 3
control study suggests that patients with prolonged disordered consciousness following ABI can feasibly
be assessed instrumentally in terms of swallowing function, allowing swallowing as a treatment modality
whilst in a state of disordered consciousness.141
D
Instrumental assessment of dysphagia in patients post TBI should be considered where:
yy b
edside assessment indicates possible pharyngeal stage problems (which would potentially
include the aspiration of food and fluid into the lungs)
yy t he risks of proceeding on the basis of the bedside assessment outweigh the possible benefits
(the patient at very high risk of choking or aspiration if fed orally), and
yy t he bedside assessment alone does not enable a sufficiently robust clinical evaluation to permit
the drawing up of an adequate plan for swallowing therapy.
7.2.2management
Managing dysphagia is important for the maintenance of nutrition and hydration as well as the prevention of
complications, such as chest infection. Typical management of dysphagia post TBI incorporates compensatory
techniques, restorative exercises and modification of the texture of the diet as appropriate. Compensatory
techniques are designed to enable oral feeding despite the presence of swallowing impairments; for example,
adopting a different posture or an alternative swallowing technique to increase the safety of the swallow.
Restorative exercises are aimed at directly improving the swallow physiology; for example, exercises to
improve the strength of the tongue to improve oral transit of food. Texture modification is undertaken where
safe swallowing can only be achieved with specific food textures; for example, a minced-mashed consistency
diet may help where oral preparation of food is impaired.
30 |
7 • Communication and swallowing
No evidence was identified relating to any form of restorative exercises in dysphagic patients post-TBI other
than two studies concerning neuromuscular electrical stimulation (NMES) (a technique involving electrical
stimulation of relevant peripheral nerves with the aim of improving swallowing function). One very small
non-comparative study including only one participant with TBI concludes that NMES can be an effective
treatment for chronic pharyngeal dysphagia.142 One systematic review concludes that some aspects of NMES
might be beneficial for dysphagia treatment, but further research is required.143 Only one study included
in the review included patients with TBI, and the authors noted that the studies reviewed were generally
poor quality with a high risk of bias. Neuromuscular electrical stimulation is used widely in the US but is a
little-used technique in the UK and the Royal College of Speech and Language Therapists does not endorse
its use.
There is insufficient evidence to support a recommendation on restorative exercises to improve outcome
in dysphagia post TBI.
7.3
oral hygiene
Rigorous oral hygiene forms part of the routine care of patients with dysphagia, although physical deficits
and problems with patient compliance can make it difficult to carry out satisfactorily. No evidence was
identified that oral hygiene programmes reduce the incidence and severity of aspiration-associated chest
infection and pneumonia in patients with TBI. One methodologically poor RCT considered oral hygiene post
TBI but not in relation to dysphagia and aspiration pneumonia.144
It is not possible to make a recommendation on the basis of the evidence. However, common sense dictates
that thorough oral hygiene in TBI patients would be beneficial for oral comfort and dental health.
| 31
Brain injury rehabilitation in adults
8
Vocational rehabilitation
Vocational rehabilitation (VR), or supported employment, focuses on the return to work, education or duty
of an individual following injury. Return to work following ABI has been identified as the most challenging
task that a patient will face in the course of their recovery and remains the most significant marker of return
to their pre-morbid level of function.145 It has been estimated in a US study published in 2001 that the annual
loss of productivity and wages together with cost associated with care and management of TBI are estimated
to be $28 billion to the US economy.146 Vocational rehabilitation is not the core business of the NHS. However,
it is clearly important for TBI rehabilitation and supporting patients towards achieving their goals.
The evidence related to the efficacy of VR remains scattered and inconclusive. One review found it difficult
to ascertain employment outcomes considering the range of outcomes and measures that exist and showed
a range of return to work rates from 20% to 90%.147 Most of the evidence reviewed was carried out in US,
Canada, Australia and New Zealand which should be taken into account when generalising to a Scottish
population because of differences in funding streams and legislation. Evidence in this section was identified
by searching for interventions which were defined by researchers as vocational rehabilitation. This may
underestimate the total available evidence as other interventions which may be defined using cognitive,
physical or behavioural terms may also impact on the individual’s ability to return to work.
8.1benefits of returning to work
Return to work is an important stage in rehabilitation after traumatic brain injury for a number of reasons.
Firstly, being employed has been associated with better quality of life in TBI survivors and secondly the 4
financial costs associated with unemployment after TBI are substantial given that TBI disproportionately
affects young people of working age.148
8.2vocational rehabilitation interventions
The evidence on the effectiveness of specific VR interventions is inconclusive.
A quantitative synthesis of 26 studies (n=3,688) which used a wide range of interventions indicated that
patients who received VR returned to work quicker than patients who had no VR (mean percentage successful 3
adjusted return to work 71% v 47%).147
A systematic review included three studies that looked at VR. The results suggested that there is limited
evidence that VR results in improved outcomes for patients with TBI, however, the study designs were of
widely varying populations and settings.145 The authors also included one study of supported employment
3
and suggested that it improves the level of employment outcomes where there are aspects of competition
involved in securing the post, particularly for ABI survivors who are older, have more education, have no
prior work experience or who have suffered more severe injuries. There were significant problems with the
methodology of the study.
A systematic review published in 1999 identified no direct evidence from RCTs about the efficacy of supported
employment. Participants in the supported employment programme showed significantly better results 3
but the comparison group were so heterogeneous with multiple factors affecting employment that no
conclusions could be drawn from the results.149
32 |
8 • Vocational rehabilitation
There is insufficient evidence on the effectiveness of VR to make a recommendation on either approaches
or intensity of intervention and further research is required.
E arly in the rehabilitation pathway patients should be asked about vocational activities and liaison
initiated with employers. Once work requirements are established patients should have appropriate
assessments made of their ability to meet the needs of their current or potential employment.
HS Boards should consider providing a specific local expert therapist to provide advice to
N
rehabilitation teams including signposting to relevant statutory services such as Disability Employment
Advisors at Job Centres, organisations specifically providing opportunities for people with disabilities,
eg Momentum, or voluntary services which can provide help and support, eg Headway, Disability
Alliance (see section 11.1).
| 33
Brain injury rehabilitation in adults
9
Management of the patient in the minimally
conscious or vegetative state
Advances in acute medical and neurosurgical treatments are resulting in increasing numbers of individuals
surviving severe TBI. The annual incidence for individuals surviving severe brain injury in the US has been
estimated at around 170 per million population150 with annual incidence in the UK around half this figure.151
For patients who survive acute coma, the annual incidence of individuals remaining in the vegetative state
(VS) in the UK has been estimated at 14 per million population at one month post injury, eight per million at
three months and five per million at six months for acute causes.152,153 Prevalence estimates have only been
computed for the US and vary between 40 and 168 per million population.152,153 Due to developments in
diagnostic terminology and assessment procedures, no figures regarding incidence or prevalence for the
minimally conscious state (MCS) are available.151
This patient group presents with complex ongoing nursing and medical needs and represents a considerable
challenge in terms of assessment and multidisciplinary rehabilitation. The importance of closely monitoring
patients in order to reliably differentiate states of disordered consciousness was underlined by two studies
which found that up to 40% of patients considered to be in a chronic or persistent vegetative state were
actually demonstrating behavioural responses consistent with the MCS thereby indicating a higher level of
awareness and rehabilitation potential.154,155
9.1Definitions
Considerable progress has been made in reaching consensus regarding the specific diagnostic criteria used
to differentiate patients at various points after injury.156 This work has focused on identifying patterns of
behavioural responses which indicate increased conscious level and emergence from coma, through the
VS into the MCS and beyond. For patients who remain in the VS, issues of chronicity and permanence have
been described in relation to prognosis.
9.1.1vegetative state
Diagnosis of VS can only be made a minimum of one month after injury and requires the presence of all the
following:
yy no evidence of awareness of self or environment and an inability to interact with others
yy no evidence of sustained, reproducible, purposeful, or voluntary behavioural responses to visual, auditory,
4
tactile or noxious stimuli
yy no evidence of language comprehension or expression
yy intermittent wakefulness manifested by the presence of sleep-wake cycles
yy sufficiently preserved hypothalamic and brain stem autonomic functions to permit survival with nursing
and medical care
yy bowel and bladder incontinence
yy variably preserved cranial nerve reflexes and spinal nerve reflexes.157
It has been proposed that the issue of permanence of the VS may be raised when a patient has remained
in the VS for more than 12 months after a traumatic brain injury and more than three months after a brain
injury of non-traumatic cause (eg cerebral anoxia). After this point, recovery of consciousness can be
considered highly improbable but not impossible156 and critical issues regarding life sustaining treatment
and interventions may therefore become pertinent in individual cases.
34 |
9 • Management of the patient in the minimally conscious or vegetative state
9.1.2minimally conscious state
A patient can be considered to be functioning in the MCS if there is clear evidence of being able to perform
one or more of the following behaviours:156
yy
yy
yy
yy
follow simple commands
demonstrate gestural or verbal yes/no responses (regardless of accuracy)
verbalise intelligibly
demonstrate purposeful behaviour, including movements or affective behaviours which are contingent
upon environmental stimuli (eg appropriate smiling/crying, visual tracking object, vocalised/gestural
response appropriate to questions or instruction).
A patient can be considered to have emerged from the MCS when they are able to reliably and consistently
demonstrate one or both of the following:
yy functional interactive communication (eg verbal/gestural yes/no responses to questions, or written
questions)
yy functional use of two different objects.
A wide range of medical, surgical, pharmacological, environmental and sensory stimulation intervention
techniques has been used with patients in states of disordered consciousness. Many published studies have
reported outcomes with single cases or a small case series. There are very few group designs reported in the
literature and a lack of control data for comparative purposes.
9.2assessing changes in conscious level
One systematic review evaluated the evidence for assessment scales to measure disorders of consciousness
and concluded that the Coma Recovery Scale – Revised (CRS-R) can be used with minor reservations due to
unproven criterion validity.158 The Sensory Modality and Rehabilitation Technique, Western Neuro Sensory 2++
Stimulation Profile, Sensory Stimulation Assessment Measure, Wessex Head Injury Matrix and Disorders
of Consciousness Scale may be used with moderate reservations due to limited evidence of reliability or
criterion validity.
A systematic review of individual cases investigated the use of functional imaging techniques (eg positron
emission tomography, functional magnetic resonance imaging) with patients in the vegetative state and
concluded that evidence of ‘higher level’ cortical activation in response to complex, personally salient auditory 3
stimuli can provide important information regarding residual brain function and prognosis. However, the
available literature was noted to be sparse, with unblinded and uncontrolled studies using a wide range of
different assessment and intervention procedures.
BThe Coma Recovery Scale - Revised should be used to assess patients in states of disordered
consciousness.
iven the challenges associated with assessing patients with disorders of consciousness, it is important
G
that clinicians should have training in administering disorders of consciousness assessment tools and
also an appreciation of the range of assessment tools available for use with this population.
9.3pharmacological therapy
One systematic review of mostly single case series evaluated pharmacological interventions for patients
in the VS or MCS.159 The authors found some supporting evidence for the use of dopaminergic agents
(levodopa and amantadine) to improve conscious level with a very small number of patients (n=6). There
was also some evidence to support the use of the hypnotic agent zolpidem (n=21), however conflicting 3
treatment effects were seen across patients with only a small proportion showing a clear benefit (n=7). The
authors report the results of a small series of patients (n=5) treated with intrathecal baclofen for spasticity
who also demonstrated associated improvements in conscious level. Considerable limitations were noted
within the literature, including a lack of cohort or blinded and controlled study designs, a lack of consistency
| 35
Brain injury rehabilitation in adults
regarding measures of conscious level, and considerable heterogeneity regarding patient characteristics. It
3
is not possible to draw robust conclusions from this evidence base.
A systematic review identified evidence for the use of amantadine in improving cognition, arousal and other
behavioural/functional responses following traumatic brain injury.160 The review included three retrospective
studies (n=209), two randomised, double blinded, placebo controlled crossover studies (n=45), two case
reports (n=2) and one retrospective case series (n=12). Inconsistent results were found between the two 3
randomised controlled trials which may reflect differences between the two study designs, including patient
samples, outcome measures and treatment duration. The authors conclude that there may be evidence to
support the use of amantadine (200-400 mg/day) to improve cognition and arousal post-traumatic brain
injury, however further prospective controlled studies are required.
A further randomised, placebo controlled trial of amantadine with a large sample of patients enrolled between
4-16 weeks after severe traumatic brain injury (n=184) and presenting in the VS and MCS found that whilst
both groups improved during the four-week treatment period (measured by changes on the CRS-R) the active
treatment group demonstrated a significantly faster rate of recovery.161 During a two week post treatment
1++
wash out period these gains were maintained in both groups, however the rate of improvement slowed
in the active treatment group, such that at the six week point there was no significant difference between
the two groups in CRS-R scores. There was no evidence of increased risk of adverse side effects in the active
treatment group. The authors concluded that a dosage of 200-400 mg of amantadine can be used safely in
patients following severe traumatic brain injury and may facilitate faster recovery of behaviours consistent
with improved conscious level.
A general overview of awakening agents in patients with a range of disorders of consciousness, including
akinetic mutism concluded that in the early phase of recovery (ie <1 month post injury) there is evidence
to support the use of bromocriptine with patients in the vegetative state and akinetic mutism and
methylphenidate and hyperbaric oxygen for patients in coma or the minimally conscious state.162 In the
4
chronic phase (ie >1 month post injury) there is evidence to support the use of bromocriptine and levodopa
for patients in the vegetative state, amitriptyline, hyperbaric oxygen and amantadine for patients in the MCS
and hyperbaric oxygen for patients in prolonged coma. Considerable methodological issues were noted by
the authors, including a lack of adequate baseline measures of conscious level, heterogeneity regarding
assessment of outcome and conflicting results between studies.
