Medical data is for informational purposes only. You should always consult your family physician, or one of our referral physicians prior to treatment.
®
Supplement to The Art of Getting Well
Vitamin C: How to Use
The Great Missing Vitamin
Sources are given in references.
Authors of
contributions\quotations are alphabetically arranged; major author, if any, is underlined. Robert F. Cathcart, III M.D., Nancy
Chandler, A. Kalokerinos, Fred R. Klenner, M.D., Linus Pauling,
Ph.D., Irwin Stone, Anthony F. Verlangieri, Ph.D., Jonathan V.
Wright, M.D./writer Anthony di Fabio.
Copyright 1994 All rights reserved by the The Roger WyburnMason and Jack M.Blount Foundation for Eradication of
Rheumatoid Disease AKA The Rheumatoid Disease Foundation
AKA The Arthritis Trust of America®
7376 Walker Road, Fairview, TN 37062
Robert Cathcart, M.D.
You are probably familiar with Linus Pauling's views in favor of the heavy use of Vitamin C1, one of the great anti-oxidants.
Much original work with large dosages of Vitamin C was done
by Fred R. Klenner, M.D. of North Carolina. Dr. Klenner found
that viral diseases could be cured by intravenous sodium ascorbate in amounts up to 200 grams per 24 hours.
Irwin Stone2 pointed out the significance of Vitamin C in the
treatment of many diseases, and also that humans were unable to
synthesize ascorbate, resulting in the medical condition called
hypoascorbemia -- diseases attributed to or caused by the
insufficiency of Vitamin C.
Linus Pauling, Ph.D., reviewed the literature on Vitamin C
and led the crusade to make it known to the public and the
medical profession.
Ewing Cameron in association with Linus Pauling showed
the usefulness of ascorbate when treating cancer1.
It is of great significance that humans, primates, guinea pigs
and a very small number of bird species are unable to synthesize Vitamin C. An easy conclusion to reach is that all of these
mammals passed through an evolutionary period where each lost
the ability to synthesize Vitamin C. Irwin Stone described the
genetic defect -- whereby higher primates lost the ability to
synthesize ascorbate -- as caused by a mutated defective gene for
the liver enzyme L-gulonolactone oxidase. All higher mammals
except primates, guinea pigs and the few bird species mentioned
developed a biochemical feedback mechanism which causes an
increase in ascorbate synthesis under the influence of external
or internal stresses.
Robert F. Cathcart, M.D.4, of California, in his paper "Vitamin C, Titrating to Bowel Tolerance, Anascorbemia, and Acute
Induced Scurvy", presents his brilliantly developed clinical findings demonstrating rather clearly how the body tolerates increasing amounts of Vitamin C when it is under the stress of various
diseases. He shows from his clinical findings on 9,000 patients
that the body's ability to absorb Vitamin C is directly proportional to the severity of stress and/or disease. Diseases improve or
are cured by his "bowel tolerance" measuring technique for determining the exact amount of Vitamin C required by the body
at the moment, and he will label a "100 gram cold," for example,
when the cold requires 100 grams to be rid of its symptoms, a "50
gram cold" when it takes but 50 grams, and so on.
Mammals that do not have the ability to synthesize Vitamin C
are at a distinct disadvantage, and obviously can be affected by
external organisms and stress more easily than those that can synthesize their Vitamin C. Those that do so, synthesize Vitamin C
with a precision that would shame most scientific laboratories.
They manufacture and meter out throughout their bodily systems
exact quantities of Vitamin C dependent upon their present degree
of stress and their degree of need for a given set of infections. The
more infection and/or stress, the more Vitamin C is manufactured. The less infection and/or stress, the less Vitamin C is manufactured. Haven't you ever wondered how it is that certain pets,
like dogs and cats, can eat bacteria-ridden garbage and, providing they are not poisoned, they have no difficulty in staying healthy?
Whether establishment physicians accept the fact or not, tens
of thousands -- no hundreds of thousands -- have already verified good results through usage of Vitamin C. Many of our referral physicians know and use these techniques to fight infection,
reduce stress and to assist the immunological system.
