Research Cerebrovascular Surgery Reduce Intraoperative Stroke Risk with Volume Flow Measurements • Identify Inadvertent Vessel Compromise • Confirm Flow Preservation • Quantify Flow Augmentation Research Cerebrovascular Surgery Charbel Flowprobes® Provide On-the-Spot Quantitative Measurements Intraoperative measurements with the bayonet-style Charbel Flowprobe® take the guesswork out of blood flow during aneurysm clipping, extracranial to intracranial (EC-IC) bypass surgeries, arteriovenous malformations (AVMs), dural fistula obliteration, and tumor resection surgeries. During aneurysm clipping surgery, flow measurements help surgeons achieve optimal clip placement to obliterate the aneurysm without compromising flow in parent vessels and distal branches that might cause an intraoperative stroke. Measurements either confirm the surgeon’s clinical assessment of flow preservation, or expose the need for immediate correction of flow deficits. Moreover, during temporary clippings, flow measurements offer an assessment of collateral flow reserve and predict the safety of the temporary clipping. “Flow is a vital parameter during cerebrovascular surgery; including flow in my surgical approach gives me a high degree of control over surgical outcome. When I close the patient, I know the patient will recover without ischemia surprises. This translates into peace of mind for the patient and me, and saves money for the hospital.” F Charbel, MD, FACS “One of the major risks associated with aneurysm surgery is the potential for inadvertent occlusion or compromise of the vascular branches from which the aneurysm arises, which can result in stroke.” “Use of the ultrasonic flow probe provides real-time immediate feedback concerning vessel patency … Intraoperative flow measurement is a valuable adjunct for enhancing the safety of aneurysm surgery.“ S Amin-Hanjani, MD, FACS “Transit-time flow measurements are useful for surgical management during cerebrovascular surgery. The technique was simple to use and provided sensitive, stable, reliable results. The method revealed distal branch flow drop after aneurysm clipping, or residual flow during temporary clipping, and has the potential to predict post-operative complications in bypass or carotid endarterectomy surgeries. N Nakayama, MD TRANSIT-TIME ULTRASOUND TECHNOLOGY MEASURES VOLUME FLOW, NOT VELOCITY During EC-IC bypass surgery to preserve or augment distal cerebral perfusion, intraoperative flow measurements help the surgeon choose the most appropriate bypass and predict its future patency. Intraoperative flow measurements provide invaluable quantitative flow information to augment the surgeon’s clinical armamentarium. No other technology produces flow data so quickly, accurately, and non-intrusively during cerebrovascular surgery as do Transonic® intraoperative Flowmeters. Two transducers pass ultrasonic signals, alternately intersecting the vessel in upstream and downstream directions. The difference between the two transit times yields a measure of volume flow. Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected] CerebrovascularCover(NS-300-fly-A4)RevB 3-14 Cerebrovascular Surgery Charbel Micro-Flowprobes® Volume Flow When Minutes Count! Cerebrovascular surgery seeks to preserve blood flow in intracranial vessels or to augment flow to cerebral territories. Intraoperative measurements of volume flow assure the integrity of flow in cerebral vessels or they alert the surgeon to dangerous flow deficits during: • Aneurysm Obliteration Surgery: Quantitative flow data guides clip placement for full preservation of flow in parent vessels and distal branches. • Revascularization (EC-IC Bypass) Surgery for Occlusive Disease: Flow measurement quantifies an increase in flow after revascularization. Intracranial measurements decrease the need for disruptive intraoperative angiography. Measurements also provide documentation of flow for the patient’s record. A shorter bayonet handle MB-S and MR-S Micro Flowprobes are designed to be used under the microscope for extracranial vessels such as the superficial temporal artery during STA-MCA bypass surgery. SPECIFICATIONS PROBE CATALOG # VESSEL SIZE size x = N, D; k = R, B outer diameter mm 1.5 mm 2 mm 3 mm HQx 1.5 Mk HQx 2 Mk HQx 3 Mk 1.0 - 1.5 1.5 - 2.7 2.5 - 3.7 3 mm 4 mm 6 mm HQx 3 Mk-S HQx 4 Mk-S HQx 6 Mk-S 2.5 - 3.7 3.3 - 4.7 4.4 - 6.6 MB-Series Flowprobes ship pre-sterilized for use where Creutzfeldt-Jakobs disease transmission is a concern. MR-Series Flowprobes are re-sterilizable (up to 16 sterilization cycles for HQNxMR and up to 50 cycles for HQDxMR). INTRACRANIAL FLOWPROBES Flexible neck Probe body Long bayonet neck Reflector Fig. 1: MB-Series & MR-Series Charbel Micro-Flowprobes® are designed for deep intracranial surgery. Their long bayonet handle permits use under a surgical microscope. A flexible neck segment permits the Flowprobe neck to be bent, as needed, to optimally position the probe around a vessel. Fig. 2: Charbel Micro-Flowprobes® are available in three sizes, 1.5 mm, 2 mm and 3 mm. EXTRACRANIAL FLOWPROBES Intracranial Flexible neck Extracranial Fig. 3: Comparison of Flowprobe bodies of intracranial Flowprobes (top) and extracranial Flowprobes. Short bayonet Probe neck body Reflector Fig. 4: MB-S & MR-S-Series Micro-Flowprobes (3 mm, 4 mm, 6 mm) feature a shorter bayonet handle and larger flowsensing body to be used during on extracranial vessels during EC-IC bypass surgery. Intracranial Extracranial Fig. 5: Comparison of bayonet handles of the MB-Series Charbel Micro-Flowprobes® for intracranial vessels and the MB-S & -MR-S-Series