meet the faculty Research Faculty continued from page 4 NeurOSurGerY At MOuNt SINAI A Newsletter Published for Colleagues and Friends of the Department of Neurosurgery Fall 2008 Fatima Sehba, PhD Marat Avshalumov, PhD Yuangen Chen, PhD Luni Emdad, MBBS, PhD Associate Professor Assistant Professor Assistant Professor Assistant Professor Chairman’s message continued from page 1 develop original NIH-funded research laboratories and evolve the different neurosurgical subspecialties. We are fortunate that Dr. Post remains an active member of the department, continuing his clinical, academic and educational activities at full pitch. It is on the shoulders of these giants in neurosurgery that I take over as chair, with hopes to bring the department to even greater achievements in the years to come. As you will see from the pages that follow, the department is richly endowed with talented surgeons, physicians, and researchers all dedicated to advancing the field of neurosurgery. Our residency, the subject of our next newsletter, has never been stronger, and our alumni are achieving great things. Over the coming months this newsletter will feature many of the remarkable individuals that make up the neurosurgical community at Mount Sinai. As always, we invite our friends, guests, alumni, and collaborators to participate in our numerous educational offerings, which can be found near the end of each newsletter. Joshua B. Bederson, MD Professor and Chairman Neurosurgery at Mount Sinai Department of Neurosurgery One Gustave L. Levy Place Box 1136 New York, NY 10029-6574 Neurosurgery at Mount Sinai is published for colleagues and friends of the Department of Neurosurgery at The Mount Sinai Medical Center. Please contact Debbie Winn [email protected] for submissions, suggestions or questions. Visit our website, www.mssm.edu/neurosurgery index.html. Message from the Chairman It is a great honor to take over the reigns of chairman of the Department of Neurosurgery at Mount Sinai, which has a long and illustrious history stemming from Mount Sinai’s founding in 1852. Our neurosurgery service was established in 1914 under Charles elsberg, cofounder of the Society of Neurological Surgeons. He was succeeded by Dr. Harold Neuhof and in 1932 by Dr. Ira Cohen who formed the Department of Neurosurgery, established the residency training Program in 1947 and remained its head to 1950. Dr. Leo M. Davidoff became chair in 1951. A prolific writer, he was also President of the Society of Neurosurgical Surgeons and was succeeded by Dr. Sidney Gross who was chair from 1956 to 1970. under Dr. Gross’ leadership the AMA and ABMS approved our neurosurgery residency in 1956. Dr. Leonard Malis was chair of the department from 1970 to 1991. Among many firsts attributed to Dr. Malis was the first microneurosurgical operation in 1965, Mount Sinai’s first practical course in 1968, and numerous technological advances including creation of the first automatic angiographic cassette changer, full-column myelography, the first description of Bragg peak radiation effects in neural tissue and development of the dedicated bipolar spark-gap. the “Malis” bipolar is widely cited as the most common neurosurgical instrument in use throughout the world today. under our immediate past chair, Dr. Kalmon Post, the department more than doubled in size. During Dr. Post’s 17 year tenure from 1991 to 2008 the department benefited from his world class clinical practice, his numerous contributions to the neurosurgical literature and his ability to foster young academic neurosurgeons to continued on page 12 Transition Joshua B. Bederson, MD, named Chair of Neurosurgery Joshua Bederson, MD, Professor of Neurosurgery and Director of the Cerebrovascular Surgery Program, was named Chair of the Department of Neurosurgery, effective July 1, 2008. Dr. Bederson has served as Vice Chairman of the Department since 2001 and Director of the Neurosurgery residency Program since 2002. He succeeds Kalmon D. Post, MD, who over the past 17 years, led the department to a position of national prominence. “It is an honor for any neurosurgeon to be named chair of any major academic neurosurgery training program in this country,” says Dr. Bederson. “to achieve this goal at Mount Sinai, one of the country’s great institutions, and the same institution where I was born, is an honor that carries much responsibility.” continued on page 2 Kalmon D. Post, MD, becomes Chairman Emeritus Dr. Post succeeded Dr. Leonard Malis as Chairman of Mount Sinai’s