2014 POSTGRADUATE CANCER RESEARCH SYMPOSIUM Monday, 3 NOVEMBER 2014 New Law Building, The University of Sydney PLENARY SESSION New Law Lecture Theatre 026 Chair: Sarah Frost 9.30 Welcome and introduction 9.40 PLENARY ADDRESS Professor Peter Lay ARC Professorial Fellow and Professor of Inorganic Chemistry, The University of Sydney Q&A 10.00 CONCURRENT SESSIONS Session 2 – Cell biology New Law Seminar Room 020 10.10 10.25 10.40 10.55 11.10 11.25 Chair: Indhu Subramanian P1: DIFFERENCE IN CHROMATIN STRUCTURE BETWEEN ALT AND TELOMERASE CANCER CELLS Monica Brygula Children’s Medical Research Institute P2: ENDOMETRIAL GLAND SPECIFIC ANDROGEN ACTIONS REGULATE PTEN INACTIVATION INDUCED UTERINE DISORDERS Jaesung Peter Choi ANZAC Research Institute P3: ROLE OF TGF-β SIGNALLING IN THE CYTOSKELETAL DYNAMICS OF CYTOTOXIC T CELLS DURING MIGRATION IN THE TUMOUR MICROENVIRONMENT Jorge Galeano Sydney Medical School P4: THE P38-MK2-HUR PATHWAY POTENTIATES EGFRVIII-IL-1ΒDRIVEN IL-6 SECRETION IN GLIOBLASTOMA CELLS Fadi Gurgis School of Medical Science (Pharmacology) P5: CELLULAR IRON DEPLETION INDUCES THE AMPK MEDIATED STRESS PATHWAYS IN CANCER CELLS Sukriti Krishan Molecular Pathology and Pharmacology Program, Department of Pathology, Sydney Medical School Session 3 – Drug development New Law Seminar Room 022 Chair: Krystal Lester P6: STUDIES ON SYNTHESIS AND ACTIVITY OF MONOFUNCTIONAL PALLADIUMS Md Nur Alam Discipline of Biomedical Science P7: ACTIVITY OF MYCOPHENOLIC ACID AND KAEMPFEROL AGAINST OVARIAN TUMOUR MODELS Md Sheikh Anwar Discipline of Biomedical Science P8: GENERATION OF NEW HISTONE DEACETYLASE INHIBITORS THROUGH DEVELOPMENTS IN CHEMICAL BIOLOGY Tomas Richardson-Sanchez Discipline of Pharmacology P9: THE EFFECTS OF METALS-BASED DRUGS IN THE BIOCHEMICAL CHANGES OF LIVE CELLS Anna Safitri School of Chemistry P10: SYNTHESIS AND CHARACTERISATION OF STERICALLY HINDERED PYRIDINE BASED MULTINUCLEAR PLATINUM ANTICANCER COMPLEXES AND THEIR CYTOTOXICITY Michael Apps Faculty of Pharmacy MORNING TEA CONCURRENT SESSIONS Session 4 – Targeted therapies New Law Seminar Room 020 Chair: Sarah Frost 11.40 P11: SYNERGISM FROM COMBINATION OF TARGETED THERAPY AND PHYTOCHEMICALS IN COLORECTAL CANCER Muhammad Almoyad Discipline of Biomedical Sciences 11.55 P12: COMBINATIONS OF TARGETED THERAPY AND PHYTOCHEMICALS AIMED TO PROVIDE AN AFFORDABLE MEANS TO OVERCOME DRUG RESISTANCE IN OVARIAN CANCER Fahad Nasser Al-Onazi Sydney Medical School P13: STUDIES ON COMBINATIONS OF TARGETED DRUGS WITH TUMOUR ACTIVE PLANT COMPOUNDS IN CANCER Hana Bali Discipline of Biomedical Science, School of Medical Sciences 12.10 Session 5 – Cancer control, care and quality of life New Law Seminar Room 022 Chair: Adam Walczak P17: EVALUATION OF THE FIRST YEAR OF THE SYDNEY SURVIVORSHIP CLINIC AT CONCORD CANCER CENTRE: FEASIBILITY, FUNCTION AND CLINICAL PATHWAYS Jane Turner Centre for Medical Psychology & Evidence-based Decision-making P18: NUTRITIONAL RISK FOLLOWING EXTRAPLEURAL PNEUMONECTOMY FOR MALIGNANT PLEURAL MESOTHELIOMA Jason Fowler Centre for Medical Psychology & Evidence-based Decision-making P19: MANAGING AND ENHANCING FAMILY INVOLVEMENT IN CANCER CONSULTATIONS: DEVELOPING A NEW CONCEPTUAL FRAMEWORK