Micro-Flowprobes for extracranial vessels during EC-IC bypass surgery. CerebrovascularsurgeryFlowprobesFlowmeters(NS-350-ds)RevF 12/13 Cerebrovascular Surgery Flowmeters: Cerebrovascular Surgery Transonic’s new Optima Flow-QC® Meter takes transit-time ultrasound flow measurement resolution to the highest level. The Optima’s unprecedented resolution accompanies lower offsets, and doubles the accuracy for low flows. The Optima can be used alone or with the AureFlo® System to continuously measure, display, record and document absolute volume flow • Provides unsurpassed accuracy and resolution • Ensures flow integrity • Immediate, quantitative flow measurements HT353 Single-channel Optima Flowmeter The AureFlo® system continuously measures, displays, records and documents absolute volume flow and other derived parameters. Shown here with the new HT353 single-channel Optima Flowmeter, it can be used with Transonic’s Charbel Micro-Flowprobes®. HT364 Dual-channel Optima Flowmeter Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected] Cerebrovascular Surgery Medical Note Intraoperative Blood Flow Measurement during Aneurysm Clipping Surgery Courtesy of F.T. Charbel, M.D., F.A.C.S. Charbel Micro-Flowprobes® measure blood flow in major cerebral vessels. The Flowprobes use ultrasonic transit-time principles to directly measure volume blood flow, not velocity. Measurements detect low flow states that might result in intraoperative strokes. Measurements Steps: 1. Identify Vessels at Risk Expose and identify parent vessels and distal outflow vessels of the aneurysm. 2. Select Flowprobe Size Measure the vessel diameter of the vessels at risk with a gauge before opening the Probe package. Select a Probe size so that the vessel will fill between 75% - 100% of the ultrasonic sensing window of the Probe. 3. Apply Flowprobe Determine the optimal position for applying the Probe on the vessel. Select a site wide enough to accommodate the Probe’s acoustic reflector without compromising perforating arteries coming off the vessel. Apply the Probe so that the entire vessel lies within the ultrasonic sensing window of the Probe and aligns with the Probe body. Bend the Probe’s flexible neck segment as needed. As the Flowprobe is being applied to the vessel, listen to FlowSound®. The higher the pitch, the greater the flow. Sterile saline or cerebrospinal fluid may be used to flood the Probe lumen and provide ultrasound coupling. Do not irrigate continuously because the Flowprobe will also measure saline flow. The Signal Quality Indicator (bucket display) on the Flowmeter indicates acoustic contact. If acoustic contact falls below an acceptable value, an acoustic error message will be displayed. 4. Measure Baseline Flows Before clipping the aneurysm, measure baseline flows in all vessels at risk. Measure baseline flows following burst suppression, since these protective agents will decrease AneurysmClippingMedicalNoteA4(NS-308-mn)RevF 2013 baseline flows. Record the baseline flow measurements and the patient’s blood pressure on the Flow Record. 5. Document Flows After applying the Flowprobe, wait 10-15 seconds for mean readings to stabilize. Then press the PRINT button on the Flowmeter or take a snapshot on AureFlo® to document the phasic flow patterns for the case record. If the Flowmeter displays a negative flow, press the INVERT button to change the polarity before printing the waveform. 6. Post-Clip Flows & Compare to Baseline After an aneurysm has been clipped, remeasure flow in each of the vessels and compare the post-clip flows with baseline flows. Each measurement should be equal or greater than the respective baseline flow. Greater flows are expected in cases where the aneurysm has compromised flow well below the vessel’s expected flow level (chart on back side). Temporary clipping can also produce hyperemia which can cause flows to be 20-30 % higher than baseline. RIGHT SUPERIOR CEREBELLAR ANEURYSM with Flowprobe placed on superior cerebellar artery (SCA) to measure restoration of flow after clipping the aneurysm. Intraoperative Blood Flow Measurement during Aneurysm Clipping Surgery POSTERIOR CIRCULATION PCA Basilar PCom ICA ACom MCA ACA ICA ANTERIOR CIRCULATION Vertebral Common sites for anterior circulation aneurysms include the carotid ophthalmic artery (OpthA), Internal Carotid Artery (ICA) bifurcation, Middle Cerebral Artery (MCA) bifurcation, M1 Segment MCA, Anterior Cerebral Communicating Artery (AComA), and Posterior Communicating Artery (PComA) artery. The most common sites for aneurysms in the posterior cerebral circulation include the basilar artery (BA), posterior Inferior cerebellar artery (PICA) and superior cerebellar artery (SCA). Flow Measurement Protocol Identify Vessels at Risk Select Proper Flowprobe Size Measure Baseline Flows in all vessels at risk Measure Post-clip Flows in all vessels at risk Compare Post-clip Flows to Baseline Flow Flow equal or more than baseline Flow Preserved in vessels at risk Flow less than baseline Re-examine/adjust clip and remeasure flow. Flow Measurement Summary • Measure vessel and select a Flowprobe size so that the vessel will fill at least 75% of the Flowprobe’s lumen. Use sterile saline or cerebrospinal fluid to obtain good ultrasonic contact between the Flowprobe and the vessel. • Bend the Flowprobe’s flexible segment to best position the Flowprobe around the vessel. Listen to FlowSound® to hear volume flow. • When readings stabilize, flow data can be captured by recording or taking a snapshot on the Aureflo®, or by pressing PRINT on a HT300-Series Flowmeter. If the HT300-Series LED flow reading