Neurosurgery Department in 1991. Having trained under Dr. Joseph ransohoff at New York university, Dr. Post came to Mount Sinai from Columbia, where he had been Vice Chairman of the Department of Neurological Surgery. During his tenure, Dr. Post significantly expanded the department, in personnel, areas of clinical, academic and research expertise, resources and physical space. under his leadership, the faculty grew to 12 full-time and 13 voluntary neurosurgeons, four basic scientists, and seven more faculty with joint appointments in Neurology, radiology, endocrinology and Anesthesia. Dr. Post added specialists in Functional, Skull Base, endovascular and Spine. this more specialized faculty pioneered advances in frameless stereotactic cranial surgery, computer-assisted image-guided continued on page 2 Dr. Bederson named chair continued from page 1 Dr. Post steps down continued from page 1 Dr. Bederson’s career at Mount Sinai began in 1992 as the Director of the Cerebrovascular Surgery Program. He established the first basic science lab in the Department of Neurosurgery, developing models of stroke and subarachnoid hemorrhage. His laboratory has been continuously funded by the National Institutes of Health (NIH) since 1997. minimally invasive surgery, endoscopic neurosurgery, microsurgery, physiologic monitoring in the operating room, spinal disease, management of neurovascular abnormalities and tumors of the nervous system, and the surgery of epilepsy. the number of operations performed in microvascular neurosurgery, pituitary and acoustic surgery, epilepsy and movement disorder surgery, and spine surgery dramatically increased. He recruited two neurointensivists, neurologists with a joint appointment in Neurosurgery, to work with the neurosurgeons in the ICu. In terms of its physical resources, the department remodeled the eighth floor of Annenberg to accommodate 19 academic offices, four operating rooms, an additional waiting room, and a neurosurgical ICu that was expanded from 12 to 16 beds. Dr. Post created a Clinical Center for Skull Base Surgery at Mount Sinai in conjunction with the Department of Otolaryngology and recruited a scientist who organized the department’s intraoperative neurophysiological monitoring team. He also facilitated the purchase of the Novalis system, at the time one of the most sophisticated approaches to stereotactic radiosurgery and radiotherapy. In 2002, Dr. Joshua Bederson was appointed Vice Chairman and residency Program Director, and in 2003, Dr. H. richard Winn joined the faculty as Director of research. the number of NIH grants increased to two rO1s and one rO3. In 2002, Dr. Bederson was the first neurosurgeon at Mount Sinai to receive an NIH rO1 as a principal investigator. He developed one of the first interdisciplinary clinical programs with the Department of Neurology Stroke Program, and continues his collaborative efforts with the Departments of Otolaryngology, the Cancer Institute, and the translational Neuroscience Center. Dr. Bederson has served as Chair of the American Association of Neurological Surgeons/ Congress of Neurological Surgeons Cerebrovascular Section. He is Chair of the American Heart Association’s writing group on Subarachnoid Hemorrhage and serves on numerous neurosurgical societies. “Neurosurgery is a vibrant field that attracts talented individuals committed to understanding the complexities of surgical problems of the nervous system,” Dr. Bederson says. “By collaborating with the many accomplished physicians and scientists at Mount Sinai, I hope we will continue to advance the field and develop treatments for the challenging problems our patients face.” under Dr. Post’s Chairmanship, the department created the Leonard. I. Malis, MD/Corinne and Joseph Graber endowed Chair in Neurosurgery, as well as four annual lectureships: the Sidney A. Hollin, MD, endowed Lecture; the Jeannette and Bernard S. Post, MD, endowed Lecture; the Ved P. Sachdev, MD, endowed Lecture; and the Leonard I. Malis, MD, endowed Lecture. the Kalmon D. Post resident research Prize, which acknowledges and promotes excellence in scholarship, was established to be awarded annually for the best peer-reviewed manuscript by a resident that has been published or accepted for publication during the preceding year. Dr. Bederson earned his medical degree and completed a residency in neurosurgery at the university of California, San Francisco. During residency he completed advanced study programs in neuropathology at the university