Program Schedule
Wednesday, November 5
5:00 pm – 8:00 pm
Registration
Woodrow Wilson Lobby
Thursday, November 6
7:00 am – 6:30 pm
Registration
5:15 pm – 6:00 pm
State of SITC: Membership Business Meeting
6:00 pm – 7:30 pm
6:00 pm – 7:30 pm
SITC Annual Meeting Welcome Reception
Speed Networking Event
Woodrow Wilson Lobby
Woodrow Wilson A
Woodrow Wilson Lobby
Annapolis Rooms
Friday, November 7
7:00 am – 6:30 pm
Registration
Woodrow Wilson Lobby
7:00 am – 8:00 am
General Breakfast
Woodrow Wilson Lobby
7:15 am – 8:00 am
Meet-the-Expert Breakfast (Early Career Scientist Event)
0 AMA PRA Category 1 Credits™ (not CME-certified)
Presidential Welcome and Update Session
.5 AMA PRA Category 1 Credits™
Presidential Welcome
Francesco M. Marincola, MD – Sidra Medical and Research Center
Update Session: U.S. Food and Drug Administration
Raj K. Puri, MD, PhD – U.S. Food and Drug Administration
Update Session: National Cancer Institute
William D. Merritt, PhD – National Cancer Institute
8:00 am – 8:35 am
8:00 am – 8:05 am
8:05 am – 8:20 am
8:20 am – 8:35 am
Baltimore 1-2
Woodrow Wilson A-D
SITC welcomes attendees to take advantage
of the official SITC 2014 Meeting App. The app
allows attendees to have the most up-to-date
SITC 2014 information as well as provides
note-taking and networking features.
About Annual Meeting
To download the SITC 2014
App, please scan the QR code
or visit:
www.eventscribe.com/2014/
sitc/aaConferenceApp.asp
• App Store (iOS)
• Google Play (Android)
SITC 2014 Meeting App generously supported by Genentech, Inc. & Novartis Oncology
sitc 2014
40
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
Program Schedule
Friday, November 7 (continued)
8:35 am – 9:25 am
8:35 am – 8:40 am
8:40 am – 9:25 am
9:25 am – 12:00 pm
9:25 am – 9:30 am
9:30 am – 9:55 am
9:55 am – 10:20 am
Richard V. Smalley, MD Memorial Lectureship:
Cancer as a Disease of the Metaorganism
.75 AMA PRA Category 1 Credits™
Introduction
Francesco M. Marincola, MD – Sidra Medical and Research Center
Cancer as a Disease of the Metaorganism
Giorgio Trinchieri, MD – National Cancer Institute
Inflammation, Innate Immunity and Microbiome
2.25 AMA PRA Category 1 Credits”
Co-Chairs:
Marco Colonna, MD – Washington University
William J. Murphy, PhD – University of California-Davis
Session Overview
William J. Murphy, PhD – University of California-Davis
Natural Killer Cell Subsets in Immune Regulation and Tumor
Immunity
William J. Murphy, PhD – University of California-Davis
Natural Killer Cells and Innate Lymphoid Cells in Inflammation
and Cancer
Marco Colonna, MD – Washington University
Break
10:40 am – 10:55 am
Direct Activation of STING in the Tumor Microenvironment with
Synthetic Cyclic Dinucleotide Derivatives Leads to Potent and
Systemic Tumor-Specific Immunity
Leticia Corrales, PhD – University of Chicago
Evidence Implicating the Commensal Microbiota in Shaping AntiTumor Immunity in Melanoma
Ayelet Sivan – University of Chicago
The Role of the Intestinal Microbiome on GVHD
Marcel R.M. van den Brink, MD, PhD – Memorial Sloan-Kettering
Cancer Center
Roles of the Microbiota in Immunity and Inflammation
Yasmine Belkaid, PhD – National Institutes of Health
Late-Breaking Abstract Session
0 AMA PRA Category 1 Credits™ (not CME-certified)
TCR Repertoire Divergence Reflects Microenvironmental
Immune Phenotypes in Glioma
