Sample Charts and Background Information (Updated) from Rachel carson councilrs Basic Guide to Pesticid,es by shirley Briggs and Rachel carson council , rggz TABLE OF CONTENTS Explanatton of Ratings on Pesticide Charts from Bcsic Gulde to Pesticides ...................2 Other Explanations and Definitions ............. Sample Herblclde Information ....................4 from Baslc Gulde to Pestlcldes and EPA ..........................5 Chemical Class - Trlazine ,,.,.......:.... Chart on Atrazlne (a Trlazine class chenicalf ......5 from .Baslc (itfide to Pesticides.......6 Rating of Atrizine from EPA on carcinogenicity Sample Insecticide fnformatlon fron ....................7 Baslc Qrttd,eto Pestlcld.es and EPA ........................8 Chemlcal Class -'Organophosphate (OPl ......... .;.............. Chart on Chlorpyrifos from Basic Guide to Pestlcldes .......8 ...........9 Sanple tr\rngictde Inforrnation from .Bcsic Guid.e to Pe*lcldes and EPA ........................11 Chemical Class - Benzonitrile .......... from Basi c Gttld.eto Pegtlcldes ............. Chart on Chlorothalonil Rating on Chlorothalonil Addttlonal from EPA on carclllogenicity .........12 ......,13 Information Chemlcal Class - Pyrithoid ..................14 Updated Chart on Permethrin........ ...........15 Updated Chart on Plperonyl Butoxide Updated Chart on D1a21non............. .....17 Rachel Carson Council, Inc. IRCC) PO Box tOZTg Silver Spring, MD 20lgt4 (3OUse3-75o7 [email protected] httpr/ / RachetCiisonCouncil. com -?EXPLANATION OF RATTNGS ON PESTICIDE CIIARTS FOP. ''BASTC GUIDE TO PESTTCIDES'' IMMEDIATE TOXICITY MTINGS Oral and dermal terms of LC-^. raEings are expressed in centrs of LD-^; )u' inhalation in )u RATING EPA fiPE OF RATING EXPOSURE HUIIAN OR TEST Al\IltAL DOSE PROBABLELETHAL DOSE TOR 150 LB. HUMAN Very high I Oral Dermal Inhalation 0-50 rng/kg 0-200 urg/kg 0-2000 i./I=rg/r3 0-1 reaspoon High II Oral 50-500 urg/kg 1 reaspoon I ounce Dermal Inhalation 200-2000 mg/kg 2000-20,000 rnc/l Oral' 500-5000 rng/kg Mediun III 'Dermal Low IV Inhalation 2ooo-2o,ooo ng/kg no rating given Oral over 5000 mg/kg Dermal Inhalation over 20,000 ng/kg no ratlng given I ounce-l pinc t pound) :t over I pint I pound or DEFINITIONS LD.^ = lethal dose Ehat kills 50 percenE of test animals in a given time. )U LC.., = lethal concenEration, in air or waEer in which test animals live, Jv thac kills 50 percent in a given time. rnc/l = microgramt Fg) per liter. A microgram is one slillionth of a gram. (ppb). T h i s m e a s u r e m e n ti s c o m p a r a b l e t o p a r t s p e r b i l l i o n mg/kg= milligrams (of a coxin) per kilograms (of body weighc of aninal). T h i s r n e a s u r e m e n Ei s c o m p a r a b l e t o p a r t s p e r n i l l i o n (ppur). PERSISTENCERATINGS I{e have reduced the persistence of these pesticides to four stages, in accordanee with the scale used in the firsr annual report of the Councll on EnvironmenEal Qualltyr*a970, page 132: Non-pers = non-persistent.: effectiveness lasts from a few hours to several days, never more than 12 weeks. Mod-pers = moderaEely persisten[: from I Eo 18 months. Pers = persiscent: 50 co 100. Perm = permanent: non-degradable environmenE,. recains coxicity for years, perhaps as many as to non-toxic materials in the I"IARKS:where no quanciEative data has been found but Ehere is QUOTATION a statemenE on an atEribuEe, in a usually Erustworthy source, we use iE. in quotaEion marks to show that it nay not fit into our raEing system but does give a c1ue. EFFECTS:slnce nosc of our rellable dara musr be yot*/Tq3*rAl{ learned froo careful tests on approprtate test anlnars,-""J-"rid"1'. 