of torino in Italy, as well as microvascular and skull base neurosurgery at the university Hospitals of Zurich, Switzerland, and the university Medical Center in Ljubljana, Slovenia. He completed a fellowship in cerebrovascular surgery at the Barrow Neurological Institute. Dr. Bederson specializes in the treatment of complex intracranial and spinal pathology such as meningiomas, schwannomas, craniopharyngiomas, pituitary tumors, giant intracranial aneurysms, acoustic neuromas, neurovascular compression syndromes like trigeminal neuralgia, Chiari malformations, as well as treatment of cervical and lumbar spine disease. His vascular practice includes the treatment of aneurysms, arteriovenous malformations, cavernous malformations, cartoid artery disease, moyamoya disease and extracranial-intracranial bypass procedures. Dr. Bederson has performed more than 2500 neurosurgical operations at Mount Sinai. Dr. Post trained 38 residents, including more women neurosurgeons than have been trained in any other department in the country. He built one of the country’s largest neurosurgical practices, specializing in acoustics with hearing preservation, pituitary and other skull base tumors. In addition to his busy surgical schedule, he chaired or served on many boards and committees at Mount Sinai, including the leadership of searches for the chairs of Otolaryngolgy and Surgery, the chairmanship of the executive Board, and, for four years, the presidency of the Faculty Practice Association. Dr. Post inherited a strong department with robust potential, continued the tradition of excellence and vision, and leaves an extraordinary legacy at the Mount Sinai Hospital. Rising in the Rankings U.S. News analyzed data on 5,453 medical centers to produce this year’s specialty rankings. Mount Sinai’s Neurology and Neurosurgery ranked 16, up from 21 in 2007. “This is a remarkable achievement,” says Dean Kenneth Davis, MD. These specialties are fiercely competitive.” 2 Meet the Faculty Full Time Neurosurgery Faculty Joshua B. Bederson, MD Kalmon D. Post, MD Isabelle M. Germano, MD H. Richard Winn, MD Professor and Chairman Professor and Chairman Emeritus Professor Professor Cerebrovascular and Skull Base Surgery Pituitary Tumors, Acoustic Neuroma Radiosurgery, Stereotactic Neurosurgery Cerebrovascular, Tumors 212-241-2377 212-241-0933 212-241-9638 212-241-9128 Ron L. Alterman, MD Aman Patel, MD Chun S. Chen, MD Tanvir Choudhri, MD Associate Professor Associate Professor Assistant Professor Assistant Professor Functional Neurosurgery Endovascular Treatment of Cerebrovascular Disorders Skull Base Tumors Complex Spine Disorders 212-241-0050 212-241-3457 212-241-8480 212-241-8560 Arthur L. Jenkins III, MD Nirit Weiss, MD Errol Gordon, MD Jennifer Frontera, MD Assistant Professor Assistant Professor Assistant Professor, Neurologist Assistant Professor, Neurologist Complex Spine Disorders Complex Spine, General Neurosurgery Neurointensivist Neurointensivist 212-241-8175 212-241-6820 212-241-2114 212-241-9512 continued on page 4 3 New Faculty meet the faculty continued Jamie Ullman, MD, ELMHURST FACULTY Hang Byun, MD, ELMHURST FACULTY Associate Professor Associate Professor Assistant Professor Cerebrovascular therapy, spine interventions Intraoperative Monitoring Neurotrauma, Neurosurgical Critical Care General Neurosurgery, Neurotrauma 212-241-3457 212-241-9543 718-334-2772 718-334-2772 Don Weisz, PhD David M. Johnson, MD Assistant Professor Neurointerventional Radiology: Voluntary Clinical Faculty Marc S. Arginteanu, MD Martin Camins, MD Frank M. Moore, MD Alfred A. Steinberger, MD Associate Clinical Professor Clinical Professor Associate Clinical Professor Assistant Clinical Professor Complex Spine and General Neurosurgery Complex Spine and General Neurosurgery Complex Spine and General Neurosurgery Complex Spine and General Neurosurgery 212-570-0100 212-410-6990 212-410-6990 212-410-6990 Faculty with Secondary Appointments Robert Aiken, MD Eliza B. Geer, MD Eu-Meng Law, MD Thomas Naidich, MD Irene P. Osborn, MD Associate Professor Assistant Professor Associate Professor Professor Associate Professor Neuro-Oncology, Brain Tumors Endocrinology, Pituitary Diseases Neuroradiology Neuroradiology Anesthesiology 212-241-4503 212-241-7975 212-241-4261 212-241-3423 212-241-7467 Resident Graduation Dr. errol Gordon, MD, came to Mount Sinai in July 2008 as an assistant professor with a joint appointment in Neurology and Neurosurgery after spending two years at Columbia university Medical Center