Program Schedule
Program Schedule Wednesday, November 5 5:00 pm – 8:00 pm Registration Woodrow Wilson Lobby Thursday, November 6 7:00 am – 6:30 pm Registration 5:15 pm – 6:00 pm State of SITC: Membership Business Meeting 6:00 pm – 7:30 pm 6:00 pm – 7:30 pm SITC Annual Meeting Welcome Reception Speed Networking Event Woodrow Wilson Lobby Woodrow Wilson A Woodrow Wilson Lobby Annapolis Rooms Friday, November 7 7:00 am – 6:30 pm Registration Woodrow Wilson Lobby 7:00 am – 8:00 am General Breakfast Woodrow Wilson Lobby 7:15 am – 8:00 am Meet-the-Expert Breakfast (Early Career Scientist Event) 0 AMA PRA Category 1 Credits™ (not CME-certified) Presidential Welcome and Update Session .5 AMA PRA Category 1 Credits™ Presidential Welcome Francesco M. Marincola, MD – Sidra Medical and Research Center Update Session: U.S. Food and Drug Administration Raj K. Puri, MD, PhD – U.S. Food and Drug Administration Update Session: National Cancer Institute William D. Merritt, PhD – National Cancer Institute 8:00 am – 8:35 am 8:00 am – 8:05 am 8:05 am – 8:20 am 8:20 am – 8:35 am Baltimore 1-2 Woodrow Wilson A-D SITC welcomes attendees to take advantage of the official SITC 2014 Meeting App. The app allows attendees to have the most up-to-date SITC 2014 information as well as provides note-taking and networking features. About Annual Meeting To download the SITC 2014 App, please scan the QR code or visit: www.eventscribe.com/2014/ sitc/aaConferenceApp.asp • App Store (iOS) • Google Play (Android) SITC 2014 Meeting App generously supported by Genentech, Inc. & Novartis Oncology sitc 2014 40 November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING Program Schedule Friday, November 7 (continued) 8:35 am – 9:25 am 8:35 am – 8:40 am 8:40 am – 9:25 am 9:25 am – 12:00 pm 9:25 am – 9:30 am 9:30 am – 9:55 am 9:55 am – 10:20 am Richard V. Smalley, MD Memorial Lectureship: Cancer as a Disease of the Metaorganism .75 AMA PRA Category 1 Credits™ Introduction Francesco M. Marincola, MD – Sidra Medical and Research Center Cancer as a Disease of the Metaorganism Giorgio Trinchieri, MD – National Cancer Institute Inflammation, Innate Immunity and Microbiome 2.25 AMA PRA Category 1 Credits” Co-Chairs: Marco Colonna, MD – Washington University William J. Murphy, PhD – University of California-Davis Session Overview William J. Murphy, PhD – University of California-Davis Natural Killer Cell Subsets in Immune Regulation and Tumor Immunity William J. Murphy, PhD – University of California-Davis Natural Killer Cells and Innate Lymphoid Cells in Inflammation and Cancer Marco Colonna, MD – Washington University Break 10:40 am – 10:55 am Direct Activation of STING in the Tumor Microenvironment with Synthetic Cyclic Dinucleotide Derivatives Leads to Potent and Systemic Tumor-Specific Immunity Leticia Corrales, PhD – University of Chicago Evidence Implicating the Commensal Microbiota in Shaping AntiTumor Immunity in Melanoma Ayelet Sivan – University of Chicago The Role of the Intestinal Microbiome on GVHD Marcel R.M. van den Brink, MD, PhD – Memorial Sloan-Kettering Cancer Center Roles of the Microbiota in Immunity and Inflammation Yasmine Belkaid, PhD – National Institutes of Health Late-Breaking Abstract Session 0 AMA PRA Category 1 Credits™ (not CME-certified) TCR Repertoire Divergence Reflects Microenvironmental Immune Phenotypes in Glioma Jennifer