3- are also eoncerned about the effects of thede p.oa""t"'o1 o,r. fellow maaorals, we combine all avallable data to deternlne the.raclngs for boch inurediace and long-term Eoxicicy. ' ! L O N G - T E L YT O X I C I T Y i n c l u d e s long-lasting or permanent danage from .iccunulaCion one exposure, or fro;r conCinuing exposures, graCual in che body, or effecEs chac rnay appear long after che crucial exposure, some affecEing only subsAquent. generalions. OTHER ADVERSE EFFEcrs, TNCLUDTNc ittosE oN NoN-TARGET spEcrES AND THE GENERAL ENVIROII}IENT : I I t I E D I A T E . L \ D L O I I G - T E R . YT O X I C I f i for oEher crearures fo1low rhe )lutations oreceding scales. in plants are a'"rarninq for all forms of life, since some pla:rc cells reacE very much as anirnal cel_ls do. SOLUtsILITY,eitre; in';ater or oil: our scale mOdlfies che U.S. Pharmacopeia scale to. a iour-scate scale, as Drecise as rnosE of our we give higher-sounding daca permits. ratings Eo lower concenEraEions because ln deallng with toxic substances these are proporEtons Ehac have Lmportant effects. Water solublllty can deEermlne the spread of a maEerial through Ehe envlronmenc; o11 iolubiliry can decerurlne whecher ic may accurnulaEe in fatry animal tissues. our raEing solubilicv aE room Ee:irperacure (20 co 30'C.,6g to g6'F.) insol-uble less thaa I parc per srillion (ppn) slighcly soluble I to lO pgm 10 co 100 ppm soluble 100 co 1000 ppm 1000 tc 10,000 pgm (.I ue:;r soluble co lZ) 10,0C0 cc 33,333 ppn 3li,333 ;o lO0,0C0 r:n 1 0 0 ,C 0 0 r o 1 , 0 0 0 , 0 0 0 . o o m( L 0 7 , t o 1 0 0 2 ) over 1,000,000 (over l00Z) buc ni sc ible misciSle U. S. Pharmacopeia ra cing insoluble very slighrly soluble s1ightly soluble sparingly soluble, sclubl e ireely solu'rle very soluble \ infinitely soluble voLATILIfi: che raE.e ac which a subsEance evaporat,es, thus leaving its original place oi- applicar,ion and possibly being rransporred for great disEances: volaciliey raci:r3 non-.ro1aE,i1e slighcly vola;ile volacile hi3hJ.;rvolaci,la vapor pressure at 20 co 30" C. less than I :< l0-7 nmHg (;0000001r.nillimecers oi uercury) 10-/ co l0-- anllg (.0000001"to .0001 miig) 10-q to 10-' rmrHg (.0001 to . ot uunHg) greater than .ol uur4g FLr\oL{3rLrrY: iased cn che flash poine, che tempera:ure ac which the vapor of a flanra:le liquid will ignire in air. flamnable conbustible flash poinr (r.p.) beLow 140" F., vapor pressure noE orrer 40 pouads per square inch ac 100' F flash poi.nE ar or o"er l10c F. -"+Ormn Expr,axarroNsaxl DnrrxrrroNs U.S. EPA Toxic ReleaseInventory (TRI) Definition The United StatesEnvironmental Protection Agency (EPA) collects data annually on more than 600 toxic chemicalsthat threatenhuman health and the environment in its Toxics ReleaseInventory (TRI) database.The TRI is a recent extensionof the EmergencyPlanning and Commmity Right-To-Know Act. The list is intended for tracking and regulating the destruction,storageor spillage of hazardous chemicalsby corporationsor manufacturers.There is a thresholdamount for the toxic chemical above which reporting is required. Chemicals(even thosewhich appearon the list), when