Any football fan knows the best offense is a good defense. The American Urological Association Foundation’s Prostate Health PLAYBOOK Now that you know the score, please help us get the word out in your community! The AUA Foundation is committed to helping the one in six men who will develop prostate cancer in their lifetime. One in six — that means that one of your friends may already be facing a future with prostate cancer. Please help today by making a donation in support of this vital educational outreach program. For more information, contact the AUA Foundation 1000 Corporate Blvd. Linthicum, MD 21090 Urology Health Line: 1-800-828-7866 www.AUAFoundation.org The NFL has teamed up with the AUA Foundation to bring you the Know Your Stats campaign. Your teammates are counting on you. Log on to KnowYourStats.org to make a donation today. 1 © 2009 AUA Foundation. All rights reserved. The American Urological Association Foundation is a 501(c)(3) nonprofit organization. Donations made to the foundation are tax deductible to the fullest extent of the law. The American Urological Association Foundation’s www.KnowYourStats.org 2 About the American Urological Association Foundation The AUA Foundation is the world’s leading nonprofit urological health foundation and the Official Foundation of the American Urological Association. Our mission is to promote health, provide hope and promise a future free of urologic disease, including cancer. As the official foundation of the AUA, the professional organization of approximately 16,000 urologists, the AUA Foundation is the trusted public source for the most accurate and current information relating to urological health. Knowledge is power. By reading and learning from this Playbook, you are taking the first step toward your Game Plan for continued urologic health and well-being. Monitor your prostate health with regular exams and a simple blood test. Knowing your “stats” or baseline levels of prostate-specific antigen (PSA) and having annual prostate exams will help you keep track of changes and seek medical care for problems that could put you on the sidelines – or take you out of the game for good. Pregame Preparation: What you should know about your prostate Prostate health — much like success in football — depends primarily upon key members of the team. In prostate health, the urologist is your Head Coach — the leader of your healthcare team, which also includes you, your family and your friends — who designs and executes a game plan that best suits your needs. Any football fan or player knows the best offense is a good defense. Learning about your prostate can help you know your opponent and give you the best plays to keep you off the sidelines and in the game — the game of life, that is. Only men have a prostate.* Part of the male reproductive system, the prostate is located just below the bladder and in front of the rectum. It surrounds the urethra, the tube that carries urine from the bladder and semen through the penis and out of the body. The prostate’s main job is to help create semen — the fluid that helps protect and energize the sperm — by producing ejaculatory fluid. Think of semen as the offensive line. As the sperm run into the end zone, where the female egg is waiting, the semen protects the sperm so they can fertilize the egg and form a new life — touchdown! The seminal vesicles, located next to the prostate, also add fluid to semen. The most common prostate health problems are non-cancerous enlarged prostate (benign prostatic hyperplasia, or BPH), inflammatory disease (prostatitis) and prostate cancer. Because of its location inside the pelvis, there are no simple self-exams for men to check their own prostate. Doctors use two tests to monitor prostate health: the digital rectal examination (DRE) and a blood test called prostate-specific antigen (PSA). The American Urological Association (AUA) recommends that early detection and risk assessment of prostate cancer should be offered to men 40 years of age or older. Your baseline PSA value in your 40s can then be used to compare with future PSA tests to help identify life-threatening prostate cancer. *All words that appear in italics are explained in the glossary. www.KnowYourStats.org 1 What is the PSA test? This blood test measures the level of prostate-specific antigen (PSA) in the blood. Very little PSA is found in the blood of a man with a completely healthy prostate. Keeping your opponent’s score low is the name of the game and a low PSA is better for prostate health. A rapid rise in PSA (known as velocity) may be a sign that something is wrong. One possible cause of a high PSA level is enlargement of the prostate. Inflammation of the prostate, called prostatitis, is another possible cause. Prostate cancer is the most serious cause of an increased PSA level. You should know your PSA score and discuss changes with your doctor so you can stay on top of your game. The male urinary tract. The prostate surrounds the urethra, through which urine leaves the bladder. Image provided courtesy of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health What is the DRE? During the DRE, the doctor inserts a lubricated gloved finger into the rectum. He or she feels