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xGen® Predesigned Gene
Capture Pools and Plates
xGen® Predesigned Gene Capture Pools and Plates help you create and optimize panels at a lower
cost with less waste. Target your selected regions of interest with high uniformity and specificity.
Design Your Custom Panel by Gene; Pooled or in Separate Wells
Enhance and Optimize Existing Panels
xGen® Predesigned Gene Capture Plates
GENE POOL,
MIXED
GENE1
GENE2
GENE3
GENE4...
– OR –
xGen® AML
Panel
Begin Your Experiment in 7–10 Days
OCTOBER
xGen®
Pan Cancer
Panel
xGen®
Other
Inherited
Predesigned
Disease Panel
Panel
Self-Designed
Custom
Panel
Find Your Balance of Customization and Price
$$$
Custom Probe
Design and
Synthesis xGen®
Predesigned
Gene Capture
Pools
+ Custom Probes
Predesigned
Panels
$
+ Custom Probes
Ready-Made
Custom
Learn more: http://bit.ly/ASHG-xgen
xGen® Predesigned Gene Capture Pools and Plates are optimized probe designs for all human gene coding
sequences that are shipped in 7–10 days. Order premixed or with each gene probe pool in a separate plate well.
Available for 16 or 96 reactions. www.idtdna.com/xgen
T H E C U S TO M B I O LO G Y C O M PA N Y
xGen® Lockdown® Probes
Scalable Target Capture Probes for Next Generation Sequencing
xGen® Lockdown® Probes are individually synthesized probes for target capture applications in next generation sequencing.
These probes enhance the performance of existing capture panels, rescuing poorly represented regions such as areas of high
GC content. xGen Lockdown Probes are also suitable for creating custom capture panels that can be optimized, expanded, and
combined with other panels as necessary.
100
90
Achieve greater coverage with individually
synthesized and quality-controlled capture probes.
80
Develop custom panels by pooling up 2000 probes
per tube.
% of Targets
70
Start your project faster with a 7- to 10-day turnaround
time.
60
50
40
30
20
Transition from discovery to application easily with
three production scales.
10
0
>0.2 x Mean
>0.5 x Mean
>1.0 x Mean
Figure 1. Excellent Uniformity of Coverage Obtained With
xGen®Pan-Cancer Panel. The uniformity of coverage of targeted
regions is represented as the proportion of targets with >0.2 x
mean coverage (blue), >0.5 x mean coverage (green) and >1.0 x
mean coverage (grey). The data demonstrate that with a mean
coverage depth of 100X, 99.9% of the targets captured using
the xGen® Pan-Cancer Panel will have >20X depth of coverage.
Sequencing was performed on the MiSeq® System (Illumina) using
2 x 150 paired-end reads.
http://www.idtdna.com/xgen
Spike into array-derived baits to improve capture performance
Create custom capture panels against small target regions.
t
Rescue drop-out regions of array-derived exome
captures or large captures.
t
Develop specific sub-panels against target regions
of interest.
t
Improve uniformity of coverage across your
target space.
t
Achieve sufficient coverage depth to detect
rare alleles.
t
Discover more genetic mutations with high
confidence.
t
Sequence hundreds of samples cost effectively.
t
Optimize, expand, or combine custom panels
as necessary.
t
Selectively improve specific regions of interest
without redesigning a new panel.
Contact Information
USA & Canada
[email protected]
1-800-328-2661
Europe
[email protected]
+32 (0) 16 28 22 60
Asia Pacific
[email protected]
+65 6775 9187
Australia
[email protected]
1800 092 259
For Research Use Only. ©2014 Integrated DNA Technologies,
Inc. All rights reserved. Trademarks contained herein are
the property of Integrated DNA Technologies, Inc. or their
respective owners. For specific trademark and licensing
information, see www.idtdna.com/trademarks.
Web Chat: www.idtdna.com
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INTEGRATED DNA TECHNOLOGIES