Juan R. Del Valle - CV Juan R. Del Valle, Ph.D. Curriculum Vitae October 22, 2014 CURRENT POSITION Assistant Professor Chemical Biology & Molecular Medicine Program H. Lee Moffitt Cancer Center & Research Institute 12902 Magnolia Drive, MRC 3East Tampa, FL 33612 CURRENT ACADEMIC APPOINTMENTS Affiliate Assistant Professor Department of Chemistry College of Arts and Sciences University of South Florida 4202 E. Fowler Ave. Tampa, FL 33620 EDUCATION 1999-2004 1995-1999 Tel: Fax: Email: Web: (813) 745-6142 (813) 745-6817 [email protected] labpages.moffitt.org/delvallej Assistant Professor Department of Oncologic Sciences College of Medicine University of South Florida 12901 Bruce B. Downs Blvd. Tampa, FL 33612 Ph.D. in Organic Chemistry; University of California at San Diego B.A. in Chemistry; Carleton College POSTGRADUATE TRAINING 2004-2006 Postdoctoral Fellowship in Bioorganic Chemistry, Université de Montréal EMPLOYMENT AND ACADEMIC APPOINTMENTS 2009-present Assistant Professor, Chemical Biology & Molecular Medicine Program H. Lee Moffitt Cancer Center & Research Institute 2009-present Affiliate Assistant Professor, Department of Chemistry, University of South Florida 2006-2008 Assistant Professor, Department of Chemistry and Biochemistry, New Mexico State University 2004-2006 Postdoctoral Fellow, Department of Chemistry, Université de Montréal (PI: Stephen Hanessian) 1999-2004 Graduate Research Associate, Department of Chemistry and Biochemistry, University of California at San Diego (PI: Murray Goodman) 1998 REU Fellow, Department of Pharmaceutical Chemistry, University of Utah (PI: Bradley Anderson) RESEARCH INTERESTS Peptide mimicry; Medicinal chemistry; Inhibitors of protein-protein interactions; Constrained amino acids; Structure-based drug design; Natural product synthesis Page 1 of 9 Juan R. Del Valle - CV PEER-REVIEWED PUBLICATIONS (underline denotes corresponding authorship) 28. Kang C, Ranatunga S, Sarnowski MP, Del Valle JR. Solid-phase tetrahydropyridazinedione-constrained peptides. Org. Lett. (2014), In press. synthesis of 27. Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR. Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt. Bioorg. Med. Chem. Lett. (2014) 24, 4650. 26. Ranatunga S, Tang CA, Kang C, Kloppenburg B, Kriss CL, Hu CA, Del Valle JR. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J. Med. Chem. (2014) 57, 4289. ** Highlighted in SciBx ‘This Week in Therapeutics’ DOI: 10.1038/scibx.2014.702** 25. Tang, CA, Ranatunga S, Kriss, CL, Cubbitt CL, Pinilla-Ibarz JA, Del Valle JR, Hu CA. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J. Clin. Inv. (2014) 124, 2585. ** Highlighted in Cancer Discovery ‘Research Watch’ DOI: 10.1158/2159-8290.CD-RW2014-114** ** Highlighted in SciBx ‘This Week in Therapeutics’ DOI: 10.1038/scibx.2014.702** 24. Dorich S, Del Valle JR, Hanessian S. Synthesis of functionalized octahydroindoles related to daphnyphyllum alkaloids. Synlett. (2014) 25, 799-804. 23. Kang C, Sun Y, Del Valle JR. Substituted peptidomimetics. Org. Lett. (2012) 14, 6162-5. imidazo[1,2-a]pyridines as beta-strand 22. Ranatunga S, Tang CA, Hu CA, Del Valle JR. Total synthesis and structural confirmation of lucentamycin A. J. Org. Chem. (2012) 77, 9859-64. 21. Cha JW, Park JS, Sim T, N SJ, Kwon HC, Del Valle JR, Fenical W. Structure assignment of lucentamycin E and revision of the olefin geometries of the marine-derived lucentamycins. J. Nat. Prod. (2012) 75, 1648. 20. Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR. Synthesis and evaluation of substituted hexahydronaphthalene derivatives as novel inhibitors of the Mcl-1/BimBH3 interaction. Bioorg. Med. Chem. Lett. (2012) 22, 5961-5. 19. Kriss CL, Pinilla-Ibarz JA, Mallioux A, Powers JJ, Tang CA, Kang C, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM, Del Valle JR, Hu, CA. Overexpression of TCL1 activates endoplasmic reticulum stress response: A novel mechanism of leukemic progression in mice. Blood (2012) 120, 1027-1038. 