is negative, press INVERT to reverse the polarity of the flow reading from negative to positive before printing out the waveform. Measurement Review • Measure baseline flows before clipping • • aneurysm. Measure flow after temporary clipping of an aneurysm to check integrity of flow. Confirm flow restoration after permanent clipping by comparing post-clipping flows with baseline flows. Case Report: Flow-based SCA Aneurysm Clipping Courtesy: F.T. Charbel, M.D., F.A.C.S., Professor and Head, Neurosurgery, University of Illinois at Chicago, USA 2) 1) Flowprobe Oculomotor Nerve Optic Nerve Basilar a. ICA ACA SCA MCA PCA Aneurysm A patient presented with headaches and diplopia. A cerebral angiogram confirmed a right cerebellar aneurysm. Meticulous dissection on the right side exposed an aneurysm between the superior cerebellar artery (SCA) and posterior cerebral artery (PCA). Baseline SCA flow, 18 mL/min 30 mL/min Vessel(s) at Risk Identified Aneurysm 0 Baseline Flow Measurements The Charbel Micro-Flowprobe® was first placed on the SCA. Flow measured 6-18 cc/min. The Flowprobe was then placed on the PCA and flow measured 34-36 cc/min. 4) 3) Clip being positioned Clip in place mL/min 0 Integrity of Flow Checked after aneurysm clipping SCA flow dropped to 2-4 cc/min. PCA flow was recorded as 55-60 cc/min 30 Clip repositioned: SCA flow restored to baseline mL/min Initial clip placement compromises SCA flow 30 0 Correction The SCA was found to be partially incorporated in the clip. Following repositioning of the clip, SCA and PCA flows returned almost to baseline levels. Cerebrovascular Surgery Intraoperative Blood Flow Measurement during Ameurysm Clipping Surgery Cont. TECHNICAL RECOMMENDATIONS: ANEURYSM SURGERY M1 2.0 Expected Flows* ml/min 80-110 A1 2.0 40-60 ICA 3.0 120-170 M1 2.0 80-110 A1 2.0 40-60 ICA 3.0 120-170 M1 2.0 80-110 A1 2.0 40-60 ICA 3.0 120-170 AChA 1.5 20-60 M1 2.0 80-110 A1 2.0 40-60 A1 (ipsilateral) 2.0 40-60 A1 (contralateral) 2.0 40-60 A2 (both) 1.5 40-50 Middle Cerebral A (MCA) M2 (outlet) 2.0 50-80 Post. Inferior Cerebellar A (PICA) VA 3.0 100-200 PICA 2.0 10-15 Superior Cerebellar A (SCA) SCA (ipsilateral) 1.5 18-20 PCA 2.0 26-30 P2 (ipsilateral) 2.0 26-30 SCA 1.5 18-20 Aneurysm Site Carotid Ophthamic A (Opth) Posterior Communicating A (PCom) Anterior Choroidal A (ACh) Carotid Bifurcation (ICA) Anterior Communicating A (ACom) Basilar Tip A (BA) Probe Placement Size mm Tips Usually large aneurysms with no proximal control. Flow must be preserved in the the ICA and M1 and A1 outlet vessels. Usually large aneurysms with no proximal control. Flow must be preserved in the the ICA and M1 and A1 outlet vessels. Flow in the anterior choroidal is particularly important. The 1.5 mm probe is good for this vessel. The technical challenge is to preserve flow in the M1 and A1 outlet vessels. Flow in the ICA (3 mm) can be checked also. High risk. The technical challenge is to preserve flow in the A2 outlet vessels.No change in both A2s indicates flow is fully preserved. One A1 usually predominates and feeds both vessels. This is a straightforward, relatively low stress case for the surgeon. One of the easiest places to put the probe. Check flow in proximal or distal VA and PICA. Check flow in ipsilateral SCA and PCA (Posterior Cerebral Artery). The perforators will still need to be inspected. PCom (prelude to sacrifice) * Expected Flow rates courtesy of F.T. Charbel M.D., F.A.C.S Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected] Cerebrovascular Surgery Medical Note Intraoperative Blood Flow Measurement during Arterial EC-IC Bypass Surgery Courtesy of FT Charbel, M.D., F.A.C.S. Introduction When an arterial extracranial-intracranial (ECIC) bypass is selected to augment flow during surgery for occlusive cerebrovascular disease, the Charbel Micro-Flowprobe® assesses the patency and adequacy of flow before, during and after construction of the bypass. Transonic ® Flow-QC either confirms that the bypass is working well, or prompts a revision if a technical error is suspected. Measurements are also taken periodically during closure of the skin incision to make sure the bypass has not kinked or twisted (See Case Report on page 3). Arterial Bypass For an arterial bypass (Fig. 1), baseline flows are first measured in the extracranial and intracranial vessels. After the extracranial artery is cut, free flow of the artery is measured by allowing the cut distal end to bleed freely for 15-20 seconds (Fig. 2). This free flow represents the amount of flow at zero resistance or the “carrying capacity” of the bypass, the maximum flow that the artery can deliver. Once the bypass is constructed, post-anastomotic flow is measured (Fig. 3) in the donor artery. The Cut Flow Index (CFI) is calculated by dividing the Post-Bypass Flow by the Free Flow. If post-bypass flow exceeds 50% of (CFI > 0.5), the bypass can be considered successful. If bypass flow is below 50% of free flow with no clinical justification such as a poor quality recipient vessel, the surgeon should reexamine the bypass for technical problems, and revise if necessary. Reference 1Amin-Hanjani, S., Du, X., Milnarevich, N., Meglio, G., Zhao, M., Charbel, F.T., “The Cut Flow Index: An Intraoperative Predictor of the Success of EC-IC Bypass for Occlusive Cerebrovascular Disease,” Neurosurgery 2005; 56:75-85. (Transonic Reference # 2922AH) ArterialEC-ICBypassMedicalNoteA4(NS-311-mn)RevD2013 Fig. 1: Lateral view of an arterial workhorse STA-MCA EC-IC Bypass. The STA is exposed, cut and anastomosed to the MCA via an end-to-side anastomosis. Fig. 3: Flow being measured on the bypass after its anastomosis to recipient artery. Fig. 2: Measurement of free “cut” flow of extracranial artery before anastomosis to an intrcranial artery.. Intraoperative Blood Flow Measurement during Arterial EC-IC Bypass Surgery Cont. Measurements Steps: Measurement Protocol Extracranial Donor Artery Measure and record baseline flows in recipient intracranial artery proximal and distal to target anastomotic site. 1.Choose the appropriate size Probe to measure baseline flow in the extracranial donor artery. Record flow on the EC-IC Bypass Record. Probe Size Vessel Range, Outer Diameter 3 mm 2.5 - 3.7 mm 4 mm 3.3 - 4.7 mm 6 mm 4.4 - 6.6 min 2.After cutting the extracranial artery, measure the free flow in the donor (Fig. 2) to determine the flow or “carrying” capacity of the bypass. Record flow on the EC-IC Bypass Record. 