BAmantadine may be considered as a means of facilitating recovery of consciousness in patients
following severe brain injury.
9.4non-pharmacological therapy
One RCT with methodological limitations provided evidence regarding the efficacy of a family visiting
programme in improving conscious level.163 Fifty patients in coma were randomly allocated to either
a treatment condition (n=25) or to standard nursing care condition (n=25). The treatment condition
incorporated six daily visits from a close family member lasting 15 minutes during which the visitor was 1trained to verbally interact with the patient and provide tactile stimulation to the hands and face. The authors
reported a significant difference between the two groups’ conscious level (mean GCS scores) after the final
treatment session on day six but no significant difference at baseline.
An overview of intervention options reviewed the evidence for multisensory stimulation, music therapy,
and contingent stimulation and assistive technology.164 The three multisensory stimulation studies (n=15)
incorporated two single cases and one case series of 13 patients using a multiple baseline methodology.
Some positive effects were noted following stimulation however the results as a whole are equivocal and
methodological issues were noted (eg lack of clear diagnosis of conscious level, lack of adequate control data, 4
use of multimodal treatment techniques with variation between studies and lack of clarity with regards to
specific techniques used). The three music therapy studies (n=36) included two single case reports and one
case series which provided some evidence of improved response level and behavioural changes following
treatment. However, in the absence of control data, conclusions regarding treatment efficacy must be made
with considerable caution.
36 |
9 • Management of the patient in the minimally conscious or vegetative state
A Cochrane review of evidence for multisensory stimulation of patients in coma or vegetative state identified
one RCT (n=14) and two controlled clinical trials (n=54). Due to methodological and statistical limitations in
all three studies, the authors concluded that the results were invalid and therefore no clinical outcomes or
practice recommendations could be made.165
An RCT reported positive effects on conscious level for a sample of patients in the vegetative state or minimally
conscious state less than three months post injury treated with branched chain amino acids via intravenous
infusion (n=22) compared with isonitrogenous placebo (n=19) over a 15 day period.166 All patients were 1
assessed using the Disability Rating Scale (log transformation score) the day after active treatment/placebo
intervention and at the point of discharge from hospital (mean=137 days since injury). The trial did not
report randomisation methods and caregivers were not blinded to treatment allocation. Further studies are
warranted in order to establish treatment efficacy beyond the results of this single sample.
9.5surgical interventions
Two studies reviewed evidence for transcranial and deep brain stimulation surgical interventions for patients
in the vegetative state and minimally conscious state.159,164 The one transcranial stimulation (n=1) and two
deep brain stimulation (n=6) studies provided some evidence for the effectiveness of these treatments on
arousal, interaction with the environment and functional ability. However, the numbers of patients under 3
4
review were very small and only one study introduced a control component by incorporating a crossover
single case design. One review reported the results of one large, prospective observational study using spinal
cord stimulation in a sample of patients in the vegetative state (n=214) with mixed aetiology and found a
response incidence rate of 54%.164
Although a number of surgical interventions have shown some promise in enhancing arousal/consciousness
level, given the lack of consistency of results and the methodological limitations of most studies, no specific
recommendation can be made.
| 37
Brain injury rehabilitation in adults
10 Service delivery
10.1inpatient care
There is little direct evidence to support the rehabilitation of brain injured patients within a specialist unit
compared with a non-specialist/general unit. Ethical considerations surrounding the differential provision
of care to different groups limit the availability of high quality randomised data.
A specialist service has been defined as a group of (therapeutic) interventions delivered by one or more people
or organisation(s), which may incorporate one or more programmes, methods, techniques or approaches.
Such services are:
yy n
ot generic primary, intermediate or secondary health or social services (although much of the care
received by people with these conditions are provided by such generic services), and
yy generally provided by more than one professional grouping.167
One Cochrane systematic review considered multidisciplinary rehabilitation for ABI in adults aged 16-65
years.18 The review included all causes of ABI including stroke and compared specialist inpatient rehabilitation
with rehabilitation carried out by local services. Two studies specifically considered specialist inpatient
rehabilitation in patients with either TBI or stroke. Both of these studies were small and of low methodological
2++
quality and provided limited evidence that specialist inpatient rehabilitation improved functional outcome
over local non-specialist services. The review cited the UK National Clinical Guidelines for Stroke which
suggests the key features of a successful rehabilitation service comprise a specialist multidisciplinary team
with relevant expertise which is generally found in a specific geographical base or location.
A systematic review of multidisciplinary rehabilitation services identified twelve reviews covering five
populations - stroke, brain injury, rheumatoid arthritis, hip fracture and older adults.16 In addition to the
above Cochrane review, this reported a further review which included 2,183 people with mixed diagnoses 1+
(mostly stroke) which showed that specialised rehabilitation resulted in increased likelihood of discharge
home from hospital, greater functional outcomes and higher rates of survival.
The Evidence Based Review of Rehabilitation of Moderate to Severe Acquired Brain Injuries, (ERABI),51 a
modular systematic review including randomised and non-randomised studies concluded that ABI patients
benefit from a dedicated inpatient rehabilitation service. These services vary from institution to institution
but generally include some type of intensive therapy programme for physical, social, behavioural and 2+
cognitive difficulties. The review also showed that early rehabilitation is associated with a shorter length of
stay, higher cognitive levels on discharge, better FIM scores and increased chance of discharge to home.
Patients receiving increased intensity of therapy had better outcomes in most aspects of FIM and FAM and
experienced shorter lengths of stay.
One single-blinded RCT (n=68) in patients with moderate to severe TBI compared different intensities of
treatment (two versus four hours per day for up to six months).168 This demonstrated that after the second
week most patients could tolerate more than two hours of therapy per day. While no significant difference
+
was found between the two groups beyond three months, a higher number of patients in the high intensity 1
group achieved a maximum FIM score at three months and Glasgow Outcome Scale score (GOS) at two
months although these early gains did not impact on overall length of stay. This study suggests that intensive
rehabilitation may speed up overall recovery.
Intensity of rehabilitation is a relative term defined differently by different studies. Some studies of intensity
compare interventions carried out for longer duration than controls, while others define it in terms of the
volume or frequency of delivery of rehabilitation. While there is evidence suggesting an association between
both increased intensity and earlier intervention with positive outcomes, it is not possible to quantify a
threshold for recommendation.
B
For optimal outcomes, higher intensity rehabilitation featuring early intervention should be
delivered by specialist multidisciplinary teams.
38 |
10 • Service delivery
10.2community rehabilitation
10.2.1Introduction
Post-acute inpatient rehabilitation is not available comprehensively throughout Scotland and in many
areas community rehabilitation services of variable composition are providing both short and long term
rehabilitation support to patients with traumatic brain injuries.169
While there is limited research comparing the outcomes of community rehabilitation with other or no
rehabilitation, there is evidence of beneficial outcomes for patients with TBI who have access to the following
features of community rehabilitation services:
yy
yy
yy
yy
yy
interdisciplinary rehabilitation170-173
planned transfer of patient care from hospital to community services169,170
ongoing family and carers support170
neuropsychology rehabilitation programmes171
community rehabilitation many years post injury172,173
There is no consistency in current studies regarding the definition and make up of optimal community
rehabilitation services nor of specific rehabilitation programmes, however common themes emerge which
are outlined in the following sections.
10.2.2
Interdisciplinary community rehabilitation
Patients who have access to services providing interdisciplinary rehabilitation in their community demonstrate
benefits that outlive the treatment period in comparison to those who have ‘usual care’.
A case control study compared a group receiving multidisciplinary outpatient rehabilitation with a group
receiving no rehabilitation.174 Patients who participated in the multidisciplinary rehabilitation programme
achieved greater improvement on the community integration questionnaire outcome measure than controls. 2+
However, there was no significant improvement in community socialisation outcome or work or school status.
The small sample size and lack of randomisation limits its application to other areas.
ommunity rehabilitation services for patients with brain injuries should include a wide range of
C
disciplines working within a co-ordinated interdisciplinary model/framework and direct access to
generic services through patient pathways.
Each patient should have a named worker.
A guideline from the British Society of Rehabilitation Medicine and Royal College of Physicians recommends
that, as a minimum, a community specialist service to support people with brain injuries should include:175
yy
yy
yy
yy
yy
yy
yy
yy
yy
yy
yy
specialist brain injury nurses
physiotherapists
occupational therapists
speech and language therapists
4
clinical psychologists
specialist social workers
dietitians
technical instructors
generic assistants
consultants in rehabilitation medicine
with access to other relevant services such as neurology, neurosurgery, neuropsychology, neuropsychiatry
and mental health services as required.
| 39
Brain injury rehabilitation in adults
10.2.3
Transfer from inpatient to community rehabilitation
The transition of patient care from hospital to home is covered in section 10.4. The recommendation for
planned discharge is also relevant when transferring patients from hospital to community rehabilitation
services. It is important that the transition is planned with community services which have an awareness of
the problems faced by individuals with ABI.169,170
10.2.4
Family and carer support
The National Traumatic Brain Injury Study followed up patients referred to community rehabilitation services
across ten sites in England and included interviews with 507 adults (of whom 68% had severe injuries, 25.5%
had moderate injuries and 6.5% had mild injury severity).170 Authors of this study noted through narrative
analysis that if family and carers are supported, it has been shown to have a positive outcome for the person
3
with a brain injury. They noted the difficulties in demonstrating this effect in objective terms: “ The presence
of an informed and competent carer and the location of the head-injured person within an effective support
network revealed their importance only gradually as implicit contrasts were made between those clients who
seemed to do well and those who did badly. It was not, and may never be, possible to set up programmes
to demonstrate these effects by means of statistical analysis.” The study reported that ongoing support for
families and carers helped to maintain social networks and personal resilience.
10.2.5
F amily and carers should be provided with access to ongoing support when the patient with brain
injury is living within the community.
hildren and adolescents affected by a family member with brain injury may require referral to
C
specialist support services through education, health or social work.
NeuropSYchological Rehabilitation Programmes
Section 5 of this guideline, covering cognitive rehabilitation, is as relevant in the context of community
rehabilitation services as in the inpatient setting. In community rehabilitation it is important for patients
with TBI to have access to comprehensive and holistic neuropsychology rehabilitation programmes.
An RCT of 68 patients with moderate to severe brain injuries showed that a group receiving a comprehensive,
holistic programme of neuropsychological rehabilitation in a community setting demonstrated greater
improvement in the community integration questionnaire and the perceived quality of life scale than a
group receiving standard rehabilitation in the same setting.171 The Intensive Cognitive Rehabilitation Program
consisted of 15 hours of individual and group therapies conducted three days per week. Patients used a 1+
variety of functional and social problem-solving tasks to tackle their individual problems, while pragmatic
and interpersonal communication was addressed through role playing, interpersonal and videotaped
feedback, and analysis of social interactions. Functional compensatory strategies were used (for example,
note-taking) and the application and monitoring of strategies reviewed within each participant’s home and
community, including regular homework exercises. At completion of treatment, significantly more patients
in the neuropsychological rehabilitation programme group were engaged in community based employment
than in the standard rehabilitation group (47% v. 21%; p=0.02).
10.2.6
LONG TERM ACCESS TO REHABILITATION
An RCT of multidisciplinary rehabilitation in the community for patients with moderate to severe TBI (n=110)
showed improvements in functional outcomes compared with an information provision intervention.
Outreach participants who received individualised programmes of rehabilitation from a multidisciplinary
team which used a goal planning framework where participants were seen for two to six hours per week
1+
demonstrated significantly larger gains on the Barthel Index (35% v. 20%, p<0.05), the Brain Injury Community
Rehabilitation Outcome-39 (BICRO-39) (80% v. 70%, p=0.05) but not in FIM and FAM scales (85.4% v. 88.9%,
not significant). Median changes on individual subscales were small, reflecting the diversity of the clinical
population; however, 40% of outreach but only 20% of information participants made a clinically significant
improvement of at least 2 points on at least one BICRO-39 scale. The cohort included patients up to 20
years post injury, and the authors noted a weak positive correlation between time since injury and extent
40 |
10 • Service delivery
of improvement. There were no significant improvements in socialising, predictive employment or anxiety +
1
and depression.173
In one small retrospective cohort study (n=55) which used the European Brain Injury Questionnaire, patients
with a traumatic brain injury who received post acute community based rehabilitation subjectively reported 3
improved psychosocial outcomes. The effect was demonstrated even for a subgroup (n=26) beyond two
years post injury. Carers in this subgroup did not report the same improvements as patients.172
The British Society of Rehabilitation Medicine and Royal College of Physicians, commenting on rehabilitation
in the community, recommend that it “should move progressively from formal therapy to a guided and
supported resumption of chosen activities over months or years.”175
10.3Telemedicine
Scotland is a demographically varied nation with areas of high density urbanisation as well as many large
areas which are remote and rural. Telerehabilitation (TRH) is a potentially useful delivery method for outreach
rehabilitation.
10.3.1definitions
Telehealth is the provision of health care to patients at a distance using a range of technologies, such as (but
not limited to) mobile phones, internet services, digital televisions, video-conferencing and self monitoring
equipment.
Telecare is the use of technology (for example, falls monitors, motion sensors, alarms) to support individuals
with a range of health and/or social care needs to live more independently and remain at home safely. These
services are mainly provided by local authorities.
Telerehabilitation is the provision of rehabilitation services at a distance using telecommunications technology
as the delivery medium.176
10.3.2limitations in the evidence base
Many patients with a brain injury have particular difficulties with new learning and concentration. It may
be unsafe to assume that telerehabilitation strategies shown to be effective in other conditions could
be extrapolated to be effective in patients with a brain injury. One crossover study found that younger
participants with TBI did less well than older participants following stroke at learning to use a telemedicine
intervention despite having a presumed generational advantage of being more familiar with digital
technologies.177 For this section of the guideline, evidence from studies where the majority of the population
did not have TBI was excluded.
