Diagnostic Center for Population & Animal Health | 4125 Beaumont Road, Lansing, MI 48910-8104 | PH: 517.353.1683 FX: 517.353.5096 | animalhealth.msu.edu Guide to sample selection and DCPAH tests for differential diagnosis of toxins that cause CNS excitation Toxicant (*) Avitrol Bromethalin Samples of choice Stomach contents, serum, urine, liver Stomach contents, serum, urine, liver Stomach contents, serum, urine, liver Stomach contents, serum, urine, liver Stomach contents, bait Stomach contents, bait Boric acid Serum, liver, kidney Carbamate pesticides Whole blood in EDTA, stomach contents, liver, brain hemisphere, environmental samples Amphetamines Antidepressants Anti-diabetics Antihistamines Chlorinated pesticides Cyanide salts Serum, stomach contents, liver, brain, fat, environmental samples Whole blood in EDTA, stomach contents, liver, environmental samples DCPAH tests (test codes) Comments GC/MS (70006) Medications, illicit drugs GC/MS (70006) Medications GC/MS (70006) Medications GC/MS (70006) Medications Avitrol (70061) Convulsants (70021) ICP minerals (70025 or 70004) Pesticide Pesticide Household pesticides GC/MS (70006), cholinesterase (70067, 70018) Pesticides Pesticides, chlorinated (70020) Pesticides Cyanide (70022) Scientific and industrial uses Diethyl toluamide (DEET) Hair, serum GC/MS (70006) Pesticide, cats most sensitive Dinitrophenol Stomach contents, serum, urine, liver GC/MS (70006) Lumber preservative Ethylene glycol Bait, serum, urine, liver, kidney Ethylene glycol (70023) or Minerals tissue (70004) Antifreeze Hair, serum GC/MS (70006) Shampoos, cats most sensitive Stomach contents, foam GC/MS (70006) Foam materials Stomach contents, liver GC/MS (70006) Germicidal products Essential oils (pennyroyal, Dlemonene), Flame retardants (organophosphorous type) Hexachlorophene WEBCD.TOX.REF.004.01 Issue Date: 08/24/2010 Page 1 of 2 Diagnostic Center for Population & Animal Health | 4125 Beaumont Road, Lansing, MI 48910-8104 | PH: 517.353.1683 FX: 517.353.5096 | www.animalhealth.msu.edu Toxicant (*) Lead Metaldehyde Methylphenidate Methylxanthines (caffeine, theobromine, theophylline) Mushrooms (Psilocibe, Amanita pantherina) Nicotine Organophosphorus pesticides Oxalic acid Pentachlorophenol Phenolic disinfectants Phosphine (zinc, magnesium or aluminum phosphide) Polyethylene glycol (paint balls) Pseudoephedrine Pyrethrins and pyrethroids Recreational drugs (cocaine, lysergic acid diethylamide [LSD]; methamphetamines) Samples of choice Whole blood in EDTA, liver, kidney Stomach contents, liver Stomach contents, serum Stomach contents, serum, environmental samples DCPAH tests (test codes) Lead, blood (70019), Minerals tissue (70004) GC/MS (70006) Comments Heavy metal Pesticide GC/MS (70006) Medication Methylxanthines (70062) Food Plant ID (70043) Natural toxins GC/MS (70006) Pesticide, tobacco GC/MS (70006), cholinesterase (70067, 70018) Pesticide Serum calcium (10381); Minerals tissue (70004) Household GC/MS (70006) Wood preservative GC/MS (70006) Germicidal products Phosphine (70063) Pesticide GC/MS (70006) Household GC/MS (70006) Medication Hair, fat, liver, brain GC/MS (70006) Pesticides, cats most sensitive Urine, stomach contents, environmental samples GC/MS (70006) Illicit drugs Mushroom specimen Stomach contents, serum, environmental samples Bait, stomach contents, whole blood, environmental samples, liver, brain hemisphere Serum, kidney Stomach contents, liver, environmental samples Stomach contents, liver, environmental samples Stomach contents, bait Stomach contents, paint balls Stomach contents, serum, liver Sodium ion Serum, CSF, brain Strychnine Bait, stomach contents, urine, liver Tremorgenic mycotoxins (penitrem A and roquefortine) Stomach contents, environmental samples Electrolytes, serum (10130); Minerals tissue (70004) Strychnine (70052) or GC/MS (70006) Convulsants (70021) Food, de-icers Pesticide Mycotoxins (*)Please contact the lab for assistance if you have any questions concerning sample or test selection WEBCD.TOX.REF.004.01 IssueDate 08/24/2010 Page 2 of 2
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