3.After the bypass has been anastomosed to the recipient vessel, measure post-bypass flow in the donor (Fig. 3) and compare with free flow. Record flow on the EC-IC Bypass Record. 4.If post-bypass flow in the donor artery is substantially less (<50%) than free flow, reexamine the anastomosis and redo, if necessary. Intracranial Recipient Artery 1.Choose an appropriate size Flowprobe and measure and record baseline flow in the intracranial recipient artery. Probe Size Vessel Range, Outer Diameter 1.5 mm 1.0 - 1.5 mm 2 mm 1.5 - 2.7 mm 3 mm 2.5 - 3.7 mm 2.After the bypass has been constructed, measure flow in the recipient vessel and compare to pre-bypass (bypass) flow. Record flow on the EC-IC Bypass Record. 3.If post-bypass flow in the recipient artery is considerably less than pre-bypass flow, reexamine the bypass and redo, if necessary and press the PRINT button on the Flowmeter to document the phasic flow patterns for the case record. If the HT300-Series Flowmeter displays a negative flow, press the INVERT button to change the polarity before printing the waveform. Select Flowprobe Size for Donor Extracranial Artery Measure in situ baseline flow in donor extracranial artery Cut donor extracranial artery Measure and record free (cut) flow in donor artery Anastomose donor artery to intracranial recipient to create EC-IC bypass Measure and record post-bypass flow in donor artery Calculate Cut Flow Index (CFI) Post Bypass Flow CFI = ——————— Cut ”Free” Flow CFI < 0.5 Examine bypass for kinks etc.; Analyze recipient bed. CFI > 0.5 Patent Bypass Measure post-bypass flows at proximal and distal recipient artery sites to document surgical success. Case Report: Blood Flow Measurement Detects Embolus at Anastomosis Courtesy: F.T. Charbel, M.D., F.A.C.S., Professor and Head, Neurosurgery, University of Illinois at Chicago, USA Background In 2004, University of Illinois at Chicago cerebrovascular surgeons F.T. Charbel and S. Amin-Hanjani introduced the concept of a Cut Flow Index to evaluate the quality of an extracranial to intracranial (EC-IC) bypass used to augment flow during cerebral ischemia.1 EC-IC Bypass Surgery A surgical team headed by Dr. Sepideh Hanjani undertook extracranial to intracranial (EC-IC) bypass surgery to create a bypass from the superficial temporal artery (STA) to the middle cerebral artery (MCA). Cut Flow Measured Per their standard protocol, they measured the Cut Flow of the intended bypass conduit, the STA, with a Transonic® Flowprobe. STA Cut Flow measured 82 mL/ min indicating that the STA had a good carrying capacity for use as a bypass. Bypass Flow Measured The bypass was created with the STA and bypass flow was measured. It measured 80 mL/min. The surgeons were pleased with an excellent Cut Flow Index of 0.98. After repeated measurements and stable flows, wound closure commenced. Last Flow Check before Wound Closure Just before placing the last few skin stitches, the surgeon again rechecked the STA bypass flow. To the surgical team’s surprise, the flow had dropped to less than 20 mL/min. Measurement of free “cut” flow of the extracranial bypass. Embolus Removed/Flow Measured/Flow Restored The wound was reopened and the surgeon discovered an embolus at the anastomosis. The embolus had presumably formed in the STA during the surgery and had dislodged after removal of the muscle retractors and had travelled into the anastomotic site. The microscope was quickly returned into the field and Dr. Hanjani made a small cut in the recipient artery at a branching site distal to the anastomosis. The incision allowed the thrombus to escape. Subsequent intraoperative flow measurements corroborated restoration of flow in the bypass to the pre-embolus level. STA Flow Summary Free Flow 82 mL/min STA Bypass 80 mL/min STA Bypass at wound closure 20 mL/min STA Bypass after embolus release 80 mL/min Cut Flow Index 0.98 Reference 1Amin-Hanjani, S., Du, X., Milnarevich, N., Meglio, G., Zhao, M., Charbel, F.T., “The Cut Flow Index: An Intraoperative Predictor of the Success of EC-IC Bypass for Occlusive Cerebrovascular Disease,” Neurosurgery 2005; 56:75-85. (Transonic Reference # 2922AH) Flow Measurement Summary Measure vessels and choose correct size Flowprobe. Add saline/cerebrospinal fluid as needed to obtain good ultrasonic contact. When the flow reading is stable, press PRINT on a HT300-Series Flowmeter or take a snapshot on the AureFlo® to document flow for the patient’s record. Cerebrovascular Surgery Intraoperative Blood Flow Measurement during EC-IC Bypass Surgery Cont. Equipment: Flowmeters Intracranial and Extracranial Flowprobes INTRACRANIAL FLOWPROBES Flexible neck Probe body Long bayonet neck Reflector Fig. 6: -MB Series & -MR-Series Charbel Micro-Flowprobes® are designed for deep intracranial surgery. Their