When using EDTA Chelation Therapy, Vitamin C along
with other vitamins and minerals are added. Vitamin C can be used
intravenously by itself in sufficiently large dosages to reverse a
number of otherwise intransigent disorders that have a causation
based on free-radical pathology. Cathcart says: "Well nourished
humans contain not much more than 5 grams of Vitamin C in their
bodies. The majority of people have much less, and therefore are
at risk for many problems related to failure of metabolic processes
that depend on ascorbate. Stone calls this condition 'chronic
subclincial scurvy'.
"Some of the increased need for ascorbate," Cathcart relates, "occurs in areas of the body not primarily involved in the
disease and can be accounted for by such functions as the adrenals
producing more adrenalin and corticoids; the immune system producing more antibodies, interferon, and other substances to fight
infection; the macrophages utilizing more ascorbate with their
increased activity; and production and protection of a substance
called c-AMP and c-GMP with subsequent increased activity of
other endocrine glands, and so on." Cathcart continues with "...
there must be a tremendous draw on ascorbate locally by increased metabolic rates in the primarily infected tissues. The infecting organisms themselves liberate toxins which are neutralized by ascorbate, but in the process destroy ascorbate. The
Medical data is for informational purposes only. You should always consult your family physician, or one of our referral physicians prior to treatment.
levels of ascorbate in the nose, throat, eustachian tubes and bronchial tubes locally infected by a 100 gram cold must be very low,
indeed. With this acute induced scurvy localized in these areas, it
is a small wonder that healing can be delayed and complications
such as chronic sinusitis, otitis media and bronchitis, etc. develop."
For a cold in the nose, there is a lack of vitamin C in that
portion of the anatomy. Linus Pauling recommends 3.1 grams of
sodium ascorbate in 100 ml of water. Use 20 drops into each nostril
with an eye dropper.This gives local concentration of 1000 times
more than oral dosages would provide1.
Cathcart adds that from his personal experience and from that
of patients, it is apparent that the adrenals are capable of utilizing
large amounts of ascorbate with benefit if made available. According to Cathcart, the following medical problems should be expected with increased incidence as ascorbate is depleted: "disorders of the immune system such as secondary infections, Rheumatoid Arthritis and other collagen disease, allergic reactions to drugs,
foods and other substances, chronic infections such as herpes, or
sequelae of acute infections such as Guillain-Barre' and Reye's
syndromes, rheumatic fever, or scarlet fever; disorders of the blood
coagulation mechanisms such as hemorrage, heart attacks, strokes,
hemorroids, and other vascular thrombosis; failure to cope properly with stresses due to suppression of the adrenal functions
such as phlebitis, other inflammatory disorders, asthma and
other allergies; problems of disordered collagen formation such
as impaired ability to heal, excessive scarring, bed sores, varicose veins, hernias, stretch marks, wrinkles, perhaps even wear of
cartilage or degeneration of spinal discs; impaired function of
the nervous system such as malaise, decreased pain tolerance,
tendency to muscle spasms, even psychiatric disorders and senility; and cancer from the suppressed immune system and carcinogens not detoxified; etc."
Cathcart does not say that ascorbate depletion is the only cause
for the diseases above, but that a lack of the Vitamin can predispose to these diseases and that each one of the systems involved
in the above diseases are known to be dependent upon ascorbate
to function properly. Further, that patient improvement has been
noted when Vitamin C has been provided in proper amounts by
himself and others, including A. Kalokerinos and F.R. Klenner3.
All readers should rush out to the local health food store and
purchase Vitamin C tablets. Right? Wrong! The problem with tablets is this: Tablets contain ascorbic acid or Sodium or Calcium
ascorbate crystals held together by binders. If you were to take a
sufficient amount of ascorbic acid in this form to alleviate most
conditions, you would discover yourself with diarrhea from some
of the binders alone, and this would happen long before you
determined the correct “bowel tolerance level” dosage of Vitamin
C for your present condition.
Vitamin C is also often quite expensive when purchased in
tablet form in large quantities from retail health products outlets.
You need to find a source of ascorbate that is reasonably low cost,
without binders, and purchase it in large quantity, so that you feel
free to add the Vitamin C to your diet as a supplement each day.
How much you should take is to be determined by your physical
condition, amount of stress, whether or not seriously ill, and so on.
The means of determining the proper amount will be described
via Cathcart's "Bowel Titration" technique.
