Legend Plenary Clinical Workshop Other Basic workshop Industry Session Poster Session Debate Basic and clinical workshop Athena Hermes Thursday, May 14, 2015 16:30-16:45 Opening Ceremony 16:45-17:30 Keynote lecture: The J. Edmond Charlton Lecture (45 minutes) Allan I. Basbaum, USA Gallieni 1+2 Gallieni 5 Coffee Break 17:30-17.45 THE ENIGMA OF PAIN AND AFFECTIVE DISORDERS COMORBIDITY IN ANIMAL MODELS AND PATIENTS WITH NEUROPATHIC PAIN DEBATE - NEUROPATHIC PAIN QUESTIONNAIRES ARE SUITABLE FOR NEUROPATHIC CLASSIFICATION 17:45-19:15 19:30 Gallieni 4 Chair : A. Stubhaug Pro: Rainer Freynhagen, Germany Con: Per Hansson, Norway UPDATE ON NEUROPATHIC PAIN AND INFECTIOUS DISEASES Chair: Aki Hietaharju, Finland Neuropathic pain in leprosy Andrew Rice, UK HIV-associated sensory neuropathy Peter Kamerman, South Africa Postherpetic Neuralgia Ralf Baron, Germany POTASSIUM CHANNELS IN NEUROPATHIC PAIN: OPTIONS FOR PHARMACORESISTANT PATIENTS WITH Chair: Esther Berrocoso, Spain ADVANCES, CHALLENGES AND EMERGING IDEAS TRIGEMINAL NEURALGIA Neuroplastic changes triggered by the comorbidity of Chair: Alain Eschalier, France Chair: Giorgio Cruccu, Italy neuropathic pain and affective disorders Emerging Kv targets for chronic pain pharmacotherapy The problem of pharmacoresistance in trigeminal neuralgia Esther Berrocoso, Spain Christoforos Tsantoulas, UK Giorgio Cruccu, Italy The anterior cingulate cortex: a critical hub for the M-current modulation of pain processing Alternative options for pharmacoresistant patients anxiodepressive consequences of neuropathic pain Jose Lopez-Garcia, Spain Turo Nurmikko, UK Ipek Yalcin, France Pathophysiology and pharmacology of potassium channels in How to choose the type of surgical intervention A strong association between cognitive function, anxiety and neuropathic pain Denis Fontaine, France mood and the development of chronic neuropathic pain in Jérome Busserolles, France humans Sophie Baudic, France Welcome Reception Gallieni 7 Legend Plenary Clinical Workshop Other Basic workshop Industry Session Poster Session Debate Basic and clinical workshop Athena Hermes Friday, May 15, 2015 07:30-09:00 Breakfast Parallel Industry Session Gallieni 1+2 Breakfast Parallel Industry Session Gallieni 5 Gallieni 4 Gallieni 7 Plenary II: Small fiber pathology, neuropathies and pain 09:00-10:00 Diabetic neuropathies: latest developments in assessment and therapy Solomon Tesfaye, UK Small fiber pathology: a culprit for many painful conditions Nurcan Uceyler, Germany Coffee Break, Poster Viewing, Visit Exhibition 10:00-10:30 RELEVANCE OF NEUROPHYSIOLOGIC TESTS FOR THE STUDY OF PAINFUL NEUROPATHIES: AN UPDATE 10:30-12:00 RISK FACTORS AND PREVENTION OF POSTSURGICAL NEUROPATHIC PAIN PERIPHERAL SODIUM AND CALCIUM CHANNELS AS OPPORTUNE TARGETS FOR NEUROPATHIC PAIN TREATMENT CHEMOTHERAPY – INDUCED PAINFUL NEUROPATHY: LATEST PERSPECTIVES Chair: Dib-Hajj Sulayman, USA Chair: Rolf-Detlef Treede, Germany Chair: Sarah Flatters, UK Mutations in peripheral sodium channels Nav1.7, Nav1.8 and Contact heat, cold, mechanical, electrical and chemical Chair: Audun Stubhaug, Norway Mitochondrial dysfunction and oxidative stress in Nav1.9 in rare pain disorders and common peripheral DEBATE- FIBROMYALGIA IS PRIMARILY A CENTRALIZED stimuli to elicit small fiber potentials: merits and limitations Neuropathic aspects of persistent postsurgical pain: state of Chemotherapy-induced painful neuropathy neuropathy PAIN AMPLIFICATION DISORDER for basic science & clinical use the art Sarah Flatters, UK Dib-Hajj Sulayman, USA Chair: Serge Perrot, France Rolf-Detlef Treede, Germany Christian Duale, France Targeting