There are also concerns about the generalisability of some studies which originate from healthcare systems
which are significantly different from NHSScotland.178
10.3.3interventions using telerehabilitation
One high quality systematic review considered TRH for different medical conditions.179 RCTs involving patients
with TBI showed TRH to be effective in reducing depressive symptoms, improving behavioural outcomes
and increasing the probability of returning to employment. Non-randomised studies cited in this review
suggested that TRH was as effective as standard methods. One quasi-experimental study showed that 1++
telephone groups were as effective as FTF groups in providing support and education with rural caregivers
of people with brain injury. An observational study found that there was no difference in performance to
retell stories between participants in the TRH or FTF groups.
| 41
Brain injury rehabilitation in adults
The authors of one RCT cited in this systematic review, which showed that telephone counselling was more
effective than usual care in patients with moderate to severe TBI measured up to one year post injury, aimed
to replicate this result in a larger multicentre RCT using a more diverse patient group. This second RCT,
however, did not show benefit of TRH in the main comparisons, or in pre-specified patient subgroups, nor
++
was there any dose-response effect.114 The reasons for this inconsistent result are not clear, although may 1
be related to subtle differences in how the treatment protocols were implemented by counsellors providing
the interventions. The authors concede the possibility that the treatment may simply have been ineffective
in the specific population in this trial.
A small controlled trial (n=20) compared CBT delivered either remotely or face-to-face with an education
intervention control in patients with chronic TBI and reported that CBT was more effective. The authors +
2
conclude that CBT administered either by telephone or in a FTF group setting can significantly improve
emotional wellbeing in chronic ABI (see section 6.2.1).115
One small, randomised crossover study with a high drop-out rate reported that two types of cognitive
intervention using diaries/calendars were of comparable effectiveness. In one group the intervention was 1delivered mainly using the internet.180
A small case series of the use of videophone support for carers of patients with severe brain injury following
discharge from hospital included only nine patients. Although the videophone support was reported to be 3
acceptable to participants, no conclusions regarding effectiveness or outcomes could be drawn from this
report.181
Further information about follow up after acute admission for head injury, including the use of telephone
follow up, can be found in section 9 of SIGN 110 on early management of patients with a head injury.3
10.4
here further rehabilitation is indicated for patients with brain injury who are discharged from
W
inpatient care, it may be offered by telephone or face-to-face methods to alleviate long term burdens
due to depression, behavioural and cognitive consequences.
Discharge planning
Early assessment of discharge needs and involvement of patients and carers are important in discharge
planning. Discharge should be divided into three parts: pre-discharge, discharge and post-discharge. The
level of intervention required by an individual will depend on their ability to participate.5
ischarge policies should be implemented for inpatient rehabilitation to home transitions for patients
D
with brain injuries.
The strength of the evidence base is limited by ethical difficulties, for example randomly allocating treatment
to some patients with brain injuries while discharging others as part of the design of an RCT. Furthermore,
while many of the randomised studies carried out in this area involve patients with stroke,16, 182 the results
of these are confirmed in observational studies in patients with brain injury.
10.4.1
Discharge planning
Planned discharge for patients with brain injuries has been associated with:
yy
yy
yy
yy
yy
yy
improvement in knowledge of their disability182
improvement in Mayo Portland Adaptability Inventory results183
improvement in functional status184
slight decrease in mortality rates184
improvement in Activities of Daily Living scores16
improvement in psychological re-integration and global functioning.183
Studies identified the need for individualised programmes and a focus on early intervention and
participation.183,185-187
42 |
1+
2+
3
10 • Service delivery
Evidence has also suggested the potential for increased carer and patient stress levels and lack of integration
back into family, community and activities of daily living if there were no planned discharge in place.51
It may be helpful to consider planned discharge as a specific and distinct phase following on from acute
care, post-acute care and linked to improved community reintegration. Such phases should be linked in a
planned manner, appropriate to each NHS area.186
D
Planned discharge from inpatient rehabilitation to home for patients who have experienced an
ABI provides beneficial outcomes and should be an integrated part of treatment programmes.
SIGN 118 on Management of patients with stroke: rehabilitation, prevention and management of complications,
and discharge planning includes the following evidence statement and good practice point on discharge
planning.5
Discharge planning should be documented in a discharge document. Discharge documents may be paper
or electronic (eg in Electronic Clinical Communications Implementation format). See SIGN 128, the SIGN
discharge document for further advice on discharge documentation.188
The following information should be accurately and legibly displayed in the discharge documents:
yy
yy
yy
yy
yy
yy
yy
yy
yy
yy
yy
yy
Diagnoses
Investigations and results
Medication and duration of treatment if applicable
Levels of achievement, ability and recovery (including patient goals and outcome measures)
Team care plan
Further investigations needed at primary care level with dates
Further investigations needed at hospital and dates
Further hospital attendance with dates (including follow-up therapy and review arrangements)
Transport arrangements
The hospital name, hospital telephone number, ward name or number, ward telephone number
Consultant’s name and named nurse
The date of admission and discharge.
Consideration should be given to such information being retained by the patient as a patient-held record,
to allow all members of the primary care team, allied health professionals (AHPs) and care agencies to see
clearly what the care plan for the patient should be. The wishes of the patient in respect of the confidentiality 1+
of this record should be paramount. There is evidence that patient-held records may enhance the patient’s 4
understanding and involvement in their care.189 There is also evidence to show that discharge planning
increases patient satisfaction.190
At the time of discharge, the discharge document should be sent to all the relevant agencies and teams.
10.4.2Pre-Discharge
The following evidence statements and recommendations are drawn from SIGN 118.5
4
Pre-discharge home visits performed by various members of the multidisciplinary team (usually an
occupational therapist) aim to give staff (hospital and community), patients and carers the opportunity to
identify actual and likely problems, as well as to address any other needs that the patient/carer may have.
The UK College of Occupational Therapists defines a home visit as a visit to the home of a hospital inpatient
which involves an occupational therapist in accompanying the patient to assess his/her ability to function
independently within the home environment or to assess the potential for the patient to be as independent
as possible with the support of carers.191
| 43
Brain injury rehabilitation in adults
T he pre-discharge process should involve the patient and carer(s), primary care team, social services
and allied health professionals as appropriate. It should take account of the domestic circumstances
of the patient or, if the patient lives in residential or sheltered care, the facilities available there.
E ssential alterations to the patient’s home should be completed and necessary aids installed prior
to discharge.
Pre-discharge home visits are considered a vital part of the discharge planning process.192
D
10.4.3
Pre-discharge home visits should be undertaken for patients who require them.
Post discharge
More research is required regarding optimal post-discharge care for patients with brain injuries following
inpatient rehabilitation. The NHSScotland National Managed Clinical Network for Acquired Brain Injury
(www.sabin.scot.nhs.uk) has mapped services in each NHS Board area.
44 |
4
11 • Provision of information
11 Provision of information
This section reflects the issues likely to be of most concern to patients and their carers. These points are
provided for use by health professionals when discussing brain injuries with patients and carers and in
guiding the production of locally produced information materials.
11.1sources of further information
11.1.1national organisations providing support for patients
Brain and Spine Foundation
3.36 Canterbury Court, Kennington Park, 1-3 Brixton Road, London SW9 6DE
Tel: 020 7793 5900 • Fax: 020 7793 5939
www.brainandspine.org.uk • Email: [email protected]
Brain and Spine Helpline: 0808 808 1000
Email: [email protected]
The Brain and Spine Foundation develops research, education and information programmes aimed at
improving the prevention, treatment and care of people affected by disorders of the brain and spine.
Headway – The Brain Injury Association
Scotland Office, Astley Ainslie Hospital, Canaan Lane, Edinburgh EH9 2HL
Tel: 0131 537 9116 • Helpline: 0808 800 2244
www.headway.org.uk • Email: [email protected]
Headway is a charity set up to give help and support to people affected by a head injury. A network of
local groups throughout the UK offers a range of services including rehabilitation programmes, carer
support, community outreach and respite care.
Health and Social Care Alliance Scotland
Venlaw Building, 349 Bath Street, Glasgow G2 4AA
Tel: 0141 404 0231 • Fax: 0141 246 0348
www.alliance-scotland.org.uk • Email: [email protected]
Health and Social Care Alliance Scotland represents the two million people who live with long term
conditions in Scotland. It has members drawn from over 250 organisations and works as a conduit
between these groups, the people they represent and key stakeholders across government and statutory
services.
Momentum Head Office
Pavilion 7, Watermark Park, 325 Govan Road, Glasgow, G51 2SE
Tel: 0141 419 5299 • Fax: 0141 419 0821
www.momentumscotland.org • Email: [email protected]
Momentum is a voluntary organisation offering a range of support and rehabilitation programmes to
those who have had a head injury.
National Managed Clinical Network for Acquired Brain Injury
NMCN Team, 2nd Floor, Waverley Gate, 2 - 4 Waterloo Place, Edinburgh, EH1 3EG
Tel: 0131 465 5574
www.sabin.scot.nhs.uk • Email: [email protected]
The National Managed Clinical Network for Acquired Brain Injury is a Scottish national network. Its aim is
to improve access to and the quality of services for children and adults with acquired brain injury.
| 45
Brain injury rehabilitation in adults
Scottish Head Injury Forum
SHIF, c/o Charles Bell Pavilion, Astley Ainslie Hospital, 133 Grange Loan, Edinburgh EH9 2HL
www.shif.org.uk • Email: [email protected]
A registered Scottish charity with an educational purpose that organises training events aimed at
professionals with limited specialist knowledge of brain injury but who treat or work with brain injured
people as part of a wider remit.
Scottish National Disability Information Service
UPDATE, Hays Community Business Centre, 4 Hay Avenue, Edinburgh, EH16 4AQ
Tel: 0131 669 1600
www.update.org.uk • Email: [email protected]
Range of disability information from commonly asked questions through to equipment information,
holiday information and local sources of help and advice.
11.1.2national organisations providing support for carers and families
Carers Scotland
The Cottage, 21 Pearce Street, Glasgow, G51 3UT
Tel: 0141 445 3070
www.carersuk.org/scotland
Carers Scotland provides information and advice to carers on all aspects of caring.
Contact a family – Scotland
Craigmillar Social Enterprise and Arts Centre, 11/9 Harewood Road, Edinburgh, EH16 4NT
Tel: 0131 659 2930
Helpline: 0808 808 3555 • Textphone: 0808 808 3556 • Email: [email protected]
www.cafamily.org.uk • Email: [email protected]
Contact a Family is a charity which provides support, information and advice to families of children and
young people with a disability or health condition.
Crossroads Caring Scotland
24 George Square, Glasgow, G2 1EG
Tel: 0141 226 3793
www.crossroads-scotland.co.uk
Crossroads provides practical support to carers.
Princess Royal Trust for Carers in Scotland
Charles Oakley House, 125 West Regent Street, Glasgow G2 2SD
Tel: 0141 221 5066 • Fax: 0141 221 4623
www.carers.org • Email: [email protected]
The Princess Royal Trust for Carers in Scotland works to improve support, services and recognition for
anyone living with the challenges of caring, unpaid, for a family member or friend who is ill, frail, disabled
46 |
11 • Provision of information
or has mental health or addiction problems.
11.2checklist for provision of information to patients
This section gives examples of the information patients/carers may find helpful at the key stages of the
patient journey. The checklist was designed by members of the guideline development group based on their
experience and their understanding of the evidence base. The checklist is neither exhaustive nor exclusive.
At ALL stages
Healthcare professionals should:
yy e
nsure that advice and support from the multidisciplinary team for
patients (and, where appropriate, carers) is available in a variety of
formats, taking account of each patient’s communication abilities.
In primary care
At presentation to primary care:
yy e
xplain to patients the importance of accurately recording the full
history including when problems were first noted, by whom and
how they manifest
yy ascertain what information or advice the patient was given if they
attended the emergency department and reiterate this information
(see also SIGN 110, Annexes 8-12)3
yy if the patient is presenting following MTBI in the post-acute period,
provide reassurance and information about the likelihood of good
prognosis.
At referral for further assessment:
yy e
xplain to the patient and carers why they are being referred for
further assessment and where this assessment will be carried out.
yy ensure that the patient understands what they can do to help
themself and provide written information, if available.
At assessment appointment(s)
T he specialist team receiving the
referral should:
yy e
nsure the patient receives information about the process which
will follow referral, including likely timescale and who will be
involved
yy keep patients advised of correspondence with other members
of the rehabilitation team when arranging further assessments.
Following assessment appointment(s)
Specialist team should:
yy e
nsure that the referring healthcare professional is kept informed
of any outcome and interventions that they should support or be
involved in
yy consider the inclusion of patient and family in goal setting or case
planning.
At discharge from rehabilitation
Specialist team should:
yy p
rovide information tailored to the patient’s individual needs and
communication abilities which includes contact details for any
liaison or outreach professionals who can provide ongoing contact
and support following discharge.
| 47
Brain injury rehabilitation in adults
12 Implementing the guideline
This section provides advice on the resource implications associated with implementing the key clinical
recommendations, and advice on audit as a tool to aid implementation.
12.1implementation strategy
Implementation of national clinical guidelines is the responsibility of each NHS Board and is an essential
part of clinical governance. Mechanisms should be in place to review care provided against the guideline
recommendations. The reasons for any differences should be assessed and addressed where appropriate.
Local arrangements should then be made to implement the national guideline in individual hospitals, units
and practices.
The National Managed Clinical Network for Acquired Brain Injury (SABIN) is a Scottish national network
established by the National Services Division in 2007. Its aim is to improve access to and the quality of
services for children and adults with ABI. The Network will support the launch of the SIGN guideline through
a combination of education events and other means of raising awareness and reference to the guideline.
Full details will be available from the SABIN website (www.sabin.scot.nhs.uk).