18. Ranatunga S, Kim JS, Pal U, Del Valle JR. An Ester Enolate-Claisen Rearrangement Route to Substituted 4-Alkylideneprolines. Studies toward a Definitive Structural Revision of Lucentamycin A. J. Org. Chem. (2011) 76, 8962-76. ** Selected for ACS ‘Virtual Issue on Peptide Chemistry’. http://pubs.acs.org/page/vi/2012/peptide.html** 17. Ranatunga S, Del Valle JR. Synthesis of GSK3b-Mimetic Inhibitors of Akt Featuring a Novel Extended Dipeptide Surrogate. Bioorg. Med. Chem. Lett. (2011) 21, 7166-9. 16. Kim YB, Del Valle JR. Synthesis of a diversifiable cis-dehydrodecalin scaffold based on meiogynin A. Tetrahedron Lett. (2011) 52, 6396-8. 15. Hanessian S, Vakiti RR, Dorich S, Banerjee S, Lecomte F, Del Valle JR, Zhang J, DeschenesSimard B. Total synthesis of pactamycin. Angew. Chem. Int .Ed. (2011) 50, 3497-500. Page 2 of 9 Juan R. Del Valle - CV 14. Ranatunga S, Liyanage W, Del Valle JR. Synthesis and conformational analysis of bicyclic extended dipeptide surrogates. J. Org. Chem. (2010) 75, 5113-25. PMCID: 2914495. 13. Ranatunga S, Del Valle JR. Synthesis of Boc-protected bicycloproline. Tetrahedron Lett. (2009) 50, 2464-6. 12. Pal U, Ranatunga S, Ariyarathna Y, Del Valle JR. Total synthesis of the putative structure of lucentamycin A. Org. Lett. (2009) 11, 5298-301. 11. Hanessian S, Wang X, Ersmark K, Del Valle JR, Klegraf E. Total synthesis and structural revision of the presumed aeruginosins 205A and B. Org. Lett. (2009) 11, 4232-5. 10. Liyanage W, Weerasinghe L, Strong RK, Del Valle JR. Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives. J. Org. Chem. (2008) 73, 7420-3. 9. Ersmark K, Del Valle JR, Hanessian S. Chemistry and biology of the aeruginosin family of serine protease inhibitors. Angew. Chem. Int. Ed. (2008) 47, 1202-23. 8. Hanessian S, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y. Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. Bioorg. Med. Chem. Lett. (2007) 17, 3480-5. 7. Hanessian S, Del Valle JR, Xue Y, Blomberg, N. Total synthesis and structural confirmation of chlorodysinosin A. J. Am. Chem. Soc. (2006) 128, 10491-5. 6. Zapf CW, Del Valle JR, Goodman M. Utilizing the intramolecular Fukuyama-Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design. Bioorg. Med. Chem. Lett. (2005) 15, 4033-6. 5. Hanessian S, Tremblay M, Marzi M, Del Valle JR. Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers. J. Org. Chem. (2005) 70, 5070-85. 4. Del Valle JR, Goodman M. An efficient RCM-based synthesis of orthogonally protected mesoDAP and FK565. J. Org. Chem. (2004) 69, 8946-8. 3. Del Valle JR, Goodman M. Asymmetric hydrogenations for the synthesis of Boc-protected 4alkylprolinols and prolines. J. Org. Chem. (2003) 68, 3923-31. 2. Del Valle JR, Goodman M. Stereoselective synthesis of Boc-protected cis and trans-4trifluoromethylprolines by asymmetric hydrogenation reactions. Angew. Chem. Int. Ed. (2002) 41, 1600-2. 1. Goodman M, Del Valle JR, Amino Y, Benedetti E. Molecular basis of sweet taste in dipeptide taste ligands. Pure Appl. Chem. (2002) 74, 1109-16. PATENTS Del Valle JR, Hu CA. Inhibitors of the IRE-1/XBP-1 pathway and methods of using thereof. (2014) PCT/US2014/035164. Page 3 of 9 Juan R. Del Valle - CV BOOK CHAPTERS AND CONFERENCE PROCEEDINGS 4. Del Valle JR, Thierren E, Hanessian S. Aeruginosins as thrombin inhibitors. In Natural Products in Medicinal Chemistry, Vol. 60: Wiley-VCH; 2013. p. 333-56. 3. Ranatunga S, Kim JS, Del Valle JR. Synthetic studies toward lucentamycin A and 3-alkyl-4nd alkylideneprolines via ester enolate-Claisen rearrangement. In Peptides: Proceedings of the 22 American Peptide Symposium (2011). 