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6th CFGBC Symposium and FightingDrugFailure
FROM ARRAYS TO UNDERSTANDING DISEASES AND
PHARMACOGENOMICS OF INDIVIDUAL DRUG THERAPY
June 8-9, 2011
Faculty of Medicine, University of Ljubljana, Korytkova 2, Ljubljana, Slovenia
DAY 1: WEDNESDAY, JUNE 8, 2011
DAY 2: THURSDAY, JUNE 9, 2011
13:00-14:00
Registration
8:30-9:00
Registration
13:50-14:50
SESSION 5 (CO-CHAIRS: NATAŠA DEBELJAK, ALEŠ BELIČ)
14:00-14:30
OPENING REMARKS: SIMON HORVAT, DAMJANA ROZMAN AND GUESTS
9:00-9:30
KEYNOTE LECTURE (CHAIR: RADOVAN KOMEL)
13:50-14:05
Luca Lovrečić, Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Slovenia
14:30-15:15
OPENING LECTURE (CHAIR: DAMJANA ROZMAN)
Matthias Schwab,
Radovan Komel, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana and National
Pharmacogenetics: perspectives and future directions
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and
Department of Clinical Pharmacology, University Hospital Tuebingen, Germany
Institute of Chemistry, Ljubljana, Slovenia
Genomics and biotechnology: safety, ethical and legal issues
9:30-10:45
SESSION 3 (CO-CHAIRS: ANA ALFIREVIC, RADOVAN KOMEL)
15:15-16:05
SESSION 1 (CO-CHAIRS: HILTRUD BRAUCH, SIMON HORVAT)
9:30-9:55
Anne Nies, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
15:15-15:40
Ulrich Zanger, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Germany
Pharmacogenomic investigations in a human liver bank
15:40-16:05
16:05-16:35
9:55-10:20
Vita Dolžan, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
The role of pharmacogenetics in personalized medicine: from SNPs to pharmacogenetic models and dosing recommendations
10:20-10:45
Damjan Glavač,
COMMERCIAL PRESENTATION
Slovenia
Marco Pirotta, Life Technologies Corporation, Carlsbad, California, USA
The importance of pharmacogenetics for patients with gastrointestinal stromal
tumors (GIST)
10:45-11:05
COFFEE BREAK WITH POSTER SESSION I
COFFEE BREAK WITH POSTER SESSION I
11:05-12:35
SESSION 4 (CO-CHAIRS: TADEJA REŽEN, MATTHIAS SCHWAB)
16:55-18:15
SESSION 2 (CO-CHAIRS: NATAŠA DEBELJAK, ULRICH ZANGER)
11:05-11:30
Ana Alfirevic, University of Liverpool, UK
16:55-16:20
Simon Horvat,
Department of Animal Science, Biotechnical Faculty, University of Ljubljana,
Domžale and National Institute of Chemistry, Ljubljana, Slovenia
Generation of cytochrome P450 cholesterogenic Cyp51 conditional knockout
mice to study its function during embryogenesis and spermatogenesis
16:20-17:35
Aleš Belič, Faculty of Electrical Engineering, University of Ljubljana, Slovenia
Mathematical characterisation of cholesterol biosynthesis regulation through
SREBF2
17:35-18:00
Arthur J. Sytkowski, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center,
18:00-18:15
Klemen Španinger, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
The effect of erythropoietin on human neuronal cell line SH-SY5Y
Dan Carr, Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, UK
11:55-12:20
Omics tools can reveal the intercellular cross-talk
14:35-14:50
12:20-12:35
14:50-15:20
GS Junior System: the power of next generation sequencing in your hands
15:20-15:40
COFFEE BREAK WITH POSTER SESSION II
15:40-16:30
SESSION 6 (CO-CHAIRS: DAMJANA ROZMAN, CRAIG JORDAN)
15:40-16:05
Christina Justenhoven, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart
and University of Tuebingen, Germany
Current developments in genome wide association studies for the identification
of breast cancer risks
16:05-16:30
13:30-13:50
POSTER SESSION II
Hiltrud Brauch, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and
University of Tuebingen, Germany
Prediction of tamoxifen efficacy in early breast cancer: opportunities and challenges
16:30-17:15
CLOSING LECTURE (CHAIR: HILTRUD BRAUCH)
V. Craig Jordan, Georgetown Lombardi Comprehensive Cancer Center, Washington DC, USA
COMT and BDNF functional polymorphisms as risk factors for suicide
LUNCH BREAK
COMMERCIAL PRESENTATION
Uroš Logonder, Roche d.o.o., ODG Diagnostics, Ljubljana, Slovenia
Alja Videtič Paska, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
12:35-13:30
Tomaž Curk, Faculty of Computer and Information Science, University of Ljubljana, Slovenia
Comprehensive analysis of iCLIP high-throughput sequencing data with iCount
Boris Rogelj, Institute of Psychiatry, King's College London, UK
RNA binding proteins in amyotrophic lateral sclerosis
Helena Motaln, Department of Genetic Toxicology and Cancer Biology, National Institute of Biology,
Ljubljana, Slovenia
Exome sequencing and adrenal suppression in children
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
The pleiotropic actions of erythropoietin: scientific and clinical implications
14:20-14:35
Hypersensitivity pharmacogenomics-GWAS and beyond
11:30-11:55
Tadeja Režen, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
The human primary hepatocyte transcriptome reveals novel insights into
atorvastatin and rosuvastatin action
Department of Molecular Genetics, Faculty of Medicine, University of Ljubljana,
Ion Torrent Personal Genome Machine (PGM™): Post-Light™ technology
brings next-generation sequencing to any lab or clinic
16:35-16:55
14:05-14:20
Human uptake and efflux transporters and their role in hepatic drug absorption,
metabolism and elimination
Damjana Rozman, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
Tissue and developmental roles of cholesterogenic CYP51
Haemotranscriptomics in Huntington's disease
Deciphering drug resistance to antihormones: melding gene assays and biology
of estrogen-induced apoptosis
17:15-17:30
CLOSING REMARKS AND CLOSING OF THE MEETING