long bayonet handle permits use under a surgical microscope. A flexible neck segment permits the Flowprobe neck to be bent, as needed, to optimally position the probe around a vessel. EXTRACRANIAL FLOWPROBES Intracranial Flexible neck Short bayonet Probe neck body Extracranial Fig. 4: The AureFlo® system continuously measures, displays, records and documents absolute volume flow. Fig. 7: Comparison of Flowprobe bodies of intracranial Flowprobes (top) and extracranial Flowprobes (bottom). Reflector Fig. 8: -MB-S & -MR-S-Series Micro-Flowprobes (3 mm, 4 mm, 6 mm) feature a shorter bayonet handle and larger flowsensing body to be used during on extracranial vessels during EC-IC bypass surgery. References Fig. 5: HT353-Series Single-channel Optima Flowmeter can be used with Transonic Charbel Micro-Flowprobes®. Amin-Hanjani S, “Cerebral Revascularization: Extracranial-Intracranial bypass,” J Neurosurg Sci 2011; 55(2): 107-16. (Transonic Reference # 9554AH) Charbel, FT et al. “Superficial Temporal Artery - Middle Cerebral Artery Bypass,” Neurosurgery 2004. Amin-Hanjani, S et al, “The Cut Flow Index: An Intraoperative Predictor of the Success of EC-IC Bypass for Occlusive Cerebrovascular Disease,” Neurosurgery 2004. (Transonic Reference # 2922AH) Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected] Cerebrovascular Surgery Medical Note Intraoperative Blood Flow Measurement during STA-M4/MCA Bypass Surgery for Moyamoya Revascularization Introduction One strategy to alleviate the symptoms of Moyamoya syndrome is the surgical creation of an arterial extracranial to intracranial (EC-IC) bypass from the superficial temporal artery (STA) to the M4 middle cerebral artery branch. The bypass is designed to augment flow in the intracranial territories (Fig. 1). During surgery, the Charbel Micro-Flowprobe® is used to measure direct volume blood flow in the STA bypass and small target M4/MCA vessels. Intraoperative blood flow measurements confirm the quality of the anastomosis and assure that the target area is receiving sufficient blood from the bypass. Measurements also prompt revision if a technical error is suspected. Flow Measurement Steps Measure mean arterial pressure (MAP), end-tidal CO2 and temperature. Record values on an Bypass Flow Record. Pre-anastomosis: Intracranial Recipient Artery 1.Measure the diameter of the intracranial recipient artery (M4/MCA) and choose an appropriately sized Charbel Micro-Flowprobe® to measure recipient vessel flow. Probe Size Vessel Range, Outer Diameter 1.5 mm 2 mm 3 mm 1.0 - 1.5 mm 1.5 - 2.7 mm 2.5 - 3.7 mm 2.Measure recipient vessel (M4/MCA) flow. 3.Record flow and flow direction on EC-IC Bypass Record. Extracranial Donor Artery 4.Dissect the extracranial STA artery free, and skeletonize a segment for application of the Flowprobe. 5.Measure the diameter of the extracranial donor artery (STA) and choose the appropriately sized Flowprobe to measure STA baseline flow. Probe Size Vessel Range, Outer Diameter 1.5 mm 2 mm 3 mm 4 mm 6 mm 1.0 - 1.5 mm 1.5 - 2.7 mm 2.5 - 3.7 mm 3.3 - 4.7 mm 4.4 - 6.6 mm Moyamoya EC-IC Bypass MedicalNoteA4(NS-319-mn)Rev B 2013 Fig. 1: Lateral view of an arterial flow augmentation STA-MCA EC-IC Bypass used to revascularize cranial territories for Moyamoya syndrome. The STA is exposed, cut and anastomosed to the MCA via an end-to-side anastomosis. Post-anastomotic Flow Measurements 6.After construction of the STA-MCA bypass, measure post--anastomotic flows in the intracranial and extracranial arteries sequentially in the following order: 1) distal M4/MCA (Fig. 3); 2) proximal M4/MCA; 3) distal STA; 4) proximal STA. 7.If post-bypass flow in the recipient artery (sum of absolute values of distal and proximal M4/MCA flow) is not significantly above the pre-bypass flow, reexamine the anastomosis and the bypass for kinks or twists and redo, if necessary. Apply a vasodilator (papaverine) when there has been some vasospasm due to manipulation of the vessel and/or flow measurements seem to be low or absent. 8. Record flow rates and flow directions, MAP, end-tidal CO2, and occlusion time on the EC-IC Bypass Record. Intraoperative Blood Flow Measurement during STA-MCA Bypass Surgery for Moyamoya Revascularization Cont. Protocol: Flow Measurement during EC-IC Bypass Revascularization for Moyamoya Syndrome Measure size of recipient intracranial artery (M4/ MCA) and choose appropriate size Flowprobe. Measure baseline flow of recipient intracranial artery (M4/MCA) at anastomotic site. Record flow. Measure size of donor artery (STA) at distal end and choose appropriate size Flowprobe. Fig. 2: Photo shows the M4/MCA site just before the Flowprobe is slipped around the vessel to measure baseline M4 flow before anastomosing the bypass to the vessel. The blue background is placed to help visibility during sewing the anastomosis and as the Flowprobe is applied to the vessel. Cut donor STA Optional: measure/record free (cut) flow in donor STA. Construct EC-IC bypass by anastomosing STA to M4/MCA. Measure post-bypass flows proximal and distal to the anastomosis in the recipient vessel and donor STA. Record all flow rates. Fig. 3: Measuring blood flow in recipient M4/MCA artery after anastomosis to STA bypass. M4 flows did not increase M4 flows increased Examine anastomosis; examine bypass for kinks etc. Analyze recipient bed. References Lee M, et al, “Intraoperative blood flow analysis of direct revascularization in patients with moyamoya disease,” J Cereb Blood Flow & Metab 2011;31(1):26274. (7969AHAH) Lee M, et al, “Quantitative hemodynamic studies in moyamoya disease: a review,” Neurosurg Focus 