12.2resource implications of key recommendations
No recommendations are considered likely to reach the £5 million threshold which warrants full cost impact
analysis.
12.3
Auditing current practice
A first step in implementing a clinical practice guideline is to gain an understanding of current clinical
practice. Audit tools designed around guideline recommendations can assist in this process. Audit tools
should be comprehensive but not time consuming to use. Successful implementation and audit of guideline
recommendations requires good communication between staff and multidisciplinary team working.
The NHSScotland National Managed Clinical Network for Acquired Brain Injury has developed clinical
standards for adults aged 16-65 years with TBI.193 These standards define essential criteria which are expected
to be met where services for people with TBI are provided, and desirable criteria, which are being met in some
parts of the service, and which demonstrate levels of quality which other providers of a similar service should
strive to achieve. Desirable criteria should be regarded as developmental and should still be met, albeit in a
longer timescale to the essential criteria. Where criteria from these standards reflect recommendations from
this guideline, this is indicated with an asterisk below.
The guideline development group has identified the following as key points to audit to assist with the
implementation of this guideline:
yy t he proportion of patients managed by a dedicated multidisciplinary inpatient (or community based)
team*
yy the proportion of patients with planned discharge from rehabilitation to home which is coordinated by
a designated member of the multidisciplinary team*
yy the proportion of patients in states of disordered consciousness assessed using the Coma Recovery Scale*
yy the proportion of patients recorded as having communication deficits on initial screening by admitting
staff that is then referred on to SLT
yy a case-note review (eg last six months) of patients documented to have dysphagia, answering the following
questions: were there persisting concerns about the management of a patient’s dysphagia following
bedside assessment? If so, was the patient referred for instrumental assessment (eg videofluoroscopy
or FEES)? If not, why was the patient not referred for instrumental assessment?
48 |
12 • Implementing the guideline
yy t he proportion of patients with cognitive impairment after TBI that receives interventions for cognitive
impairments as part of a comprehensive-holistic programme delivered by a multidisciplinary team
yy the proportion of patients with memory impairment after TBI that receives training in the use of
compensatory memory strategies
yy the proportion of patients with attention impairment after TBI that receives training in the use of strategies
to manage attention problems in personally relevant situations
yy the proportion of patients with executive functioning impairments after TBI that receives training in the
use of metacognitive strategies focused on managing difficulties with planning, problem solving and
goal management in personally relevant situations.
12.4additional advice to nhsscotland from HEALTHCARE improvement scotland
and the scottish medicines consortium
In October 2011, the Scottish Medicines Consortium (SMC) advised that botulinum toxin type A (Xeomin®)
is accepted for use within NHS Scotland for adults with post-stroke spasticity of the upper limb presenting
with flexed wrist and clenched fist.
In March 2011, SMC advised that botulinum toxin type A (Botox®) is accepted for use within NHSScotland for
adults with focal spasticity, including the treatment of wrist and hand disability due to upper limb spasticity
associated with stroke.
In January 2013, SMC advised that clostridium botulinum type A toxin-haemagglutinin complex (Dysport®)
is accepted for use within NHSScotland for focal spasticity associated with stroke, including the treatment
of arm symptoms associated with focal spasticity in conjunction with physiotherapy.
| 49
Brain injury rehabilitation in adults
13 The evidence base
13.1systematic literature review
The evidence base for this guideline was synthesised in accordance with SIGN methodology. A systematic
review of the literature was carried out using an explicit search strategy devised by a SIGN Evidence and
Information Scientist. Databases searched include Medline, Embase, Cinahl, PsycINFO and the Cochrane
Library. The year range covered was 1990-2011. Internet searches were carried out on various websites
including the US National Guidelines Clearinghouse. The main searches were supplemented by material
identified by individual members of the development group. Each of the selected papers was evaluated
by two members of the group using standard SIGN methodological checklists before conclusions were
considered as evidence.
13.1.1literature search for patient issues
At the start of the guideline development process, a SIGN Evidence and Information Scientist conducted
a literature search for qualitative and quantitative studies that addressed patient issues of relevance to
rehabilitation of patients with a brain injury. Databases searched include Medline, Embase, Cinahl and
PsycINFO, and the results were summarised and presented to the guideline development group.
13.2recommendations for research
The guideline development group was not able to identify sufficient evidence to answer all of the key
questions asked in this guideline (see Annex 1). The following areas for further research have been identified:
yy p
harmacological and psychological therapies for the management of different symptoms in patients
following MTBI
yy the use of virtual reality training in rehabilitation following ABI
yy the effectiveness and cost-effectiveness of specific therapies for spasticity in patients following ABI,
including:
~~ physical therapies including casting and stretching
~~ pharmacological therapies
~~ functional electrical stimulation
~~ surgery
~~ occupational therapy
yy the effects of AFO on mobility and muscle activity in discrete TBI populations
yy physical interventions (eg fitness training, treadmill training, use of walking aids) for recovery of mobility
and function in discrete TBI populations
yy pharmacological and psychological therapies for the management of depression in patients with ABI
yy pharmacological and psychological therapies for the management of patients in the minimally conscious
and vegetative state
yy pharmacological therapies for the management of anxiety disorders in patients with ABI
yy the effectiveness of rhythmic auditory stimulation in improving elements of gait in patients with ABI
yy a framework for vocational rehabilitation research which:
~~ addresses insensitivity regarding return to work outcomes
~~ takes account of the heterogeneous nature of rehabilitation
~~ develops a standardised measure of VR needs
~~ explores the provision of an intervention which is both standardised and allows for
individualisation
~~ explores the long term impact of VR and employment after TBI
yy therapies to manage incontinence in patients following ABI
yy therapies to improve problems with language or functional communication
50 |
13 • The evidence base
yy
yy
yy
yy
therapies to improve disordered social communication skills
restorative exercises to improve dysphagia
restitution cognitive rehabilitation through computerised technology
development and evaluation of interventions that can improve insight and awareness given the potential
impact of insight difficulties on the ability to engage in rehabilitation. It is vital that studies also examine
the impact of increased awareness/insight on participation in rehabilitation and long term outcome.
13.3review and updating
This guideline was published in 2013 and will be considered for review in three years. Any updates to the
guideline in the interim period will be noted on the SIGN website: www.sign.ac.uk
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Brain injury rehabilitation in adults
14 Development of the guideline
14.1introduction
SIGN is a collaborative network of clinicians, other healthcare professionals and patient organisations and
is part of Healthcare Improvement Scotland. SIGN guidelines are developed by multidisciplinary groups of
practising clinicians using a standard methodology based on a systematic review of the evidence. Further
details about SIGN and the guideline development methodology are contained in SIGN 50: A Guideline
Developer’s Handbook, available at www.sign.ac.uk
14.2the guideline development group
Ms Ailsa McMillan
(Chair)
Lecturer, Division of Nursing, Occupational Therapy and Arts Therapies, School of Health Sciences, Queen Margaret University, Edinburgh
Dr Gillian Baer
Senior Lecturer, Division of Physiotherapy, School of Health Sciences, Queen Margaret University, Edinburgh
Mrs Avril Beattie
Clinical Coordinator, Centre for Brain Injury Rehabilitation, Royal Victoria Hospital, Dundee
Dr Alan Carson
Consultant Neuropsychiatrist, Astley Ainslie Hospital, Edinburgh
Ms Mary Edwards
Speech and Language Therapist, Royal Hospital for Sick Children, Glasgow
Professor Jonathan Evans
Professor of Applied Neuropsychology, Glasgow University
Dr Andrew Harrison
Clinical Neuropsychologist, Astley Ainslie Hospital, Edinburgh
Ms Shiona Hogg
AHP Manager for Rehabilitation, Falkirk Community Hospital
Dr Roger Holden
Consultant in Rehabilitation Medicine, Dumfries and Galloway Royal Infirmary
Dr Roisin Jack
Clinical Psychologist (Neuropsychology), Craig Court Neurorehabilitation Unit, Aberdeen
Ms Vicky Mayer
Speech and Language Therapist, Astley Ainslie Hospital, Edinburgh
Ms Gaille McCann
West Scotland Regional Coordinator, Headway, Edinburgh
Dr Gordon McLaren
Consultant in Public Health Medicine, NHS Fife, Leven
Mr Donald McLean
Coordinator/Superintendent Physiotherapist, Falkirk Community Hospital
Miss Jacqueline McPherson
Paediatric Neurology Nurse Specialist, Royal Hospital for Sick Children, Edinburgh
Dr Moray Nairn
Programme Manager, SIGN
Mrs Lynne Smith
Evidence and Information Scientist, SIGN
Miss Angela Sprott
Acquired Brain Injury Service Coordinator, West Dunbartonshire Council
Ms Dorothy Strachan
Clinical Services Manager, Momentum Pathways, Aberdeen
Dr Alastair Weir
Consultant in Rehabilitation Medicine, Southern General Hospital, Glasgow
Mrs Jenny Williams
Carer, Isle of Lewis
The membership of the guideline development group was confirmed following consultation with the member
organisations of SIGN. All members of the guideline development group made declarations of interest and
further details of these are available on request from the SIGN Executive.
52 |
14 • Development of the guideline
Guideline development and literature review expertise, support and facilitation were provided by the SIGN
Executive. All members of the SIGN Executive make yearly declarations of interest and further details of these
are available on request.
Mrs Lesley Forsyth
Events Coordinator
Mrs Karen Graham
Patient Involvement Officer
Mr Campbell Reynolds
Distribution and Office Coordinator
Mr Stuart Neville Publications Designer
Ms Gaynor Rattray
Guideline Coordinator
14.3ACKNOWLEDGEMENTS
SIGN is grateful to the following former members of the guideline development group and others who have
contributed to the development of the guideline.
Ms Shona Forsyth
Neuropaediatric Outreach Nurse, Southern General Hospital, Glasgow
Dr Nitin Gambhir
General Practitioner, Glasgow
Ms Sheena Glen
Neurorehabilitation Services Occupational Therapy Lead Clinician, Scottish Brain Injury Service, Astley Ainslie Hospital, Edinburgh
Professor Tom McMillan
Professor of Clinical Neuropsychology, University of Glasgow
Dr Sharon Mulhern
Consultant Clinical Psychologist, Ayrshire Central Hospital
Ms Claire O’Brien
Specialist Nurse, Community Treatment Centre of Brain Injury, Glasgow
Mr Kevin Williams
Lay representative, Isle of Lewis
14.4consultation and peer review
14.4.1national open meeting
A national open meeting is the main consultative phase of SIGN guideline development, at which the guideline
development group presents its draft recommendations for the first time. The national open meeting for this
guideline was held on 5 December 2011 and was attended by 137 representatives of all the key specialties
relevant to the guideline. The draft guideline was also available on the SIGN website for a limited period at
this stage to allow those unable to attend the meeting to contribute to the development of the guideline.
14.4.2specialist review
This guideline was also reviewed in draft form by the following independent expert referees, who were
asked to comment primarily on the comprehensiveness and accuracy of interpretation of the evidence base
supporting the recommendations in the guideline. The guideline group addresses every comment made by
an external reviewer, and must justify any disagreement with the reviewers’ comments. All expert referees
made declarations of interest and further details of these are available on request from the SIGN Executive.
SIGN is very grateful to all of these experts for their contribution to the guideline.
Ms Sharon Beck
Occupational Therapist, Raigmore Hospital, Inverness
Dr Nicola Brain
Consultant in Rehabilitation Medicine, Royal Derby Hospital
Dr John Burn
Consultant in Rehabilitation and Brain Injury, Poole Hospital, Poole
Dr Sheena Caldwell
Consultant in Rehabilitation Medicine, Musgrave Park Hospital, Belfast
Ms Michelle Coulson
Patient Representative, Aberdeen
Dr Breda Cullen
Clinical Neuropsychologist, Physically Disabled Rehabilitation Unit, Southern General Hospital, Glasgow
| 53
Brain injury rehabilitation in adults
54 |
Ms Andrea Duncan
Physiotherapist, Raigmore Hospital, Inverness
Dr Alasdair Fitzgerald
Consultant in Neurorehabilitation, Astley Ainslie Hospital, Edinburgh
Dr Simon Fleminger
Consultant Neuropsychiatrist, Glenside Hospital, Salisbury
Mr Douglas Gentleman
Consultant/Clinical Director in Neurorehabilitation and Honorary Consultant in Neurosurgery, Royal Victoria Hospital, Dundee
Dr Sarah Gillanders
Clinical Neuropsychologist, Liberton Hospital, Edinburgh
Dr Helen Gooday
Consultant in Rehabilitation Medicine, Woodend Hospital, Aberdeen
Dr Joanna Gouick
Head of Clinical Neuropsychology, Astley Ainslie Hospital, Edinburgh
Dr Alan Harper
Clinical Psychologist, Cameron Hospital, Fife
Ms Alison Hawitt
Lead Speech and Language Therapist, Scottish Neurobehavioural Rehabiliation Service, Royal Edinburgh Hospital
Dr Carol Hawley
Principal Research Fellow, University of Warwick, Coventry
Dr Denyse Kersel
Consultant Neuropsychologist, The Community Treatment Centre for Brain Injury, Glasgow
Ms Morag MacDonald
Senior Occupational Therapist, Dumfries and Galloway Royal Infirmary
Dr Phil Mackie
Lead Consultant, Scottish Public Health Network, Edinburgh
Dr William McKinlay
Director, Case Management Services Ltd, Edinburgh
Professor Tom McMillan
Professor of Clinical Neuropsychology, Gartnavel Royal Hospital, Glasgow
Ms Sarah McNeish
Physiotherapist, Raigmore Hospital, Inverness
Dr Sharon Mulhern
Consultant Clinical Lead Neuropsychology, Ayrshire Central Hospital, Irvine
Ms Rosie Murray
SMC Manager, Delta House, Glasgow
Ms Morag Ogilvie
Senior Dietitian, Forth Valley Royal Hospital, Larbet
Dr Brian O’Neill
Consultant in Neuropsychology and Rehabilitation, Graham Anderson House, Glasgow
Dr Brian O’Suilleabhain
Consultant in Public Health, NHS Lanarkshire, Bothwell
Ms Ailsa Paterson
Speech and Language Therapist, Ayrshire Central Hospital, Irvine
Ms Linda Prevett
Specialist Speech and Language Therapist, Dumfries and Galloway Royal Infirmary
Dr Ann-Marie Pringle
Head of Speech and Language Therapy, Astley Ainslie Hospital, Edinburgh
Ms Rhona Petrie
Lead Clinical Pharmacist, Southern General Hospital, Glasgow
Dr Hugh Rickards
Consultant in Neuropsychiatry, The Barberry National Centre for Mental Health, Birmingham
Ms Anne Rowe
Specialist Speech and Language Therapist, Western General Hospital, Edinburgh
Ms Lesley Scobie
Team Leader Physiotherapist, Royal Victoria Hospital, Dundee
Ms Ethel Sinclair
Senior Physiotherapist, Astley Ainslie Hospital, Edinburgh
Dr Lance Sloan
Consultant in Rehabilitation Medicine, Cameron Hospital, Fife
Mr John Smith
Specialist Orthotist, Stirling Community Hospital
Mr Ben Sutherland
Nurse Consultant (Rehabilitation Nursing), Cameron Hospital, Fife
Ms Morag Tait
Speech and Language Therapist, Raigmore Hospital, Inverness
Dr Robert Taylor
Consultant Clinical Neuropsychologist, Western General Hospital, Edinburgh
Dr Lorna Torrens
Head of Clinical Health Psychology, Astley Ainslie Hospital, Edinburgh
14 • Development of the guideline
Dr Killian Welch
Consultant Neuropsychiatrist, Royal Edinburgh Hospital
Ms Anne Williamson
Senior Physiotherapist, Falkirk Community Hospital
14.4.3sign editorial group
As a final quality control check, the guideline is reviewed by an editorial group comprising the relevant specialty
representatives on SIGN Council to ensure that the specialist reviewers’ comments have been addressed
adequately and that any risk of bias in the guideline development process as a whole has been minimised.
