Document 240719

What is Transdermal Pain Therapy?
A Possible Solution for You and Your Patients:
Nearly two in five (36%)
Americans would refuse
prescribed or physicianrecommended pain medication
for fear of getting addicted.
Transdermal pain therapy targets neuropathic, musculoskeletal and inflammatory pain by combining
drugs with multiple mechanisms of action into an innovative delivery system.
•
•
•
Provides localized enhanced drug delivery directly to the site of pain
Drugs for pain are incorporated into a proprietary transdermal cream that has proven
results to deliver multiple drugs through the skin (see study on following page)
Unique options for patients and confidence for prescribers
Common Challenges with Oral Medications:
1.
2.
3.
4.
5.
Lack of Efficacy
Patient develops tolerance
GI side effects
Nausea
Constipation
6. Gastric bleeding
7. CNS side effects
8. Confusion
9. Change in mood/misuse
10. Abuse/Overdose *
Benefits of Transdermal Pain Therapy:
1.
2.
3.
4.
5.
* More than 16,500 people die
of overdoses from prescription
painkillers annually, more
than all illegal drugs combined
(including Heroin and Cocaine)
Source : Centers for Disease Control & Prevention
Ease of administration/application for patients; do not need to swallow multiple medications
Ability to combine multiple drugs into one dose
Provides a goal for pain relief with reducing the dose or need for oral narcotics
Option for prescriptions with non-controlled drugs
Less potential systemic drug absorption with the goal of fewer side effects
One in three (34%) Americans
believe pain medications that
come with side effects are worse
than the pain itself.
One in three (31%) Americans
would not even speak to a
medical professional about their
pain for fear they could not
afford treatment.
Study Involving TC Neuromax’s Transdermal Cream (Lipoderm®)
Lipoderm® Proven to Deliver Four Drugs Simultaneously
Through Human Skin In Vitro – FIRST STUDY OF ITS KIND!
RESULTS The data indicate that PCCA’s Lipoderm® delivered ketamine HCl, gabapentin, clonidine HCl and baclofen,
simultaneously (and intact), into and through human cadaver skin, in vitro. The absorption profiles indicate a rapid
penetration to a peak flux for gabapentin and baclofen occurring approximately one (1) hour after dose application,
and approximately four (4) hours for ketamine HCl. Clonidine HCl exhibited a rapid penetration to an initial peak flux
occurring one (1) hour after dose application, but also a secondary peak at approximately 40 hours, possibly due to a
depot of some of the applied dose in the epidermis. (See Figures 1 through 5.) This one-of-a-kind study validates the
ability of Lipoderm® to deliver four drugs simultaneously through human skin. This information is of great value for
pharmacists and physicians utilizing topical preparations for various pain syndromes.
American Osteopathic Association Survey , October 2010
Concentration of therapeutic levels of many drugs is higher
in tissues while lower in serum
Comparison and evaluation of topical NSAIDs are difficult due to the diversity of presentations of the marketed drugs and variety of methods used
in the trials. Overall, when NSAIDs are applied topically, a high concentration is observed in the dermis and muscles (equivalent to that obtained with
oral route), with less gastrointestinal effects. Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048583/
What can Transdermal Pain Therapy be used for?
Achilles Tendonapathy
Acute Pain
Burning Foot Syndrome
Bursitis
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Complex Regional Pain Syndrome (CRPS)
Diabetic Peripheral Neuropathy (DPN)
Epicondylitis
Failed Back Syndrome
Fibromyalgia
Frozen Shoulder
Gout
Lateral & Medial Epicondylitis
Low Back Pain
:xF
Medial-tibial Stress Syndrome
Myofascial Pain Syndrome
www.tcneuromax.com
Osteoarthritis
Peripheral Neuropathy
Phantom Limb Pain
Plantar Fasciitis
Post Herpetic Neuralgia (PHN)
Post-op Pain
Radiculopathy
Rheumatoid Arthritis
Sciatica
Shingles
Sports Injuries
Tendonitis
Tendonosis
Temporomandibular Joint Disorder (TMJ)
Trigemial Neuralgia
Ph: 888.290.2244 Fx: 866.587.8915
www.tcneuromax.com
Ph: 888.290.2244 Fx: 866.587.8915
TC Neuromax Transdermal Pain Creams
MEDICATION
DEFINITION | USES
Amitriptyline
Neuropathic pain
Baclofen
Muscle relaxer, anti-spasmatic
Bromelain Proteolytic enzyme
Bupivacaine
Local anesthetic
Clonidine
Neuropathic pain
Colchicine Muscle relaxant
Flurbiprofen
NSAID; inflammatory pain
Gabapentin
Neuropathic pain
Compassionate Care
Expertise
in Transdermal Pain Therapy
Welcom e
Gout
Cyclobenzaprine
Ketamine
Leading the way with
Neuropathic pain
Nifedipine
It is often used transdermally to increase circulation
Pentoxifylline
Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and tumor necrosis factor (TNF)
Tranilast Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and TNF
For specific medication questions please email [email protected]
-
Transdermal Pain Therapy
106 Prospect Street Ridgewood, NJ 07450
Ph: 888.290.2244 Fx: 866.587.8915
www.tcneuromax.com
www.tcneuromax.com