What is Transdermal Pain Therapy? A Possible Solution for You and Your Patients: Nearly two in five (36%) Americans would refuse prescribed or physicianrecommended pain medication for fear of getting addicted. Transdermal pain therapy targets neuropathic, musculoskeletal and inflammatory pain by combining drugs with multiple mechanisms of action into an innovative delivery system. • • • Provides localized enhanced drug delivery directly to the site of pain Drugs for pain are incorporated into a proprietary transdermal cream that has proven results to deliver multiple drugs through the skin (see study on following page) Unique options for patients and confidence for prescribers Common Challenges with Oral Medications: 1. 2. 3. 4. 5. Lack of Efficacy Patient develops tolerance GI side effects Nausea Constipation 6. Gastric bleeding 7. CNS side effects 8. Confusion 9. Change in mood/misuse 10. Abuse/Overdose * Benefits of Transdermal Pain Therapy: 1. 2. 3. 4. 5. * More than 16,500 people die of overdoses from prescription painkillers annually, more than all illegal drugs combined (including Heroin and Cocaine) Source : Centers for Disease Control & Prevention Ease of administration/application for patients; do not need to swallow multiple medications Ability to combine multiple drugs into one dose Provides a goal for pain relief with reducing the dose or need for oral narcotics Option for prescriptions with non-controlled drugs Less potential systemic drug absorption with the goal of fewer side effects One in three (34%) Americans believe pain medications that come with side effects are worse than the pain itself. One in three (31%) Americans would not even speak to a medical professional about their pain for fear they could not afford treatment. Study Involving TC Neuromax’s Transdermal Cream (Lipoderm®) Lipoderm® Proven to Deliver Four Drugs Simultaneously Through Human Skin In Vitro – FIRST STUDY OF ITS KIND! RESULTS The data indicate that PCCA’s Lipoderm® delivered ketamine HCl, gabapentin, clonidine HCl and baclofen, simultaneously (and intact), into and through human cadaver skin, in vitro. The absorption profiles indicate a rapid penetration to a peak flux for gabapentin and baclofen occurring approximately one (1) hour after dose application, and approximately four (4) hours for ketamine HCl. Clonidine HCl exhibited a rapid penetration to an initial peak flux occurring one (1) hour after dose application, but also a secondary peak at approximately 40 hours, possibly due to a depot of some of the applied dose in the epidermis. (See Figures 1 through 5.) This one-of-a-kind study validates the ability of Lipoderm® to deliver four drugs simultaneously through human skin. This information is of great value for pharmacists and physicians utilizing topical preparations for various pain syndromes. American Osteopathic Association Survey , October 2010 Concentration of therapeutic levels of many drugs is higher in tissues while lower in serum Comparison and evaluation of topical NSAIDs are difficult due to the diversity of presentations of the marketed drugs and variety of methods used in the trials. Overall, when NSAIDs are applied topically, a high concentration is observed in the dermis and muscles (equivalent to that obtained with oral route), with less gastrointestinal effects. Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048583/ What can Transdermal Pain Therapy be used for? Achilles Tendonapathy Acute Pain Burning Foot Syndrome Bursitis Chemotherapy Induced Peripheral Neuropathy (CIPN) Complex Regional Pain Syndrome (CRPS) Diabetic Peripheral Neuropathy (DPN) Epicondylitis Failed Back Syndrome Fibromyalgia Frozen Shoulder Gout Lateral & Medial Epicondylitis Low Back Pain :xF Medial-tibial Stress Syndrome Myofascial Pain Syndrome www.tcneuromax.com Osteoarthritis Peripheral Neuropathy Phantom Limb Pain Plantar Fasciitis Post Herpetic Neuralgia (PHN) Post-op Pain Radiculopathy Rheumatoid Arthritis Sciatica Shingles Sports Injuries Tendonitis Tendonosis Temporomandibular Joint Disorder (TMJ) Trigemial Neuralgia Ph: 888.290.2244 Fx: 866.587.8915 www.tcneuromax.com Ph: 888.290.2244 Fx: 866.587.8915 TC Neuromax Transdermal Pain Creams MEDICATION DEFINITION | USES Amitriptyline Neuropathic pain Baclofen Muscle relaxer, anti-spasmatic Bromelain Proteolytic enzyme Bupivacaine Local anesthetic Clonidine Neuropathic pain Colchicine Muscle relaxant Flurbiprofen NSAID; inflammatory pain Gabapentin Neuropathic pain Compassionate Care Expertise in Transdermal Pain Therapy Welcom e Gout Cyclobenzaprine Ketamine Leading the way with Neuropathic pain Nifedipine It is often used transdermally to increase circulation Pentoxifylline Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and tumor necrosis factor (TNF) Tranilast Part of TC Neuromax transdermal base. Proposed mechanism in the pain cascade on IL-6 and TNF For specific medication questions please email [email protected] - Transdermal Pain Therapy 106 Prospect Street Ridgewood, NJ 07450 Ph: 888.290.2244 Fx: 866.587.8915 www.tcneuromax.com www.tcneuromax.com
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