Kuldev Singh, MD, MPH, Professor, Ophthalmology & Director
Spotlight on Pressure Reduction: Market Overview Kuldev Singh, M.D., M.P.H. Professor of Ophthalmology Director, Glaucoma Service Stanford University Glaucoma Patients by Region 160 Number of Glaucoma Patients (millions) Rest of World 140 Latin America 120 India 100 China 80 Other Wealthy Nations 60 Japan 40 Western Europe 20 United States 0 2015 2020 Courtesy of Dave Harmon Market Scope Glaucoma by Disease Category Closed Angle 15% Secondary 7% 125 Million Open Angle 42% Courtesy of Dave Harmon Market Scope Ocular Hypertension 36% Courtesy of Dr. Cynthia Mattox Glaucoma Prevalence by Age Prevent Blindness America Future of Vision Report 2014 Courtesy of Dr. Cynthia Mattox Glaucoma: The Big Picture 25-50% aware that they have disease* Those aware are often not under care Those under care are often non compliant Unpredictable natural history of disease Small percentage go blind Lowering IOP reduces but does not eliminate risk *Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95. U.S. Ophthalmologists Comprehensive with Specialty 19% Comprehensive 40% Specialty 41% Courtesy of Dr. Gregory Skuta and AAO Member Services U.S. Specialty Breakdown Glaucoma 12% Oculoplastics and Orbit 12% Pediatrics and Strabismus 14% Cataract/Anterior Segment 8% Cornea and External Disease 18% Other 3% Uveitis 1% Retina/Vitreous 29% Neuro 2% Refractive Surgery 1% Courtesy of Dr. Gregory Skuta and AAO Member Services Global Glaucoma Pharmaceutical Market Revenues by Category Fixed Combo Drugs 37% Other 2% Branded Prostaglandin 28% Generic Prostaglandin 7% Beta Blockers… Alpha Agonists 11% Carbonic Anhydrase Inhibitors 11% $4.7 Billion in 2015 Courtesy of Dave Harmon Market Scope Surgical Trends: 1994-2012 200000 180000 160000 140000 120000 100000 80000 60000 40000 20000 0 Trabec Tube CPC LTP LPI Courtesy of Drs. William Rich, Michael Repka and Gregory Skuta U.S. Glaucoma Surgical Procedures 255 250 200 150 0 2013 Filtration 54 62 42 64 20 44 50 46 100 64 US Glaucoma Surgeries (000) 300 2014 Tube Shunts 2019 (Forecast) MIGS Courtesy of Dave Harmon Market Scope Spotlight on Pressure Reduction: Addressing Unmet Needs in Glaucoma Care More effective first line and adjunctive medications Glaucoma operation safer than trabeculectomy Novel drug delivery to improve compliance SPOTLIGHT ON PRESSURE REDUCTION Company Presentations
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