How To Reduce Your Risk of Cancer by 70% Presented by: George Fox, Cellular Nutrition Specialist Sources of Information For Presentation Leading Causes of Death (Data are for the U.S.) 1. Heart disease: 616,067 2. Cancer: 562,875 (1,359,000 New Cases) 3. Stroke (cerebrovascular diseases): 135,952 4. Chronic lower respiratory diseases: 127,924 5. Accidents (unintentional injuries): 123,706 6. Alzheimer's disease: 74,632 7. Diabetes: 71,382 8. Influenza and Pneumonia: 52,717 Source: Deaths: Final Data for 2007, table B CARCINOGENESIS the process of initiating and promoting cancer Source Page 72 1. A Modest Exercise Program 2. A Healthy Diet 3. High Quality, Complete and Balanced Nutritional Supplements “When you make one or two of these lifestyle changes, I guarantee your health will definitely improve. However, when you make all three lifestyle changes the results are phenomenal.” - RAY D. STRAND, M.D. 50 percent of Americans do not engage in enough regular physical activity (2). According to the National Cancer Institute’s cited studies, moderate to vigorous exercise when compared to those that are sedentary can reduce the risk of developing certain cancers by up to 80 percent. 50 percent of Americans do not engage in enough regular physical activity (2). How much physical activity do adults need? “engage in moderate-intensity physical activity for at least 30 minutes on five or more days of the week,” or “engage in vigorous-intensity physical activity for at least 20 minutes on three or more days of the week” Moderate Activity Vigorous Activity What is the relationship between physical activity and colon cancer risk? Colorectal cancer has been one of the most extensively studied cancers in relation to physical activity, with more than 50 studies examining this association. You can reduce the risk of developing colon cancer by 30 to 40 percent relative to those who are sedentary regardless of body mass index (BMI), with the greatest risk reduction seen among those who are most active (3–7). It is estimated that 30 to 60 minutes of moderate to vigorous physical activity per day is needed to protect against colon cancer (6, 7). What is the relationship between physical activity and breast cancer risk? The relationship between physical activity and breast cancer incidence has been extensively studied, with over 60 studies published in North America, Europe, Asia, and Australia. Most studies indicate that physically active women have a lower risk of developing breast cancer than inactive women; however, the amount of risk reduction achieved through physical activity varies widely (between 20 to 80 percent) (6, 7). What is the relationship between physical activity and lung cancer risk? At least 21 studies have examined the impact of physical activity on the risk of lung cancer. Overall, these studies suggest an inverse association between physical activity and lung cancer risk, with the most physically active individuals experiencing about a 20 percent reduction in risk (4, 6) The relationship between physical activity and lung cancer risk is less clear for women than it is for men. What is the relationship between physical activity and risk of prostate cancer? Research findings are less consistent about the effect of physical activity on prostate cancer, with at least 36 studies in North America, Europe, and Asia. Overall, the epidemiologic research does not indicate that there is an inverse relationship between physical activity and prostate cancer (4, 7). Although it is possible that men who are physically active experience a reduction in risk of prostate cancer, the potential biological mechanisms that may explain this association are unknown, but may be related to changes in hormones, energy balance, insulin-like growth factors, immunity, and antioxidant defense mechanisms (7). One recent study suggested that regular vigorous activity could slow the progression of prostate cancer in men age 65 or older (9). Definition: antioxidant (AN-tee-OK-sih-dent)A substance that protects cells from the damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). Free radicals may play a part in cancer, heart disease, stroke, and other diseases of aging. Antioxidants include betacarotene, lycopene, vitamins A, C, and E, and other natural and manufactured substances. What is Oxidative Stress? The Damage Done in Our Bodies by Free Radicals. What is a Free Radical? • Free radicals are charged oxygen molecules that are missing at least one electron. Consequences of Oxidative Stress “In fact, the medical literature now shows us that over 70 chronic degenerative diseases are the result of this process. Diseases like coronary artery disease, cancer, diabetes, Parkinson’s, arthritis, macular degeneration, MS, lupus, among others are the result of small oxidative changes that occur over a long period of time.” -Dr. Ray D. Strand, M.D. Specialist in Nutritional and Preventive Medicine "don't underestimate the threat free radicals pose to our health. Scientists now believe that free radicals are causal factors in nearly every known disease, from heart disease to arthritis to cancer to cataracts. In fact, free radicals are a major culprit in the aging process itself. By controlling free radicals, antioxidants can make the difference between life and death, as well as influence how fast and how well we age.