Another fact you should know is that ascorbic acid,
sodium ascorbate and calcium ascorbate are physiologically
equivalent with ascorbic acid being, weight for weight, slightly
more concentrated. One good source for all three of the above
is from Bronson Parmaceuticals, 4526 Rinetti Lane, La Canada,
CA 91011-0628. You can order soluble, fine crystals of Vitamin
C in 1 kilo quantities for ascorbic acid and sodium ascorbate, and
in 1 pound quantity for calcium ascorbate. You will find it to your
advantage to have all three, as the ascorbic acid can be added to
fruit drinks and other fluids where the sodium and calcium ascorbate would not taste quite right, and vice versa. The two ascorbates are virtually tasteless (with a very light salty flavor, if anything), and the ascorbic acid is tart, as an acid should be. All three
can be mixed in water.
To avoid overbalancing mineral ratios, by taking too much
sodium as compared to calcium, one can mix the two ascorbates,
sodium and calcium -- and one can also supplement with magnesium and whatever minerals that your physician recommends,
the magnesium in dosages of equal weight to the calcium intake.
Cathcart's "Bowel Tolerance" technique is simple to apply.
A normal person can probably get by very well on between 4 and
15 grams per 24 hour period. This includes, of course, the amounts
you consume via green peppers, lettuce, fruits and so on. When
one comes down with a sickness, or has been under unusual stress,
one increases the amount of Vitamin C consumed each 24 hours to
the point where diarrhea just begins -- then one backs off to the
dosage used the day prior to the diarrhea. That "just lower than
required to produce diarrhea," is the exact amount your body
needs for the time being. Only ascorbic acid can be used for determining by bowel tolerance the correct amount of Vitamin C that is
required!
It may be necessary to increase your dosages by amounts of 5,
10, 15, ... grams per 24 hour period until you find the correct
dosage. These are monitoring matters best left up to you and
your personal experiences. I usually take 2 grams in the morning
and evening or between 3 and 5 grams per day, as a regular
maintenance routine. It is easy and convenient -- using a 1/4 measuring teaspoon laying beside one of the Vitamin C containers -- to
quickly slip 1 gram into my water or cold drink, whether it is fruit
or soda pop. (One quarter teaspoon approximates 1 gram of powdered or crystalline Vitamin C.) You can add the same quantity, or
more, to a glass of orange juice, or any other fruit juices, but I
would recommend using ascorbic acid, as it is the natural taste of
fruits. You should know that the amount of Vitamin C that you
consume in a commercially prepared fruit drink is insignificant
and not really enough to talk about, and certainly not sufficient to
produce a disease cure! As presented at the Second Annual Rheumatoid Disease Foundation Medical Seminar, Cathcart's findings
were shown, as follows:
USUAL BOWEL TOLERANCE DOSES
Grams Per
Number of Doses
Condition
24 Hours
Per 24 Hours
Normal
4-15
4
Mild Cold
30-60
6-10
Severe Cold
60-100
8-15
Influenza
100-150
8-20
ECHO, Coxsackievirus
100-150
8-20
Mononucleosis
150-200+
15-25
Viral Pneumonia
100-200+
15-25
Hay Fever, Asthma and
Food Allergy
0.5-50
4-8
Burn, Injury, Surgery
25-150
6-20
Anxiety, Exercise and
Other Mild Stresses
15-25
4-6
Cancer
15-100
4-15
Ankylosing Spondylitis
15-100
4-15
Reiter's Syndrome
15-60
4-10
Acute Anterior Uveitis
30-100
4-15
Medical data is for informational purposes only. You should always consult your family physician, or one of our referral physicians prior to treatment.
Rheumatoid Arthritis
Bacterial Infections
Infectious Hepatitis
Candida Infections
15-100
30-200+
30-100
15-200+
4-15
10-25
6-15
6-25
According to Cathcart, disease symptoms will persist until
the amount of Vitamin C reaches about 80-90% of bowel tolerance dosages. Perhaps it is only near this tolerance that the ascorbate is pushed into the primary sites of the disease. Further, suppression of symptoms in some instances may not be total, but
usually it is very significant and often the amelioration is complete
and rapid.
If you try this procedure and find that your bowels emit a
great deal of gas to the point of discomfort as you increase daily
dosages, then you are one who has "gas-forming" microflora
throughout your intestines, such as, but not only as, Candida
albicans. The gas is usually non-odorous carbon dioxide, and
usually, a by-product of yeast organisms, and others. This indicates a problem that should be handled if you are to have good
absorption of digested foods, and if you are to successfully use
the Cathcart technique. (See “Candidiasis: Scourge of Arthritics,”
http://www.arthritistrust.org.)