The editorial group for this guideline was as follows. All members of the SIGN Editorial group make yearly
declarations of interest and further details of these are available on request from the SIGN Executive.
Dr Keith Brown
Chair of SIGN; Co-Editor
Ms Iris Clarke
Professional Head of Service for Speech and Language Therapy NHS Highland, Raigmore Hospital, Inverness
Dr Roberta James
SIGN Programme Lead; Co-Editor
Dr Sara Twaddle
Director of SIGN; Co-Editor
| 55
Brain injury rehabilitation in adults
Abbreviations
56 |
AAC
alternative and augmentative communication strategies
ABI
acquired brain injury
ADL
activities of daily living
AFO
ankle foot orthosis
AHP
allied health professional
BDI
Beck Depression Inventory
BICRO-39
Brain Injury Community Rehabilitation Outcome-39
BNF
British National Formulary
BoNT
botulinum neurotoxin therapy
CBT
cognitive behavioural therapy
CI
confidence interval
CMP
contingency management procedures
CNS
central nervous system
CRS-R Coma Recovery Scale – Revised
DSM-IV
Diagnostic and Statistical Manual of Mental Disorders, fourth edition
ED
emergency department
ERABI Evidence Based Review of Rehabilitation of Moderate to Severe Acquired Brain Injuries
FAM
Functional Assessment Measure
FEES
fibreoptic endoscopic evaluation of swallowing
FIM
Functional Independence Measure
FTF
face-to-face
GCS
Glasgow Coma Scale
GMC
General Medical Council
GOS
Glasgow Outcome Scale
GOS-E
Extended Glasgow Outcome Scale
HADS Hospital Anxiety and Depression Scale
ICD-10
International Classification of Diseases and Related Health Problems, tenth revision
LSVT
Lee Silverman Voice Treatment
MA
marketing authorisation
MCS
minimally conscious state
MDT
multidisciplinary team
MTA multiple technology appraisal
MTBI mild traumatic brain injury
NHS National Health Service
NICE National Institute for Health and Clinical Excellence
Abbreviations
NMES
OT
neuromuscular electrical stimulation
occupational therapy
PBI
positive behaviour interventions
PCS
post-concussional syndrome
PDA personal digital assistant
PICO
population, intervention, comparison, outcome
PTA
post traumatic amnesia
PTSD post traumatic stress disorder
RCT
randomised controlled trial
SIGN Scottish Intercollegiate Guidelines Network
SMC
Scottish Medicines Consortium
SPPARC
Supporting Partners of People with Aphasia in Relationships and Conversation
TBI
traumatic brain injury
TRH
telerehabilitation
TT
treadmill training
VR
vocational rehabilitation
VS
vegetative state
WHO World Health Organisation
| 57
Brain injury rehabilitation in adults
Annex 1
Key questions used to develop the guideline
This guideline is based on a series of structured key questions that define the target population, the
intervention, diagnostic test, or exposure under investigation, the comparison(s) used and the outcomes used
to measure efficacy, effectiveness, or risk. These questions form the basis of the systematic literature search.
Key question
1.
I n patients who have had a mild/minor brain injury and later present (in
primary care) what assessment/questions can be asked/applied to facilitate 3.1-3.3
triage to the appropriate service?
2.
hat evidence is there that the following interventions in patients with
W
brain injuries improve measurable components of physical function (see
below)?
yy daily/repetitive specific physiotherapy (early/late)
yy daily/repetitive specific occupational therapy (early/late)
yy daily/repetitive practice of remedial activities (early/late)
~~ computer based exercise rehabilitation/virtual reality rehabilitation
~~ Nintendo Wii™
~~ physical games, eg basketball, racquet games etc
yy daily/repetitive practice of functional activities (early/late)
yy constraint induced therapy.
3.
4.
58 |
See guideline section
4.3
4.1.5
What is the evidence for the effectiveness of the following interventions
in the management of spasticity and muscle tone in patients with brain
injuries:
yy exercise
yy splinting
yy electrostimulation /functional electrical stimulation
yy anti-spasticity drugs (baclofen, tizanidine, dantrolene and diazepam)
yy botulinum toxin
yy surgery
yy physiotherapy (early/late)
yy occupational therapy (early/late)
yy optimum seating and positioning including specialist equipment?
4.2
In patients with brain injuries and continence problems, which of the
following interventions are effective in improving continence:
yy timed voiding/bladder retraining
yy oestrogen
yy anticholinergics, eg oxybutynin
yy biofeedback
yy anticholinergics
yy duloxetine
yy catheterisation?
4.4
Annexes
5.
6a.
hat is the evidence for the effectiveness of the following interventions
W
in improving gait, balance and mobility in patients with brain injuries
(consider also duration of therapy):
yy treadmill training
yy biofeedback (any type)
yy electrostimulation (ES or FEES)
yy orthoses (any type)
yy task-related training
yy neurophysiological training
yy physical fitness training
yy electromechanical assisted gait training
yy repetitive task training
yy walking aids (sticks, zimmers, walking frames)
yy strengthening
yy intensity?
4.1
I n patients with brain injuries, what is the evidence that the following
interventions lead to reductions in impairment:
yy daily/repetitive practice of activities (early/late)?
5.3-5.7
6b. I n patients with brain injuries, what is the evidence that the following
interventions lead to improvement in self management of disability:
yy compensatory approaches which would include; electronic aids (ie
neuropage, sense cam, watches, ictaphones, mobile phones, alarms, PDAs), 5.3-5.7
diaries, environmental modification
yy cognitive approaches including errorless learning, enhanced learning,
mnemonics, holistic approach, paper based therapies?
6c.
In patients with brain injuries is there any evidence to guide the
assessment and management of insight/awareness of the patient?
5.2
7.
Which of the following interventions reduce challenging/aggressive
behaviour (eg absconding, non-cooperation, aggression, apathy) in
patients with brain injury:
yy any psychological treatment
yy any pharmacological treatment?
6.1
What evidence is there that the following interventions in patients with
brain injuries improve emotional lability, depression and anxiety:
yy antidepressants
yy anxiolitics
yy any psychological therapy?
6.2
8.
| 59
Brain injury rehabilitation in adults
60 |
9.
o the following speech and language therapy interventions (speech
D
motor/oral exercises, computer based treatments, introduction of
alternative and augmentative communication strategies (AAC),
introduction of impairment based strategies, introduction of alternative/
total communication strategies, communication partner training, eg
SPPARC (Supporting Partners of People with Aphasia in Relationships and
Conversation)) reduce/improve:
yy dysarthria
7.1
yy dysphasia/aphasia
yy articulatory dyspraxia/apraxia of speech
yy acquired dyslexia
yy acquired dysgraphia
yy social communication skills/pragmatic impairment/right hemisphere
language disorder and improve communicative effectiveness/functional
communication?
10.
Compared with bedside evaluation alone, does instrumental assessment
of dysphagia (eg videofluoroscopy; fibreoptic endoscopic evaluation of
swallowing (FEES)) allow:
7.2.1
yy more frequent resumption of oral diet and faster resumption of oral diet
yy more frequent removal of alternative feeding tubes and quicker removal
of alternative feeding tubes?
11.
What is the evidence that restorative exercises improve outcome in
dysphagia compared with compensatory techniques alone?
7.2.2
12.
patients with brain injury, what is the evidence that oral hygiene
In
programmes reduce the incidence and severity of aspiration-associated
chest infection and pneumonia?
7.3
13.
What is the evidence that vocational rehabilitation improves outcome for
patients with brain injuries?
8.1, 8.2
14.
patients with brain injuries is rehabilitation in a specialist unit (a unit
In
which specialises in the care of patients with ABI, ie a dedicated neurorehabilitation unit) better than rehabilitation in a non-specialised/general
unit in terms of:
yy increased understanding and awareness of condition
yy reduced aggressive/challenging behaviours
yy more rapid return to work
yy more rapid return to education
yy more rapid return to carer role
yy more rapid return to leisure pursuits
yy reduced carer stress
yy improved physical functioning
yy improved functional ability (activities of daily living - ADL)?
10.1
Annexes
15.
Is there any evidence of improvement in the following if patients with
brain injuries follow a formally agreed discharge pathway (goal planning
meetings, pre-discharge planning) when they are discharged from rehab
to home:
yy increased understanding and awareness of condition
yy reduced aggressive/challenging behaviours
yy more rapi return to work
yy more rapid return to education
yy more rapid return to carer role
yy more rapid return to leisure pursuits
yy reduced carer stress
yy improved physical functioning
yy improved functional ability (activities of daily living - ADL)?
10.4
16.
What is the evidence that, in patients with brain injuries who live in remote
and rural areas or have limited access to centralised care, the following
are improved with telemedicine (remote assessment and delivery of
interventions) compared to usual care:
yy mood/depression (ie HADS, BDI, etc)
yy goal attainment
yy increased ability to carry out personal or domestic activities of daily living
– by self report, carer/relative report/occupational therapy (OT) assessment 10.3
yy return to independent living
yy return to caring role
yy return to education
yy return to work
yy return to leisure pursuits
yy carer burden
yy Extended Glasgow Outcome Scale (GOS-E)?
17.
I n patients with brain injuries who are minimally conscious or in a
persistent vegetative state, do sensory stimulation and/or pharmaceutical
interventions (zopiclone, zolpidem, levodopa) improve responsiveness or
awareness?
18.
9.1-9.4
In patients with brain injuries is rehabilitation in the community by an MDT
better than usual care (GP etc) in terms of:
yy increased understanding and awareness of condition
yy reduced aggressive/challenging behaviours
yy more rapid return to work
yy more rapid return to education
10.2
yy more rapid return to carer role
yy more rapid return to leisure pursuits
yy reduced carer stress
yy improved physical functioning
yy improved functional ability (ADL)?
| 61
Brain injury rehabilitation in adults
References
1. Thornhill S, Teasdale GM, Murray GD, McEwen J, Roy
CW, Penny KI. Disability in young people and adults one
year after head injury: Prospective cohort study. BMJ
2000;320(7250):1631-5.
2. McMillan TM, Teasdale GM, Weir CJ, Stewart E. Death after
head injury: the 13 year outcome of a case control study. J
Neurol Neurosurg Psychiatry. 2011;82(8):931-5.
3. Scottish Intercollegiate Guidelines Network (SIGN). Early
management of patients with a head injury. Edinburgh:
SIGN; 2009. (SIGN publication no. 110). [cited 20 Feb
2013]. Available from url: http://www.sign.ac.uk/guidelines/
fulltext/110/index.html
4. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis
and management of headache in adults. Edinburgh:
SIGN; 2008. (SIGN publication no. 107). [cited 20 Feb
2013]. Available from url: http://www.sign.ac.uk/guidelines/
fulltext/107/index.html
5. Scottish Intercollegiate Guidelines Network (SIGN).
Management of patients with stroke: Rehabilitation, prevention
and management of complications and discharge planning.
Edinburgh: SIGN; 2010. (SIGN publication no. 118). [cited 20
Feb 2013]. Available from url: http://www.sign.ac.uk/guidelines/
fulltext/118/index.html
6. Scottish Intercollegiate Guidelines Network (SIGN).
Management of patients with stroke: Identification and
management of dysphagia. Edinburgh: SIGN; 2010. (SIGN
publication no. 119). [cited 20 Feb 2013]. Available from url:
http://www.sign.ac.uk/guidelines/fulltext/119/index.html
7. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis
and management of epilepsy in adults. Edinburgh: SIGN; 2003.
(SIGN publication no. 70). [cited 20 Feb 2013]. Available from
url: http://www.sign.ac.uk/guidelines/fulltext/70/index.html
8. Daisley A, Webster G. Familial Brain Injury: Impact on and
Interventions with Children. In: Tyerman A, King NS, editors.