Sims, PhD – Columbia University Activation of Toll-Like Receptor-2 by Tumor Associated Matrix Metalloproteinase-2 Modulates Dendritic Cell Function Nina Bhardwaj, MD PhD – Icahn School of Medicine at Mt. Sinai Lunch, Poster Viewing and Exhibits Oral Poster Session 12:50 pm – 1:40 pm See the Poster Book for full listing of presentations 10:55 am – 11:10 am 11:10 am – 11:35 am 11:35 am – 12:00 pm 12:00 pm – 12:30 pm 12:00 pm – 12:15 pm 12:15 pm – 12:30 pm 12:30 pm – 2:00 pm sitc 2014 41 Woodrow Wilson A-D Woodrow Wilson A-D Prince George’s Exhibit Hall C November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING About Annual Meeting 10:20 am – 10:40 am Woodrow Wilson A-D Program Schedule Friday, November 7 (continued) 2:00 pm – 4:15 pm 2:00 pm – 2:05 pm 2:05 pm – 2:30 pm 2:30 pm – 2:55 pm 2:55 pm – 3:10 pm 3:10 pm – 3:25 pm 3:25 pm – 3:50 pm 3:50 pm – 4:15 pm 4:15 pm – 4:45 pm 4:45 pm – 6:10 pm About Annual Meeting 4:45 pm – 4:50 pm 4:50 pm – 5:10 pm 5:10 pm – 5:35 pm sitc 2014 Lung Cancer: Immunology and Immunotherapy 2.25 AMA PRA Category 1 Credits™ Co-Chairs: Roy S. Herbst, MD, PhD – Yale Cancer Center Laurence Zitvogel, MD, PhD – Institute Gustave Roussy Session Overview Laurence Zitvogel, MD, PhD – Institute Gustave Roussy Personalizing Lung Cancer Immunotherapy Laurence Zitvogel, MD, PhD – Institute Gustave Roussy Personalized Immunotherapy for Non-Small Cell Lung Cancer Roy S. Herbst, MD, PhD – Yale Cancer Center TG4010 Immunotherapy Combined with First-Line Therapy in Advanced Non-Small Cell Lung Cancer (NSCLC): Phase IIb Results of the TIME Study John Nemunaitis, MD – Mary Crowley Medical Research Center PD-L1 Expression Correlates with Immune Response in a Phase I Trial of CCL21 Gene Modified Dendritic Cell Therapy in Lung Cancer Jay M. Lee, MD – University of California, Los Angeles Manipulating Tumor-Immune Cell Interactions in NSCLC Mikael J. Pittet, PhD – Mass General Hospital PD-1 Immune Checkpoint Blockade: Patient Characteristics and Biomarkers Associated with Response Julie R. Brahmer, MD – Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Break Concurrent Session — Tumor Microenvironment and Immunosuppression 1.5 AMA PRA Category 1 Credits™ Co-Chairs: Suzanne Ostrand-Rosenberg, PhD – University of Maryland Baltimore County Weiping Zou, MD, PhD – University of Michigan Session Overview Suzanne Ostrand-Rosenberg, PhD – University of Maryland Baltimore County Neutralizing Immune Suppression in the Tumor Microenvironment Suzanne Ostrand-Rosenberg, PhD – University of Maryland Baltimore County Integrating Immunoregulatory and Vascular Signaling Programs Through Lectin-Glycan Interactions Gabriel A. Rabinovich, PhD – Instituto de Biología y Medicina Experimental (IBYME) 42 Woodrow Wilson A-D Prince George’s Exhibit Hall C Woodrow Wilson A November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING Program Schedule Friday, November 7 (continued) 5:35 pm – 5:55 pm 6:10 pm – 7:30 pm Immune Impact on Cancer Stemness Weiping Zou, MD, PhD – University of Michigan FcgRIIIA (CD16)-Expressing Monocytes Mediate the Depletion of Tumor-Infiltrating Tregs Via Ipilimumab-Dependent ADCC in Melanoma Patients Emanuela Romano, MD, PhD – University Hospital of Lausanne Concurrent Session — Immunopotentiation by Radiotherapy: Mechanisms and Opportunities 1.5 AMA PRA Category 1 Credits™ Co-Chairs: Sandra