AND CLINICAL STRATEGIES Rebekah Laidsaar-Powell Centre for Medical Psychology & Evidence-based Decision-making PAUSE 12.30 P14: 3D SCAFFOLD FREE LIVER CANCER MODEL FOR NANOPARTICLE BASED ANTI-CANCER DRUG DELIVERY Dipesh Khanal Faculty of Pharmacy P20: AN INVESTIGATION OF FACTORS THAT AFFECT ADOPTION AND COMPLIANCE WITH POST-PROSTATECTOMY TREATMENTS FOR ERECTILE DYSFUNCTION Patrick Lumbroso School of Psychology 12.45 1.00 1.15 P15: TARGETED TREATMENT OF LUNG CANCER USING SILKBASED DRUG CARRIERS Sally Yunsun Kim Faculty of Pharmacy P16: THE IMPACT OF AUDIOVISUAL BIOFEEDBACK ON LUNG TUMOR MOTION CONSISTENCY Danny Lee Radiation Physics Laboratory, Sydney Medical School LUNCH CONCURRENT SESSIONS Session 6 – Breast and prostate cancers New Law Seminar Room 020 Chair: Jasmine Yee 2.00 2.15 2.30 P21: THE IMPACT OF SEIZURES ON COGNITION AND HEALTH RELATED QUALITY OF LIFE IN PRIMARY BRAIN TUMOUR Zebunnessa Rahman Westmead Hospital P22: CANCER IN FARMERS, NON-FARM RURAL AND URBAN RESIDENTS IN THE NSW ‘45 AND UP’ STUDY COHORT Julie Depczynski Australian Rural Health Research Collaboration P23: A ROLE FOR ADIPOCYTE LIPOLYSIS IN BREAST CANCER PROGRESSION Seher Balaban Discipline of Physiology, School of Medical Sciences P24: MICROSCOPIC DIFFUSION PROPERTIES OF BREAST TISSUE Narina Norddin Faculty of Health Sciences P25: DIFFUSION MICROIMAGING OF LYMPH NODES: PRELIMINARY FINDINGS Mariaulpa Sahalan Brain & Mind Research Institute Session 7 – Treatment and applied cell biology New Law Seminar Room 022 Chair: Belinda Wright P29: UNDERSTANDING NANOPARTICLE ENHANCEMENT OF RADIOTHERAPY Hilary Byrne Institute of Medical Physics, School of Physics P30: DESIGN, EVALUATION AND SYNTHESIS OF NOVEL ANTICANCER AGENTS Zechariah Marting Faculty of Pharmacy P31: SYNTHESIS AND IMMUNOLOGICAL EVALUATION OF SELFADJUVANTING MUC1 MALP2 CONJUGATE VACCINE CANDIDATES David McDonald Infectious Diseases and Immunology, Faculty of Chemistry PAUSE 2.50 3.05 P26: VITAMIN D3 (CHOLECALCIFEROL) ACTS AS A NEGATIVE REGULATOR OF BREAST CANCER CELL MOTILITY AND INVASIVENESS IN ACTIVATION OF VDR IN THE ABSENCE OF CLASSICAL VDR SIGNALLING PATHWAY Md Musharraf Hossain Faculty of Engineering P27: ROLE OF RUNX TRANSCRIPTION FACTORS IN PROSTATE CANCER Alison Ferguson Bosch Institute P32: MULTI-DIMENSIONAL IMMOBILISED METAL AFFINITY CHROMATOGRAPHY FOR THE ISOLATION OF BACTERIAL METABOLITES Jiesi Gu Discipline of Pharmacology P33: THE METASTASIS SUPPRESSOR NDRG1 DOWN-REGULATES THE EXPRESSION OF SNAIL AND SLUG TO PROMOTE ECADHERIN EXPRESSION IN PANCREATIC CANCER Sharleen Menezes Sydney Medical School P34: HONING THE ONCOLYTIC WEAPON: INCREASED INVASIVENESS OF VACCINIA-INFECTED CELLS Anjali Gowripalan School of Molecular Bioscience 3.20 P28: CHANGES IN TISSUE COMPOSITION PREDICT WATER DIFFUSION COEFFICIENT CHANGES IN PROSTATE CANCER Aritrick Chatterjee Medical Radiation Sciences 3.35 AFTERNOON TEA 3.50 – 4.00 AWARDS CEREMONY New Law Seminar Room 020 Chair: Sarah Frost 3.50 Most outstanding student presenter within each of the following sessions: 4.00 • • • • • • FINISH Cell biology Drug development Targeted therapies Cancer control, care and quality of life Breast and prostate cancers Treatment and applied cell biology