as a Post Doctoral Fellow and Clinical Instructor in Neurocritical Care. After earning a BS at Sophie Davis City College, Dr. Gordon attended SuNY Downstate Medical College and did his residency at the Medical College of Wisconsin. He will be working in the Neurosurgical ICu. Drs. Joshua Bederson, Harlan Bruner, Alex Post and Kalmon Post Luni emdad, MBBS, PhD, joined the Department of Neurosurgery in June 2008 as an Assistant Professor on the research track, coming from Virginia Commonwealth university in richmond, Virginia, where she was an Assistant Professor in the Department of Human Genetics. Prior to that, she served as a Postdoctoral research Scientist (12/2002-5/2006) and an Associate research Scientist (5/2006-12/2007) in the Department of Pathology and urology at Columbia university, College of Physicians and Surgeons. She will be working in the laboratory of Isabelle Germano, MD, investigating the effects of mouse and human embryonic stem cells-derived astrocytes conditionally expressing pro-apoptotic genes on human malignant glioma. the annual neurosurgery farewell to the chief resident dinner was held at tavern on the Green on June 19. Parents and family members of Harlan Bruner and Alex Post joined other residents, faculty, nurses and staff of the department and were touched to hear the heartfelt tributes to both chiefs whose year of leadership was especially successful. Harlan and his wife Kathleen Converse are heading to Milwaukee, Wisconsin, where Harlan will be doing a spine fellowship at Froedtert Memorial Lutheran Hospital of the Medical College of Wisconsin. Alex Post, Lauren and son Hayden (who visited the offices in the department regularly and will be missed!) will be in Chicago where Alex is doing a fellowship in Pediatric Neurosurgery at Children’s Memorial Hospital, and Lauren will continue her work as an emergency room physician. We wish them all the very best in their new adventures. New Residents Sharona Ben-Haim, MD MD: University of California, San Diego BA: University of California, Berkeley, Molecular Biology While in medical school, Sharona was honored by the San Diego Medical Society with the robert e. Hertzka Student Leadership Award. Some of her leadership positions included Medical Student Board representative for the San Diego Medical Society Foundation, Medical Student Director of the San Diego County Medical Society, Vice President of the American Medical Student Association at uCSD and Student Coordinator of the student–run free clinic at uCSD. She also was editor-in-Chief of The Human Condition, uSCD’s Art and Literary Magazine, as well as a food critic for the San Diego Community Newspaper Group. During a one-year research fellowship at Harvard Medical School under emad eskandar, MD, Director of Functional and Stereotactic Neurosurgery at MGH, Sharona studied the role of the globus pallidus in the inhibition of motor programs using microelectrode recordings in a primate model. Madhu Jannapureddy, MD MD: Baylor College of Medicine BS: Johns Hopkins University, Biomedical Engineering In addition to his outstanding academic record, Madhu exhibited his leadership skills while in medical school: he was a health careers mentor in the National Youth Leadership Forum, a peer resource network mentor, as well as a Baylor College of Medicine representative to the texas Political Action Committee and a charter officer of the school’s Professionalism Committee. He served on the Medical ethics Curriculum review Committee and the Compassion in the Art of Medicine Curriculum Advisory Committee, and found time to volunteer for Habitat for Humanity. His biomedical engineering background is helpful in his hobby of building computer hardware and learning about new technologies. the Department is looking forward to his contributions to our baseball team next year! Research Faculty continued on page 12 4 5 News Briefs Dr. Isabelle Germano was awarded an rO1 from the NIH/NCI. the $1,700,000 five year grant is for Transgenic in vivo delivery of mda-7/Il-24 for malignant glioma therapy. At the AANS meeting in Chicago in April, Dr. Germano participated on the faculty of a practical course on brain mapping and epilepsy. On September 13 she spoke at a Medical education Oncology Seminar on “treatment of neurological malignancy including surgical treatment.” A Grand Tribute to Kalmon D. Post, MD on aneurysms and next on stroke and carotid stenosis. In April, he was a visiting professor at the Department of Neurological Surgery at the university