According to Cathcart, the Bowel Tolerance test should be
made only with ascorbic acid, but once the tolerance dosage is
learned, for that particular problem, then you can use the other
ascorbates. For general maintenance dosages, either ascorbic acid
or the sodium or calcium ascorbates are O.K. As I've mentioned
earlier, every person responds to substances differently. Vitamn C
is no exception. According to Cathcart, at least 80% of his patients tolerated ascorbic acid well. Perhaps among those who did
not are those who also had the gas generation problem from organisms that did not belong to the human symbiote family. (See
“Friendly Bacteria -- Lactobacillus acidophilus & Bifido bacterium,”
http://www.arthritistrust.org.)
Evidently Vitamin C when taken properly can provide an
important supplement to restoring the body's natural health just
as EDTA Chelation Therapy restores the ability of the cell to nourish itself. (See “Chelation Therapy,” http://www.arthritistrust.org.)
While degenerative arthritis will sometimes be improved, it
is the various inflammatory Rheumatoid Diseases where most
improvement shows, using Vitamin C therapy. There are probably several reasons why. There is, first, the general free-radical
scavenging effect of Vitamin C that can temporarily, at least,
clean-out damaging inflammatory products and toxins. Then there
is the fact that Vitamin C when placed in all organs and tissues in
appropriate amounts for a given person will permit the bodily
functions to behave properly. Third, there is the fact of eliminating altogether, or at least reducing attacks on, tissues by foreign
invaders, thus helping ourselves in the restoration of health or to
maintain health. There is also a related factor where Vitamin C
can block allergic reactions with augmented adrenal functions,
and allergic reactions may be prevalent in a large number of Rheumatoid Arthritis patients as well as in Candidiasis patients. Remember, Candidiasis almost certainly accompanies many who have
Rheumatoid Diseases. Finally, and maybe most importantly, Vitamin C in proper dosages has the ability to relieve stress that produces continuous and damaging cortisol via the adrenal glands.
Maintenance dosages are difficult for a physician to
state properly, as the individual needs of the patient varies greatly
and, also, the needs vary considerably in terms of degree of stress
and sickness of the moment. Each Rheumatoid Arthritis victim
must learn and make quantity determinations for him/herself.
In addition to a multiplicity of uses that the human body has
for Vitamin C, its concentration "directly determines the stability
of the tissues. It does so primarily via the protein collagen, which
has a similar function in the human body as the iron reinforcement
has in a skyscraper. As a consequence of acute Vitamin C deficiency the connective tissue dissolves and the body literally breaks
apart, as we know from the sailors' disease scurvy5." This is of
immediate concern to every kind of arthritic. "While acute and
complete Vitamin C depletion are essentially unknown today,
chronic dietary Vitamin C deficiency is widespread. The consequences of insufficient Vitamin C intake over decades on the tissues of the body, in particular on the wall of the blood vessels, is
disastrous. The sequence of events is
"a. decrease of stability and elasticity of the blood vessel walls
by Vitamin C deficiency
"b. loss of the cellular barrier between bloodstream and vessel wall,
"c. increased infiltration and massive deposition of dangerous blood constituents in the vessel wall,
"d. development of atherosclerosis, in particular at those sites
where high pressure and turbulences prevail (e.g. at those arteries
close to the heart),
"e. narrowing of the vessel diameter and decrease of the blood
circulation,
"f. eventually heart attack and stroke occur. . . . Heart disease
is an early stage of scurvy, a chronic Vitamin C deficiency of the
body tissues5."
Our intake of Vitamin C has either been excreted or utilized
within 24 hours of ingestion, according to Jeffrey Bland, Ph.D.,
President of Health-Comm, Inc6. It is important, therefore, that we
eat foods containing this essential vitamin daily, or supplement with
a good source.
Inter-Cal Corporation of Arizona has produced a new form of
Vitamin C called Ester-C PolyascorbateTM, which, according to
the research of Anthony F. Verlangieri, Ph.D. of Oxford, Mississippi, "reaches and maintains blood levels more rapidly than ordinary Vitamin C6; and, according to the research of Jonathan V.