legally applied as pesticides,are not required to be reportedunder the TRI program. The Rachel CarsonCouncil has included the TRI list information so that the public will be awareof the toxicity of some commonly used chemical pesticidesand seek safer alternatives.Information on these altemativesis available from the Rachel CarsonCouncil, and we encouragethe public to inquire. From Rachel Carson Council, Inc.' May 1998. Two Endocrine Disruptor Delinitions ' "An environmentalendocrinedisruptor is an exogenousagentthat interfereswith the synthesis, secretion,transport,binding action or elimination of natural hormonesin the body that are responsible for the maintenanceof homeostasis,reproduction,developmentand behavior." From Environmental Health Perspectives,V. I 06, Supplement I , p. I I -56, I 998. "An endocrinedisruptor is a chemical that affects the structureand function of the endocrinesystem." From Dr. Janette Sherman Restricted Use Pesticide As determinedby the U.S. EPA or a stateagency,a pesticidethat is available for purchaseand use only by certified pesticide applicatorsor personsunder their direct supervisionand only for thoseuses coveredby the Certified Applicator's certification. This group of pesticidesis not available for use by the generalpublic becauseof the very higlr toxicities and/or environmentalhazardsassociatedwith these materials. Frcm Farm Chemicals Hondbook,1998. Definitions of EPA CarcinogenicPesticideRatings From June I I 1998 Memorandum: tU.S. gpAl OIIice of Pesticide Programs List of Chemicals Evaluated for Carcinogenic Potential A B C D E - Human carcinogen Probablehuman carcinogen - Indicates limited human evidence Bl 82 - Indicates sufficient evidencein animals and inadequateor no evidencein humans - Possiblehuman carcinogen - Not classifiable as to human carcinogenicity - Evidence of noncarcinogenicityfor humans -5Sample Herbicide Information from Basic Guide to Pesticides Chemical Class- Triazine TRIAZINE ametryn anilazine atrazine aziprotryne chlorinatedisocyanurates cyanazine cyprazine cyromazine desmetryn diproPetryn ethiozin hexazinone promaton Promatryn propazine simazine terbutryn Mode of action:May disturb the metabolismof vitamins. Immediateeffects:Skin and eye irritation; nausea; vomiting; diarrhea; muscular weakness;salivation. Long-term effects: Carcinogens; suspect mutagens; iirmunotoxin; adrenal damage; kidney .and irinary tract stone formation; teratogens;lung damage; suspect fetotoxins; liver and kidney damage; disturbancesin sperm production. Environmental effects: Groundwater contaminants. REFERENcES (2); (3) Hallenbeck,W H,, and K. M. Burns. 1985.Pesticidesand human health. New York: Springer-Verlag' S.lupr,r Hnnrrcrpn Cn.mr FRoMB,qstcGann... vlt .. =8 r. --9 €P X L F= ..c loi t 7i''. .I ? :: * e .=€r sl=ia 5UE lggEl€=Eq '.e=e=Fii3';=E #.e'E :a.: E qt =5fi JFY -, ti +Y . -ovd l=XsgE 3z -=. = 9 - E . l I i 5 #e V ) E : E # !E E i - Y) q) cn6 p.9 €H 9,IH .eE d l-. >?f ..: EEEi= #i + $ HH i: hooqr.I; Ee T$Ee- EE il6 h eE s g; €Eeg .xe c) .= ;F tE (.,o' dq i " EDES '!i ). /r =clcd #,: -E sig€st;i !:i?€F. E:g=€E x;;E';jiF =ie=;!l==e ! = \o l.- ? 