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16th Workshop of the International Stroke Genetics Consortium
Preliminary Program
Maison de l’Amérique Latine, 217 Boulevard Saint Germain, Paris, France
Thursday November 6th 2014
8:00-8:40: Welcoming participants
8:40
Workshop opening, François Chollet, French Neurovascular Society (Toulouse, France)
Welcome from Meeting Co-chairs, Stéphanie Debette (Bordeaux, France) and Guillaume Paré
(Hamilton, Canada)
8:50
ISGC Chair’s opening, Jane Maguire (Newcastle, Australia)
9:00
New findings from stroke GWAS in large consortia
Chairs Sudha Seshadri (Boston, USA) and Vincent Thijs (Leuven, Belgium)
Steven Kittner & Brackie Mitchell (Baltimore, USA): GWAS of Ischemic Stroke and Stroke
Subtypes
Rainer Malik (Munich, Germany) and Brad Worrall (Charlottesville, USA): METASTROKE 1000
genome GWAS of ischemic stroke update
SiGN-speaker (to be specified): Sex-Specific GWAS of Ischemic Stroke and Stroke Subtypes
SiGN-speaker (to be specified): Admixture mapping study of Ischemic Stroke among AfricanAmericans
Jonathan Rosand (Boston, USA) and Dan Woo (Cincinnati, USA): Second wave GWAS of
hemorrhagic stroke
Matthew Traylor (Cambridge, UK): Case-only GWAS of Age of onset of Ischemic Stroke
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10:40 Coffee Break
11:00 GWAS of stroke-related phenotypes
Chairs Brad Worrall (Charlottesville, USA) and Steve Bevan (Cambridge, UK)
- Arne Lindgren (Lund, Sweden), Jane Maguire (Newcastle, Australia): GWAS of stroke outcome
(GISCOME)
Pankaj Sharma (London, UK): GWAS of cerebral venous thrombosis
- Ynte Ruigrok (Utrecht, Netherlands): GWAS mega-meta-analysis of intracranial aneurysms (title
to be confirmed)
- Stéphanie Debette (Bordeaux, France): Genetics of cervical artery dissection
- Ken Hanscombe (London and Cambridge, UK): Polygenic analysis looking at overlap between
coagulation and stroke
12:30 Lunch
13:30 Invited lecture: Roderick Corriveau, NIH/NINDS (Bethesda, USA): Vascular Contributions to
Cognitive Impairment and Dementia (VCID), Genetics and Stroke/Alzheimer’s Synergy
Chair Geneviève Chêne, National Public Health Institute Inserm/CNRS (Bordeaux, France)
14:00 Genetics of small vessel disease part 1
Chairs Christophe Tzourio (Bordeaux, France) and Natalia Rost (Boston, USA)
- Natalia Rost (Boston, USA): Report from the Imaging Working Group and update on ISGC
neuroimaging repository
- Hieab Adams (Rotterdam, Netherlands): GWAS of cerebral microbleeds in CHARGE
- Anne-Katrin Giese (Rostock, Germany): GWAS of white matter hyperintensities in the SIFAP
study
- Matthew Traylor (Cambridge, UK): GWAS of white matter hyperintensities 2.0
- Hugh Markus (Cambridge, UK): GWAS of SVD ischemic stroke
- Charles deCarli (Sacramento, USA): A new vascular MRI phenotype for SVD genetics
- Arfan Ikram (Rotterdam, NL): HD-READY and high dimensional vascular imaging genetics
15:30 Coffee Break
15:45 Invited lecture: Elisabeth Tournier-Lasserve (Paris, France): Genetics of monogenic small vessel
disease: what’s new?