Jennifer Sims, PhD – Columbia University
Activation of Toll-Like Receptor-2 by Tumor Associated Matrix
Metalloproteinase-2 Modulates Dendritic Cell Function
Nina Bhardwaj, MD PhD – Icahn School of Medicine at Mt. Sinai
Lunch, Poster Viewing and Exhibits
Oral Poster Session 12:50 pm – 1:40 pm
See the Poster Book for full listing of presentations
10:55 am – 11:10 am
11:10 am – 11:35 am
11:35 am – 12:00 pm
12:00 pm – 12:30 pm
12:00 pm – 12:15 pm
12:15 pm – 12:30 pm
12:30 pm – 2:00 pm
sitc 2014
41
Woodrow Wilson A-D
Woodrow Wilson A-D
Prince George’s
Exhibit Hall C
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
About Annual Meeting
10:20 am – 10:40 am
Woodrow Wilson A-D
Program Schedule
Friday, November 7 (continued)
2:00 pm – 4:15 pm
2:00 pm – 2:05 pm
2:05 pm – 2:30 pm
2:30 pm – 2:55 pm
2:55 pm – 3:10 pm
3:10 pm – 3:25 pm
3:25 pm – 3:50 pm
3:50 pm – 4:15 pm
4:15 pm – 4:45 pm
4:45 pm – 6:10 pm
About Annual Meeting
4:45 pm – 4:50 pm
4:50 pm – 5:10 pm
5:10 pm – 5:35 pm
sitc 2014
Lung Cancer: Immunology and Immunotherapy
2.25 AMA PRA Category 1 Credits™
Co-Chairs:
Roy S. Herbst, MD, PhD – Yale Cancer Center
Laurence Zitvogel, MD, PhD – Institute Gustave Roussy
Session Overview
Laurence Zitvogel, MD, PhD – Institute Gustave Roussy
Personalizing Lung Cancer Immunotherapy
Laurence Zitvogel, MD, PhD – Institute Gustave Roussy
Personalized Immunotherapy for Non-Small Cell Lung Cancer
Roy S. Herbst, MD, PhD – Yale Cancer Center
TG4010 Immunotherapy Combined with First-Line Therapy
in Advanced Non-Small Cell Lung Cancer (NSCLC): Phase IIb
Results of the TIME Study
John Nemunaitis, MD – Mary Crowley Medical Research Center
PD-L1 Expression Correlates with Immune Response in a Phase
I Trial of CCL21 Gene Modified Dendritic Cell Therapy in Lung
Cancer
Jay M. Lee, MD – University of California, Los Angeles
Manipulating Tumor-Immune Cell Interactions in NSCLC
Mikael J. Pittet, PhD – Mass General Hospital
PD-1 Immune Checkpoint Blockade: Patient Characteristics and
Biomarkers Associated with Response
Julie R. Brahmer, MD – Sidney Kimmel Comprehensive Cancer
Center at Johns Hopkins
Break
Concurrent Session — Tumor Microenvironment and
Immunosuppression
1.5 AMA PRA Category 1 Credits™
Co-Chairs:
Suzanne Ostrand-Rosenberg, PhD – University of Maryland
Baltimore County
Weiping Zou, MD, PhD – University of Michigan
Session Overview
Suzanne Ostrand-Rosenberg, PhD – University of Maryland
Baltimore County
Neutralizing Immune Suppression in the Tumor Microenvironment
Suzanne Ostrand-Rosenberg, PhD – University of Maryland
Baltimore County
Integrating Immunoregulatory and Vascular Signaling Programs
Through Lectin-Glycan Interactions
Gabriel A. Rabinovich, PhD – Instituto de Biología y Medicina
Experimental (IBYME)
42
Woodrow Wilson A-D
Prince George’s Exhibit
Hall C
Woodrow Wilson A
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
Program Schedule
Friday, November 7 (continued)
5:35 pm – 5:55 pm
6:10 pm – 7:30 pm
Immune Impact on Cancer Stemness
Weiping Zou, MD, PhD – University of Michigan
FcgRIIIA (CD16)-Expressing Monocytes Mediate the Depletion
of Tumor-Infiltrating Tregs Via Ipilimumab-Dependent ADCC in
Melanoma Patients
Emanuela Romano, MD, PhD – University Hospital of Lausanne
Concurrent Session — Immunopotentiation by
Radiotherapy: Mechanisms and Opportunities
1.5 AMA PRA Category 1 Credits™
Co-Chairs:
