BMES Robert A. Pritzker Distinguished Lecture
Pritzker Distinguished Lecturer:
James J. Collins, PhD
Howard Hughes Medical Institute Department of Biomedical Engineering & Center of
Synthetic Biology, Boston University
Wyss Institute for Biologically Inspired Engineering, Harvard University
Thursday, october 23, 2014
10:30am
LILA COCKRELL THEATRE,
HENRY B. GONZALES CONVENTION CENTER
Life Redesigned: The Emergence of Synthetic Biology
S
ynthetic biology is bringing together
James J. Collins is a William F. Warren Distinguished Professor, Uni-
engineers, physicists and biologists to model, design and
versity Professor, Professor of Biomedical Engineering, Professor of
construct biological circuits out of proteins, genes and
Medicine and Director of the Center of Synthetic Biology at Boston
other bits of DNA, and to use these circuits to rewire and
University. He is also a core founding faculty member of the Wyss
reprogram organisms. These re-engineered organisms are going to
Institute for Biologically Inspired Engineering at Harvard University,
change our lives in the coming years, leading to cheaper drugs, rapid
and an Investigator of the Howard Hughes Medical Institute. His
diagnostic tests, and targeted therapies to attack "superbugs". In this
research group works in synthetic biology and systems biology, with
talk, we highlight recent efforts to create synthetic gene networks
a particular focus on using network biology approaches to study an-
and programmable cells, and discuss a variety of synthetic biology
tibiotic action, bacterial defense mechanisms, and the emergence of
applications in biocomputing, biotechnology and biomedicine.
resistance. Professor Collins' patented technologies have been licensed by over 25 biotech, pharma and medical devices companies,
and he has helped to launch a number of companies, including Sample6 Technologies, Synlogic and EnBiotix. He has received numerous awards and honors, including a Rhodes Scholarship, a MacArthur
"Genius" Award, an NIH Director's Pioneer Award, a Sanofi-Institut
Pasteur Award, as well as several teaching awards. Professor Collins is an elected member of the National Academy of Sciences, the
National Academy of Engineering, the Institute of Medicine, and the
American Academy of Arts & Sciences, and a charter fellow of the
National Academy of Inventors.
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BMES 2014
special plenary session | thursday
BMES Special Interest Group: Medical Devices –
Computational Modeling and Simulation
for Medical Devices
thursday october 23, 2014
6:15PM - 7:30PM
LILA COCKRELL THEATRE
HENRY B. GONZALES
Computer Modeling and Simulation for Medical Devices
T
he BMES Medical Device Special Interest
Session Chair:
Group was formed in 2014 as a forum for medical
Walt Baxter, Medtronic Co-Chair, BMES-FDA
device biomedical engineering interests. The initial
Frontiers in Medical Devices Conference
focus, Computational Modeling and Simulation for
Medical Devices, brings together people from the medical device
and simulation software industries and academic, clinical and other
researchers to share scientific findings. Today, there are limited models that are shared publically therefore limited common understanding of simulation results and discussion of their interpretation. We
SPEAKERS:
Modeling and Simulation
for Medical Devices:
An FDA Perspective
Donna Lochner, FDA Co-Chair, BMES-FDA
aim to provide a symposium for modeling and simulation for medical
Frontiers in Medical Devices Conference
devices to promote best methods, identify credible boundary and
encourage future discovery. We focus on applications of modeling
Translation of Modeling
& Simulation Tools from Research
to R&D/Clinical Applications
and simulation that advance the design, evaluation and production of
Anthony Petrella, Colorado School of Mines
system conditions, share interpretation of simulation results, and
medical devices. This Special Session at the BMES Annual Meeting
will introduce the Medical Devices SIG and explore how modeling
and simulation can play a role in:
• ensuring the safety and effectiveness of medical devices,
• speeding the translation of academic models to clinical application,
• improving the regulatory evaluation process providing credible
methods to evaluate medical devices.