Wright, M.D. "produced higher intracellular ascorbate levels, . . ,"
was retained by the body longer, and produced less oxalate excretion, "presumably creating less risk of oxalate kidney stones6."
According to Nancy Chandler, VicePresident of Operation at
Inter-Cal Corporation, ". . . the chelated form of Ester-C's ascorbate has ideal characteristics: resistance to oxidation while in the
gut, rapid transport out of the gut, and facile dissociation when in
blood or tissues7." Chandler also comments that Ester-C has had
much of its acidity removed, and therefore there is no laxative, or
other side effects from its use when higher doses are taken.
Ester-C is an interesting product, and deserves to be investigated and used by those in need of large quantities of Vitamin C. If
you do not find the product available nearby, then Inter-Cal Corporation, 421 Miller Valley Road, Prescott, AZ 86301, can tell you
how to obtain it.
One last point, from personal experience: I once poo-poohed
use of large quantities of Vitamin C as I was taught by very well
meaning "establishment" physicians that I got sufficient vitamins
and minerals in my daily foods. I didn't question at the time how
others could know this when they did not follow me about daily to
see how badly I ate or how lacking in nutrition was the food available for purchase. I took Vitamin C in tablet form only a few milligrams per day, and saw absolutely no effect on colds. Not until
reading Cathcart, Pauling, Stone and others did I realize how
truly ignorant and almost superstitious we are in protecting
"establishment" medical Authoritarianism.
I suffered from colds and flu as a child, throughout my
Medical data is for informational purposes only. You should always consult your family physician, or one of our referral physicians prior to treatment.
teens,and throughout the next forty years, until I began following
Pauling's advice with sufficient quantities of Vitamin C. I am almost never sick from those diseases, at most, perhaps once a year
or less. And even then, it lasts but several days, and I'm well again.
Vitamin C in large dosages may not cure Rheumatoid Disease, but it will sure make life easier -- and protect your body
while doing so!
References
1. Linus Pauling, Ph.D., How to Live Longer and Feel Better,
Avon Publishers, W. H. Freeman and Co., 1986. (ISBN 0-38070289-4); also see Vitamin C and the Common Cold, Op.Cit.
(ISBN: 0-7167-0361-0); Cancer and Vitamin C, The Linus Pauling
Institute for Science and Medicine, Menlo Park, 1979.
2. Irwin Stone, The Healing Factor, Worldwide, New York,
1972 (ISBN:0-448-11693-6).
3. A. Kalokerinos, Every Second Child,Thomas Nelson, Australia; 1974 (ISBN: 0-879-83-250-9).
4. Robert F. Cathcart, "Vitamin C, Titrating to Bowel tolerance, Anascorbemia, and Acute Induced Scurvy, Medical Hypotheses 7:1359-13767, 1981.
5. "How Vitamin C Can Prevent Heart Attack and Stroke,"
The Linus Pauling Institute of Science and Medicine Newsletter,
March 1992.
6. The Key to the Power of Vitamin C, Ester-C
PolyascorbateTM, Inter-Cal Corporation, 421 Valley Road,
Prescott, AZ 86301.
7. Nancy Chandler, Personal Letter from Inter-Cal Corporation, May 3, 1989.
Bill Burke writes:
I have had osteoarthritis (known, that is) for 23 years, manifesting itself in the following sequence: neck, hands, left hip, left
knee. I lived on aspirin and Indocin until early 1978, when a piece
in the Saturday Review by Norman Cousins prompted me to give
high-dose Vitamin C a secret trial. (I was a complete skeptic, and
didn’t want to look like a fool if the stuff didn’t work). Reading
between the lines, I picked 10 grams per day as a large dose; being
a total neophyte and naive, I had to feel my way in the dark. On the
4th day the improvement was so marked that I experimentally
dropped Indocin and did not miss it at all. In time I experimentally
dropped aspirin for a week; it was a misearable week, and I went
back on aspirin thankfully. Some time later I read (Chemtech, Feb.
