Abstract ID 14-440 Glickman Urological and Kidney Institute “Getting to Zero": Phenotype, Symptom Severity and Treatment in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Patients Who Self Report Symptom Resolution Chad Reichard MD; Irene Makovey MD; Daniel Shoskes MD BACKGROUND / RATIONALE RESULTS •The NIH-Chronic Prostatitis Symptom Index (CPSI) quantifies the extent and severity of symptoms in chronic pelvic pain syndrome (CPPS) and impact on quality of life. •A 6 point drop correlates with perceived patient improvement. •Symptom improvement is not equivalent to "cure" and no studies have examined CPSI score targets in patients who consider their CPPS completely resolved. •There are sufficient non-specific questions in the CPSI that would allow many otherwise normal patients to have a score greater than zero. •We describe a cohort of CPPS patients who considered their symptoms completely resolved •Demographics, clinical phenotype, treatments and CPSI scores were analyzed STUDY METHODS Subject Selection CPPS patients with initial clinic visits from January 2006 to January 2014 at our tertiary referral center were reviewed and data complied on 35 patients who at a follow up visit subjectively self-reported that they felt their symptoms to be completely resolved ("cured"). Data Collection all p<0.0001 •Median •Two follow up was 12 months (range 3 to 93 months). thirds of patients had no history of urologic surgery. •None of the cured patients had irritable bowel syndrome. •Median post-void residual was 9cc and only 6% had a residual >100 ml. •Most prevalent treatment: pelvic floor physical therapy (71% of patients) •9 patients (26%) report total post-treatment CPSI score of 0 •74% report post-treatment scores range 1-21 •22% with score = 0 still under ongoing treatment •50% with score >0 still under ongoing treatment •Median •Most of 3 UPOINT domains positive (range 1-5) prevalent domain: urinary (71%) •No difference in age or UPOINT phenotype between groups •Cured group had lower total and pain CPSI scores compared to control (pre-treatment) Demographic information, clinical variables, UPOINT phenotypes, treatments, and pre-treatment and post-treatment CPSI scores were examined. This data was obtained from our IRB approved Men’s Health Registry. We also compared these variables to an existing database of 220 CPPS patients CONCLUSIONS previously evaluated and phenotyped at our clinic. Statistical analysis Pairwise parametric comparisons performed using Student’s t-test Fisher’s exact test used to assess difference in categorical variables GraphPad Prism v5.0 (significance set at p>0.05) · Many men with CPPS can reach a subjective cure · The majority do not reach a CPSI score of 0 · 43% overall continued on treatment at time of self-reported cure This group of "cured" patients is similar to our typical tertiary referral cohort in terms of age and phenotype but differs in having slightly lower starting CPSI pain scores.