for abnormal size, shape or consistency in the prostate. The DRE can help the doctor decide if a man has an enlarged prostate or other prostate problems. However, the DRE by itself is not the only way to detect prostate cancer. A man should also have a PSA test. Digital rectal exam (DRE). Image provided courtesy of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health www.KnowYourStats.org 2 www.KnowYourStats.org AUA International Prostate Symptom Score Index Total score: 0–7 mildly symptomatic; 8–19 moderately symptomatic; 20-35 severely symptomatic. Not at all Less than 1 time in 5 Less than half the time About half the time More than half the time Almost always Incomplete emptying — Over the past month, how often have you had a sensation of not emptying your bladder completely? 0 1 2 3 4 5 Frequency — Over the past month, how often have you had to urinate again less than two hours after you finished urinating? 0 1 2 3 4 5 Intermittency — Over the past month, how often have you found you stopped and started again several times when you urinated? 0 1 2 3 4 5 Urgency — Over the last month, how difficult have you found it to postpone urination? 0 1 2 3 4 5 Weak stream — Over the past month, how often have you had a weak urinary stream? 0 1 2 3 4 5 Straining — Over the past month, how often have you had to push or strain to begin urination? 0 1 2 3 4 5 None 1 time 2 times 3 times 4 times 5 times or more 0 1 2 3 4 5 Delighted Pleased Mostly satisfied Mixed: about equally satisfied and dissatisfied Mostly dissatisfied Unhappy Terrible 0 1 2 3 4 5 6 Nocturia — Over the past month, how many times on average did you typically get up to urinate, from when you went to bed until you got up in the morning? Your score Your score Total IPSS score Quality of life due to urinary symptoms If you were to spend the rest of your life with your urinary condition the way it is now, how would you feel about that? www.KnowYourStats.org 3 Enlarged Prostate The prostate may become larger and start to cause problems as a man ages. Enlarged prostate is also known as benign prostatic hyperplasia (BPH). The prostate of a 50-year-old man weighs about 20 to 30 grams and is about the size of a walnut or golf ball; however, it may grow to 50 to 100 grams (almost the size of a baseball) or more. As the prostate enlarges, it can squeeze the urethra, which can cause some men to experience lower urinary tract symptoms (LUTS), including symptoms from the International Prostate Symptom Score Index on the previous page. Who is at risk for enlarged prostate? Men who have close relatives with an enlarged prostate are more likely to have an enlarged prostate. Being overweight may also increase a man’s risk; however, aging is the biggest risk factor for an enlarged prostate. How is an enlarged prostate diagnosed? The American Urological Association (AUA) designed a series of questions to determine how often symptoms occur. The International Prostate Symptom Score Index, on the previous page, helps doctors measure the problems caused by an enlarged prostate, ranging from mild to severe. When a doctor checks a man for an enlarged prostate, he or she takes a thorough medical history. The doctor performs a physical exam, including a DRE. He or she may also ask questions from the AUA International Prostate Symptom Score Index. The doctor will often do a urine test called a urinalysis and may offer to conduct other medical tests, including the PSA blood test, for a man who may have an enlarged prostate. When should a man see a urologist about an enlarged prostate? A man should see a doctor if he has any of the symptoms mentioned previously. In addition, he should see a doctor immediately if he has blood in his urine, pain or burning with urination or is unable to urinate. An enlarged prostate is not cancer and cannot lead to cancer, although both conditions can exist together. There are usually no symptoms during the early stages of prostate cancer; therefore, yearly physical examinations and PSA tests are highly recommended. What is the game plan to treat enlarged prostate problems? Side view drawing of the male urinary tract, showing the prostate. Image provided courtesy of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health As men age, enlarged prostates can get worse. Knowing your opponent can help your game plan. An enlarged prostate can lead to bladder damage, infection, and even kidney damage. A doctor will examine a man with an enlarged prostate to determine the best treatment options for him. One way to tackle an enlarged prostate may include medications. If medication does not work, some minimally invasive options and surgical procedures can help with the lower urinary tract symptoms. If the symptoms do not improve after treatment, men should consult their doctor to determine if a different issue might be causing their symptoms. www.KnowYourStats.org 4 www.KnowYourStats.org Researchers estimate that 10–12% of men experience prostatitis-like symptoms. www.KnowYourStats.org 5 Prostatitis Occurring mostly in young and middle-aged men, prostatitis is a common and painful disease of the prostate gland and its surrounding structures. Although prostatitis is not the end of the game, it can put any