1978) an interview with Robert F. Cathcart, III, M.D., an orthopedic-surgeon-turned-general-practitioner, who had discovered the
bowel-tolerance phenomenon: i.e., that instead of being a nuisance
side effect encountered by some people taking larger-thanvitaminlike doses of ascorbic acid, diarrhea is a God-given indicator that any person has taken more than he can absorb, and therefore more than he needs, at any given time. Having learned how to
establish my needed intake, I quickly found that on about 30 grams
per day I was without pain and essentially without discomfort. That
was in May of 1978. From that time (to June 1984) I have never
taken an aspirin or other painkiller and have needed none. (Which
is not to say that I have never had discomfort since, but rather that
when I have it, either more C will help or nothing will help.)
Wanting to know what was the rationale, if any, behind this
dramatic relief (and freeing from synthetic drugs), and also why
my doctor didn’t know about it (I having previously been a leading
exponent of the If-it’s-any-good-my-doctor-will-tell-me-about-it
school of thought), I began to read and correspond intensively. In
the ensuing six years I have learned that there are at least two ways
in which C encompasses the relief of arthritic (or any inflammatory) pain: (1) By competitively inhibiting the enzyme phosphodi-
esterase, it protects the cyclonucleotide cyclic AMP and thus makes
more of the latter available to mediate the production of cortisone - which, being home-made, does not have the undesireable side
effects of the synthetic steroids; and (2) by maximizing the conversion of dietary linoleic acid into steroids; and (2) by maximizing
the conversion of dietary linoleic acid into PGE-2, which among
other things governs the inflammatory process. (Aspirin and the
prescription anti-inflammatory drugs are prostaglandin blockers,
but they do so rather indiscriminately, so that in suppressing the
semi-Bad Guy E-2 they also tend to suppress the super Good Guy
E-1. Since E-1, among other things, governs the production of Tlymphocytes, this accounts for the fact that these drugs depress the
immune system.) (E-2 is by no means all bad, so it should not be
suppressed totally. It is involved in protecting the stomach against
ulceration, which explains why the prostaglandin blockers so often
cause ulcers. One Rheumatoid Disease patient was -- before I got
to her -- on Motrin, and had to have emergency surgery for a perforated ulcer. She later got the [recommended Arthritis Trust of
America] treatment from Dr. Plagenhoef, and is now free of Rheumatoid Disease.) [See Essential Fatty Acids are Essential, http://
www.arthritistrust.org.]
It is probably significant that my left knee was the last joint to
become arthritic, and was the one that had bothered me least.
It appears to me that Pybus’ treatment [See Intraneural Injections for Rheumatoid Arthritis and Osteoarthritis & The Control of
Pain in Arthritis of the Knee, http://www.arthritistrust.org.] is designed to interrupt a source of stress on the knee long enough to
allow nutrients (essentially protein and ascorbic acid) access to the
cartilage so that repair may proceed. It would then seem that [your]
“other health-improvement programs” should above all include a
bowel-tolerance intake of Vitamin C. Not only for the repair aspects, but also for the relief of residual inflammation. (A recent
paper states that L-arginine considerably speeds up the deposition
of collagen in healing wounds in rats and might well do the same in
humans, so perhaps adding L-arginine to the regimen might be prudent.)
It was thanks to Dr. Cathcart that I learned about WyburnMason. Cathcart’s paper asserts that while Rheumatoid Arthritis
significantly increases bowel tolerance, Osteoarthritis doesn’t. I
wrote, about a year ago, to argue that point on the basis of my own
high intake. He replied that he stood by his observation, and that if
my allergies were not enough to account for my large need, then
perhaps there was an unsuspected rheumatoid component in my
arthritis; and he referred me to Wyburn-Mason’s Medical Hypothes
paper of 1979. [See “The Roger Wyburn-Mason, M.D., Ph.D. Treatment for Rheumatoid Disease,” http://www.arthritistrust.org.] So
in time I went to Dr. Plagenhoef and said I wanted to be tested for
Rheumatoid Disease. All tests were negative. I said I wanted the
[treatment] anyway. He resisted. I prevailed. In the 4th and 5th
weeks I had an unmistakable Herxheimer reaction. After the 6th
week my arthritis was significantly improved -- about 50%. More
to the point, my bowel tolerance for C plummeted by 40%, showing that a chronic source of stress had been removed from my body.
While I was on the metronidazole treatment, incidentally, I
used no prednisone. I simply increased my intake of Vitamin C as
necessary to control the discomfort, which meant going as high as
4 grams an hour on the Herxheimer days. Exogenous steroids are
not necessary -- not when Vitamin C so well facilitates the endogenous stuff.