Demaria, MD – New York University Susan Knox, MD, PhD – Stanford University Session Overview Susan Knox, MD, PhD – Stanford University New Directions with NKT Cells and Nanoscale Flow Cytometry Jennifer Clare Jones, MD, PhD – National Cancer Institute Radiotherapy with TGF-β Blockade Jump-Starts Tumor-Specific T Cells and Immune Checkpoint Inhibitors Keep Them Going Sandra Demaria, MD – New York University The Anti-Tumor Immune Response Generated by Radiation Therapy May be Limited by Tumor Cell Adaptive Resistance and Can be Circumvented by PD-L1 blockade Simon Dovedi, PhD, MSc, BSC – University of Manchester CD47 Limits Cooperation between Adaptive Tumor Immunity and Radiation Therapy David D. Roberts, PhD – National Cancer Institute Poster Reception and Poster Viewing 8:00 pm – 10:00 pm Early Career Scientist Networking Event 5:55 pm – 6:10 pm 4:45 pm – 6:10 pm 4:45 pm – 4:50 pm 4:50 pm – 5:15 pm 5:15 pm – 5:40 pm 5:40 pm – 5:55 pm 5:55 pm – 6:10 pm Woodrow Wilson B-D Prince George’s Exhibit Hall C Annapolis Rooms Saturday, November 8 7:00 am – 5:30 pm Registration Woodrow Wilson Lobby 7:00 am – 8:00 am General Breakfast Woodrow Wilson Lobby 8:00 am – 8:35 am Welcome and Update Session .5 AMA PRA Category 1 Credits™ Welcome and Overview 8:00 am – 8:05 am 8:10 am – 8:35 am sitc 2014 Update Session: SITC Biomarkers Task Force Lisa H. Butterfield, PhD – University of Pittsburgh Update Session: Cancer Immunotherapy Trials Network Martin A. Cheever, MD – Fred Hutchinson Cancer Research Center 43 November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING About Annual Meeting 8:05 am – 8:10 am Woodrow Wilson A-D Program Schedule Saturday, November 8 (continued) 8:35 am – 9:25 am 9:25 am – 12:00 pm 9:25 am – 9:45 am 9:45 am – 10:05 am 10:05 am – 10:25 am 10:25 am – 10:45 am 10:45 am – 11:00 am 11:00 am – 11:15 am 11:15 am – 11:35 am 11:35 am – 11:55 am 11:55 am – 12:00 pm 12:00 pm – 12:30 pm About Annual Meeting 12:00 pm – 12:15 pm sitc 2014 Keynote Address .75 AMA PRA Category 1 Credits™ Prophylactic Cancer Vaccines: Feasibility and Progress Olivera J. Finn, PhD – University of Pittsburgh Barriers to Successful Vaccines 2.25 AMA PRA Category 1 Credits™ Co-Chairs: Jonathan L. Bramson, PhD – McMaster University Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the University of Lausanne Session Overview Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the University of Lausanne Immunotherapy and the Immunosuppressive Tumor Network Gosse J. Adema, PhD – Radboud University Medical Center Antigen-Specific T Cell Responses to Breast Cancer Jill E. Slansky, PhD – University of Colorado Break Functional Redundancy of PI3K Isoforms in Conventional T Cells Provides a Selective Treg-Targeting Strategy Through Inhibition of PI3K-Delta Isoform Shamim Ahmad, PhD – Georgia Regents University Cancer Center Vaccine Targeting HIF1A in Triple Negative Breast Cancer Mary L. Disis, MD, FACP – University of Washington Local, Regional, and Systemic Effects of TLR Agonists and IFA as Adjuvants for Peptide Vaccines Craig L. Slingluff, Jr., MD – University of Virginia The Use of Peptides in the Therapeutic Vaccination of Cancer Hans-Georg Rammensee, PhD – Universitäet Tüebingen Closing Remarks Daniel E. Speiser, MD – Ludwig Center for Cancer Research of the University of Lausanne Late-Breaking Abstract Session 0 AMA PRA Category 1 