player on the sidelines. Doctors may have difficulty diagnosing prostatitis because the symptoms are not the same for every man. Many of the symptoms — such as painful or burning urination and incomplete emptying of the bladder — could be signs of another disease. Researchers estimate that 10–12% of men experience prostatitis-like symptoms. How is prostatitis diagnosed? Although the term prostatitis means inflammation of the prostate, doctors use the term to describe four different disorders. It can be chronic, and keep coming back. It can also be acute, and come on suddenly. Some cases of prostatitis are caused by bacteria. For some men, the cause of their prostatitis is not known. What is the game plan to treat prostatitis? The treatment is different for the different types of prostatitis disorders. It is important to make sure other conditions — such as urethritis, cystitis, an enlarged prostate, or cancer — are not causing the symptoms. To help make an accurate diagnosis, several types of examinations are useful. These include a DRE and PSA. During a prostate infection the PSA can be falsely high. The doctor may also analyze samples of urine and prostatic fluid for signs of inflammation and infection. These samples may help the urologist determine whether the problem is inflammation or infection and whether the problem is in the urethra, bladder, or prostate. The urologist may use cystoscopy — passing a small telescope through the urethra to see inside the urethra, prostate, and bladder. The urologist may also order urine flow studies, which help measure the strength of your urine flow and any blockage caused by the prostate, urethra, or pelvic muscles. There is no scientifically proven medication to cure prostatitis. The treatment recommended often depends on the type of prostatitis a man has. For many men with prostatitis, the urologist may give antibiotics. Depending on his symptoms, a man may receive other treatments as well. Although prostatitis may place you on the sidelines, it is not life threatening and can be effectively treated once diagnosed. www.KnowYourStats.org 6 www.KnowYourStats.org Prostate Cancer This year more than 192,000 American men will learn they have prostate cancer1 — more than twice the number of fans who could fit in FedEx Field, home of the NFL Washington Redskins, on a playoff weekend! Sometimes this cancer can be small, slow growing, and of limited risk to the patient. Other prostate cancers may threaten a man’s well-being or life. More than 27,000 men die each year from prostate cancer in the United States. What are the causes and risks of prostate cancer? Although prostate cancer is rare before age 40, the risk increases with age. One in six men faces a diagnosis of prostate cancer in his lifetime.2 Researchers are still studying what causes prostate cancer, but men with a close family member (father, brother, or uncle) and those with a high intake of fat in their diets are at a greater risk of getting prostate cancer. Most doctors agree that, if you do things that are heart healthy, you will also help keep your prostate healthy. Eating right, exercising, watching your weight and not smoking can improve men’s health and help them stay in the game. What are the symptoms of prostate cancer? In the early stage, prostate cancer often causes no symptoms. When symptoms do occur, they may include any of the following: dull pain in the lower pelvic area; frequent urination; problems with urination, such as the inability to urinate, pain, burning, or weakened urine flow; blood in the urine or semen; painful ejaculation; general pain in the lower back, hips, or upper thighs; loss of appetite and/or weight; and persistent bone pain. Some of the symptoms can be similar to those of BPH, so it is very important to have a PSA and DRE when you have such symptoms. How is prostate cancer diagnosed? The DRE and PSA are the main methods for screening for prostate cancer (see page 2). Based on 2009 recommendations from the American Urological Association, men should be offered a baseline DRE and PSA starting at age 40. Each man should talk to his doctor about his risk factors and the best screening 1,2 National Cancer Institute schedule for him. Just as knowing the score and time in football games leads to a particular game plan, knowing your PSA “score” will help you identify changes in your baseline PSA that may indicate prostate problems — including cancer. If the DRE and or PSA suggest further testing, a prostate biopsy is the next step for diagnosing prostate cancer. The biopsy removes small pieces of prostate tissue. A pathologist, a physician who examines human tissue to see whether it is normal or diseased, examines the prostate tissue to confirm if cancer is present. If cancer is detected, the pathologist will also grade the tumor. The grade indicates the tumor’s degree of aggressiveness — that is, how quickly it is likely to grow and spread. On the playing field, it helps to know the kind of attack that your opponent is likely to bring so you can set your game plan and strategy accordingly. What is the game plan to treat prostate cancer? There are many treatment game plans for men with prostate cancer. The most common treatments include