Chair Marie-Germaine Bousser (Paris, France)
16:15 Genetics of small vessel disease part 2
Chairs Hugh Markus (Cambridge, UK), John Cole (Baltimore, USA)
- Paul Nyquist (Baltimore, USA): Heritability of Ischemic White Matter Lesions in a Family
Population with Increased Susceptibility of Vascular Disease
- Helena Schmidt (Graz, Austria) – TBC : Genetics of white matter hyperintensities stratified on
hypertension
- Joanna Wardlaw (Edinburgh, UK): From stroke prone rat to cerebral small vessel disease in the
general population
- Kristiina Rannikmae (Edinburgh, UK): COL4A1/2 genes and cerebrovascular phenotypes (15’)
- Ganesh Chauhan (Bordeaux, France, for Leducq TNE): CADASIL pathway genes and cerebral
small vessel disease in older community persons
- Christof Haffner (Munich, Germany, for Leducq TNE): Latent TGF-β binding protein 1 (LTBP-1) –
a new player in familial small vessel disease
17:45 End of day 1
Visit and Dinner at Musée d’Orsay
Friday November 7th 2014
9:00
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GWAS of acute stroke
Chairs Dan Chasman (Boston, USA) and Turgut Tatlisumak (Helsinki, Finland)
Jin-Moo Lee (St Louis, USA): GWAS of delta-NIHSS during the acute phase of stroke
Israel Fernandez (Barcelona, Spain): genetic risk factors associated with Hemorrhagic
Transformations after rt-PA
Natalia Rost (Boston, USA) and Paul Bentley (London, UK): Genetics of acute infarct lesions
10:00 Brief grant proposal and new member presentations
Chair Arne Lindgren (Lund, Sweden), Jennifer Majersik (Salt Lake City, USA)
- Agniezska Slowik (Krakow, Poland): Brief update from Outreach Committee
- Michelangelo Mancusi (Pisa, Italy): Mitochondria, mitochondrial DNA and stroke
- Foad Abd-Allah (Cairo, Egypt): Genetics of carotid atherosclerosis in Egypt
- Lawrence Wee (Singapore): Machine Learning for Stroke GWAS: Opportunities and Challenges
- Jin-Moo Lee (St Louis, USA): Quantitative CT imaging endophenotypes: Genetics of cerebral
edema following acute ischemic stroke
- Guido Falcone (Boston, USA): R24 proposal for a centralized stroke genetics repository
- Dan Woo (Cincinnati, USA) and Paul Nyquist (Baltimore, USA): Brief update on Utah grant
proposal workshop
11:10 Coffee Break
11:30 Invited lecture: Josée Dupuis (Boston, USA): Association and meta-analysis strategies for rare
variants
Chair Sudha Seshadri (Boston, USA)
12:00 Rare variant analyses: what can we learn from our initial experience?
Chairs Paul de Bakker (Utrecht, Netherlands) and Jonathan Rosand (Boston, USA)
- Anna Bersano (Milano, Italy): Targeted sequencing in sporadic lacunar stroke in Lombardia
- Guillaume Paré (Hamilton, Canada): Rare variants and small vessel disease stroke, an extreme
phenotype approach (the INTERSTROKE study)
- Myriam Fornage (Houston, USA) and Josh Bis (Seattle, USA): Whole exome sequence analysis of
hippocampal volume in CHARGE
- Paul de Bakker (Utrecht, NL) : Genome of the Netherlands project
13:30 Lunch
14:30 Translational projects and large-scale biobanking projects
Chair Chris Anderson (Boston, USA)
- Chris Anderson (Boston, USA): Report from the Function Genomics Working Group
- Johan Bjorkegren (NY, USA): Toward Diagnostics and Therapies of Molecularly Defined
Subcategories of Coronary Artery Disease Patients -The Stockholm-Tartu Atherosclerosis
Reverse Network Engineering Task (STARNET)
- David Tregouet (Paris, France): DNA methylation and cardiovascular phenotypes
- Fadi Charchar (Melbourne, Australia): Functional genomics in cardiovascular disease
- Cathie Sudlow (Edinburgh, UK): UK biobank and stroke related projects
16:15 Coffee Break
16:30 Point-Counterpoint Roundtable & Debate
Chairs Guillaume Paré (Hamilton, Canada) and Stéphanie Debette (Bordeaux, France)
- Point-Counterpoint: Where should the money go? Bigger samples and GWAS versus existing
samples and novel approaches (NGS, epigenetics, etc.)
Paul de Bakker, François Cambien, Donna Chen (TBC), Josée Dupuis, Myriam Fornage, Steven
Kittner, Jane Maguire, Rainer Malik, Hugh Markus, Jonathan Rosand, Sudha Seshadri, Dan Woo,
Brad Worrall
17:15 Introduction to next meeting, Hamilton, Canada, by Guillaume Paré
17:30 General Assemblee, Jane Maguire
18:00 End of meeting
Visit and Dinner