ASSET™ EZ4-NCO Dry Sampler for Isocyanates Providing Ultimate Sensitivity for Vapor Phase and Particulate Isocyanates Isocyanates are used in the production of polyurethane (PUR) materials, one of the most widely used plastics in the world. Workers who are exposed to these compounds are at risk for respiratory disorders, asthma and other health conditions. Particulates form incomplete reactions with the reagent as well as with the isocyanate monomers and oligomers being measured, which results in underestimation of exposure. Isocyanates exposure is frequently underestimated with other air sampling devices because the particulates form incomplete reactions with both, the reagents and the isocyanate compounds. Features to achieve low detection limits • Ability for both vapor and particulate phase isocyanates • Sampling from 5 minutes to > 8 hours derivatization reactions into stable • Fast derivatives • No field extraction/desorption • High capacity • No interferences special storage requirements before • No and after sampling The ASSET EZ4-NCO sampling device is a unique dry sampler based on derivatization of isocyanate groups with di-n-butylamine (DBA). The sampler consists of a denuder and a filter, both impregnated with DBA. The extract is analyzed using LC-MS or LC-MS-MS offering the ultimate sensitivity and low detection limits not capable with other methods. Isocyanate Dibutylamine Isocyanate dibutylamine derivative (urea derivative) Ordering Information Product Description Sampling Device ASSET EZ4-NCO Dry Sampler Analytical Columns LC-MS-MS Ascentis® Express C18, 5 cm x 2.1 mm, 2.7 μm particles LC-MS Ascentis Express C18, 15 cm x 4.6 mm, 2.7 μm particles Analytical Standard DBA Isocyanate Mix (acetonitrile:methanol, 99:1, varied conc) Qty. Cat. No. 10 50 5027-U 5028-U 1 1 53822-U 53829-U 6 x 1 mL 40141-U 6 x 1 mL 40142-U 2 x 1 mL 40143-U Isocyanic acid-di-n-butylamine (ICA-DBA) 1 μg/mL Ethyl isocyanate-di-n-butylamine (EIC-DBA) 1 μg/mL Hexamethylene diisocyanate-2(di-n-butylamine) (HDI-2(DBA)) 1 μg/mL Isophorone isocyanate-2(di-n-butyl amine) isomer 1 (IPDI-2(DBA)) 1 μg/mL Isophorone isocyanate-2(di-n-butyl amine) isomer 2 (IPDI2-2(DBA)) 0.4 μg/mL 4,4’-Methylenediphenyl diisocyanate-2(di-n-butylamine) (4,4’-MDI-2(DBA)) 1 μg/mL Methyl isocyanate-di-n-butylamine (MIC-DBA) 1 μg/mL Phenyl isocyanate-di-n-butylamine (PhI-DBA) 1 μg/mL Propyl isocyanate-di-n-butylamine (PIC-DBA) 1 μg/mL 2,4-Toluene diisocyanate-di-n-butylamine (2,4-TDI-2(DBA)) 1 μg/mL 2,6-Toluene diisocyanate-2(di-n-butylamine) (2,6-TDI-2(DBA)) 1 μg/mL d9-DBA Isocyanate Internal Standard Mix Isocyanic acid-di-n-butylamine-d9 (ICA-DBA- d9) 1 μg/mL Ethyl isocyanate-di-n-butylamine-d9 (EIC-DBA-d9) 1 μg/mL Hexamethylene diisocyanate-2(di-n-butylamine-d9) (HDI-2(DBA-d9)) 1 μg/mL Isophorone diisocyanate-2(di-n-butylamine-d9) isomer 1 (IPDI-2(DBA-d9)) 1 μg/mL Isophorone diisocyanate-2(di-n-butylamine-d9) isomer 2 (IPDI2-2(DBA-d9)) 0.28 μg/mL 4,4-Methylenediphenyl diisocyanate-2(di-n-butylaine-d9) (4,4’-MDI-2(DBA-d9)) 1 μg/mL Methyl isocyanate-di-n-butylamine-d9 (MIC-DBA-d9) 1 μg/mL Phenyl isocyanate-di-n-butylamine-d9 (PhI-DBA-d9) 1 μg/mL Propyl isocyanate-di-n-butylamine-d9 (PIC-DBA-d9) 1 μg/mL 2,4-Toluene diisocyanate-2(di-n-butylamine-d9) (2,4-TDI-2(DBA-d9)) 1 μg/mL 2,6-Toluene diisocyanate-2(di-n-butylamine-d9) (2,6-TDI-2(DBA-d9)) 1 μg/mL DBA Isocyanate Standard Kit Includes 1 mL of DBA Isocyanate Mix and 1 mL of d9-DBA Internal Standard Mix 11462_ASSET EZ4-NCO Dry Sample Flyer_NL.indd 1 10/29/2012 2:45:04 PM Analytical Service: References Methods: 1. ISO 17734-1:2006, Determination of organonitrogen compounds in air using liquid chromatography and mass spectrometry — Part 1: Isocyanates using dibutylamine derivatives. 2. ISO 17734-2:2006, Determination of organonitrogen compounds in air using liquid chromatography and mass spectrometry — Part 2: Amines and aminoisocyanates using dibutylamine and ethyl chloroformate derivatives. Institutet För Kemisk Analys Norden AB Esplanadgatan 9 SE-281 38 Hässleholm Sweden Contact: Mikael Adamsson Office: +46-451-655-61 Email: [email protected] 3. In a technical ISO report, the technology is described as the only methodology that covers all situations. ISO/TR 17737:2007, Workplace air – Guidelines for selecting analytical methods for sampling and analyzing isocyanates in air. Publications: 1. Title: Solvent-Free Sampling with Di-n-Butylamine for Monitoring of Isocyanates in Air Authors: Asa Marand, Daniel Karlsson, Marianne Dalene and Gunnar Skarping Affiliation: Department of Analytical Chemistry, Work Environment Chemistry, Stockholm University, P.O. Box 460, S-28124 Hassleholm, Sweden Journal: Journal of Environmental Monitoring, 2005, 7, pg. 335-343 Bureau Veritas Industrial Hygiene 22345 Roethel Drive Novi, MI 48375 US Calls: (800) 806-5887 International and US Calls: (248) 344-1770 Fax: (248) 344-2656 [email protected] 2. Title: Determination of Airborne Isocyanates as Di-n-Butylamine Derivatives Using Liquid Chromatography and Tandem Mass Spectrometry Authors: Daniel Karlsson, Jakob Dahlin, Asa Marand, Gunnar Skarping and Marianne Dalene Affiliation: Department of Analytical Chemistry, Work Environment Chemistry, Stockholm University, P.O. Box 460, S-28124 Hassleholm, Sweden Journal: Analytica Chimica Acta 534 (2005) 263-269 For more information, visit sigma-aldrich.com/asset For more information or if you would like to become an Analytical Service partner, contact: Kristen Schultz Environmental Arena Team Leader Air Monitoring Product Manager Phone: (814) 359-5718 [email protected] Enabling Science to Improve the Quality of Life Order/Customer Service (800) 325-3010 • Fax (800) 325-5052 Technical Service (800) 325-5832 • sigma-aldrich.com/techservice Development/Custom Manufacturing Inquiries (800) 244-1173 Safety-related Information sigma-aldrich.com/safetycenter ©2012 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA-ALDRICH and SUPELCO are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. ASSET is a trademark of SigmaAldrich Co. LLC. Supelco brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on the reverse side of the invoice or packing slip. 11462_ASSET EZ4-NCO Dry Sample Flyer_NL.indd 2 World Headquarters 3050 Spruce St. St. Louis, MO 63103 (314) 771-5765 sigma-aldrich.com OTB 11462 / T412089 1102 10/29/2012 2:45:10 PM