sphingosine-1-phosphate in ChemotherapyThe contribution of specific sodium channels to pain signaling Pro: Jules Desmeules, Switzerland The relevance of LEPs in patients with suspected neuropathic Psychological and somatic risk factors for neuropathic Induced Peripheral Neuropathy pathways Con: Claudia Sommer, Germany pain postsurgical pain Daniela Salvemini, USA John Wood, UK Luis Garcia-Larrea, France Julie Bruce, UK New psychophysical and functional findings in chemotherapyInvolvement of calcium channels in pathophysiology of Autonomic tests for the study of painful neuropathies: where Perioperative interventions: how to individualize treatments treated patients neuropathic pain: electrophysiological and behavioral do we stand ? Audun Stubhaug, Norway Patrick Dougherty, USA evidences Roy Freeman, USA Emmanuel Bourinet, France 12:00-12:30 Break and Visit Exhibition 12:30-14:00 Poster Viewing Session 1 THE ROLE OF GLIA IN PAIN DISORDERS: FROM RODENTS TO HUMANS Chair: Marco Loggia, USA Astrocyte signaling in neuropathic pain Yong-Jing Gao, China Microglial-neuronal signalling in the maintenance of neuropathic pain Marzia Malcangio, UK Evidence of glial activation in the brain of patients with chronic low back pain Marco Loggia, USA Plenary III: From phenotyping to genotyping neuropathic pain 14:00-15:00 Reappraising NP in humans: how symptoms help disclose mechanisms Andrea Truini, Italy Painful and painless channelopathies: effect of genetics David Bennett, UK (UN)DOUBTFUL NEP COMPONENT IN NONNEUROPATHIC PAIN DISORDERS Chair: Ralf Baron, Germany 15:00-16:30 Insights from questionnaires Didier Bouhassira, France Insights from quantitative sensory testing Johanna Höper, Germany Insights from brain imaging Thomas Tölle, Germany CENTRAL NERVOUS SYSTEM STIMULATION FOR NEUROPATHIC PAIN: THE EVIDENCE DEBATE - THE CULPRIT FOR CHRONIC NEUROPATHIC PAIN IS IN THE CENTRAL NERVOUS SYSTEM Chair: Matthias Ringkamp, USA Pro: Anthony Dickenson, UK Con: Jordi Serra, Spain Coffee Break, Poster Viewing, Visit Exhibition 16:30-17:00 17:00-18:30 BRAIN IMAGING IN NEUROPATHIC PAIN: ROLE IN Parallel Industry Session EXPERIMENTAL DESIGN, CONDUCT AND REPORTING OF IN VIVO NEUROPATHIC PAIN MODELLING: DEVELOPING CLINICALLY USEFUL CANNABINOID Chair: Luis Garcia-Larrea, France ASSESSING MECHANISMS AND TREATMENT EFFECTS RELATED ANALGESICS FOR NEUROPATHIC PAIN WORKING TOWARDS SUCCESFUL TRANSLATION Evidence-based studies in neurostimulation: a difficult task Chair: Karen Davis, Canada Chair: Rafael, Maldonado, Spain Chair: Andrew Rice, UK but we are moving forward Brain imaging of treatment effects in chronic pain conditions Clinical limitations of conventional CB1 agonists Multi-centre animal studies- the way forward for Giorgio Cruccu, Italy Karen Davis, Canada Turo Nurmikko, UK translational research? Evidence-based efficacy of spinal cord stimulation in Brain network properties predict individual variability in FAAH inhibition: a new therapeutic target for neuropathic Andrew Rice, UK neuropatic pain analgesia related to psychological aspects of treatment in Back to basics- the importance of pharmacology in the design pain Rod Taylor, UK chronic pain patients Daniele Piomelli, Italy and conduct of experiments Motor cortex stimulation in neuropathic pain: from anecdote Javeria Hashmi, USA CB2 receptor agonists for the prevention of neuropathic pain Jeffrey Kennedy, USA to evidence The maladaptive neuroplasticity theory - 20 years on Martin development Experimental design, conduct and reporting in studies of Luis Garcia-Larrea, France Diers, Germany Rafael Maldonado, Spain animal models of neuropathic pain