Name: ____________________________ Date: _____________________ Mutations Videos for Review! Homework: Mutations 1. Sickle-shaped red blood cells result from a mutation in the gene that codes for hemoglobin. This mutation results in sickle-cell anemia. A partial sequence of bases from a normal hemoglobin gene and a sequence that results in sickle-cell anemia are shown below. What type of mutation is depicted in this sequence? A Substitution B Insertion C Deletion D Frameshift Sequence 1: THE DOG SAW THE CAT Sequence 2: THE DOG SAW THE TAC 2. The change between the original and altered sequences above is most similar to which of the following types of mutations? A translocation B duplication C inversion D deletion 3. The change between the two chromosomes above is best described as which of the following types of chromosomal mutations? A translocation B duplication C inversion D deletion 4. Early-onset Alzheimer’s disease affects people under the age of 65. Less than five percent of people who are diagnosed with Alzheimer’s disease have this type. Many cases of early-onset Alzheimer’s disease are inherited, a type known as familial Alzheimer’s disease (FAD). Which statement is best supported by this information? A FAD is the result of a genetic change in one or more chromosomes. B Natural selection will continue to reduce the incidence of FAD. C FAD affects only the genes of middle-aged people. D Deletion of one amino acid causes FAD. Original Sequence: THE RED CAT SAW THE FAT RAT Altered Sequence: THE RED CAT SAW THE FAT FAT RAT 5. The change between the original and altered sequences above is most similar to which of the following types of mutations? A translocation B duplication C inversion D deletion 6. A deletion of a DNA base from a gene affects an organism by — A causing future gametes to have additional chromosomes B changing the sequence of amino acids in a protein C causing chromosome fragments to form long chains D changing the structure of ribose sugar in nucleic acids 7. The picture below shows the chromosomes of a human. What caused the chromosomal alteration in number 21? A part of one chromosome attached to another (translocation) B some of the genes on a chromosome were reversed (inversion) C a duplicated chromosome failed to separate (nondisjunction) D a part of a chromosome was lost (deletion) 8. Which of the following is a change that could be passed on to an organism’s offspring? A Damage to the DNA of gamete cells B Damage to skin cells from exposure to sunlight C Damage to DNA in the cytoplasm of cheek cells D Damage to hair pigment cells with permanent dyes 9. The diagram to the right demonstrates how non-homologous chromosomes might incorrectly exchange genetic material. This form of chromosomal mutation is referred to as – A translocation C duplication B inversion D nondisjunction 10. A change within a single base pair in DNA is least likely to be observable if the change affects — A the production of a stop codon C an unexpressed recessive trait B actions of a codominant allele D the expression of a sex-linked trait 11. The diagram shows the normal sequence of genes in a particular chromosome. Which chromosome could have resulted from an inversion that occurred in this chromosome? A C B D 12. The assembly of a messenger RNA strand that normally begins with UAC has been changed so that the newly assembled messenger RNA strand begins with UAG. Which of the following will most likely occur? A Missense mutation C Nonsense Mutation B Silent Mutation D Frame shift
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