“ -Lester Packer, Head of Packer Laboratory, Dept. of Molecular and Cell Biology, University of California Berkeley. Antioxidants Are The Answer “Those individuals who have the highest levels of total antioxidants in their body compared with those who have the lowest levels have a 2to-3 fold decrease risk of cancer, heart disease, diabetes, and even Alzheimer’s dementia.” -Dr. Ray D. Strand, M.D. Specialist in Nutritional and Preventive Medicine What Are Antioxidants? Examples of Antioxidants: • Vitamin E • Vitamin C • Beta Carotene • Alpha Lipoic Acid • Bioflavonoid Complex (plant compounds) • Carotenoids • Grape seed extract - 50 times more potent than vitamin E, 20 times more potent than vitamin C as an antioxidant. Extra electrons to freely donate without its self becoming a free radical. How Do Antioxidants Work? Antioxidant Free Radical Healthy Atom Oxidative Damage to DNA It is proven that free radicals damage DNA. Most scientists believe it is free radical damage to the DNA that begins many forms of cancer. Oxidative Damage to Artery Wall Why Not Get All The Antioxidants I Need From My Food? Antioxidants In Food Supply Where do Free Radicals come from? • Smoking • Stress • Sunlight • Pesticides • Pollution • Airline Travel • Medications • Foods • Food Additives • X-Rays • Exercise • Chlorine in Treated Water • Mercury in Seafood and Teeth Fillings • And Many More… Free Radicals We Are NOT Getting Optimal Nutrition at Advanced Levels • The USDA surveyed 16,000 Americans and found that not one person obtained 100% of essential nutrients such as magnesium, vitamin E, and zinc. • 68% of Americans are magnesium deficient.1 1.“Dietary Magnesium and C-reactive Protein Levels,” Journal of the American College of Nutrition, Vol. 24, No. 3, 166-171 (2005). JAMA Vitamins for Chronic Disease Prevention in Adults The Journal of the American Medical Association Scientific Review and Clinical Applications Vol. 287 No. 23, June 19, 2002 "Insufficient vitamin intake is apparently a cause of chronic diseases". Most people do not consume an optimal amount of all vitamins by diet alone. Pending strong evidence of effectiveness from randomized trials, it appears prudent for all adults to take vitamin supplements." Concept of Cellular Nutrition “Cellular nutrition would be defined as providing ALL of the micronutrients to the cell at these optimal or advanced levels that have been shown to provide a health benefit in our medical literature.” - RAY D. STRAND, M.D. Specialist in Nutritional Medicine “I concluded that the only way you have a chance of preventing oxidative stress is by taking high quality, complete and balanced nutritional supplements that provide, what I refer to as, cellular nutrition.” - RAY D. STRAND, M.D. Specialist in Nutritional Medicine Basic Nutritional Supplement Recommendations Source Page 158 Basic Nutritional Supplement Recommendations Source Page 159 Basic Nutritional Supplement Recommendations Source Page 158 Basic Nutritional Supplement Recommendations Source Page 159 Amount of Food Needed to Achieve Optimal Levels of Nutrients Source Page 181 Vitamin D3 Studies are showing that those who have the highest levels of serum 25-hydroxyvitamin D levels are experiencing a reduction in most cancers in the 70% range. Vitamin D3 is need for: Transcription(DNA transcription); the process by which one strand of DNA is copied into a complementary sequence of RNA. RNA functions in the translation of the genetic information encoded in DNA to proteins. Women in the Women’s Health Initiative that evaluated the effect of calcium and vitamin D on risk of developing colorectal cancer revealed that women who were vitamin D deficient and followed for eight years had a 253% increase risk of developing colorectal cancer. These data are also supported by a recent observation by Lappe et al who reported that women ingesting 1,100 IU of vitamin D and 1,200 milligrams of calcium a day reduced overall risk of developing cancer by almost 70%. American Journal of Clinical Nutrition, Vol. 85, No. 6, 1586-1591, June 2007 © 2007 American Society for Nutrition . 