Sandra Demaria, MD – New York University
Susan Knox, MD, PhD – Stanford University
Session Overview
Susan Knox, MD, PhD – Stanford University
New Directions with NKT Cells and Nanoscale Flow Cytometry
Jennifer Clare Jones, MD, PhD – National Cancer Institute
Radiotherapy with TGF-β Blockade Jump-Starts Tumor-Specific T
Cells and Immune Checkpoint Inhibitors Keep Them Going
Sandra Demaria, MD – New York University
The Anti-Tumor Immune Response Generated by Radiation
Therapy May be Limited by Tumor Cell Adaptive Resistance and
Can be Circumvented by PD-L1 blockade
Simon Dovedi, PhD, MSc, BSC – University of Manchester
CD47 Limits Cooperation between Adaptive Tumor Immunity
and Radiation Therapy
David D. Roberts, PhD – National Cancer Institute
Poster Reception and Poster Viewing
8:00 pm – 10:00 pm
Early Career Scientist Networking Event
5:55 pm – 6:10 pm
4:45 pm – 6:10 pm
4:45 pm – 4:50 pm
4:50 pm – 5:15 pm
5:15 pm – 5:40 pm
5:40 pm – 5:55 pm
5:55 pm – 6:10 pm
Woodrow Wilson B-D
Prince George’s
Exhibit Hall C
Annapolis Rooms
Saturday, November 8
7:00 am – 5:30 pm
Registration
Woodrow Wilson Lobby
7:00 am – 8:00 am
General Breakfast
Woodrow Wilson Lobby
8:00 am – 8:35 am
Welcome and Update Session
.5 AMA PRA Category 1 Credits™
Welcome and Overview
8:00 am – 8:05 am
8:10 am – 8:35 am
sitc 2014
Update Session: SITC Biomarkers Task Force
Lisa H. Butterfield, PhD – University of Pittsburgh
Update Session: Cancer Immunotherapy Trials Network
Martin A. Cheever, MD – Fred Hutchinson Cancer Research Center
43
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
About Annual Meeting
8:05 am – 8:10 am
Woodrow Wilson A-D
Program Schedule
Saturday, November 8 (continued)
8:35 am – 9:25 am
9:25 am – 12:00 pm
9:25 am – 9:45 am
9:45 am – 10:05 am
10:05 am – 10:25 am
10:25 am – 10:45 am
10:45 am – 11:00 am
11:00 am – 11:15 am
11:15 am – 11:35 am
11:35 am – 11:55 am
11:55 am – 12:00 pm
12:00 pm – 12:30 pm
About Annual Meeting
12:00 pm – 12:15 pm
sitc 2014
Keynote Address
.75 AMA PRA Category 1 Credits™
Prophylactic Cancer Vaccines: Feasibility and Progress
Olivera J. Finn, PhD – University of Pittsburgh
Barriers to Successful Vaccines
2.25 AMA PRA Category 1 Credits™
Co-Chairs:
Jonathan L. Bramson, PhD – McMaster University
Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the
University of Lausanne
Session Overview
Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the
University of Lausanne
Immunotherapy and the Immunosuppressive Tumor Network
Gosse J. Adema, PhD – Radboud University Medical Center
Antigen-Specific T Cell Responses to Breast Cancer
Jill E. Slansky, PhD – University of Colorado
Break
Functional Redundancy of PI3K Isoforms in Conventional T Cells
Provides a Selective Treg-Targeting Strategy Through Inhibition of
PI3K-Delta Isoform
Shamim Ahmad, PhD – Georgia Regents University Cancer Center
Vaccine Targeting HIF1A in Triple Negative Breast Cancer
Mary L. Disis, MD, FACP – University of Washington
Local, Regional, and Systemic Effects of TLR Agonists and IFA as
Adjuvants for Peptide Vaccines
Craig L. Slingluff, Jr., MD – University of Virginia
The Use of Peptides in the Therapeutic Vaccination of Cancer
Hans-Georg Rammensee, PhD – Universitäet Tüebingen
Closing Remarks
Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the
University of Lausanne
Late-Breaking Abstract Session