2009; 26(4):E5. (6762AH) Guzman R, et al, “Clinical Outcome after 450 Revascularization Procedures for Moyamoya Disease,” J Neurosurg 2009; May 22. Veeravagu A, Guzman R, Patil CG, Hou LC, Lee M, Steinberg GK “Moyamoya disease in pediatric patients: outcomes of neurosurgical interventions,” Neurosurg Focus 2008;24(2):E16. Good bypass. M4 flows increased significantly Aggressive post-op management indicated to avoid complications. Chang, SD, Steinberg, GK, “Surgical Management of Moyamoya Disease,” http:// www.moyamoya.com/journals/moyamoya.html Golby, AJ et al, “Direct and Combined Revascularization in Pediatric Moyamoya Disease,” 1999;45:50-60. Kawaguchi, S et al, “Effect of Direct Arterial Bypass on the Prevention of Future Stroke in Patients with the Hemorrhagic Variety of Moyamoya Disease.” J Neurosurg, 2000;93:397-401. (7248AH) Zipfel, GJ, et al, “Moyamoya Disease in Adults: The Role of Cerebral Revascularization.” Skull Base, 2005; 1:27-41. www.transonic.com Cerebrovascular Surgery Medical Note Intraoperative Blood Flow Measurement during Venous EC-IC Bypass Construction Courtesy of FT Charbel, M.D., F.A.C.S. When construction of an arterial extracranial to intracranial (EC-IC) bypass is impossible due to atherosclerosis, twisting or a poor section of the temporal artery, the cerebrovascular surgeon may elect to harvest a vein to use as an EC-IC bypass (Fig. 1) in order to preserve or augment intracranial flow. Transonic’s quick intraoperative flow measurements provide valuable on-the-spot feedback during the surgery as the surgeon identifies and defines specific hemodynamic requirements for the bypass and formulates an ongoing operative strategy for the case. Venous Bypass Since the proximal end of the vein graft is anastomosed to a carotid artery, one concern with this type of bypass is that it will produce too much flow for the recipient vasculature. Free flow is, therefore, measured in the graft once it has been anastomosed to the carotid artery to determine the maximum flow capacity for the graft and to match the graft hemodynamically to the recipient arterial vasculature. Baseline flows are also measured in the intracranial recipient vessel before anastomosis. Fig. 1: Frontal view of a venous EC-IC Bypass. A venous graft is harvested and then anastomosed proximally to the External Carotid Artery (ECA) and distally to the Middle Cerebral Artery (MCA). After the graft has been anastomosed intracranially to the recipient cerebral artery, post-anastomotic flows are measured in the graft and recipient artery and compared with baseline flows. Flow Measurement Steps Extracranial Donor Venous Graft 1.Choose the appropriate size probe to measure baseline flow in the extracranial venous graft. Record flow on the EC-IC Bypass Record (Fig. 4). Probe Size Vessel Range, Outer Diameter 3 mm 2.4 - 4.0 mm 4 mm 3.2 - 5.3 mm 6 mm 4.5 - 7.5 mm 2.After anastomosing the venous graft proximally to the carotid artery, measure the free flow or “carrying capacity” of the graft. Record flow on the EC-IC Bypass Record (Fig. 3). Venous EC-IC Bypass MedicalNote(NS-312-mn-A4)Rev D 2013 Fig. 2: Venous bypass from the External Carotid Artery (ECA) to the Posterior Cerebral Artery (PCA). Intraoperative Blood Flow Measurement during Venous EC-IC Bypass Construction Cont. 3.After the bypass has been anastomosed to the recipient vessel, measure post-bypass flow in the donor graft. Record flow on the EC-IC Bypass Record (Fig. 3). Compare the flow hemodynamically with flow in the recipient artery and with free flow. 4.If post-bypass flow in the donor artery is substantially less (<50%) than free flow, reexamine the anastomosis and redo, if necessary. Protocol: Flow Measurements during Venous EC-IC Bypass Measure and record baseline flows in recipient intracranial artery proximal and distal to target anastomosis site. Intracranial Recipient Artery 1.Choose an appropriate size flowprobe and measure and record baseline flow in the intracranial recipient artery. Probe Size Vessel Range, Outer Diameter 1.5 mm 1.0 - 1.5 mm 2 mm 1.5 - 2.7 mm 3 mm 2.5 - 3.7 mm 2.After the bypass has been constructed, measure flows in the recipient vessel and compare with graft flows. Record flows on the EC-IC Bypass Record. 3.Evaluate the hemodynamic match between the donor flows and recipient vessel flows. Select probe size for donor extracranial vein. Anastomose vein graft to carotid artery Anastomose donor vein graft to intracranial recipient artery to create EC-IC bypass Measurement Tips • Select a Flowprobe size so that the vessel will fill at least 75% of the lumen of the Flowprobe. Use sterile saline or cerebrospinal fluid to obtain good ultrasonic contact between the Flowprobe and vessel. • Bend the Flowprobe’s flexible segment to best position the Flowprobe around the vessel. Listen to FlowSound® to hear volume flow. • When flow readings are stable, flow data can be captured by recording or taking a snapshot on the Aureflo®, or by pressing PRINT on a HT300-Series Flowmeter. If the HT300-Series flow reading is negative on the LED, press INVERT to reverse the polarity of the flow reading from negative to positive before printing out the waveform. Measure and record post-bypass flow in the donor vein. Assess bypass flow hemodynamically in relation to recipient artery. Flows did not increase Check anastomosis; examine bypass for kinks etc. Analyze recipient bed. M4 flows increased Good bypass. Measure post-bypass flows at proximal and distal recipient artery sites to document surgical success. Fig.3: Example of a Flow Record to record flow readings during EC-IC Bypass. www.transonic.com