surgery and radiation. Like going for it on fourth down, you and your healthcare team must examine the risks associated with each treatment and determine the most effective play for you to win. The best option for each man depends on various factors, including age, overall health, stage and grade of the cancer, and personal preferences. Just as a head coach must prepare a separate game plan for every opposing team, prostate cancer patients are treated differently depending upon the characteristics of both themselves and their disease. Once diagnosed, men should discuss their treatment options with their healthcare team. www.KnowYourStats.org 7 More than 27,000 men die each year from prostate cancer in the United States. www.KnowYourStats.org 8 www.KnowYourStats.org POST-Game Wrap Up Prostate health is important for all men. Winning the battle against prostate diseases involves a team approach. With a solid head coach (urologist) leading the way and a team made up of healthcare workers and your family and friends, you will be on the path to victory. When a prostate problem arises, be sure to huddle up with your entire team, move into formation, and keep your head up as you advance toward your ultimate treatment option, leading to a cure … touchdown and the extra point! The American Urological Association Foundation The AUA Foundation provides this information based on current medical and scientific knowledge. This information is not a tool for self-diagnosis or a substitute for professional medical advice and should not be used or relied upon for such purposes. Please see your urologist or other healthcare provider regarding any health concerns, and always consult a healthcare professional before you start or stop any treatments, including medications. Please go to our Web site — www.KnowYourStats.org — or call the National Urology Health Line at 1-800-828-7866 for more information about prostate or other urological health concerns. www.KnowYourStats.org 9 The Prostate Health Playbook Glossary Biopsy: A tiny piece of prostate tissue is removed (with a needle or during surgery) for examination under a microscope to determine if cancer or other abnormal cells are present. Bladder: The balloon-shaped pouch of thin, flexible muscle in which urine is temporarily stored before being discharged through the urethra. Cystitis: Urinary tract infection involving the bladder that causes inflammation of the bladder and results in pain and a burning feeling in the pelvis or urethra. Cystoscopy: An examination using a narrow, flexible tube-like instrument passed through the urethra to examine the bladder and urinary tract for structural abnormalities or obstructions, such as tumors or stones. Digital Rectal Examination (DRE): The insertion of a gloved, lubricated finger into PSA: Also referred to as prostate-specific antigen. This protein is made only by the prostate gland. High levels of PSA in the blood may be a sign of prostate cancer. Rectum: The lower part of the large intestine, ending in the anal opening. Semen: Also known as seminal fluid or ejaculate fluid. Seminal vesicles: Produce fluid that provides sperm with a source of energy that helps sperm move. The fluid of the seminal vesicles makes up most of the volume of a man’s semen. Sperm: Also referred to as spermatozoa. Male reproductive cells that are produced by the testicles and that are capable of fertilizing the female partner’s eggs. Tissue: Group of cells in an organism that are similar in form and function. the rectum to feel the prostate and check for any abnormalities. Tumor: An abnormal mass of tissue or growth of cells. Ejaculation: Release of semen from the penis during sexual climax (orgasm). Urethra: In males, this narrow tube carries urine from the bladder to the outside of Pathologist: Scientist who is skilled in identifying the cause and progress of diseases by examining tissue and fluid from the body. Pelvic: Relating to, involving, or located in or near the pelvis. Penis: The male organ used for urination and sex. Prostate: In men, a walnut-shaped gland that surrounds the urethra at the neck of the bladder. The prostate supplies fluid that goes into semen. Prostatitis: Inflammation or infection of the prostate. Chronic prostatitis refers to the repeated inflammation of the prostate. The most common form of prostatitis is not associated with any known infecting organism. PSA Test: Also called the prostate-specific antigen test, this blood test is used to help detect prostate cancer. the body; it also serves as the channel through which semen is ejaculated. Extends from the bladder to the tip of the penis. Urethritis: Inflammation of the urethra. Urinalysis: An examination of the urine to determine the general health of the body. Urinary Tract: The system that takes wastes from the blood and carries them out of the body in the form of urine. Passageway from the kidneys to the ureters, bladder, and urethra. Urinate: To excrete urine. Urine: Liquid waste product filtered from the blood by the kidneys, stored in the bladder, and expelled from the body through the urethra by the act of urinating (voiding). www.KnowYourStats.org 10 www.KnowYourStats.org
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