0 AMA PRA Category 1 Credits™ (not CME-certified)
DNA Vaccine VGX-3100 with Electroporation Induces
Regression of Cervical Intraepithelial Neoplasia 2/3 and Clears
HPV Infection with Robust T Cell Responses: Results of a
Randomized, Double-Blind, Placebo-Controlled Phase II Trial
Laurent M. Humeau, PhD – Inovio Pharmaceuticals
44
Woodrow Wilson A-D
Woodrow Wilson A-D
Woodrow Wilson A-D
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
Program Schedule
Saturday, November 8 (continued)
12:15 pm – 12:30 pm
12:30 pm – 2:00 pm
2:00 pm – 3:05 pm
2:00 pm – 2:05 pm
2:05 pm – 2:20 pm
2:20 pm – 2:35 pm
2:35 pm – 2:50 pm
2:50 pm – 3:05 pm
3:05 pm – 3:25 pm
3:25 pm – 4:00 pm
4:00 pm – 5:25 pm
sitc 2014
Concurrent Session — Coinhibition and Costimulation:
Targets and Strategies
1.5 AMA PRA Category 1 Credits™
Co-Chairs:
Walter J. Urba, MD, PhD – Earle A. Chiles Research Institute,
Providence Cancer Center
Robert H.Vonderheide, MD, DPhil – University of Pennsylvania
Session Overview
Walter J. Urba, MD, PhD – Earle A. Chiles Research Institute,
Providence Cancer Center
45
Prince George’s
Exhibit Hall C
Woodrow Wilson A-D
Woodrow Wilson A-D
Prince George’s
Exhibit Hall C
Woodrow Wilson A
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
About Annual Meeting
4:00 pm – 4:05 pm
OX40 Agonist Immunotherapy Expands Tumor Reactive CD8 T
Cells with a Unique T Cell Receptor Repertoire and Synergizes
with PDL1 Blockade to Promote Tumor Regression
Amy E. Moran, PhD – Earle A. Chiles Cancer Research Institute,
Providence Cancer Center
Lunch, Poster Viewing and Exhibits
Oral Poster Session 12:50 pm – 1:50 pm
See the Poster Book for full listing of presentations
Presidential Session
1.0 AMA PRA Category 1 Credits™
Introduction
Francesco M. Marincola, MD – Sidra Medical and Research Center
Tumor Derived Stress Triggers C/EBPβ Homologous Protein
(CHOP) Expression in Myeloid Derived Suppressor Cells
(MDSC) and Mediates Immunosuppressive Activity
Paul Thevenot, PhD – Stanley S. Scott Cancer Center, Louisiana State
University Health Sciences Center
Mechanisms of TIGIT-Driven Immune Suppression in Cancer
Sema Kurtulus, PhD – Center for Neurologic Diseases Brigham &
Women’s Hospital
Melanoma-Intrinsic B-Catenin Signaling Prevents T Cell
Infiltration and Anti-Tumor Immunity
Stefani Spranger, PhD – University of Chicago
Pre-Clinical Validation of a Humanized Anti-EGFR Variant III
Chimeric Antigen Receptor and Phase I Trial of CART-EGFRvIII in
Glioblastoma
Marcela Maus, MD, PhD – University of Pennsylvania
Immunoscore Update
.25 AMA PRA Category 1 Credits™
Bernard A. Fox, PhD – Earle A. Chiles Cancer Research Institute,
Providence Cancer Center
Break
Program Schedule
Saturday, November 8 (continued)
4:05 pm – 4:30 pm
5:30 pm – 6:00 pm
6:00 pm – 7:30 pm
OX40 Immunotherapy in Cancer Patients: Immunological
Observations and Implications for T Cell Immunotherapy
Brendan D. Curti, MD – Earle A. Chiles Research Institute, Providence
Cancer Center
Distinct Immunologic Changes In Vivo Following Combination
Versus Individual PD-1 or CTLA-4 Checkpoint Blockade in
Human Cancer
Kavita Dhodapkar, MD – Yale University
Melanoma Progression is Associated with NK Cell Exhaustion
Ines Pires da Silva, MD – New York University Cancer Center
CD40 Agonists in Cancer Immunotherapy
Robert H.Vonderheide, MD, DPhil – University of Pennsylvania