Flows increased significantly Aggressive post-op management indicated to avoid complications. Surgery Transonic Perivascular Flowprobes ® The widest selection of Flowprobes available Transonic’s application-customized Flowprobes measure volume flow in blood vessels and grafts from 0.5 mm to 36 mm to: •Quantify blood flow • Identify technical problems early • Improve patient outcomes FlowprobeFlyer(CV-500-fly-A4)RevB 2014 Microvascular Flowprobes Flaps • Reattachments Transonic® Microvascular Flowprobes measure volume flow in blood vessels or grafts from 0.5 to 4.0 mm diameter. Flow measurement in these vessels during microvascular procedures quantify flows in the smallest vessels in order to objectively assess the quality of the reconstruction or replantation, guide better surgical decisions and give the surgeon the opportunity to correct otherwise undetectable flow restrictions before closing the patient. Due to extreme accuracy requirements, this Microvascular Flowprobe Series is only available with the Optima Flowmeter. Flexible neck Probe body Flowprobe handle Reflector Microvascular Flowprobe (2 mm) showing handle and flexible probe neck for easy positioning of the Flowprobe around a vessel. 0.7 mm 1.0 mm 1.5 mm 2.0 mm 3.0 mm Ultrasonic sensing windows of Microvascular Flowprobe (MU) Series. Side-by-side comparison of a 0.7 mm Flowprobe with a tip of a 25g. needle. Microvascular Flowprobe (-MU) Series including 0.7 mm, 1 mm, 1.5 mm, 2 mm, and 3 mm Flowprobes. Cardiac Flowprobes Coronary Artery Grafts • Ascending Aorta Transonic® Cardiac Flowprobes include FMC-Series Flowprobes for coronary artery bypass grafting surgery and COnfidence Flowprobes® for continuous measurement on great vessels with turbulent flows. Coronary Flowprobes Elongated curved neck Probe body Probe handle Flexible neck segment FMC-Series Coronary Handle Flowprobes are available in sizes 1.5 mm to 4 mm. They feature a J-style reflector, designed for spot flow checks of coronary artery bypass grafts and an extended neck with a flexible end to reach coronary grafts even behind the heart. COnfidence Flowprobes ® Probe shell Ultrafit liner COnfidence Flowprobes® consist of a Flowprobe shell and a single-use soft, flexible Ultrafit liner. This novel concept for ultrasonic signal coupling enables immediate, accurate beat-to-beat flow measurements with a minimum of ultrasonic coupling gel. The form-fitting Ultrafit Liner slips into the transducer shell to encircle the vessel and keep the vessel in place. The liner cushions and protects the vessel during a flow measurement. Liners are incrementally sized for optimal fit on the target vessel. Pictured, from left to right, are 1.5 mm, 2 mm, 3 mm and 4 mm coronary Flowprobes showing their blue Probe bodies, J reflectors and ultrasonic sensing windows. 28 mm 20 mm 16 mm 14 mm 12 mm 10 mm 8 mm 24 mm COnfidence Flowprobes® (-AU-Series), designed with four transducers, provide highly accurate measurements in vessels with highly turbulent flows such as the ascending aorta. The Flowprobe’s slim, ergonomic profile creates a minimal footprint that fits in tight anatomical sites. The soft, pliable liner cushions and protects the vessel. Available in 15 sizes from 8 mm to 36 mm. Port-Access Flowprobes Port-Access Flowprobes, a customer-driven innovation, feature a long endoscopic handle to extend through robotic ports and measure flows on coronary grafts. They are available in three sizes: 2 mm, 3 mm, and 4 mm. Vascular Flowprobes Peripheral Vascular • Carotid Endarterectomy Transonic’s spectrum of Vascular Flowprobes measure volume flows intraoperatively in vessels and grafts from 0.5 mm to 20 mm to detect blood flow obstructions before leaving the operating room. This ability to correct otherwise undetectable flow restrictions provides the surgeon with a unique opportunity to improve the outcome for his or her patient. Handle Vascular Flowprobes Probe body J Reflector Flexible neck Handle Short Handle Vascular Flowprobes: The FMV-Series features a short handle and a J reflector designed for spot flow checks. Available in a wide range of sizes from 1.5 mm to 14 mm. Carotid Flowprobes Non-handle Flowprobes Sliding cover Probe body L reflector L reflector Flexible neck FME-Series Flowprobes feature an L-shaped reflector to protect against dislodging of plaque (such as during carotid endarterectomy) as the Flowprobe is applied. The L reflector design allows the probe to be slipped on and off a carotid artery easily, facilitating quick pre- and post-procedure measurements. Available in 1.5 mm to 10 mm sizes. Non-Handle Flowprobes (FSB-Series) feature an ultrasonic flowsensing window defined by an L reflector with a sliding cover so that the Flowprobe can remain positioned around the vessel for extended measurements. FSB-Series Flowprobes are available in sizes from 2 mm to 14 mm. OptiMax® Flowprobes ® The OptiMax® family with J reflectors (shown) and L reflectors (not shown) are available in 4, 6, 8, 10 and 12 mm. OptiMax Flowprobes’ two reflector shapes and multiple probe sizes accommodate different surgical preferences and patient anatomies. The skin tabs secure the Flowprobe so that continuous measurements can guide vascular constructions, banding or revisions until a target flow is achieved. Cerebrovascular Flowprobes Aneurysm Clipping • EC-IC Bypass • AVMs • Fistulas Transonic® Cerebrovascular (Charbel) Flowprobes measure volume flow in intracranial and extracranial vessels during cerebrovascular flow preservation or flow augmentation surgeries. Intraoperative measurements of volume flow assure the integrity of flow