Gilllian Currie, UK Parallel Industry Session Legend Plenary Clinical Workshop Other Basic workshop Industry Session Poster Session Debate Basic and clinical workshop Athena Hermes Gallieni 1+2 Breakfast Parallel Industry Session Breakfast Parallel Industry Session Saturday, May 16, 2015 07:30-09:00 Gallieni 5 Gallieni 4 Gallieni 7 AUTO-IMMUNE PAIN-AN EMERGING CONCEPT SELECTIVE SMALL MOLECULE ANGIOTENSIN II TYPE 2 RECEPTOR (AT2R) ANTAGONIST AS POTENTIAL NOVEL ANALGESICS FOR RELIEF OF NEUROPATHIC AND INFLAMMATORY PAIN Plenary IV: Neuropathic pain and the brain 09:00-10:00 Functional brain imaging: what has it brought to our understanding of neuropathic pain? Roland Peyron, France Cortical neurostimulation for NP: state of the art and perspectives Jean-Pascal Lefaucheur, France Coffee Break, Poster Viewing, Visit Exhibition 10:00-10:30 DEBATE OPIOIDS HAVE NO PLACE IN THE MANAGEMENT OF NEUROPATHIC PAIN 10:30-12:00 Chair: Andrew Moore, UK Pro: Cathy Stannard, UK Con: Elon Eisenberg, Israel DO THE EYES HAVE IT? SPATIAL REPRESENTATIONS, CLINICAL ASSESSMENT OF NEUROPATHIC PAIN: PAIN IN CNS DISORDERS-ARE WE MOVING FORWARD MULTI SENSORY INTERACTION AND VISUAL ILLUSIONS FROM QUESTIONNAIRES TO QUANTITATIVE SENSORY ? IN NEUROPATHIC PAIN TESTING - practical Chair: Troels J. Jensen, Denmark Pain in Parkinson’s Disease: time to move forward Daniel Ciampi de Andrade, Brazil Post-Stroke Pain Luis Garcia-Larrea, France Pain in multiple sclerosis and other inflammatory demyelinating diseases Andrea Truini, Italy Chair: Tasha Stanton, Australia Targeting perceptual dysfunction in people with pain Tasha Stanton, Australia Can seeing your body help? The role of visual feedback in musculoskeletal and neuropathic pain Martin Diers, Germany The influence of visuo-spatial processing on pain Diana Torta, Belgium Chair: Per Hansson, Norway Detection of neuropathic pain: how to use the screening tools ? Michel Lanteri-Minet, France Clinical sensory examination Per Hansson, Norway QST: general principles and practical applications Helena Krumova, Germany 12:00-12:30 Break & Visit Exhibition 12:30-14:00 Poster Viewing Session 2 Chair: Steven McMahon, UK Chair: Maree Smith, Australia The role of immune system in the generation of neuropathic Analgesic Efficacy and Mode of Action of Small Molecule pain AT2R Antagonists in Rodent Models of Neuropathic and Steven McMahon, UK Inflammatory Pain Pain associated with autoantibodies Maree Smith, Australia Angela Vincent, UK Clinical Mechanism of Action of AT2R Antagonists in Chronic Immunoglobulin for the treatment of peripheral neuropathy Neuropathic Pain and CRPS Praveen Anand, UK Stefano Tamburin, Italy Clinical Evaluation of AT2R Antagonists for Neuropathic Pain Andrew Rice, UK Plenary V: Psychological and emotional aspects of neuropathic pain 14:00-15:00 Placebo, nocebo and neuropathic pain Lene Vase, Denmark Fear of pain in children and adolescents with neuropathic pain and CRPS Laura Simons, USA THERAPEUTIC MANAGEMENT OF NEUROPATHIC PAIN: NEWER NEUPSIG RECOMMENDATIONS 15:00-16:30 Chair: Nanna Finnerup, Denmark Presentation of the NEUPSIG methodology Nadine Attal , France NEUPSIG recommendations on drug treatment of neuropathic pain Nanna Finnerup, Denmark NEUPSIG recommandations on interventional therapy for neuropathic pain Srinivasa Raja, USA PHENOTYPING NEUROPATHIC PAIN FOR GENETIC AND CLINICAL STUDIES : FROM MICE TO MEN IS CRPS A NEGLECT-LIKE DISORDER? Chair: Lorimer Moseley, Australia Spatially-defined deficits in CRPS Lorimer Moseley, Australia Attending to and representing the body and the space around it Alberto Gallace, Italy Disrupted body representation