of California in Los Angeles. the following month, he spoke to basic scientists at Shinshu university School of Medicine in Matsumoto City, Japan, and was also a Special Lecturer in the Department of Neurosurgery there. Dr. Winn was the Mayfield Lecturer and Graduation Speaker for the Department of Neurosurgery at the university of Cincinnati in May and the Grand rounds Lecturer and Graduation Speaker at Penn State university Medical School in Hershey, Pennsylvania, in June. As Chair of the AANS/CNS Cerebrovascular Section, Dr. Joshua B. Bederson gave a “State of the Section” presidential address at the AANS meeting in April in Chicago. He also oversaw the annual Cerebrovascular Section meeting in New Orleans in February. Associate Professor Fatima A. Sehba, PhD, lectured on Mechanisms of cerebral injury after subarachnoid hemorrhage to the Loma Linda university Neuroscience research Consortium on April 4, 2008. Dr. Sehba leads research of early brain injury after subarachnoid hemorrhage. Dr. Arthur Jenkins III, participated as a faculty member in a course titled, the Aging Spine, held May 8 and 9 in New York City. Dr. Jenkins lectured on Influence of bone cement to the blood supply of vertebrae and the adjacent discs in the course section, the uses of Cement in the Aging Spine. Dr. Jenkins has been awarded a two year grant as co-investigator for promoting recovery of spinal cord function after injury by treating with microbeam radiation therapy. the Department fielded a team to participate in the Fifth Annual Neurosurgery Charity Softball tournament sponsored by George M. Steinbrenner III and the New York Yankees on Saturday, June 7 in Central Park. Mayor Michael Bloomberg threw out the honorary first pitch, as this date has been declared “Neurosurgery Charity Softball tournament Day” in the City of New York. Competition was very stiff this year with 16 teams competing, and Sinai did not repeat its high finish of the past two years. everyone had a good time, however, and will practice harder for next year’s event! Dr. Jamie ullman was elected to the executive Committee of the Congress of Neurological Surgeons as Member-At-Large to serve a three-year term. She is an Associate editor for the Congress Quarterly. Marat Avshalumov, PhD, received a two year grant from the NIH/NINDS. His study is focused on the effect of unbalanced formation of reactive oxygen species on physiological properties of dopaminergic neurons in substantia nigra. ronit Gilad, MD, PGY 6, won the $2,000 Kalmon D. Post Neurosurgery Resident Research Award for the paper, Uncorrected sagittal plane imbalance predisposes to symptomatic instrumentation failure, published in the December 12, 2007, Spine Journal. Authors are ronit Gilad, Chirag Gandhi, Marc Arginteanu, Frank Moore, AA Steinberger and Martin Camins. Dr. and Mrs. Kalmon Post hosted three residents, erin Biro, Harshpal Singh and Alex Post, who attended Neurosurgery in the rockies in February. each resident gave a talk and also had time to enjoy the wonderful snow conditions. Congratulations to PGY2 Jake Gologorsky, MD, who was nominated by the Mount Sinai School of Medicine Class of 2009 for a special award from the Arnold P. Gold Foundation. Presented on June 30 at the Student Clinician Ceremony, Jake’s certificate reads: “the Gold Foundation Humanism and excellence in teaching Award to an Outstanding resident role Model.” NSICu news: Jennifer Frontera, MD, and the NSICu have received IrB approval for the IHOP study (Intracranial Hemorrhage Outcomes Project) which will be enrolling patients with ICH, SAH and SDH and following their outcomes at three months and one year. Dr. Frontera is also launching a subarachnoid hemorrhage MrI project where she will be looking at DWI/PWI changes from admission through the vasospasm period and correlating these findings to angiographic and clinical findings and outcomes. She lectured at the 5th New York Symposium on Neurological emergencies & Neurocritical Care meeting in June, passed the first offered Neurocritical Care boards and is editor of the Patients and Family Section of a new website launched by the Neurocritical Care Society. Scott Meyer, MD, PGY 5, has been selected as a “physician leader” to serve on a committee regarding improving physician/patient communication at Mount Sinai. Dr. H. richard Winn was interviewed and answered callers’ questions in two separate sessions on the Greek radio station, first 6 On June 2, members of the Department of Neurosurgery and the Mount Sinai