Credits™ (not CME-certified) DNA Vaccine VGX-3100 with Electroporation Induces Regression of Cervical Intraepithelial Neoplasia 2/3 and Clears HPV Infection with Robust T Cell Responses: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial Laurent M. Humeau, PhD – Inovio Pharmaceuticals 44 Woodrow Wilson A-D Woodrow Wilson A-D Woodrow Wilson A-D November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING Program Schedule Saturday, November 8 (continued) 12:15 pm – 12:30 pm 12:30 pm – 2:00 pm 2:00 pm – 3:05 pm 2:00 pm – 2:05 pm 2:05 pm – 2:20 pm 2:20 pm – 2:35 pm 2:35 pm – 2:50 pm 2:50 pm – 3:05 pm 3:05 pm – 3:25 pm 3:25 pm – 4:00 pm 4:00 pm – 5:25 pm sitc 2014 Concurrent Session — Coinhibition and Costimulation: Targets and Strategies 1.5 AMA PRA Category 1 Credits™ Co-Chairs: Walter J. Urba, MD, PhD – Earle A. Chiles Research Institute, Providence Cancer Center Robert H.Vonderheide, MD, DPhil – University of Pennsylvania Session Overview Walter J. Urba, MD, PhD – Earle A. Chiles Research Institute, Providence Cancer Center 45 Prince George’s Exhibit Hall C Woodrow Wilson A-D Woodrow Wilson A-D Prince George’s Exhibit Hall C Woodrow Wilson A November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING About Annual Meeting 4:00 pm – 4:05 pm OX40 Agonist Immunotherapy Expands Tumor Reactive CD8 T Cells with a Unique T Cell Receptor Repertoire and Synergizes with PDL1 Blockade to Promote Tumor Regression Amy E. Moran, PhD – Earle A. Chiles Cancer Research Institute, Providence Cancer Center Lunch, Poster Viewing and Exhibits Oral Poster Session 12:50 pm – 1:50 pm See the Poster Book for full listing of presentations Presidential Session 1.0 AMA PRA Category 1 Credits™ Introduction Francesco M. Marincola, MD – Sidra Medical and Research Center Tumor Derived Stress Triggers C/EBPβ Homologous Protein (CHOP) Expression in Myeloid Derived Suppressor Cells (MDSC) and Mediates Immunosuppressive Activity Paul Thevenot, PhD – Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center Mechanisms of TIGIT-Driven Immune Suppression in Cancer Sema Kurtulus, PhD – Center for Neurologic Diseases Brigham & Women’s Hospital Melanoma-Intrinsic B-Catenin Signaling Prevents T Cell Infiltration and Anti-Tumor Immunity Stefani Spranger, PhD – University of Chicago Pre-Clinical Validation of a Humanized Anti-EGFR Variant III Chimeric Antigen Receptor and Phase I Trial of CART-EGFRvIII in Glioblastoma Marcela Maus, MD, PhD – University of Pennsylvania Immunoscore Update .25 AMA PRA Category 1 Credits™ Bernard A. Fox, PhD – Earle A. Chiles Cancer Research Institute, Providence Cancer Center Break Program Schedule Saturday, November 8 (continued) 4:05 pm – 4:30 pm 5:30 pm – 6:00 pm 6:00 pm – 7:30 pm OX40 Immunotherapy in Cancer Patients: Immunological Observations and Implications for T Cell Immunotherapy Brendan D. Curti, MD – Earle A. Chiles Research Institute, Providence Cancer Center Distinct Immunologic Changes In Vivo Following Combination Versus Individual PD-1 or CTLA-4 Checkpoint Blockade in Human Cancer Kavita Dhodapkar, MD – Yale University Melanoma Progression is Associated with NK Cell Exhaustion Ines Pires da Silva, MD – New York University Cancer Center CD40 Agonists in Cancer Immunotherapy Robert H.Vonderheide, MD, DPhil – University of Pennsylvania Concurrent Session — High Throughput Technologies: Determinants of