77% risk reduction Lappe J M et al. Am J Clin Nutr 2007;85:1586-1591 ©2007 by American Society for Nutrition How Do I Get Vitamin D3? From the sun, our body’s original source Don’t burn • Amount depends on latitude, skin color, body weight, time of year but, in general about • 10-15 minutes/day • Between the hours of 11 am-1 pm • 40% of body exposed Supplements: D3-cholecalciferol, How Much Should I Take? Take whatever is necessary to get serum levels to 40-60 ng/ml (100-150 nmol/L) Get Tested For D3! Vitamin D3 Test: 25-hydroxyvitamin D Test also called a 25(OH)D Test Test until in protective range: 40-60 ng/ml (100-150 nmol/L). It takes about 3 months for the D3 level to stabilize with a new dose. Then test in March each year (lowest level), then August/September (highest) How To Choose Quality Supplements High Quality, Complete and Balanced Nutritional Supplement - Providing ALL of the micronutrients to the cell at optimal or advanced levels that have been shown to provide a health benefit in the medical literature Pharmaceutical-grade Good Manufacturing Practices (GMP) - NSF International, The Public Health and Safety Company United States Pharmacopeia (USP) - Guidelines for Potency, Uniformity, and Dissolution of the tablets Independent Scientific Authority Verified for Completeness & Balance - Comparative Guide to Nutritional Supplements Widespread Supplement Contamination • 2002 - International Olympic Committee (IOC) sampled 240 supplements purchased in America, revealing 18.8% contained steroids. • 2007 - Informed-Choice a non-profit organization that certifies products to be clean and free of banned substances tested 52 supplements purchased and tested by HFL. Results, 25% of the supplements contained traces of steroids and 11.5% had banned stimulants. Results of Contaminated Supplements Major League Baseball J.C Romero suspended and loses 1.25 million dollars for testing positive for banned substance because of contaminated supplements purchased form at a GNC and Vitamin Shoppe. By Peter Gammons ESPN.com January 6, 2009, 1:36 PM ET Competitive swimmer Kicker Vencill, 31, flunked an athletic drug test because the multivitamin that he took contained banned steroids, the product was from Ultimate Nutrition Inc. The Wall Street Journal LIFE & STYLE What's Really in Supplements? SEPTEMBER 7, 2009, 7:56 P.M. ET Are You Getting What You Pay For? NUTRITIONAL SUPPLEMENTS In a recent study, researchers discovered that 54 percent of the nutritional supplements tested did not disintegrate properly.1 1. Löbenberg R, Steinke W. Investigation of vitamin and mineral tablets and capsules on the Canadian market. 2006. J Pharm Pharmaceut Sci 9(1):40-9. Leading Multi Vitamin Cheap Vitamins Your Not Getting NUTRITIONAL SUPPLEMENTS What You Pay For? Quality Product Centrum Price Vitamin B12 mcg / Serving Servings / Bottle mcg Vitamin B12 / Bottle Number of Bottles of Centrum to Equal USANA Cost Comparison Extra Cost / Month Number of Pills $8.97 $42.50 6 200 50 28 300 5600 18.67 1.00 $167.44 $42.50 $124.94 $0.00 933 112 Content of OTC Vitamin D Low, Unpredictable The mean vitamin D3 content from 10 OTC brands was only 33% of what the label claimed, with the actual content ranging from less than 1% to 82% of the advertised level. The study was presented at the meeting of the Joint Consortium of Multiple Sclerosis Centers and America's Committee on Treatment and Research in Multiple Sclerosis. Source: Consortium of Multiple Sclerosis Centers Source reference: Eckstein C, et al "Vitamin D3 content in commercially available oral supplements" CMSC-ACTRIMS 2010; P. 33-34. Top Companies Making Quality Supplements Excerpt The Numbers Say It All. The research team at Simone Protective Cancer Institute (Charles B. Simone, II, M.D., Nicole Simone, M.D., Victoria Simone, R.N., and Charles Simone, M.D.) reviewed randomized and observational trials that involved 8,521 patients taking antioxidants as single agents (individually) or in combination concomitantly with chemo and radiation therapy. The nutrients studied were vitamin A, beta-carotene, the B vitamins, vitamin C, vitamin D, vitamin E, vitamin K, selenium, cysteine, and glutathione. After evaluating 280 peer reviewed studies, including 50 human trials dating back to the 1970s through the present, the authors concluded that antioxidants and other nutrients do not interfere with these cancer treatments. In fact, non-prescription antioxidants and other nutrients actually enhance the ability of these modalities to kill cancer cells. They also help protect healthy tissue and decrease side effects. In 15 human studies, 3,738 patients who took non-prescription antioxidants and other nutrients also had increased chances of survival! Questions? NUTRITIONALS YOU CAN TRUST™ • Olivol® —USANA’s exclusive patented olive-fruit extract* • Most comprehensive, precisely balanced supplements • Unmatched number of antioxidants • Nutrition for all generations *Patented in the United States. US Patent No. 6,358,542 or 6,361,803 “With over 1,500 nutritional supplements evaluated, USANA’s Essentials™ continue to set the gold standard, earning the NutriSearch Gold Medal of Achievement™ for proven product excellence.” —Lyle MacWilliam, BSc, MSc, FP former Canadian Member of Parliament and Member of the Legislative Assembly for British Columbia These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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