community, as well as friends, colleagues and former faculty and residents from near and far, joined to honor Kalmon D. Post, MD, for his 17 years as Chair of the Department of Neurosurgery at Mount Sinai. the tribute was in anticipation of Dr. Post’s stepping down as Chair on July 1, 2008. Happily for the department, he will be staying on the faculty, continuing his active surgical, teaching, and research schedule. the tribute included a scientific session during the day at the New York Academy of Medicine and a gala dinner at the Yale Club in the evening. the morning’s scientific session featured speakers who had worked with Dr. Post, who presently work with him and who had trained with him. the afternoon session included three named lectureships as well as comments from Dean Kenneth Davis. Morning speakers from Mount Sinai were Isabelle M. Germano, MD: The Mount Sinai Bench to Bedside Approaches to Primary Brain Tumors; Aman B. Patel, MD: The Mount Sinai Experience in Carotid Artery Stenting; eliza B. Geer, MD: Body Composition in Cushing’s Disease; ron L. Alterman, MD: Deep Brain Stimulation for Torsion Dystonia; H. richard Winn, MD: The Academic Legacy of Kalmon D. Post, MD. Dr. Pamela Freda, Assistant Professor of Clinical Medicine at Columbia, who has been collaborating with Dr. Post since 1994 on patients with pituitary tumors of different types, spoke about Biochemical Criteria for Diagnosis and Remission of Acromegaly. r. Michael Scott, MD, and Dr. Post were faculty members together at tufts in the 1970s. Dr. Scott, now a Professor and Director of Clinical Pediatric Neurosurgery at the Boston Children’s Hospital, spoke about Cavernous Malformations in Children. Paul C. McCormick, MD, Professor of Clinical Neurosurgery at Columbia university College of Physicians and Surgeons, was a resident at that institution when Dr. Post was on the faculty there and discussed Dr. Post’s influence in his talk, Hemangioblastomas: What I Learned from Kal Post. A faculty member at Mount Sinai from 1991 until 2000, Dr. Chandranath Sen is presently Chair of the Departments of Neurosurgery at St. Luke’s-roosevelt Hospital Center and Beth Israel Medical Center. the title of his talk was Clival Chordomas: Clinical Results and Complications. In the afternoon, edward Laws, MD, who shares Dr. Post’s interest and expertise in neuroendocrine disorders, delivered the Ved P. Sachdev, MD, Memorial Lecture, The Evolution of Pituitary Surgery. Dr. Laws recently joined the Department of Neurosurgery at Brigham and Women’s Hospital in Boston. Following Dr. Laws, Peter J. Jannetta, MD, was the Leonard I. Malis, MD, Memorial Lecturer. A pioneer in cranial nerve disorders and trigeminal neuralgia treatment, Dr. Jannetta is a Professor of Neurosurgery at Allegheny General Hospital in Pittsburgh, Pennsylvania. His talk was titled Vascular Brainstem Compression: Changing Perceptions, Changing Therapies. the last speaker of the day, rudolf Fahlbusch, MD, had traveled from Germany to honor his friend. Dr. Fahlbusch presented the Jeannette and Bernard Post, MD, Memorial Lecture, Intraoperative Visualization of Brain Tumors. Dr. Post and Dr. Ed Laws, Dr. Peter Jannetta, Leonard I. Malis, MD, Memorial Lecturer, Dr. Post and Dr. Rudolf Fahlbusch, Jeannette and Ved P. Sachdev, MD, Memorial Lecturer and Drs. Joshua Bederson, Kalmon Post, and Rudolf Fahlbusch Bernard Post, MD, Memorial Lecturer Drs. Kristjan Ragnarsson and Kal Post Former resident Joseph Queenan, MD, Former resident Emily Friedman, MD, and Dr. Isabelle Germano and Linda Post 7 Drs. H. Richard Winn, Russel Patterson, Ed Laws continued on page 8 Celebrating Career and Friendships Recent Publications Gandhi CD, Gilad r, Patel AB, Haridas A, Bederson JB. treatment of ruptured lenticulostriate artery aneurysms. J Neurosurg. 2008 Jul;109(1):28-37. eloy JA, Carai A, Patel AB, Genden eM, Bederson JB. Combined endoscopic-assisted transclival clipping and endovascular stenting of a basilar trunk aneurysm: case report. Neurosurgery. 2008 Mar;63(3 Suppl 1):142-3. reis C, Genden eM, Bederson JB, Som PM. A rare spontaneous osteosarcoma of the calvarium in a patient with long-standing fibrous dysplasia: Ct and Mr findings. Br J radiol. 2008 Feb;81(962):e31-4. Bederson JB, Chair, Batjer HH, Conolly eS, Dacey rG, Duldner J, Diringer M, Harbaugh re, Dion JJ, Patel AB, rosenwasser rH, Members. Guidelines for the management of aneurysmal subarachnoid hemorrhage. A statement for healthcare professionals from a special writing group of the Stroke Council. American Heart Association. Stroke, 2008. In Press. Post KD. Commentary. Surg Neurology. 