Psychological Approaches to Rehabilitation after Traumatic
Brain Injury. Oxford: Blackwell; 2009.
9. Scottish Needs Assessment Programme. Huntington’s
Disease, acquired brain injury and early onset dementia.
Glasgow: Office for Public Health in Scotland; 2000.
10. Dalton C, Farrell R, De Souza A, Wujanto E, McKenna-Slade
A, Thompson S, et al. Patient inclusion in goal setting during
early inpatient rehabilitation after acquired brain injury. Clin
Rehabil. 2012;26(2):165-73.
11. Law M, Baptiste S, McColl M, Opzoomer A, Polatajko H,
Pollock N. The Canadian occupational performance measure:
an outcome measure for occupational therapy. Can J Occup
Ther. 1990;57(2):82-7.
12. Turner-Stokes L, Nyein K, Turner-Stokes T, Gatehouse C.
The UK FIM+FAM: development and evaluation. Functional
Assessment Measure. Clin Rehabil. 1999;13(4):277-87.
13. Mahoney FI, Barthel DW. Functional Evaluation: The Barthel
Index. Md State Med J. 1965;14:61-5.
14. Johnston MV, Sherer M, Whyte J. Applying evidence
standards to rehabilitation research. Am J Phys Med Rehabil.
2006;85(4):292-309.
62 |
15. Fann JR, Hart T, Schomer KG. Treatment for depression after
traumatic brain injury: a systematic review. J Neurotrauma
2009;26(12):2383-402.
16. Prvu Bettger JA, Stineman MG. Effectiveness of multidisciplinary
rehabilitation services in postacute care: state-of-the-science.
A review. Arch Phys Med Rehabil 2007;88(11):1526-34.
17. Greenhalgh T. How to read a paper. The basics of evidence
based medicine. 3rd edition. Oxford: Blackwell Publishing Ltd;
2006.
18. Turner-Stokes L, Disler PB, Nair A, Wade DT. Multi-disciplinary
rehabilitation for acquired brain injury in adults of working age.
Cochrane Database of Systematic Reviews 2005, Issue 3.
19. Fleminger S, Greenwood RJ, Oliver DL. Pharmacological
management for agitation and aggression in people with
acquired brain injury. Cochrane Database of Systematic
Reviews 2006, Issue 4.
20. Guidance on Prescribing. In: British National Formulary No. 62.
London: British Medical Association and Royal Pharmaceutical
Society of Great Britain; 2011.
21. Medicines and Healthcare products Regulatory Agency and
Commission on Human Medicines. Drug safety update, 2(9).
[cited 21 Feb 2013]. Available from url: http://www.mhra.gov.
uk/home/groups/pl-p/documents/publication/con043810.pdf
22. Cassidy JD, Carroll LJ, Peloso PM, Borg J, von Holst H, Holm
L, et al. Incidence, risk factors and prevention of mild traumatic
brain injury: results of the WHO Collaborating Centre Task
Force on Mild Traumatic Brain Injury. J Rehabil Med. 2004(43
Suppl):28-60.
23. Teasdale GM, Murray G, Anderson E, Mendelow AD,
MacMillan R, Jennett B, et al. Risks of acute traumatic
intracranial haematoma in children and adults: implications
for managing head injuries. BMJ 1990;300(6721):363-7.
24. Strang I, MacMillan R, Jennett B. Head injuries in accident
and emergency departments at Scottish hospitals. Injury.
1978;10(2):154-9.
25. Swann IJ, MacMillan R, Strong I. Head injuries at an inner city
accident and emergency department. Injury. 1981;12(4):274-8.
26. Carroll LJ, Cassidy JD, Holm L, Kraus J, Coronado VG.
Methodological issues and research recommendations for
mild traumatic brain injury: the WHO Collaborating Centre
Task Force on Mild Traumatic Brain Injury. J Rehabil Med.
2004(43 Suppl):113-25.
27. Carroll LJ, Cassidy JD, Peloso PM, Borg J, von Holst H, Holm
L, et al. Prognosis for mild traumatic brain injury: results of the
WHO Collaborating Centre Task Force on Mild Traumatic Brain
Injury. J Rehabil Med 2004;43:84-105.
28. Frencham KAR, Fox AM, Maybery MT. Neuropsychological
studies of mild traumatic brain injury: A meta-analytic review of
research since 1995. J Clin Exp Neuropsychol 2005;27(3):33451.
29. British Psychological Society. Assessment of effort in clinical
testing of cognitive functioning for adults. 2009. [cited 21 Feb
2013]. Available from url: http://www.bps.org.uk/sites/default/
files/documents/assessment_of_effort_in_clinical_testing_of_
cognitive_functioning_for_adults.pdf
30. Broomhall LG, Clark CR, McFarlane AC, O’Donnell M, Bryant
R, Creamer M, et al. Early stage assessment and course of
acute stress disorder after mild traumatic brain injury. J Nerv
Ment Dis 2009;197(3):178-81.
References
31. Bryant RA, Harvey AG. Relationship between acute stress
disorder and posttraumatic stress disorder following mild
traumatic brain injury. Am J Psychiatry 1998;155(5):625-9.
32. Bryant RA, O’Donnell ML, Creamer M, McFarlane AC, Clark
CR, Silove D. The psychiatric sequelae of traumatic injury. Am
J Psychiatry 2010;167(3):312-20.
33. Fear NT, Jones E, Groom M, Greenberg N, Hull L, Hodgetts
TJ, et al. Symptoms of post-concussional syndrome are nonspecifically related to mild traumatic brain injury in UK Armed
Forces personnel on return from deployment in Iraq: an
analysis of self-reported data. Psychol Med 2009;39(8):137987.
34. Hill 3rd JJ, Mobo Jr BH, Cullen MR. Separating deploymentrelated traumatic brain injury and posttraumatic stress disorder
in veterans: preliminary findings from the Veterans Affairs
traumatic brain injury screening program. Am J Phy Med
Rehabil 2009;88(8):605-14.
35. Vanderploeg RD, Belanger HG, Curtiss G. Mild traumatic
brain injury and posttraumatic stress disorder and their
associations with health symptoms. Arch Phys Med Rehabil
2009;90(7):1084-93.
36. Scottish Intercollegiate Guidelines Network (SIGN). The
management of harmful drinking and alcohol dependence in
primary care. Edinburgh: SIGN; 2003. (SIGN publication no.
74). [cited 20 Feb 2013]. Available from url: http://www.sign.
ac.uk/guidelines/fulltext/74/index.html
37. Borg J, Holm L, Cassidy JD, Peloso PM, Carroll LJ, von Holst
H, et al. Diagnostic procedures in mild traumatic brain injury:
Results of the WHO Collaborating Centre Task Force on Mild
Traumatic Brain Injury. J Rehabil Med 2004;43:61-75.
38. Borg J, Holm L, Peloso PM, Cassidy JD, Carroll LJ, von Holst
H, et al. Non-surgical intervention and cost for mild traumatic
brain injury: results of the WHO Collaborating Centre Task
Force on Mild Traumatic Brain Injury. J Rehabil Med. 2004(43
Suppl):76-83.
46. Zoccolotti P, Cantagallo A, De Luca M, Guariglia C, Serino A,
Trojano L. Selective and integrated rehabilitation programs for
disturbances of visual/spatial attention and executive function
after brain damage: a neuropsychological evidence-based
review. Eur J Phys Rehabil Med. 2011;47(1):123-47.
47. Barnes MP. Rehabilitation after traumatic brain injury. Br Med
Bull. 1999;55(4):927-43.
48. Lew HL, Poole JH, Guillory SB, Salerno RM, Leskin G, Sigford
B. Persistent problems after traumatic brain injury: The need
for long-term follow-up and coordinated care. J Rehabil Res
Dev. 2006;43(2):vii-x.
49. Katz DI, White DK, Alexander MP, Klein RB. Recovery of
ambulation after traumatic brain injury. Arch Phys Med Rehabil
2004;85(6):865-9.
50. Marshall S, Teasell R, Bayona N, Lippert C, Chundamala J,
Villamere J, et al. Motor impairment rehabilitation post acquired
brain injury. Brain Inj 2007;21(2):133-60.
51. Teasell R, Marshall S, Cullen N, Bayley M, Rees L, Weiser M,
et al. Evidence-based review of moderate to severe acquired
brain injury. [cited 21 Feb 2013]. Available from url: http://www.
abiebr.com/
52. Brown TH, Mount J, Rouland BL, Kautz KA, Barnes RM, Kim J.
Body weight-supported treadmill training versus conventional
gait training for people with chronic traumatic brain injury. J
Head Trauma Rehabil 2005;20(5):402-15.
53. Freivogel S, Schmalohr D, Mehrholz J. Improved walking ability
and reduced therapeutic stress with an electromechanical gait
device. J Rehabil Med 2009;41(9):734-9.
54. Leung J, Moseley A. Impact of ankle-foot orthoses on gait
and leg muscle activity in adults with hemiplegia: systematic
literature review. Physiotherapy 2003;89(1):39-55.
55. Hellweg S, Johannes S. Physiotherapy after traumatic
brain injury: A systematic review of the literature. Brain Inj
2008;22(5):365-73.
39. Snell DL, Surgenor LJ, Hay-Smith EJC, Siegert RJ. A
systematic review of psychological treatments for mild
traumatic brain injury: An update on the evidence. J Clin Exp
Neuropsychol 2009;31(1):20-38.
56. Hassett LM, Moseley AM, Tate R, Harmer AR. Fitness training
for cardiorespiratory conditioning after traumatic brain injury.
Cochrane Database of Systematic Reviews 2008, Issue 2.
40. Al Sayegh A, Sandford D, Carson AJ. Psychological approaches
to treatment of postconcussion syndrome: a systematic review.
J Neurol Neurosurg Psychiatry 2010;81(10):1128-34.
57. Mossberg KA, Amonette WE, Masel BE. Endurance training
and cardiorespiratory conditioning after traumatic brain injury.
J Head Trauma Rehabil. 2010;25(3):173-83.
41. Comper P, Bisschop SM, Carnide N, Tricco A. A systematic
review of treatments for mild traumatic brain injury. Brain Inj
2005;19(11):863-80.
58. Mumford N, Wilson PH. Virtual reality in acquired brain injury
upper limb rehabilitation: Evidence-based evaluation of clinical
research. Brain Inj 2009;23(3):179-91.
42. Dinan TG, Mobayed M. Treatment resistance of depression
after head injury: a preliminary study of amitriptyline response.
Acta Psychiatr Scand. 1992;85(4):292-4.
59. Royal College of Physicians, British Society of Rehabilitation
Medicine, Chartered Society of Physiotherapy, Association of
Chartered Physiotherapists Interested in Neurology. Spasticity
in adults: management using botulinum toxin. National
guidelines. London: RCP; 2009. [cited 21 Feb 2013]. Available
from url: http://bookshop.rcplondon.ac.uk/contents/6988a14a1179-4071-8f56-dc2a865f0a43.pdf
43. Saran AS. Depression after minor closed head injury: role of
dexamethasone suppression test and antidepressants. J Clin
Psychiatry. 1985;46(8):335-8.
44. Saran A. Antidepressants not effective in headache
associated with minor closed head injury. Int J Psychiatry Med.
1988;18(1):75-83.
45. Tyler GS, McNeely HE, Dick ML. Treatment of post-traumatic
headache with amitriptyline. Headache. 1980;20(4):213-6.
60. Marks LJ. Specialised wheelchair seating: national clinical
guidelines. British Society of Rehabilitation Medicine; 2004.
61. Katalinic OM, Harvey LA, Herbert RD, Moseley AM, Lannin
NA, Schurr K. Stretch for the treatment and prevention of
contractures. Cochrane Database of Systematic Reviews
2010, Issue 9.
| 63
Brain injury rehabilitation in adults
62. Lannin NA, Novak I, Cusick A. A systematic review of upper
extremity casting for children and adults with central nervous
system motor disorders. Clin Rehabil 2007;21(11):963-76.
78. Chua K, Chuo A, Kong KH. Urinary incontinence after traumatic
brain injury: incidence, outcomes and correlates. Brain Inj
2003;17(6):469-78.
63. Mortenson PA, Eng JJ. The use of casts in the management
of joint mobility and hypertonia following brain injury in adults:
a systematic review. Phys Ther 2003;83(7):648-58.
79. Foxx-Orenstein A, Kolakowsky-Hayner S, Marwitz JH, Cifu
DX, Dunbar A, Englander J, et al. Incidence, risk factors,
and outcomes of fecal incontinence after acute brain injury:
findings from the traumatic brain injury model systems national
database. Arch Phys Med Rehabil 2003;84(2):231-7.
64. Moseley AM, Hassett LM, Leung J, Clare JS, Herbert RD,
Harvey LA. Serial casting versus positioning for the treatment
of elbow contractures in adults with traumatic brain injury: a
randomized controlled trial. Clin Rehabil 2008;22(5):406-17.
65. Verplancke D, Snape S, Salisbury CF, Jones PW, Ward AB.
A randomized controlled trial of botulinum toxin on lower limb
spasticity following acute acquired severe brain injury. Clin
Rehabil 2005;19(2):117-25.
66. Esquenazi A, Mayer N, Garreta R. Influence of botulinum toxin
type A treatment of elbow flexor spasticity on hemiparetic gait.
Am J Phy Med Rehabil 2008;87(4):305-10.
67. Guo F, Yue W, Ren L, Zhang YM, Yang J. Botulinum toxin type
A plus rehabilitative training for improving the motor function
of the upper limbs and activities of daily life in patients with
stroke and brain injury. Neural Regen Res 2006;1(9):859-61.