Use of Computational Modeling
in the Development of Aortic Stent
Grafts and Early Clinical
Feasibility Studies
Ben Wolf, Medtronic, Endovascular Therapies
Ensuring Models and Simulations
are Credibility for Regulatory
Decision Making
Tina Morrison, FDA
sponsored by
BMES 2014
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NIH NIBIB Lecture
NIH National Institute of Biomedical Imaging and Bioengineering Lecture:
David Kaplan, PhD
Stern Family Professor of Engineering
Professor and Chair, Department of Biomedical Engineering
Professor, Department of Chemical Engineering
Director, Bioengineering and Biotechnology Center, Tufts University
Friday, october 24, 2014
10:30AM
LILA COCKRELL THEATRE
HENRY B. GONZALES CONVENTION CENTER
Silk Biomaterials – The New Silk Road
T
he field of biomaterials and tissue
David Kaplan is a biomedical engineer who has studied biomateri-
engineering has emerged in terms of scientif-
als for his entire career. His group focuses on biopolymers and their
ic and translational impact over the past few decades
engineering for new biomaterials, covering fundamental questions
by embracing intersections between engineering,
to translational goals. He is the inaugural endowed Stern Professor
materials science, biology and medicine. We have focused our ef-
of Engineering and has been chair of the Department of Biomedical
forts on biopolymer engineering to understand structure-function re-
Engineering since its founding in 2002. His B.S. was from SUNY Al-
lationships, with studies on self-assembly, biomaterials engineering,
bany and his PhD from SUNY Syracuse and Syracuse University. His
tissue engineering and regenerative medicine. Structural proteins,
group has published over 600 peer reviewed papers, and generated
including collagens, elastins, resilins and silks have been our focus,
more than 50 patents that have led to seven startup companies and
with a particular emphasis on the study of silk-based biomaterials in
new FDA approved medical devices.
regenerative medicine, from fundamental studies of the biochemistry, molecular biology and biophysical features of these fibrous
proteins to their impact on stem cell functions and complex tissue
formation. Tissue engineering and regenerative medicine emerge
though control of biomaterials structure-function relationships and
3D tissue co-culture systems to establish and study human tissues
in the laboratory and in animal systems.
He has directed the NIH P41 Tissue Engineering Resource Center
(TERC) since 2004, a program involving Tufts University and Columbia University. He serves on the editorial boards of numerous journals and is the inaugural Editor in Chief of ACS Biomaterials Science
and Engineering. He has received a number of awards for teaching, was Elected Fellow of the American Institute of Medical and
Biological Engineering, received the Columbus Discovery Medal and
the Society for Biomaterials Clemson Award for contributions to the
literature.
Professor Kaplan also holds faculty appointments in the School of
Medicine, the School of Dental Medicine, the Department of Chemistry and the Department of Chemical and Biological Engineering at
Tufts University. He also has a university professor appointment at
Soochow University in China and fosters joint research between institutions. He has an extensive network of collaborators around the
world that providing complementary expertise and opportunities for
synergistic studies and student exchanges.
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BMES 2014
Special plenary session | friday
Stephen Oesterle, MD
Senior Vice President for Medicine & Technology
Medtronic
Friday, october 24, 2014
5:15PM - 6:15PM
LILA COCKRELL THEATRE
HENRY B. GONZALES CONVENTION CENTER
Converging Low Power Microelectronics, IT and Communication
Technologies into Implantable Medical Devices
M
edtronic is one of the world¹s
Stephen N. Oesterle, MD joined the company in 2002 as Senior
largest medical device companies. With more
Vice President for Medicine and Technology. In this role, Steve pro-
than 50,000 employees, it operates in 140 coun-
vides executive leadership for Medtronic scientific research, forma-
tries, delivering medical products to more than
tion of technological strategies and continued development of strong
10 million people each year. Medtronic must continue to innovate
cooperative relationships with the world's medicinal communities,
while delivering effective products for less cost. The challenge of
technical universities, financial institutions and emerging medical de-
developing medical devices for the more than 4 billion people who
vice companies.
today have no access to care is immediate. The incorporation of low
power and flexible microelectronics into implantable medical devices
has substantially broadened applications for these devices while allowing for less invasive delivery and reduced complications. Cardiac
pacemakers have been reduced in dimension by magnitudes; the
potential to deliver a wafer scale pacemaker will soon be realized.
