Medication Monitoring Why Combine Point of Care Testing with Laboratory Confirmation? Benefits of POCT confirmation » Although Point of Care Testing (POCT) usage is expanding in clinical settings, certain drugs such as Fentanyl, Soma, Tapentadol, Meperidine, Methylphenidate, and many others cannot be detected by POCT devices. » Confirmation testing identifies the presence or absence of a specific drug and/or its metabolite(s); whereas POCT may only show a presumptive result for a class of drugs such as Opiates or Benzodiazines. » Interferences can arise with antibody-based screens including POCT, thus false-positive results are possible. Laboratory confirmation is the best way to rule-out potential false positive results. » Confirmation testing via LC/MS/MS is a more sensitive detection method than POCT, so false negative results can be avoided. » Alere Toxicology assures specimen validity with objective measurements of pH, Creatinine, Specific Gravity, and Oxidants. Test Comparison by Cutoff Level Test Options Typical POCT Cutoff LC/MS/MS Cutoff 50 mg/dL1 Alcohol Ethyl Glucuronide 500 ng/mL Ethyl Sulfate 125 ng/mL Amphetamine 1000 ng/mL 100 ng/mL Barbiturates 300 ng/mL 200 ng/mL2 Benzodiazepines 300 ng/mL Alprazolam (Alpha-hydroxyalprazolam) 50 ng/mL Clonazepam (7-aminoclonazepam) 50 ng/mL Diazepam (Nordiazepam) 50 ng/mL Lorazepam 50 ng/mL Oxazepam 50 ng/mL Temazepam 50 ng/mL Buprenorphine 10 ng/mL Norbuprenorphine 25 ng/mL Carisoprodol 50 ng/mL Meprobamate Cocaine (Benzoylecgonine) Fentanyl Norfentanyl Gabapentin 10 ng/mL 50 ng/mL 300 ng/mL 25 ng/mL 2 ng/mL 10 ng/mL 50 ng/mL Continued on back Medication Monitoring Test Options Typical POCT Cutoff Ketamine LC/MS/MS Cutoff 100 ng/mL Norketamine 100 ng/mL MDMA 500 ng/mL 100 ng/mL MDA 100 ng/mL Meperidine 50 ng/mL Normeperidine 50 ng/mL Methamphetamine 1000 ng/mL Methamphetamine Isomer Analysis 100 ng/mL 100 ng/mL Methylphenidate 50 ng/mL Ritalinic Acid 50 ng/mL Methadone 300 ng/mL EDDP Opiate Panel 100 ng/mL 100 ng/mL 300 or 2000 ng/mL Heroin (6-MAM) 10 ng/mL Codeine 50 ng/mL Hydrocodone 50 ng/mL Norhydrocodone 50 ng/mL Hydromorphone 50 ng/mL Morphine 50 ng/mL Oxycodone 50 ng/mL Oxymorphone 50 ng/mL Noroxycodone Phencyclidine (PCP) 50 ng/mL 25 ng/mL Pregabalin Propoxyphene 50 ng/mL 300 ng/mL Norpropoxyphene THC (THC-COOH) Tramadol O-desmethyltramadol 100 ng/mL 100 ng/mL Tapentadol Tricyclic Antidepressants (TCA) 5 ng/mL 50 ng/mL 1000 ng/mL 300 ng/mL2 50 ng/mL 10 ng/mL 50 ng/mL 50 ng/mL 1. EA (Enzyme Assay) 2. EIA (Enzyme Immunoassay) lab services 800.994.2088 | aleretoxicology.com ©2012 Alere. All rights reserved. Alere is a trademark of the Alere group of companies. 800098 REV1 02/12