2008 May 13. Gandhi CD, Meyer SA, Patel AB, Johnson DM, Post KD. Neurologic complications of inferior petrosal sinus sampling. AJNr Am J Neuroradiol. 2008 Apr;29(4)760-5. Snyder, BJ, Naidich, tP, Post, KD. Cystic Lesions of the Sella. In: Swearingen, B, Biller, BMK (eds), Diagnosis and Management of Pituitary Disorders. Humana Press, totowa, New Jersey, pp445-466, 2008. Germano IM, uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: Hype or hope? Cancer Biol ther. 2008 Sept 11;7(9).[epub ahead of print] uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro Oncol. 2008 Aug 1. [epub ahead of print] WINS White Paper Committee: Benzil DL, Abosch A, Germano I, Gilmer H, Maraire JN, Muraszko K, Pannullo S, rosseau G, Schwartz L, todor r, ullman J, Zusman e. the future of neurosurgery: a white paper ono the recruitment and retention of women in neurosurgery. J Neurosurg. 2008 Seep;109(3):378-386. Britz G, Winn Hr. Assessing the constancy of intracranial aneurysm growth rates. J Neurosurg. 2008 Aug;109(2):173-4. Miekisiak G, Kulik t, Kusano Y, Kung D, Chen JF, Winn Hr. Cerebral blood flow response on adenosine 2a receptor knockout mice during transient hypoxic hypoxia. J Cereb Blood Flow Metab. 2008 June 11. [epub ahead of print] Kulik t, Kusano Y, Aronhime S, Sandler AL, Winn Hr. regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology. 2008 Sept;55(3):281-8. Winn Hr. Brain abscess. Neurosurgery Focus. 2008;24(6)e1. Dumitriu D, Collins K, Alterman r, Mathew SJ. Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation. Mt. Sinai J Med. 2008 May-June;75(3):263-75. Isaias Iu, Alterman rL, tagliati M. Outcome predictors of pallidal stimulation in patients with primary dystonia: the role of disease duration. Brain. 2008 Jul;131(pt 7):1895-902. Brozova H, Barnaure I, Alterman rL, tagliati M. the effect of 60Hz StN-DBS on gait and speech in patients with Parkinson’s Disease. Movement Disorders 23(Suppl 1): S109, 2008. tagliati M, Martin Ce, Alterman rL. Optimal pallidal stimulation frequency for dystonia may vary with age. Movement Disorders 23(Suppl 1):S113, 2008. Alterman rL, tagliati M. Preparation for Movement Disorder Surgery. In Bakay rAe (ed). Movement Disorder Surgery- the essentials, thieme, New York, 2008, pp58-69. June 2, 2008, Yale Club, New York City 8 Gupta F, Chan N, Alterman rL, Walker r, tagliati M. DBS frequency screening for programming optimization in a patient with chorea-acanthocytosis. Movement Disorders 23(Suppl 1):S384, 2008. continued on page 10 9 Recent Publications continued from page 9 Alterman rL. Outcome measures for functional neurosurgery. Congress of Neurological Surgeons Quarterly, Spring 2008, pp31-34. Gilad r, Gandhi CD, Johnson DM, Patel AB. Hyperfusion syndrome after external carotid artery stent placement in a case of bilateral internal carotid occlusion and external carotid stenosis. J Vasc Interv radiol. 2008 Sep;19(9):1373-7. Frontera JA, Parra A, Shimbo D, Fernandez A, Schmidt JM, Peter P, Claassen J, Wartenberg Ke, rincon F, Badjatia N, Naidich A, Connolly eS, Mayer SA. Cardiac arrhythmias after subarachnoid hemorrhage: risk factors and impact on outcome. Cerebrovasc Dis. 2008;26(1):71-8. Frontera JA, Fernandez A, Schmidt JM, Claassen J, Wartenberg Ke, Badjatia N, Parra A, Connolly eS, Mayer SA. Impact of nosocomial infectious complications after subarachnoid hemorrhage. Neurosurgery. 2008 Jan;62(1):80-7. Starke rM, Komotar rJ, Otten ML, Schmidt JM, Fernandez LD, rincon F, Gordon e, Badjatia N, Mayer SA, Connolly eS. Predicting Long term Outcome in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients utilizing the Glasgow Coma Scale (Accepted Journal of Clinical Neuroscience) Ohara S, Crone Ne, Weiss N, Kim JH, Lenz FA. Analysis of synchrony demonstrates that the presence of “pain networks” prior to a noxious stimulus can enable the perception of pain in response to that stimulus. exp Brain res. 2008 Feb;185(2):353-8. Freda Pu, Shen W, Heymsfield SB, reyes-Vidal CM, Geer eB, Bruce JN, Gallagher D. Lower visceral and subcutaneous but higher intermuscular adipose tissue depots on patients with growth hormone and insulin-like growth factor I excess due to acromegaly. J Clin endocrinol Metab. 