68. Simpson DM, Gracies JM, Yablon SA, Barbano R, Brashear A.
Botulinum neurotoxin versus tizanidine in upper limb spasticity:
A placebo-controlled study. J Neurol Neurosurg Psychiatry
2009;80(4):380-5.
69. Meythaler JM, Guin-Renfroe S, Johnson A, Brunner RM.
Prospective assessment of tizanidine for spasticity due to
acquired brain injury. Arch Phys Med Rehabil 2001;82(9):115563.
70. Meythaler JM, Clayton W, Davis LK, Guin-Renfroe S, Brunner
RC. Orally delivered baclofen to control spastic hypertonia in
acquired brain injury. J Head Trauma Rehabil 2004;19(2):1018.
71. Hosalkar H, Goebel J, Reddy S, Pandya NK, Keenan MA.
Fixation techniques for split anterior tibialis transfer in spastic
equinovarus feet. Clin Orthop Relat Res 2008;466(10):2500-6.
72. Horn TS, Yablon SA, Chow JW, Lee JE, Stokic DS. Effect of
intrathecal baclofen bolus injection on lower extremity joint
range of motion during gait in patients with acquired brain
injury. Arch Phys Med Rehabil 2010;91(1):30-4.
73. Ross LF, Harvey LA, Lannin NA. Do people with acquired
brain impairment benefit from additional therapy specifically
directed at the hand? A randomized controlled trial. Clin
Rehabil 2009;23(6):492-503.
80. Moiyadi AV, Devi BI, Nair KP. Urinary disturbances following
traumatic brain injury: clinical and urodynamic evaluation.
Neurorehabilitation 2007;22(2):93-8.
81. Safaz I, Alaca R, Yasar E, Tok F, Yilmaz B. Medical
complications, physical function and communication skills
in patients with traumatic brain injury: a single centre 5-year
experience. Brain Inj 2008;22(10):733-9.
82. Coggrave M, Wiesel PH, Norton C. Management of
faecal incontinence and constipation in adults with central
neurological diseases. Cochrane Database of Systematic
Reviews 2006, Issue 2.
83. Singhania P, Andankar MG, Pathak HR. Urodynamic
evaluation of urinary disturbances following traumatic brain
injury. Urol Int 2010;84(1):89-93.
84. National Clinical Guideline Centre. Urinary incontinence in
neurological disease: management of lower urinary tract
dysfunction in neurological disease. London: NICE; 2012.
(NICE guideline CG148). [cited 20 Feb 2103]. Available from
url: http://publications.nice.org.uk/urinary-incontinence-inneurological-disease-cg148
85. Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti
T, Kneipp S, et al. Evidence-based cognitive rehabilitation:
updated review of the literature from 1998 through 2002. Arch
Phys Med Rehabil 2005;86(8):1681-92.
86. Whitnall L, McMillan TM, Murray GD, Teasdale GM. Disability
in young people and adults after head injury: 5-7 year follow up
of a prospective cohort study. J Neurol Neurosurg Psychiatry.
2006;77(5):640-5.
87. Ponsford J, Draper K, Schonberger M. Functional outcome
10 years after traumatic brain injury: its relationship with
demographic, injury severity, and cognitive and emotional
status. J Int Neuropsychol Soc. 2008;14(2):233-42.
88. Ownsworth T, Fleming J. The relative importance of
metacognitive skills, emotional status, and executive function
in psychosocial adjustment following acquired brain injury. J
Head Trauma Rehabil. 2005;20(4):315-32.
74. Lannin NA, McCluskey A. A systematic review of upper limb
rehabilitation for adults with traumatic brain injury. Brain Impair
2008;9(3):237-46.
89. Rohling ML, Faust ME, Beverly B, Demakis G. Effectiveness
of cognitive rehabilitation following acquired brain injury: A
meta-analytic re-examination of Cicerone et al.’s (2000, 2005)
systematic reviews. Neuropsychology 2009;23(1):20-39.
75. Bradt J, Magee WL, Dileo C, Wheeler BL, McGilloway E.
Music therapy for acquired brain injury. Cochrane Database
of Systematic Reviews 2010, Issue 7.
90. Prigatano GP, Klonoff PS. A clinician’s rating scale for
evaluating impaired self-awareness and denial of disability
after brain injury. Clin Neuropsychol 1998;12(1):56-67.
76. Bovend’Eerdt TJ, Dawes H, Sackley C, Izadi H, Wade DT. An
integrated motor imagery program to improve functional task
performance in neurorehabilitation: a single-blind randomized
controlled trial. Arch Phys Med Rehabil 2010;91(6):939-46.
91. Crosson B, Barco PP, Velozo CA, Bolesta MM, Cooper PV,
Werts D, et al. Awareness and compensation in postacute head
injury rehabilitation. J Head Trauma Rehabil 1989;4(3):46-54.
77. Leary SM, Liu C, Cheesman AL, Ritter A, Thompson S,
Greenwood R. Incontinence after brain injury: prevalence,
outcome and multidisciplinary management on a neurological
rehabilitation unit. Clin Rehabil 2006;20(12):1094-9.
64 |
92. Prigatano GP. Principles of neuropsychological rehabilitation.
New York: Oxford University Press; 1999.
93. Ownsworth T, Clare L. The association between awareness
deficits and rehabilitation outcome following acquired brain
injury. Clin Psychol Rev 2006;26(6):783-95.
References
94. Goverover Y, Johnston MV, Toglia J, Deluca J. Treatment to
improve self-awareness in persons with acquired brain injury.
Brain Inj 2007;21(9):913-23.
95. Cappa SF, Benke T, Clarke S, Rossi B, Stemmer B, van
Heugten CM, et al. EFNS guidelines on cognitive rehabilitation:
report of an EFNS task force. Eur J Neurol 2005;12(9):665-80.
96. de Joode E, van Heugten C, Verhey F, van Boxtel M. Efficacy
and usability of assistive technology for patients with cognitive
deficits: a systematic review. Clin Rehabil 2010;24(8):701-14.
97. Cicerone KD, Langenbahn DM, Braden C, Malec JF, Kalmar
K, Fraas M, et al. Evidence-based cognitive rehabilitation:
updated review of the literature from 2003 through 2008. Arch
Phys Med Rehabil 2011;92(4):519-30.
98. Powell LE, Glang A, Ettel D, Todis B, Sohlberg MM, Albin R.
Systematic instruction for individuals with acquired brain injury:
results of a randomised controlled trial. Neuropsychol Rehabil
2012;22(1):85-112.
99. Park NW, Ingles JL. Effectiveness of attention rehabilitation after
an acquired brain injury: a meta-analysis. Neuropsychology
2001;15(2):199-210.
100. Kennedy MRT, Coelho C, Turkstra L, Ylvisaker M, Moore
Sohlberg M, Yorkston K, et al. Intervention for executive
functions after traumatic brain injury: A systematic review,
meta-analysis and clinical recommendations. Neuropsychol
Rehabil 2008;18(3):257-99.
109. Seel RT, Kreutzer JS, Rosenthal M, Hammond FM, Corrigan
JD, Black K. Depression after traumatic brain injury: a National
Institute on Disability and Rehabilitation Research Model
Systems multicenter investigation. Arch Phys Med Rehabil
2003;84(2):177-84.
110. Novack TA, Baños JH, Brunner R, Renfroe S, Meythaler JM.
Impact of early administration of sertraline on depressive
symptoms in the first year after traumatic brain injury. J
Neurotrauma 2009;26(11):1921-8.
111. Rayner L, Price A, Evans A, Valsraj K, Higginson IJ, Hotopf
M. Antidepressants for depression in physically ill people.
Cochrane Database of Systematic Reviews 2010, Issue 3.
112. Bell KR, Hoffman JM, Temkin NR, Powell JM, Fraser RT,
Esselman PC, et al. The effect of telephone counselling on
reducing posttraumatic symptoms after mild traumatic brain
injury: A randomised trial. J Neurol Neurosurg Psychiatry
2008;79(11):1275-81.
113. Bombardier CH, Bell KR, Temkin NR, Fann JR, Hoffman J,
Dikmen S. The efficacy of a scheduled telephone intervention
for ameliorating depressive symptoms during the first year after
traumatic brain injury. J Head Trauma Rehabil 2009;24(4):2308.
114. Bell KR, Brockway JA, Hart T, Whyte J, Sherer M, Fraser RT,
et al. Scheduled telephone intervention for traumatic brain
injury: a multicenter randomized controlled trial. Arch Phys
Med Rehabil 2011;92(10):1552-60.
101. Spikman JM, Boelen DH, Lamberts KF, Brouwer WH, Fasotti
L. Effects of a multifaceted treatment program for executive
dysfunction after acquired brain injury on indications of
executive functioning in daily life. J Int Neuropsychol Soc
2010;16(1):118-29.
115. Bradbury CL, Christensen BK, Lau MA, Ruttan LA, Arundine
AL, Green RE. The efficacy of cognitive behavior therapy in
the treatment of emotional distress after acquired brain injury.
Arch Phys Med Rehabil 2008;89(12 Suppl):S77-84.
102. Vas AK, Chapman SB, Cook LG, Elliott AC, Keebler M. Higherorder reasoning training years after traumatic brain injury in
adults. J Head Trauma Rehabil 2011;26(3):224-39.
116. Scottish Intercollegiate Guidelines Network (SIGN). Nonpharmaceutical management of depression in adults.
Edinburgh: SIGN; 2010. (SIGN publication no. 114). [cited 20
Feb 2013]. Available from url: http://www.sign.ac.uk/guidelines/
fulltext/114/index.html
103. Bornhofen C, McDonald S. Comparing strategies for treating
emotion perception deficits in traumatic brain injury. J Head
Trauma Rehabil 2008;23(2):103-15.
104. Bornhofen C, McDonald S. Treating deficits in emotion
perception following traumatic brain injury. Neuropsychol
Rehabil 2008;18(1):22-44.
105. Cattelani R, Zettin M, Zoccolotti P. Rehabilitation treatments
for adults with behavioral and psychosocial disorders following
acquired brain injury: A systematic review. Neuropsychol Rev
2010;20(1):52-85.
117. Soo C, Tate R. Psychological treatment for anxiety in people
with traumatic brain injury. Cochrane Database of Systematic
Reviews 2007, Issue 3.
118. Fann JR, Katon WJ, Uomoto JM, Esselman PC. Psychiatric
disorders and functional disability in outpatients with traumatic
brain injuries. Am J Psychiatry 1995;152(10):1493-9.
119. van Reekum R, Bolago I, Finlayson MA, Garner S, Links PS.
Psychiatric disorders after traumatic brain injury. Brain Inj
1996;10(5):319-27.
106. Ylvisaker M, Turkstra L, Coehlo C, Yorkston K, Kennedy M,
Sohlberg MM, et al. Behavioral interventions for children and
adults with behaviour diorders after TBI: A systematic review
of the evidence. Brain Inj 2007;21(8):769-805.
120. Bryant RA, Marosszeky JE, Crooks J, Gurka JA. Posttraumatic
stress disorder after severe traumatic brain injury. Am J
Psychiatry 2000;157(4):629-31.
107. Geurtsen GJ, van Heugten CM, Martina JD, Geurts AC.
Comprehensive rehabilitation programmes in the chronic
phase after severe brain injury: a systematic review. J Rehabil
Med 2010;42(2):97-110.
121. Bugg A, Turpin G, Mason S, Scholes C. A randomised
controlled trial of the effectiveness of writing as a self-help
intervention for traumatic injury patients at risk of developing
post-traumatic stress disorder. Behav Res Ther 2009;47(1):612.
108. Bombardier CH, Fann JR, Temkin NR, Esselman PC,
Barber J, Dikmen SS. Rates of major depressive disorder
and clinical outcomes following traumatic brain injury. JAMA
2010;303(19):1938-45.
122. Rispoli MJ, Machalicek W, Lang R. Communication
interventions for individuals with acquired brain injury. Dev
Neurorehabil 2010;13(2):141-51.
123. Ozbudak Demir SO, Gorgulu G, Koseoglu F. Comparison
of rehabilitation outcome in patients with aphasic and nonaphasic traumatic brain injury. J Rehabil Med 2006;38(1):6871.
| 65
Brain injury rehabilitation in adults
124. Fager S, Hux K, Beukelman DR, Karantounis R. Augmentative
and alternative communication use and acceptance by
adults with traumatic brain injury. Augment Altern Commun
2006;22(1):37-47.
139. Bornhofen C, McDonald S. Emotion perception deficits
following traumatic brain injury: A review of the evidence
and rationale for intervention. J Int Neuropsychol Soc
2008;14(4):511-25.
125. Baker F, Wigram T, Gold C. The effects of a song-singing
programme on the affective speaking intonation of people with
traumatic brain injury. Brain Inj 2005;19(7):519-28.
140. Leder SB. Fiberoptic endoscopic evaluation of swallowing
in patients with acute traumatic brain injury. J Head Trauma
Rehabil 1999;14(5):448-53.
126. Rosenbek JC, Rodriguez AD, Hieber B, Leon SA, Crucian GP,
Ketterson TU, et al. Effects of two treatments for aprosodia
secondary to acquired brain injury. J Rehabil Res Dev
2006;43(3):379-90.
141. Brady SL, Pape TLB, Darragh M, Escobar NG, Rao N.
Feasibility of instrumental swallowing assessments in
patients with prolonged disordered consciousness while
undergoing inpatient rehabilitation. J Head Trauma Rehabil
2009;24(5):384-91.
127. Dahlberg CA, Cusick CP, Hawley LA, Newman JK, Morey
CE, Harrison-Felix CL, et al. Treatment efficacy of social
communication skills training after traumatic brain injury: a
randomized treatment and deferred treatment controlled trial.
Arch Phys Med Rehabil 2007;88(12):1561-73.
128. Braden C, Hawley L, Newman J, Morey C, Gerber D, HarrisonFelix C. Social communication skills group treatment: a
feasibility study for persons with traumatic brain injury and
comorbid conditions. Brain Inj 2010;24(11):1298-310.