Implantable and wearable physiologic sensors will facilitate remote
management of the devices and the patients who use them. Conver-
Previously, Steve served as Associate Professor of Medicine at
the Harvard University Medical School and as Director of Invasive
Cardiology Services at Massachusetts General Hospital, Boston. A
teacher and innovator in the field of cardiac catheterization, he has
also developed and directed interventional cardiology programs at
Good Samaritan Hospital, Los Angeles; at Georgetown University;
and at Stanford University.
gence of information and communication technologies into medical
Steve is a 1973 summa cum laude graduate of Harvard College and
devices will catalyze Medtronic’s vision to distribute health care to bil-
received his doctorate from Yale University in 1977. He completed
lions of patients who have minimal access to affordable care. Chron-
his internship and residency at Massachusetts General Hospital and
ic diseases such as heart failure, diabetes and hypertension can be
also served a fellowship in interventional cardiology at Stanford.
better managed with implanted and wearable microelectronics and
adaptive closed loop algorithms. It all starts and ends with engineers.
BMES 2014
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Rita Schaffer Memorial Lecture
BMES 2014 Rita Schaffer Memorial - Young Investigator Lecturer:
Kimberly M. Stroka, PhD
Postdoctoral Fellow in the Konstantopoulos Lab
Johns Hopkins University
Saturday, october 25, 2014
10:30am
LILA COCKRELL THEATRE
HENRY B. GONZALES CONVENTION CENTER
New Paradigms for Cell Migration in Confined Microenvironments
C
ell homeostasis and diverse process-
Kimberly M. Stroka is a postdoctoral fellow at Johns Hop-
es, including migration, are tightly regulated by cell
kins University in the Department of Chemical and Biomolecular En-
volume. In vivo, metastatic tumor cells must navigate
gineering and Institute for NanoBioTechnology. In January 2015 she
complex, heterogeneous microenvironments when
will begin her appointment as Assistant Professor at the University of
migrating through tissues, including longitudinal tracks formed by
Maryland, College Park in the Fischell Department of Bioengineering.
anatomic structures. Intriguingly, we have discovered that the clas-
Dr. Stroka received her B.S. summa cum laude in Physics in 2006
sical model of cell migration on two-dimensional substrates (relying
from Denison University. She received her Ph.D. in Bioengineering
on actin polymerization, cell adhesion to the substrate, and myosin
in 2011 from the University of Maryland-College Park while working
II-mediated contractility) does not apply to metastatic tumor cells
with Helim Aranda-Espinoza. In her PhD work, Dr. Stroka developed
migrating through three-dimensional confined spaces. We therefore
a novel hydrogel-based in vitro model in order to evaluate the effects
hypothesized that an alternate mechanism based on cell volume
of blood vessel stiffening on endothelial cell biomechanics, leukocyte
regulation via ion channels and aquaporins drives cell migration in
mechanosensing, and leukocyte transmigration, during a normal im-
these confined microenvironments, where cells must deform in or-
mune response and in the context of cardiovascular disease. In Dr.
der to squeeze through physically restrictive spaces. Using a mul-
Stroka's postdoctoral work in the lab of Konstantinos Konstantopou-
tidisciplinary approach that integrates microfabrication techniques,
los, she has integrated microfabrication, molecular biology, live cell
molecular biology, live cell imaging, and theoretical modeling based
imaging, and theoretical modeling in order to uncover a new mecha-
on physics, we have discovered an "Osmotic Engine Model" of cell
nism by which metastatic tumor cells migrate through confined mi-
migration, which demonstrates that osmotically-driven water flow
croenvironments. This work was recently published in Cell.
regulates cell migration in confined microenvironments. Importantly,
our theoretical model predicts many key non-intuitive experimental
results. Collectively, this study represents a new paradigm for cell
migration in confined microenvironments and elucidates ion pumps
and aquaporins as new molecular targets that may be exploited for
future development of cancer therapeutics.
Dr. Stroka's postdoctoral and predoctoral work has been supported
by numerous highly competitive fellowships, including an NIH NRSA
F32 postdoctoral fellowship (2013-present), NIH T32 postdoctoral fellowship (2012-2013), NIH NRSA F31 predoctoral fellowship (20102011), and NSF Graduate Research Fellowship (2006-2009). Dr. Stroka was also recently awarded the Burroughs Wellcome Career Award
at the Scientific Interface (2014-2019) for her proposal on engineering
BMES established this award in 2000 to honor Rita M. Schaffer,
former BMES Executive Director. Rita’s gift of her estate, along with
contributions from her family, friends, and associates, has enabled
BMES to create the Rita Schaffer Young Investigator Award, which
includes the Rita Schaffer Memorial Lecture.