phenomena in CRPS Annika Reinersmann, Germany Chair: Peter Kamerman, South Africa Phenotyping for genetic studies in animal models of neuropathic pain Ze'ev Seltzer, Canada NeuroPPIC: Neuropathic pain phenotyping by international consensus? Peter Kamerman, South Africa Phenotyping in clinical trials of neuropathic pain Didier Bouhassira, France Coffee Break & Visit Exhibition 16:30-17:00 17:00-18:30 NEUROPATHIC ITCH Chair: Allan Basbaum, USA Neuropathic itch: an overview Earl Carstens, USA Presentation title TBA Matthias Ringkamp, USA Presentation title TBA Rolf-Detlef Treede, Germany Parallel Industry Session Parallel Industry Session SYSTEM BIOLOGY IN NEUROPATHIC PAIN – NEW APPROACH, NEW MECHANISTIC INSIGHT LESSONS TO BE LEARNED FROM CLINICAL AND PRECLINICAL META ANALYSES Chair: Tim Hucho, Germany Analysis of intracellular signaling networks indicates novel therapeutic strategies Tim Hucho, Germany Insights into neuropathic pain provided by transcriptome analysis David Bennett, UK Evolutionary genome analysis reveals novel pain genes and therapeutic targets Greg Neely, Australia Chair: Gilllian Currie, UK Challenges in pre-clinical meta-analyses of neuropathic pain, focus on animal models Gilllian Currie, UK Detecting publication bias and the impact on both preclinical and clinical research Emily Sena, UK Challenges in clinical meta-analyses in neuropathic pain Haroutounian Simon, USA Legend Plenary Clinical Workshop Other Basic workshop Industry Session Poster Session Debate Basic and clinical workshop Athena Hermes Gallieni 1+2 Breakfast Parallel Industry Session Breakfast Parallel Industry Session Sunday, May 17, 2015 07:30-09:00 Gallieni 5 Plenary VI: Molecular mechanisms, translational approach of neuropathic pain 09:00-10:00 Experimental models of neuropathic pain: validity and limitations Andreas Binder, Germany Understanding the neural substrates of chronic neuropathic pain: role of microglia Michael Salter, Canada Coffee Break 10.00-10.30 SMALL FIBERS, LARGE EFFECTS – A NEW ROLE IN FIBROMYALGIA SYNDROME ? 10.30-12.00 12:00-13:00 Chair: Nurcan Üçeyler, Germany Fibromyalgia: to be or not to be... neuropathic ? Serge Perrot, France Small fiber pathology in patients with fibromyalgia syndrome Anne Louise Oaklander, USA Abnormalities in peripheral C-nociceptors of patients with fibromyalgia syndrome Jordi Serra, Spain AFFECTIVE AND COGNITIVE PAIN MODULATION IN NEUROPATHIC PAIN Chair: Mark Jensen, USA Thalamic dysregulation and neuropathic pain Sylvia Gustin, Australia Expectation and pain relief: impact on brain activity Christian Büchel, Germany Modulation therapy of neuropathic pain (hypnosis, meditation, mindfulness, ): state of the art Mark Jensen, USA CONFOCAL CORNEAL MICROSCOPY (CCM) – A NEW DIAGNOSTIC TOOL FOR NEUROPATHY OR THE NEXT HYPE? Chair: Christoph Maier, Germany An overview of CCM methodology Rayaz Malik, UK Reliability and diagnostic pitfalls of CCM Tunde Peto, UK CCM, skin punch biopsy and QST- comparison of the diagnostic validity in neuropathic pain Maier Christoph, German PERSISTENT IDIOPATHIC FACIAL PAIN: MECHANISMS AND MANAGEMENT Chair: Barry Sessle, Canada Extraterritorial behavioral hypersensitivity and dorsal horn central sensitization in trigeminal neuropathic pain models: role of glial and genetic factors Barry Sessle, Canada Neuron-glial interactions contribute to extraterritorial spread in trigeminal neuropathic pain Koichi Iwata, Japan Assessment and management of orofacial neuropathic and idiopathic facial pain in humans TBA Closing Ceremony and Prize Presentations Gallieni 4 Gallieni 7
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