P O Box 3697 Stratford Upon Avon Warwickshire CV37 8YL T: +44 (0) 1789 450787 F: +44 (0) 1789 450682 Promoting better understanding, diagnosis, treatment and quality of life for individuals suffering with cardiac arrhythmia CARDIOTHORACIC DIVISION PROTOCOL UPDATED 27/01/05 FLECAINIDE CHALLENGE PROTOCOL Why do we carry out this test? The test is used to screen for Brugada Syndrome What is Brugada Syndrome? It is a congenital disease that presents as a ventricular arrhythmia or sudden cardiac death. It is linked to a sodium pump malfunction that leads to the myocardial tissue being more excitable and therefore vulnerable to tachyarrhythmias. It has a higher incidence in males. Pre‐test • Record baseline observations – BP, pulse, temp, ECG • Cannula During the test • The patient needs to lie on a bed and be attached to a 12 lead ECG throughout the test • 2 mg per kg body weight (max 150mg) of Flecainide is administered IV over 10 minutes • Record a 12 lead ECG every minute during the administration of IV Flecainide (10 minutes) and up to 30 minutes afterwards www.heartrhythmcharity.org.uk [email protected] President: Prof A. John Camm, QHP, MD, FRCP, FACC. Trustees: Dr Adam P Fitzpatrick, MD, FRCP, FACC, Dr Derek Connelly, MD, FRCP, Mrs Trudie Lobban, MBE, Mr Nigel Farrell, LLB(Hons) Patrons: W B Beaumont, OBE, Prof Hein J J Wellens, Prof Silvia G Priori. Registered Charity Number - 1107496 P O Box 3697 Stratford Upon Avon Warwickshire CV37 8YL T: +44 (0) 1789 450787 F: +44 (0) 1789 450682 Promoting better understanding, diagnosis, treatment and quality of life for individuals suffering with cardiac arrhythmia What if the test is positive? The test is positive if RBBB and ST elevation in the anterior chest leads develops. The patient may require VT stimulation studies. CRM NURSE TEAM, CCU: EXT 2806 PAGER NO: 07699 721256 www.heartrhythmcharity.org.uk [email protected] President: Prof A. John Camm, QHP, MD, FRCP, FACC. Trustees: Dr Adam P Fitzpatrick, MD, FRCP, FACC, Dr Derek Connelly, MD, FRCP, Mrs Trudie Lobban, MBE, Mr Nigel Farrell, LLB(Hons) Patrons: W B Beaumont, OBE, Prof Hein J J Wellens, Prof Silvia G Priori. Registered Charity Number - 1107496