Spotlight on Pressure Reduction:
Market Overview
Kuldev Singh, M.D., M.P.H.
Professor of Ophthalmology
Director, Glaucoma Service
Stanford University
Glaucoma Patients by Region
160
Number of Glaucoma Patients (millions)
Rest of World
140
Latin America
120
India
100
China
80
Other Wealthy
Nations
60
Japan
40
Western Europe
20
United States
0
2015
2020
Courtesy of Dave Harmon Market Scope
Glaucoma by Disease Category
Closed
Angle
15%
Secondary
7%
125 Million
Open Angle
42%
Courtesy of Dave Harmon Market Scope
Ocular
Hypertension
36%
Courtesy of Dr. Cynthia Mattox
Glaucoma Prevalence by Age
Prevent Blindness America Future of Vision Report 2014
Courtesy of Dr. Cynthia Mattox
Glaucoma: The Big Picture
 25-50% aware that they have disease*
 Those aware are often not under care
 Those under care are often non compliant
 Unpredictable natural history of disease
 Small percentage go blind
 Lowering IOP reduces but does not eliminate
risk
*Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95.
U.S. Ophthalmologists
Comprehensive
with Specialty
19%
Comprehensive
40%
Specialty
41%
Courtesy of Dr. Gregory Skuta and AAO Member Services
U.S. Specialty Breakdown
Glaucoma
12%
Oculoplastics and
Orbit
12%
Pediatrics and
Strabismus
14%
Cataract/Anterior
Segment
8%
Cornea and External
Disease
18%
Other
3%
Uveitis
1%
Retina/Vitreous
29%
Neuro
2%
Refractive
Surgery
1%
Courtesy of Dr. Gregory Skuta and AAO Member Services
Global Glaucoma Pharmaceutical
Market Revenues by Category
Fixed Combo
Drugs
37%
Other
2%
Branded
Prostaglandin
28%
Generic Prostaglandin
7%
Beta Blockers…
Alpha Agonists
11%
Carbonic Anhydrase
Inhibitors
11%
$4.7 Billion in 2015
Courtesy of Dave Harmon Market Scope
Surgical Trends: 1994-2012
200000
180000
160000
140000
120000
100000
80000
60000
40000
20000
0
Trabec
Tube
CPC
LTP
LPI
Courtesy of Drs. William Rich, Michael Repka and Gregory Skuta
U.S. Glaucoma Surgical Procedures
255
250
200
150
0
2013
Filtration
54
62
42
64
20
44
50
46
100
64
US Glaucoma Surgeries (000)
300
2014
Tube Shunts
2019 (Forecast)
MIGS
Courtesy of Dave Harmon Market Scope
Spotlight on Pressure Reduction:
Addressing Unmet Needs in Glaucoma Care
More effective first line and adjunctive medications
Glaucoma operation safer than trabeculectomy
Novel drug delivery to improve compliance
SPOTLIGHT ON PRESSURE REDUCTION
Company Presentations