the Immune Response to Cancer 1.5 AMA PRA Category 1 Credits™ Co-Chairs: Katherine L. Nathanson, MD – University of Pennsylvania Paul F. Robbins, PhD – National Institutes of Health/National Cancer Institute Session Overview Katherine L. Nathanson, MD – University of Pennsylvania Use of High Throughput Sequencing to Identify Mutated Tumor Antigens Paul F. Robbins, PhD – National Institutes of Health/National Cancer Institute Inherited Genetic Response Kevin M. Brown, PhD – National Cancer Institute Single Cell Functional Analysis Provides Insights into Cancer Patient Responses, including the Development of Resistance, to Cell-Based and Combination Immunotherapies James R. Heath, PhD – California Institute of Technology T Cell Receptor Diversity Evaluation to Predict Patient Response to Ipilimumab in Metastatic Melanoma Michael Postow, MD – Memorial Sloan-Kettering Cancer Center Award Presentation Presidential Reception 6:10 pm – 7:30 pm Poster Viewing 8:00 pm – 11:00 pm The CheckPoints Party 4:30 pm – 4:45 pm 4:45 pm – 5:00 pm 5:00 pm – 5:25 pm 4:00 pm – 5:25 pm 4:00 pm – 4:05 pm 4:05 pm – 4:30 pm 4:30 pm – 4:50 pm 4:50 pm – 5:10 pm About Annual Meeting 5:10 pm – 5:25 pm sitc 2014 46 Woodrow Wilson B-D Woodrow Wilson A Prince George’s Exhibit Hall C Prince George’s Exhibit Hall C Woodrow Wilson Ballroom November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING Program Schedule Sunday, November 9 7:30 am – 12:00 pm 7:00 am – 8:00 am 8:00 am – 10:15 am 8:00 am – 8:05 am 8:05 am – 8:30 am 8:30 am – 8:55 am 8:55 am – 9:10 am 9:10 am – 9:25 am 9:25 am – 9:50 am 9:50 am – 10:15 am 10:15 am Registration General Breakfast Adoptive Immunotherapy 2.25 AMA PRA Category 1 Credits™ Co-Chairs: Helen E. Heslop, MD – Baylor College of Medicine Per thor Straten, PhD – Centre for Cancer Immune Therapy (CCIT) Session Overview Helen E. Heslop, MD – Baylor College of Medicine Moving Tumor Infiltrating Lymphocytes and Biomarkers Forward Patrick Hwu, MD – University of Texas, MD Anderson Cancer Center Melanoma Therapy using Adoptive Transfer of Expanded Tumor Infiltrating T cells; Prospects and Pitfalls Per thor Straten, PhD – Centre for Cancer Immune Therapy (CCIT) Toward Cell Transfer Immunotherapy Against Patient-Specific Mutations in Gastrointestinal Cancers Eric Tran, PhD – National Insitutes of Health/National Cancer Institute Modulating Immunometabolism of Tumor Specific CD8 T Cells to Enhance T Cell Based Therapy for Cancer Madhusudhanan Sukumar, PhD – National Cancer Institute Enhancing the IQ of CAR T Cells Michael C.V. Jensen, MD – University of Washington CAR Therapy: The CD19 Paradigm Michel Sadelain, MD, PhD – Memorial Sloan-Kettering Cancer Center Annual Meeting Adjourns Woodrow Wilson Lobby Woodrow Wilson Lobby Woodrow Wilson A-D Hot Topic Symposia 10:30 am - 12:00 pm Free for Annual Meeting attendees! (Separate registration is required) Inquire at the Registration Desk for more details. Professional Development Session: A Roadmap for Thriving in Your Career 12:05 pm - 3:30 pm (Separate registration is required) sitc 2014 47 November 7-9, 2014 • National Harbor, MD 29TH ANNUAL MEETING About Annual Meeting Symposium Topics • Hot Topic Symposium I: Accelerating Tumor Immunity with Agonist Antibodies • Hot Topic Symposium II: Managing Engineered T Cell Toxicities
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