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BMES 2014
blood-brain barrier mechanobiology in the context of tumor cell metastasis. She is the recipient of 9 different awards for travel to national
and international conferences (2008-2011).
BMES Diversity Award Lecture
Diversity Lecture:
Naomi Chesler, PhD
Vice Chair of Biomedical Engineering
University of Wisconsin-Madison
Saturday, october 25, 2014
11:15am
LILA COCKRELL THEATRE
HENRY B. GONZALES CONVENTION CENTER
The Power of Privilege – Using Our Strengths to Overcome
Our Weaknesses in Diversity and Inclusivity
T
he current pool of biomedical
engineers is not diverse enough to solve
the complex health and medical technology
problems facing our society today. In the undergraduate experience, being part of a diverse classroom
and community leads to increased student engagement in
learning and greater gains in critical thinking, problem solving and self-confidence. Also, motivation to consider multiple perspectives, which is an important skill in teamwork,
increases with diversity, as does productivity and innovation.
Therefore, increasing the diversity of our discipline will have
concrete and significant benefits for the current and future
biomedical engineering workforce.
Mechanical Engineering from MIT and a PhD in Medical En-
Often, the most visible and vocal proponents of increased
findings in this area regularly in biomedical and mechanical
diversity and inclusivity are members of under-represented
engineering journals as well as physiology journals and is a
groups. While biomedical engineering has a higher percent-
recipient of the NSF CAREER Award and funding from the
age of women than almost any other engineering discipline,
Whitaker Foundation, the American Heart Association and
most senior leaders in biomedical engineering both in in-
the NIH both independently and collaboratively. dustry and academia are members of the majority. Thus,
in order to improve and enhance the diversity and inclusivity of our discipline, I propose we use these strengths – our
many majority members -- and their privilege. In particular,
I challenge our community to use the power of privilege to
promote inclusive excellence and thereby improve critical
thinking and problem-solving, teamwork and innovation in
biomedical engineering.
gineering from the Harvard-MIT joint program in Health Sciences and Technology. Dr. Chesler’s biomechanics research seeks to improve cardiovascular health through the integration of mechanical
engineering, vascular biology and imaging tools, to advance
knowledge in these fields, and to educate the next generation of leaders in cardiovascular engineering and science. In particular, her lab (vtb.bme.wisc.edu) strives to better
understand and prevent ventricular failure by focusing on
three aspects of physiology and pathophysiology: ventricular function, blood flow dynamics, and changes in the large
and small artery structure and function. She publishes her
Dr. Chesler also investigates mentoring and curricular
change strategies for improving the recruitment and retention of women and underrepresented minorities in engineering. Her scholarly contributions in this area have been
published in the Journal of Engineering Education, Journal
of Women and Minorities in Science and Engineering, Advances in Engineering Education and also the BMES flagship
journal Annals of Biomedical Engineering. She is an integral
Naomi C. Chesler is Professor and Vice Chair
part of the Epistemic Games Group at UW-Madison (edgaps.
of Biomedical Engineering at the University of Wisconsin-
org), which is funded by the NSF to design and implement
Madison. Her research accomplishments are in the areas
engineering epistemic games for first-year curricula with in-
of cardiovascular biomechanics and engineering education.
tegrated mentoring and assessment. Her broad contributions to the physical, biological and social
sciences have been recognized by courtesy appointments
in the Departments of Mechanical Engineering, Medicine,
Pediatrics and Educational Psychology at UW-Madison. One
key foundation for this wide-ranging impact was her liberal
arts education from Swarthmore College, where she earned
a BS in engineering (general). She then obtained an MS in
She is a Fulbright Scholar, fellow of the American Society of
Mechanical Engineers and prior recipient of the Denice D.
Denton Emerging Leader Award from the Anita Borg Institute for Women and Computing. She was recently named a
Vilas Distinguished Achievement Professor at UW-Madison
and is honored to receive the BMES Diversity Award.
BMES 2014
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