129. Togher L, McDonald S, Code C, Grant S. Training
communication partners of people with traumatic brain injury:
a randomised controlled trial. Aphasiology 2004;18(4):313-35.
130. Sellars C, Hughes T, Langhorne P. Speech and language
therapy for dysarthria due to non-progressive brain damage.
Cochrane Database of Systematic Reviews 2005, Issue 3.
131. Palmer R, Enderby P. Methods of speech therapy treatment
for stable dysarthria: a review. Adv Speech Lang Pathol
2007;9(2):140-53.
132. Yorkston KM, Hakel M, Beukelman DR, Fager S. Evidence
for effectiveness of treatment of loudness, rate or prosody in
dysarthria: A systematic review. J Med Speech Lang Pathol
2007;15(2):xi-xxxvi.
133. Wenke RJ, Theodoros D, Cornwell P. The short- and longterm effectiveness of the LSVT for dysarthria following TBI
and stroke. Brain Inj 2008;22(4):339-52.
134. McGhee H, Cornwell P, Addis P, Jarman C. Treating dysarthria
following traumatic brain injury: investigating the benefits of
commencing treatment during post-traumatic amnesia in two
participants. Brain Inj 2006;20(12):1307-19.
135. Cherney LR, Gardner P, Logemann JA, Newman LA, O’NeilPirozzi T, Roth CR, et al. The role of speech-language
pathology and audiology in the optimal management of the
service member returning from Iraq or Afghanistan with a blastrelated head injury: position of the Communication Sciences
and Disorders Clinical Trials Research Group. J Head Trauma
Rehabil 2010;25(3):219-24.
136. Evans JJ, Whyte M, Summers F, Torrens L, McKinlay WW,
Dutch S, et al. Post-acute and community rehabilitation
of the head injured patient. In: Whitfield PC, Thomas EO,
Summers F, Whyte M, Huchtinson PJ, editors. Head Injury: A
multidisciplinary approach. Cambridge: Cambridge University
Press; 2009. p.245-65.
137. Ladtkow M. Traumatic brain injury and severe expressive
communication impairment: the role of augmentative
communication. Semin Speech Lang 1993;14(1):61-73.
138. Ylvisaker MS, Urbanczyk B. The efficacy of speech-language
pathology intervention: traumatic brain injury. Semin Speech
Lang 1990;11(4):215-26.
66 |
142. Carnaby-Mann GD, Crary MA. Adjunctive neuromuscular
electrical stimulation for treatment-refractory dysphagia. Ann
Otol Rhinol Laryngol. 2008;117(4):279-87.
143. Clark H, Lazarus C, Arvedson J, Schooling T, Frymark T.
Evidence-based systematic review: effects of neuromuscular
electrical stimulation on swallowing and neural activation. Am
J Speech Lang Pathol 2009;18(4):361-75.
144. Zasler ND, Devany CW, Jarman AL, Friedman R, Dinius A.
Oral hygiene following traumatic brain injury: a programme to
promote dental health. Brain Inj 1993;7(4):339-45.
145. Cullen N, Chundamala J, Bayley M, Jutai J. The efficacy of
acquired brain injury rehabilitation. Brain Inj 2007;21(2):113-32.
146. Yasuda S, Wehman P, Targett P, Cifu D, West M. Return to
work for persons with traumatic brain injury. Am J Phys Med
Rehabil. 2001;80(11):852-64.
147. Kendall E, Muenchberger H, Gee T. Vocational rehabilitation
following traumatic brain injury: a quantitative synthesis of
outcome studies. J Vocat Rehabil 2006;25(3):149-60.
148. Fadyl JK, McPherson KM. Approaches to vocational
rehabilitation after traumatic brain injury: a review of the
evidence. J Head Trauma Rehabil 2009;24(3):195-212.
149. Chesnut RM, Carney N, Maynard H, Mann NC, Patterson P,
Helfand M. Summary report: evidence for the effectiveness of
rehabilitation for persons with traumatic brain injury. J Head
Trauma Rehabil 1999;14(2):176-88.
150. Giacino JT, Zasler ND. Outcome after severe traumatic brain
injury: Coma, the vegetative state and the minimally responsive
state. J Head Trauma Rehabil 1995;10:40-56.
151. Beaumont JG, Kenealy PM. Incidence and prevalence of the
vegetative and minimally conscious states. Neuropsychol
Rehabil. 2005;15(3-4):184-9.
152. Jennett B. The vegetative state. J Neurol Neurosurg Psychiatry.
2002;73(4):355-7.
153. Jennett B. The Vegetative State: Medical facts, ethical and
legal dilemmas. Cambridge: Cambridge University Press;
2002.
154. Andrews K, Murphy L, Munday R, Littlewood C. Misdiagnosis
of the vegetative state: retrospective study in a rehabilitation
unit. BMJ 1996;313(7048):13-6.
155. Childs NL, Mercer WN, Childs HW. Accuracy of diagnosis of
persistent vegetative state. Neurology. 1993;43(8):1465-7.
156. Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI,
et al. The minimally conscious state: definition and diagnostic
criteria. Neurology. 2002;58(3):349-53.
References
157. Practice parameters: assessment and management of patients
in the persistent vegetative state (summary statement). The
Quality Standards Subcommittee of the American Academy
of Neurology. Neurology. 1995;45(5):1015-8.
171. Cicerone KD, Mott T, Azulay J, Sharlow-Galella MA, Ellmo
WJ, Paradise S, et al. A randomized controlled trial of holistic
neuropsychologic rehabilitation after traumatic brain injury.
Arch Phys Med Rehabil 2008;89(12):2239-49.
158. Seel RT, Sherer M, Whyte J, Katz DI, Giacino JT, Rosenbaum
AM, et al. Assessment scales for disorders of consciousness:
Evidence-based recommendations for clinical practice and
research. Arch Phys Med Rehabil 2010;91(12):1795-813.
172. Coetzer R, Rushe R. Post-acute rehabilitation following
traumatic brain injury: are both early and later improved
outcomes possible? Int J Rehabil Res. 2005;28(4):361-3.
159. Georgiopoulos M, Katsakiori P, Kefalopoulou Z, Ellul J,
Chroni E, Constantoyannis C. Vegetative state and minimally
conscious state: A review of the therapeutic interventions.
Stereotact Funct Neurosurg 2010;88(4):199-207.
160. Sawyer E, Mauro LS, Ohlinger MJ. Amantadine enhancement
of arousal and cognition after traumatic brain injury. Ann
Pharmacother 2008;42(2):247-52.
161. Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi
A, et al. Placebo-controlled trial of amantadine for severe
traumatic brain injury. N Engl J Med. 2012;366(9):819-26.
162. DeMarchi R, Bansal V, Hung A, Wroblewski K, Dua H,
Sockalingam S, et al. Review of awakening agents. Can J
Neurol Sci 2005;32(1):4-17.
163. Abbasi M, Mohammadi E, Sheaykh RA. Effect of a regular
family visiting program as an affective, auditory, and tactile
stimulation on the consciousness level of comatose patients
with a head injury. Jpn J Nurs Sci 2009;6(1):21-6.
164. Lancioni GE, Bosco A, Belardinelli MO, Singh NN, O’Reilly MF,
Sigafoos J. An overview of intervention options for promoting
adaptive behavior of persons with acquired brain injury and
minimally conscious state. Res Dev Disabil 2010;31(6):112134.
165. Lombardi F, Taricco M, De Tanti A, Telaro E, Liberati A.
Sensory stimulation for brain injured individuals in coma or
vegetative state. Cochrane Database of Systematic Reviews
2002, Issue 2.
166. Aquilani R, Boselli M, Boschi F, Viglio S, Iadarola P, Dossena
M, et al. Branched-chain amino acids may improve recovery
from a vegetative or minimally conscious state in patients with
traumatic brain injury: a pilot study. Arch Phys Med Rehabil
2008;89(9):1642-7.
167. Gladman J, Radford KA, Edmans JA, Sach T, Parry R, Walker
MF, et al. Specialist rehabilitation for neurological conditions:
literature review and mapping study. London: National
Coordinating Centre for the Service Delivery and Organisation
(NCCSDO) research programme; 2007. [cited 21 Feb 2013].
Available from url: http://www.netscc.ac.uk/hsdr/files/project/
SDO_FR_08-1604-132_V01.pdf
168. Zhu XL, Poon WS, Chan CC, Chan SS. Does intensive
rehabilitation improve the functional outcome of patients with
traumatic brain injury (TBI)? A randomized controlled trial.
Brain Inj 2007;21(7):681-90.
169. Traumatic brain injury in adults. Service mapping report.
Edinburgh: The National Managed Clinical Network for
Acquired Brain Injury; 2009. [cited 20 Feb 2013]. Available
from url: http://www.sabin.scot.nhs.uk/files/service-mappingreport2.pdf
170. Stilwell J, Hawley C, Stilwell P, Davies C. The National
Traumatic Brain Injury Study. Report for the Department of
Health. University of Warwick, Coventry; 1998.
173. Powell J, Heslin J, Greenwood R. Community based
rehabilitation after severe traumatic brain injury: a randomised
controlled trial. J Neurol Neurosurg Psychiatry. 2002;72(2):193202.
174. Goranson TE, Graves RE, Allison D, La Freniere R. Community
integration following multidisciplinary rehabilitation for
traumatic brain injury. Brain Inj 2003;17(9):759-74.
175. Royal College of Physicians and British Society of Rehabilitation
Medicine. Rehabilitation following acquired brain injury:
national clinical guidelines (Turner-Stokes L, ed.). London:
RCP, BSRM; 2003. [cited 21 Feb 2013]. Available from url:
http://bookshop.rcplondon.ac.uk/contents/43986815-41094d28-8ce5-ad647dbdbd38.pdf
176. Russell TG. Physical rehabilitation using telemedicine. J
Telemed Telecare. 2007;13(5):217-20.
177. Brennan DM, Georgeadis AC, Baron CR, Barker LM. The effect
of videoconference-based telerehabilitation on story retelling
performance by brain-injured subjects and its implications
for remote speech-language therapy. Telemed J E Health
2004;10(2):147-54.
178. Salazar AM, Warden DL, Schwab K, Spector J, Braverman
S, Walter J, et al. Cognitive rehabilitation for traumatic brain
injury: A randomized trial. Defense and Veterans Head Injury
Program (DVHIP) Study Group. JAMA 2000;283(23):3075-81.
179. Hailey D, Roine R, Ohinmaa A, Dennett L. Evidence on
the effectiveness of telerehabilitation applications. Institute
of Health Economics, Alberta, Canada and Finnish Office
for Health Technology Assessment; 2010. [cited 21 Feb
2013]. Available from url: http://www.ihe.ca/documents/
Telerehab%20Applications.pdf
180. Bergquist T, Gehl C, Mandrekar J, Lepore S, Hanna S, Osten
A, et al. The effect of Internet-based cognitive rehabilitation
in persons with memory impairments after severe traumatic
brain injury. Brain Inj 2009;23(10):790-9.
181. Hauber RP, Jones ML. Telerehabilitation support for families
at home caring for individuals in prolonged states of reduced
consciousness. J Head Trauma Rehabil 2002;17(6):535-41.
182. Allen K, Hazelett S, Jarjoura D, Hua K, Wright K, Weinhardt
J, et al. A Randomized Trial Testing the Superiority of a
Postdischarge Care Management Model for Stroke Survivors.
J Stroke Cerebrovasc Dis 2009;18(6):443-52.
183. Turner B, Fleming J, Cornwell P, Haines T, Ownsworth T.
Profiling early outcomes during the transition from hospital to
home after brain injury. Brain Inj 2009;23(1):51-60.
184. Grill E, Ewert T, Lipp B, Mansmann U, Stucki G. Effectiveness
of a community-based 3-year advisory program after acquired
brain injury. Eur J Neurol 2007;14(11):1256-65.
185. McColl MA. Postacute programming for community integration:
A scoping review. Brain Impair 2007;8(3):238-50.
| 67
Brain injury rehabilitation in adults
186. Turner B, Fleming J, Cornwell P, Worrall L, Ownsworth T,
Haines T, et al. A qualitative study of the transition from hospital
to home for individuals with acquired brain injury and their
family caregivers. Brain Inj 2007;21(11):1119-30.
187. Turner B, Ownsworth T, Cornwell P, Fleming J. Reengagement
in meaningful occupations during the transition from hospital
to home for people with acquired brain injury and their family
caregivers. Am J Occup Ther 2009;63(5):609-20.
188. Scottish Intercollegiate Guidelines Network (SIGN). The
SIGN discharge document. Edinburgh: SIGN; 2012. (SIGN
publication no. 128). [cited 20 Feb 2013]. Available from url:
http://www.sign.ac.uk/guidelines/fulltext/128/index.html
189. Ayana M, Pound P, Ebrahim S. The views of therapists on the
use of a patient held record in stroke patients. Clin Rehabil
1998;12(4):328-37.
190. Shepperd S, McClaran J, Phillips CO, Lannin NA, Clemson
LM, McCluskey A, et al. Discharge planning from hospital to
home. Cochrane Database of Systematic Reviews 2010, Issue
1.
191. College of Occupational Therapists. Professional standards for
occupational therapy practice. London: COT; 20011. [cited 21
Feb 2013]. Available from url: http://www.cot.co.uk/standardsethics/professional-standards-occupational-therapy-practice
192. Patterson CJ, Mulley GP. The effectiveness of predischarge
home assessment visits: a systematic review. Clin Rehabil
1999;13(2):101-4.
193. Traumatic Brain Injury in Adults. Standards. Edinburgh: The
National Managed Clinical Network for Acquired Brain Injury;
2009. [cited 20 Feb 2013]. Available from url: http://www.sabin.
scot.nhs.uk/files/standards.pdf
68 |
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