in cerebral vessels or they alert the surgeon to dangerous flow deficits at a time when every minute counts. Intracranial Flowprobes Flexible neck Probe body Long bayonet neck Reflector Probe head Close-up Long bayonet neck Long bayonet neck intracranial Charbel Micro-Flowprobes® are available in three sizes, 1.5 mm, 2 mm and 3 mm, for aneurysm clipping, AVM and dural fistula obliteration surgeries. -MB & -MR-Series Charbel Micro-Flowprobes® are designed to measure flow in major intracranial vessels of the Circle of Willis. Their long bayonet neck permits use under a surgical microscope and a flexible neck segment permits bending the Flowprobe as needed to most easily position the probe around the vessel. Extracranial Flowprobes Short bayonet neck Short bayonet neck extracranial Charbel Probes® are available in three sizes, 3 mm, 4 mm and 6 mm, for extracranial vessels such as the superior temporal artery during extracranial-intracranial (EC-IC) bypass surgeries. Their short bayonet neck permits use under a surgical microscope and a flexible neck segment permits bending the Flowprobe as needed to most easily position the probe around the vessel. Side-by-side comparison between intracranial Charbel Micro-Flowprobes® and shorter neck extracranial Charbel Flowprobes® used during EC-IC bypass surgery. Surgery Transplant Flowprobes Liver • Renal • Heart/Lung • Pancreas Transonic® Flowprobes work with HT300-Series Flowmeters to measure volume flow in blood vessels and grafts from 0.5 to 36.0 mm. In critical transplant surgeries, intraoperative measurement of flow in vessels can guide surgical decisions to ensure vessel patency prior to closing. Probe body Flexible neck Reflector Handle FMV-Series 4 and 6 mm Vascular Flowprobes recommended for measuring hepatic arterial flow. Picture shows Flowprobe handle with size of Probe in mm, the Probe’s flexible neck for optimal positioning of the Probe around the vessel, the Probe body that houses the ultrasonic transducers, and the Probe reflector. Vessel is positioned within the Probe sensing window that is defined by the Probe body and its stationary reflector. Vascular Flowprobes (FMV-Series) in sizes 8 mm to 14 mm are used for spot portal venous flow measurements. COnfidence Flowprobes® (-AU-Series) can also be used for continuous portal venous flow measurements. Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells “gold standard” transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems. www.transonic.com AMERICAS EUROPE ASIA/PACIFIC JAPAN Transonic Systems Inc. 34 Dutch Mill Rd Ithaca, NY 14850 U.S.A. Tel: +1 607-257-5300 Fax: +1 607-257-7256 [email protected] Transonic Europe B.V. Business Park Stein 205 6181 MB Elsloo The Netherlands Tel: +31 43-407-7200 Fax: +31 43-407-7201 [email protected] Transonic Asia Inc. 6F-3 No 5 Hangsiang Rd Dayuan, Taoyuan County 33747 Taiwan, R.O.C. Tel: +886 3399-5806 Fax: +886 3399-5805 [email protected] Transonic Japan Inc. KS Bldg 201, 735-4 Kita-Akitsu Tokorozawa Saitama 359-0038 Japan Tel: +81 04-2946-8541 Fax: +81 04-2946-8542 [email protected] Surgery Flowprobe Selection Guide PERIVASCULAR FLOWPROBE SERIES & AVAILABLE SIZES SUFFIX DESCRIPTION SIZES (mm) -FMC Coronary 1.5, 2, 3, 4 -FMV Vascular 1.5, 2, 3, 4, 6, 8, 10, 12, 14 -FME Carotid (L-reflector for carotid endarterectomy) 1.5, 2, 3, 4, 6, 8, 10 -FTV OptiMax® (hands-free, J-reflector) 4, 6, 8, 10, 12 -FTE OptiMax® (hands-free, L-reflector carotid endarterectomy) 4, 6, 8, 10, 12 -MU Microvascular (handle) 0.7, 1, 1.5, 2, 3 -AU Cardiac Output COnfidence Flowprobe 8, 10, 12, 14, 16, 20, 24, 28, 32, 36 -MB Intracranial Charbel Micro-Flowprobe® (long bayonet handle) 1.5, 2, 3 -MB-S Extracranial EC-IC Bypass: Micro-Flowprobe (short bayonet handle) 3, 4, 6 -FSB Basic (no handle, L-reflector, sliding cover) 1.5, 2, 3, 4, 6, 8, 10, 12, 14 ® Recommended Sizes and/or Flowprobe Series for Specific Vessels or Applications CARDIAC SURGERY CABG: ON OR OFF PUMP Probe Size (mm) VASCULAR SURGERY Probe Series Arterial conduits 1.5, 2, 3, 4 -FMC Saphenous vein 2, 3, 4 -FMC CARDIAC OUTPUT Ascending aorta 28, 32, 36 -AU Pulmonary artery 24, 28, 32 -AU Pediatric heart 8, 10, 12, 14, 16, 20 -AU TRANSPLANT SURGERY Probe Size LIVER (mm) CAROTID ENDARTERECTOMY Probe Size (mm) Common carotid artery 8, 10 -FTE -FME -FSB External carotid artery 6 -FTE -FME -FSB Internal carotid artery 6 -FTE -FME -FSB Radial artery 2, 3 -FMV Brachial artery 3, 4, 6 -FMV -FTV -FSB Graft venous outflow 4, 6 -FMV -FTV -FSB 4, 6 -FMV -FTV -FSB AV FISTULAS & GRAFTS Renal bypass Aortoiliac shunt 4, 6, 8 -FMV -AU Portal vein 10, 12, 14 -FMV -AU Renal artery 4, 6 -FMV -FSB Portocaval shunt Renal vein 10 -FMV -FSB Splenorenal shunt External iliac artery 6, 8 -FMV -FSB LOWER EXTREMITY BYPASS Hypogastric artery 4, 6 -FMV -FSB 8 -FMV -FSB KIDNEY PANCREAS CEREBROVASCULAR SURGERY ANEURYSM CLIPPING Cerebral arteries Probe Size (mm) -FSB ABDOMINAL Probe Series Hepatic artery Common iliac artery Probe Series Probe Series 1.5, 2, 3 -MB -MR Extracranial 3, 4, 6 -MB-S MR-S Intracranial 1.5, 2, 3 -MB -MR EC-IC BYPASS aorta 16, 20 -AU common iliac 10, 12 -FMV -FTV -AU -FSB 10, 12, 14 -FMV -FTV -AU -FSB 10, 12, 14 -FMV -FTV -AU -FSB Profunda femoris 8 -FMV -FTV -AU -FSB Common femoral 8, 10 -FMV -FTV -AU -FSB Popliteal 4, 6 -FMV -FTV -FSB Tibial 3, 4 -FMV -FTV -FSB MICROVASCULAR SURGERY REATTACHMENTS/FLAPS Probe Size (mm) Probe Series Microvessels in hand, wrist 0.7, 1, 1.5, 2, 3 -MU AVM, TUMOR RESECTION, DURAL FISTULA Outflows variable FlowprobeSelectionGuide(CV-66-tn-A4)RevE 2014 -MB, -MR www.transonic.com
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