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'J-|J - o4 E?f, 50- o -8Sample Insecticide Information from Basic Guide to Pesticides Chemical Class - Organophosphate ' ORGANOPHOSPHATE acephate acephate-met Akton azinphos-ethyl azinphos-methyl bensulide Bomyl Bromophos Bromophos-ethyl carbophenothion chlorfenvinphos chlormephos chlorphoxim chlorpyrifos (.oumaphos crotoxyphos t-rufomate cyanophenphos cyanophos cythioate DEF demeton demeton-methyl dialifor diamidfos diazinon dicapthon dichlofenthion dichlorvos dicrotophos dimefox dimethoate dioxabenzofos dioxathion disulfoton ditalimfos DMPA edifenphos EPN ethephon ethion ethoproP etrimfos famphur fenamiphos fenitrothion fensulfothion fenthion fonofos fosetyl-al cc 6506 glyphosate isazophos isofenphos leptophos malathion methidathion methylparathion mevinphos monocrotofos naled omethoate oxydemeton-methYl parathion phorate phosalone phosmet phosphamidon phoxim pirimiphos-ethyl pirimiphos-methyl ronnel sulfoTEPP sulprofos temephos TEPP terbufos tetrachlorvinPhos triaziphos trichlorfon vamidothion inhibitor, Mode of action:Acetocholinesterase damagingnervefunction, exceptfor glyphosate. tmmediateeffects:Behavioraldisturbances;uncoordination;muscle twitchinS; headache;nausea; dizziness; anxiety;irritability;loss.ofmemory;sleep pattern ghgng.e;r.e9lleqsgrgs.s; Wqakles.s;trgrmol aF , "]aominai iiamps; diarrhea;sweating;salivation;tear-i j ing; excessive'nasaldischarge;blurred vision; con- i i striction of pupil; slowed heartbeaU confusion;.1 I incolti nelcei hyperten sion. Long-term effects: Delayed neurotoxicity t". . . tinglingand burning sensationsin the limb extremities followed by weaknessin the lower limbs and ataxic. This progressesto paralyses,which, in several cases,affect the upper limbs also.. . . Recovering is seldom completein adults;with the passage of time the clinicalpicture changesfrom flaccidto anspastictype paralysis"WHO (1985,p. 59)l;some are cumulative;persistentanorexia;weakness;malaise;nervedamagevia destructionof myelinsheath ' around nerve fibers; carcinogens;mutagens;fetotoxins; hormonal inhibition; eye damage; suspect mutagens;suspectcarcinogens;sterilityand impotence; embryotoxins;suspectteratogens;immuno; toxins; indication of bone marrow damage and aplasticanemia;kills white blood cells;sperm and other reproductiveabnormalities;suspectviral enhancers;ulcers;abnormalbrainwaves;reducedprotein synthesisin fetus;liver damage;kidneydamage; suppressedantibodyreproduction;decreasedauditory attention,visualmemory problem solving,balance,and dexterity. Environmental effects.' Responsible for the deathsof largenumbersof birds on turf and in agriculture; affect breedingsuccessin birds; embryotoxins in birds; can change feeding habits in birds; para-Nitrophenol, a transformation product of parathion,is a groundwatercontaminant. I ; , l' RrrrnrNcrs (3) Bennett,R. S. 1989.Role of dietarychoicesin the ability of boL white to discriminatebetween insecticidetreated and untreated food. Environ. Toxicol. Chem. 8:731-738. Duffy, F.H., et al. 1980.Long-termeffectsof the organophosphate sarin on EECs in monkeys and humans. Neurotoxicology 1:56.7-689. Hallenbeck,W H., and K. M. Burns. 1985.Pestrcidesand human health. New York: Springer-Verlag. Hoffman, D. ,. 1981.Effectsof malathion,diazinon, and parathion on mallard embryo development and cholinesteraseactiyity. Envi ron m ental Researchx:xxx-xxx. fshikawa,S.1971. Eyediseaseinduced by organic phosphorous insecticides.Acta, Soc.Opthamol. lap. 75:M1-855. Rosenstock,L, et al. 1991.Chronic central nervous systemeffects of acute organophosphatepesticideintoxication. The Lancet 338:223-227. Tamura,O., et al. 1975.Organophosphorous pesticidesas tause of myopia in school children: an epidemiologicalstudy.,fap. l. Opthalmol. 