1. No category

Sarcosine
INCI: Sarcosine
CAS#: 107-97-1
Description:
Sarcosine, also known as N-methylglycine, is ubiquitous in biological mater ials and is
present in such foods as egg yolks, turkey, ham, vegetables, legumes, etc. It reduced the production of sebum and imperfections linked to hyperseborrhea, thereby refining skin texture.
Sarcosine matifies skin perfecting treatments and treatments for oily skin. Sarcosine is a natural amino acid found in muscles and other body tissues. It is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other
applications.
Technical Data:
Test
Specification
Appearance
white and deliquescence crystalline power
Melting Point
204-212º C
Residue on Ignition
Less than 0.1%
Loss on Drying
Not more than 0.5%
Content Assay
Not less than 98.0%
Applications:
Sarcosine reduces dihydrotestosterone (DHT) by inhibiting the enzyme 5 alphareductase. Sebum production is stimulated by androgens. 5 alpha-reductase metabolises testosterone in the skin into its more potent form dihydrotestosterone (DHT) that
is responsible for the overproduction of sebum.
As a result, sarcosine reduces shine, tightens and reduces pore size, evens tone and
complexion.
McKinley Resources, Inc.
P.O. Box 810472 • Dallas, TX 75381
Phone: 972-620-9730 • Fax: 972-421-1860
[email protected] • www.mckinleyresources.com
Sarcocine Reduces Sebum Production
The activity and development of sebaceous glands are highly dependant on androgens. Among them, dihydrotestosterone (DHT)
plays a crucial role.
DHT levels are directly determined by the specific activity of the
5α-reductase. This membrane-bound enzyme catalyzes the formation of DHT by reducing the double bond between carbons 4
and 5 of testosterone.
Screening for the Effect on Type 1 5α-reductase
Targeting 5α-reductases is a classical route to minimize sebum impact in cosmetic and skin care
products. Reducing the 5α reductase 1 is the best way to reduce seborrhea.
McKinley Resources, Inc.
P.O. Box 810472 • Dallas, TX 75381
Phone: 972-620-9730 • Fax: 972-421-1860
[email protected] • www.mckinleyresources.com