Concurrent Session — High Throughput Technologies:
Determinants of the Immune Response to Cancer
1.5 AMA PRA Category 1 Credits™
Co-Chairs:
Katherine L. Nathanson, MD – University of Pennsylvania
Paul F. Robbins, PhD – National Institutes of Health/National Cancer
Institute
Session Overview
Katherine L. Nathanson, MD – University of Pennsylvania
Use of High Throughput Sequencing to Identify Mutated Tumor
Antigens
Paul F. Robbins, PhD – National Institutes of Health/National Cancer
Institute
Inherited Genetic Response
Kevin M. Brown, PhD – National Cancer Institute
Single Cell Functional Analysis Provides Insights into Cancer
Patient Responses, including the Development of Resistance, to
Cell-Based and Combination Immunotherapies
James R. Heath, PhD – California Institute of Technology
T Cell Receptor Diversity Evaluation to Predict Patient
Response to Ipilimumab in Metastatic Melanoma
Michael Postow, MD – Memorial Sloan-Kettering Cancer Center
Award Presentation
Presidential Reception
6:10 pm – 7:30 pm
Poster Viewing
8:00 pm – 11:00 pm
The CheckPoints Party
4:30 pm – 4:45 pm
4:45 pm – 5:00 pm
5:00 pm – 5:25 pm
4:00 pm – 5:25 pm
4:00 pm – 4:05 pm
4:05 pm – 4:30 pm
4:30 pm – 4:50 pm
4:50 pm – 5:10 pm
About Annual Meeting
5:10 pm – 5:25 pm
sitc 2014
46
Woodrow Wilson B-D
Woodrow Wilson A
Prince George’s
Exhibit Hall C
Prince George’s
Exhibit Hall C
Woodrow Wilson
Ballroom
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
Program Schedule
Sunday, November 9
7:30 am – 12:00 pm
7:00 am – 8:00 am
8:00 am – 10:15 am
8:00 am – 8:05 am
8:05 am – 8:30 am
8:30 am – 8:55 am
8:55 am – 9:10 am
9:10 am – 9:25 am
9:25 am – 9:50 am
9:50 am – 10:15 am
10:15 am
Registration
General Breakfast
Adoptive Immunotherapy
2.25 AMA PRA Category 1 Credits™
Co-Chairs:
Helen E. Heslop, MD – Baylor College of Medicine
Per thor Straten, PhD – Centre for Cancer Immune Therapy (CCIT)
Session Overview
Helen E. Heslop, MD – Baylor College of Medicine
Moving Tumor Infiltrating Lymphocytes and Biomarkers Forward
Patrick Hwu, MD – University of Texas, MD Anderson Cancer Center
Melanoma Therapy using Adoptive Transfer of Expanded Tumor
Infiltrating T cells; Prospects and Pitfalls
Per thor Straten, PhD – Centre for Cancer Immune Therapy (CCIT)
Toward Cell Transfer Immunotherapy Against Patient-Specific
Mutations in Gastrointestinal Cancers
Eric Tran, PhD – National Insitutes of Health/National Cancer
Institute
Modulating Immunometabolism of Tumor Specific CD8 T Cells
to Enhance T Cell Based Therapy for Cancer
Madhusudhanan Sukumar, PhD – National Cancer Institute
Enhancing the IQ of CAR T Cells
Michael C.V. Jensen, MD – University of Washington
CAR Therapy: The CD19 Paradigm
Michel Sadelain, MD, PhD – Memorial Sloan-Kettering Cancer
Center
Annual Meeting Adjourns
Woodrow Wilson Lobby
Woodrow Wilson Lobby
Woodrow Wilson A-D
Hot Topic Symposia
10:30 am - 12:00 pm
Free for Annual Meeting attendees! (Separate registration is required)
Inquire at the Registration Desk for more details.
Professional Development Session: A Roadmap for Thriving in Your Career
12:05 pm - 3:30 pm
(Separate registration is required)
sitc 2014
47
November 7-9, 2014 • National Harbor, MD
29TH ANNUAL MEETING
About Annual Meeting
Symposium Topics
• Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies
• Hot Topic Symposium II: Managing Engineered T Cell Toxicities