19:25G-253. U.S. EPA.1990.National pesticide survey.Office of water. P8911?5765. White, D, H., et al. 1979.Parathioncausessecondarypoisoningin faughing gull breeding colony- Bull. Environ. Contam. Toxicol.23:281-2M- World Health Organization WHO). 1985. Environmental health criteria no. 63 organophosphorusinsecticides:A Seneral introduction. Ceneva:WHO. -9" DAIVIL.U g E 6_ ;!. s *: gPu E i-: E * 5 L <oii E >.9 dc-ge 5F€ .1 IK(rlYl IrA'tIL rtUIAE... F=E-c + ?g== ..:F-! E gF *EE EE.=! = Fn gi^;Fi rEg gfEitE?,; ?E Egi=EgE?E sEi=:5€.g=i€= g;. €;EEE s- 9 c e \-.tlAr(r INSUUTTUTDE : c o 2 I 1) .-> == G EiE 5;S .J e, a) .J -'- a'= 2 .- - F . ! ; -J ' t \) ! a) ta l : 5= 9; 29 (J9 =c, i' Ea =E : 6i 3 ='= € =1 = ='-4 *,-= Ei65 a z *-EE E '182 jo =E=E .-- di : .5 ': - ='J s j* a ' - ; e. E9E 3 o _ t 5=: -rl o i3 B=s;z€ e!t Fa ;C == oF o =Al =6 _€ b5 !!+ EVr a- = 3c.r =<(u = E: E.r E EE33 LJ U 6e Saupr,nIxsncrrcroE FRoMBasrc Gump ro pnsrrcrnns (coxr.) cE rj o?) )- E 3 vG L O L r! ..c 3 Z . =3 e,:-,'t ; <cii L >=: 8n :qF 3 EF = > EH() ; a)= E s oo oJ-<) uDi I,I nr ,9' (v '- EE -4)* F<o x= q€9 AE 5F -sa As o .J u E gX "H .= o EE ;E ; >.y .:-u c c ;9 '.96 ?.= A E . C= Z E J:H n 6: f iu 'H dd g 8b l"r'5 'E F jH^E j; e! .iE b€E EBg .2 2 A E :XrJ :F*;> o)d bt Tg :..9 .:> P. c) CS t E 1s: ; c& EE:5B; t As 39 Lbo = -'- !'= '= !: .j. 89tr 2- Hx i e- - v - - HOf ; H frg ,9 & 6C 'qFl vaA U(J sg . 1 4 (H J ,YH ar FO <E Er tu.g rrlt E d €; fl 5b sE=E o : '= =!=1 c=lq >. Ei65 h, :o o : =r, : z E E R 3 a E ; ii € E g fl EA E{ E r EF Efi 'a p : rii 3 - =.6 i,t C- = .tt Ee g E^E I bo-l .9 e 5 't IE AE .E? .F E I fl €a rn .E g -A P t r e. g fu; H H tr-g o c,*- *:9 .E A'fi i E €E :E s6r I : == e& g; 5EE h,* E H Frq '66 yHE cl d E o ,tr-- <+o 5 6A fiE HFf; '^ lo' -llSample Fungicide Information from Bssic Guide to Pesticides Chemical Class- Benzonitrile EENZONITRILE bromoxynil chlorothalonif dichlobenil ioxynif Mode of action: May be due to uncoupling of oxydative phosphorylation and inhibiting of efectron transport,with inhibition of some enzymes. Immediate effects: lrritation of skin, mucous membranes;dermatitis.loxynil: excessblood in afl organs;edemaof lungsand brain. Bromoxynil;dizziness;elevationof some enzymes;headache;hyperthermia; muscle pain; thirst; vomiting; weakness; weight loss;anorexia.Chlorothalonil:hyperexcitability. Long-term effects:Carcinogens;teratogen; skin, eye, kidney damage. Suspected-dichlobenil: anorexia;blood in urine; kidney damage;liver damage; reproductive changes with postnatal damage. Chlorothalonil:growth suppression;pre' and postnatal damage;kidney destruction. REFERENcES (3) -1985. Pestrcidesand human Haflenbeck, W. H., and K. M. Burns. hea/th. New York: Springer-Verlag. SAMPLE,TIUNGICID T] UHAlt'I' II R(,IVI I' A J I L 1TUI I' E... -12v d ;I ;.9 -g --(lJ L. -ro :r E ?E l-- L -,o c: 8 .!1 zE'st <E B E C)* H 3H € 'rd 5 F.g '36v - i; i?i;! A3€ iJ(D OP x= a)o A6 lr)- - F o a)E tro .' Ei-;lsrA, ;ii h . * IJts B€. A V C+ -e' >\.= ?:Ei = 55 ll-V z. ! L e)H !rE t) q 2 56 - H H* 'o 7d> l"5 $i E" Es';;€. g 't tt, -9U6 €ge =xE E';s a -r9 v^.. -E ' t : €^ g b tr (t) rtn = 6 I ,nn H - Q)l E bE9 E 3b BE TE 3:E E ?du?nrB - 5 EB q) 5o:J Gl Z 3 ql - oco -A -' yE a<- c - ? d H (t)'= A"o ge e" 3.9 v'5 o^5 ; 'a E."g .z €-3 Ft a o) En8; HqaB .E if; r; oakB 6 €v o otrr Ytr ; ti 6E t'1 d6tl,BE - h - - cl q) a q, o bo * I T ? ru .g g d o d dr do '-, . 