2008 Jun;93(6):2334-43. etz CD, Homann tM, Luehr M, Kari FA, Weisz DJ, Kleinman G, Plestis KA, Griepp rB. Spinal cord blood flow and ischemic injury after experimental sacrifice of thoracic and abdominal segmental arteries.eur J Cardiothorac Surg. 2008 Apr 10. [epub ahead of print] Halstead JC, Meier M, Wurm M, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp rB. Optimizing selective cerebral perfusion: deleterious effects of high perfusion pressures.J thorac Cardiovasc Surg. 2008 Apr;135(4):784-91. Gracies M, Lugassy M, Weisz DJ, Vecchio M, Flanagan S, Simpson DM. Botulinum toxin Dilution and endplate targeting in spasticity: A double-blind controlled study. Archives of Physical Medicine and rehabilitation, accepted for publication. Som PM, Park ee, Naidich tP, Lawson W. Crista galli pneumatization is an extension of the adjacent frontal sinuses. AJNr Am J Neuroradiol. 2008 Sep 3 [epub ahead of print] Delman BN, Fatterpekar GM, Law M, Naidich tP. Neuroimaging for the pediatric endocrinologist. Pediatr endocrinol rev. 2008 Feb;5 Suppl 2:708-19. Zacharia tt, Law M, Naidich tP, Leeds Ne. Central nervous system lymphoma characterization by diffusion-weighted imaging and Mr spectroscopy. J Neuroimaging. 2008 May 19. [epub ahead of print] Lu H, Pollack e, Young r, Babb JS, Johnson G, Zagzag D, Carson r, Jensen JH, Helpern JA, Law M. Predicting Grade of cerebral glioma using vascular-space occupancy Mr imaging. AJNr. 2008 Feb; 29(2):373-78. Lui Y, Law M, Babb J, Johnson G, Gruber M, Chacko J, Allen J. Correlation of Diffusion tensor Metrics with Clinical Outcome in Brainstem Gliomas. Neurosurgery 2008. Lin K, Law M, Babb J, Pramanik NBK. Accuracy of the Alberta Stroke Program early Ct Score during the first 3-hours of middle cerebral artery stroke: comparison of noncontrast Ct, Ct angiography source images, and Ct perfusion. AJNr. 2008 Mar; 29(5):931-936. Law M, Young r, Babb J, Peccerelli N, Chheang S, Gruber M, Golfinos J, Miller D, Zagzag D, Johnson G. Predicting time to progression or survival in gliomas with cerebral blood volume measurements using dynamic susceptibility. radiology 2008 247:490-498. 10 Announcements Chen S. Chen, MD, and Martin Camins, MD, were selected for the recent New York Magazine Castle Connolly Guide to Best Doctors in New York City. Save the Dates Radiosurgery Spine Symposium for Patients and Caregivers Spine Radiosurgery: New Hope for Cancer Sidney A. Hollin, MD, Endowed Lecture Wednesday, October 22, 2008 October 28, 2008 Brain AVMs: Endovascular Nidal Occulsion Mount Sinai Hospital Goldwurm Auditorium 1480 Madison Avenue and Paradigm Shift in Multi-Modality Treatment For more information on this event, call Kathleen Maloney-Lutz, 212-241-5052 Aman Patel, MD, Associate Professor Mount Sinai School of Medicine Isabelle M. Germano, MD, Director Annenberg 5 Boardroom 7:30 AM October Grand Rounds October 8: 7-8:50 AM: Quality Assurance: Mount Sinai Hospital ron Alterman, MD, Department of Neurosurgery, Mount Sinai School of Medicine October 15: 7-7:50 AM: Quality Assurance: elmhurst Queens Hospital Jamie ullman, MD, Department of Neurosurgery, elmhurst Queens Hospital 8-8:50 AM: Practicing Excellence in Patient Care Deborah Marin, MD, Medical Director, Physician Access Services, Mount Sinai School of Medicine October 22: Sidney A. Hollin, MD, Memorial Lecture (see Save-the-Date on this page) October 29: 7-7:50 AM: Clinical and Radiographic Comparison of Mini-Open TLIF to Open TLIF in 42 Patients with Long-Term Follow Up Sanjay Dhall, MD, Chief resident, Department of Neurosurgery, emory university School of Medicine 8-8:50 AM: Mount Sinai School of Medicine Master of Public Health Degree: Options for Resident and Fellow Physicians emily Senay, MD, MPH, Master of Public Health Program, Mount Sinai School of Medicine New Clinical Trial: Phase I trial of MPC-6827 and Carboplatin for the Management of relapsed Glioblastoma Multiforme MPC-6827 is a drug that has a novel mechanism of action and is being studied here in patients who have relapsed or progressive glioblastoma. this unique drug reaches a concentration 20-fold greater in brain tumor tissue than in blood and appears to be unusually effective in shrinking tumors in experimental animals. When used with a platinum based drug like carboplatin, there appears to be a synergetic response promoting an anti-tumor response. Appropriate patients for this protocol are individuals with glioblastoma who have not responded to temodar and radiation. Prospective patients do not require further surgery but need to meet certain performance and health minima. If you think that you may have an appropriate patient, please call robert Aiken, M.D. at 212-241-4503. 11
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