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L -9 L, o |gU' >6 q, 4J o(J c - g -- $O - .g5E 5 PE t*5 r tv 6J 3E" .3, ce rO- €r. oE o o t, lt (,Oe c!l ]a, o> ao L 6 ft o ca, 3:! c croa, ec6 cca, oaL -|J(L q l, 6 6 H - A - .U (, O o v t! t€ 3 e .o: !TBI tt.- c(l a9 rJoLcc -J o.a, c)o - v .a ' ts ooL 'a >eC JE giI* I , Bt 86 = a ! E E;E oc 0a 9U IaA.-t :-C cIt ocha Aa + b o" ' o! 6 aaL 3 83.; at O O o* :o3> = ot <* g c6 A G- p-i 6 !J O ! - - .r ,-'{ 5 :tt c !a .'; o9 o3 0 .99$e 35a d i:II C- t a .c u, ! 3;f 8 € -cO 'O' .6L ".8 u, CL S o , tEf E 8! b IU alt g;li c 3t' oClI c.Fo E -3 5 g oc!otr :e 3€ t . $s= qT U' 6.Ut OJ c u L o a, ct ao IJ r o o l! F f J >l! ol -J lr, < ts> o 4 U aa .J UJ - 6 - 6 ,'- U 4 nt CI (J (r- oorCO O >F .a (,Y CL= '- O (,\t { L g,.o \t UJ A. g ! lrs* OE . ..aro 3-.. o u, (, tt--3 3 !.5t: ' C6L> €;ag: €tu OI oo co O. !ru of a soc ogoec 90 L t, L.- .e I € 5br: 'o t. .-t> o? EL t 3t E3EE: €(L :5 6:$ >Y .,3L / r {CL CL ;8;3 E >o glL LCL 5.. coEt.a -O 6 .: a oc tFCO 9ao oJa99 (, Esi i€ c' € O aEv J4 JL .a ! >. .v 5L n .,F- .atl oo!e .-oca ueOE O C'OO0O. O OFs 690 Ob E _e:Ee€ w e aa U' ul 4 o 5 L 5 . 1o o c at c IU g - g. g E (J d :$ g *-d Cf o r{ $i o o I I r'EI o {r: I u oatt) rrr L L E atra, e L I stt L' v, c 6 ,= to, r22-. ts & 8A: 6'-|JL J J o w o ?g orJ rto !! }P E: I(, o.6 t; hu :tUE Eot6 =v, tr< cr ao OrC' 9 ct u, <! c \O aO .ct 3' .lrl- o co C' f.!- ct 4 c{ at (, '.O +6 O c ao.ct (: t8u C,F. i- .c E ,o= 9-C, o. L./r< o<c J(,U a o 0c (, ts 'c, J (J .c> u, U IJ ->. <c .5 OE 7? u, <, < oEI ' IJ ct v u, ao CT .J *-3silEngE' ,a slF :lF ,.E8 -E rs !i': E'i'g *i; -rE6 -ii ::f; :if; EHgipi 8E =A 68 o i i . ; EEf; piq EI8 eiE s:! .lE f:E €lE ti: =-o.io : 41.1 F;:;;:EiiS i3E A-t.- E;: F3E !38 $3fi 53d ( , G r 3 "(, ilE :;I ;;E d;;;i;EA: F6- ,f..e.r , 3' - |,4*' PYRETHROID allethrin barthrin bifenthrin bioallethrin bioresmethrin cismethrin cyfluthrin \[cyhalothrin cypermethrin lethrin d-cis,trans-al deltamethrin dimethrin esbiothrin fenpropathrin fenvalerate flucythrinate fluvalinate z-fluvalinate kadethrin karate permethrin phenothrin resmethrin S-bioallethrin syntheticpyrethrum, pyrethrins tefluthrin tetramethrin tetramethrin (1R)-isomers tralomethrin and Mode of action:Pyrethroidsinhibit sodium 'block potassium conduction in nerve cells and Many timespyrethroids nerveimpulsetransmission. are mixed with piperonylbutoxidein formulations' lmmediate effects: Symptoms similar to DDT poisoning. T-syndrome:tremors; exaggeratedstariled respbnsei hyperthermia.CS-syndrome:excessive writhing and salivation;decreasedstartle response; inciease in adrenalin and blood sugar. Other possibleeffects:convulsions;diarrhea;headache; vomiting; labored breathing; excessivenasal mucous discFarge;irritability; sweating; sudden swefling ol face,eyelids,lips, mouth, and throat tissues.Hly fever-likesymptoms;elevatedpulse. Long-term effects: Suspect mutagens; suspect teratogens;suspectcarcinogens;immunotoxins;decrease?hormone releasefrom brain; some may be cumulative. Environmental effects:Highly toxic to fish, bees, and aquaticanthropods. REFERENCES 12) Hallenbeck,W. H., and K. M. Burns. 1985.Pesticidesand human health. New York: Springer-Verlag. 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