2. Del Valle JR, Wang X, Ersmark K, Hanessian S. Beta-substituted D-leucines and their relevance in the total synthesis of natural and unnatural aeruginosins. In Asymmetric Synthesis and Application of alpha-Amino Acids: American Chemical Society; 2009. p. 443-61. 1. Goodman M, Del Valle JR, Smith ND. Novel building blocks for peptidomimetic chemistry. Biopolymers (2003) 71, 292. SCIENTIFIC ABSTRACTS/POSTERS 21. Ranatunga S, Tang CA, Kang C, Kloppenburg B, Kriss CL, Hu CA, Del Valle JR. Novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. Moffitt Scientific Symposium, Tampa, May 2014. 20. Kang C, Sun Y, Del Valle JR. IP-tides: Imidazo[1,2-a]pyridine-based peptidomimetics. American Peptide Society Symposium, Waikaloa, June 2013. 19. Ranatunga S, Del Valle JR. Total synthesis and structural revision of lucentamycin A. American Peptide Society Symposium, Waikaloa, June 2013. 18. Ranatunga S, Del Valle JR. Design and synthesis of novel macrocyclic beta-strand orthotics. American Peptide Society Symposium, Waikaloa, June 2013. 17. Kim YB, Kang C, Yang, Sebti SM, Del Valle JR. Peptidomimetic inhibitors of Akt and SGK targeting the substrate binding domain. American Peptide Society Symposium, Waikaloa, June 2013. 16. Kim YB, Kang C, Ranatunga S, Yang, Sebti SM, Del Valle JR. Design and synthesis of substrate-mimetic Akt inhibitors based on the structure of GSK3beta. Moffitt Scientific Symposium, Tampa, FL, May 2013. 15. Kim YB, Balasis ME, DuBoulay C, Wang HG, Sebti SM Guida W, Hu CA, Del Valle JR. Synthesis of hexahydronaphthalene derivatives and their biological evaluation as Mcl-1 antagonists. Gordon Research Conference Bioorganic Chemistry, Andover, NH, June 2012. 14. Kim YB, Balasis ME, DuBoulay C, Wang HG, Sebti SM Guida W, Hu CA, Del Valle JR. Synthesis of hexahydronaphthalene derivatives and their biological evaluation as Mcl-1 antagonists. Moffitt Scientific Symposium, Tampa, May 2012. 13. Ranatunga S, Del Valle JR. Synthesis of Novel Extended Dipeptide Surrogates and their Incorporation into Peptidomimetic Inhibitors of Akt. National Meeting of the American Peptide Society, San Diego, June 2011. 12. Ranatunga S, Kim JS, Del Valle JR. Synthetic Studies Toward Lucentamycin A and 3-Alkyl-4Alkylideneprolines via Ester Enolate-Claisen Rearrangement. National Meeting of the American Peptide Society, San Diego, June 2011. Page 4 of 9 Juan R. Del Valle - CV 11. Ranatunga S, Kim JS, Del Valle JR. Exploring an Ester Enolate-Claisen Rearrangement Route to Lucentamycin A and Related 3-Alkyl-4-Alkylideneprolines. 87th ACS FAME Conference, Palm Harbor, Florida, May 2011. 10. Ranatunga S, Kim JS, Del Valle JR. Exploring an Ester Enolate-Claisen Rearrangement Route to Lucentamycin A and Related 3-Alkyl-4-Alkylideneprolines. 9th Annual Castle Conference, Tampa, April 2011. 9. Ranatunga S, Pal U, Del Valle JR. Synthetic Studies Toward the Cytotoxic Marine Tripeptide Lucentamycin A. National Meeting of the American Chemical, Boston, MA, August 2010 8. Ranatunga S, Yang H, Sebti S, Del Valle JR. Synthesis of Akt Inhibitors Using a Bicyclic Prolineth Based Scaffold as the Peptidomimetic Core. 8 Annual Castle Conference, Tampa, FL, April 2010. 7. Ranatunga S, Yang H, Sebti S, Del Valle JR. Synthesis of Akt Inhibitors Using a Bicyclic ProlineBased Scaffold as the Peptidomimetic Core. Moffitt Symposium, Tampa, FL, March 2010. 6. Ranatunga S, Del Valle JR. Synthesis of Extended Dipeptide Surrogates for Akt Inhibitor Design. FCoE-BITT Symposium on Drug Design, Discovery, and Delivery, Tampa, FL, October 2009. 5. Liyanage W, Del Valle JR. Reactions of a/b-Proline Enolates for the Synthesis of Constrained Peptidomimetics. National Meeting of the American Peptide Society, Bloomington, June 2009. 4. Del Valle JR. Total Synthesis and Structural Confirmation of Chlorodysinosin A. Quebec-Ontario Symposium of Bioorganic Chemistry, St. Adéle, November 2005. 3. Del Valle JR, Goodman M. Asymmetric Hydrogenations for the Synthesis of 4-Alkylprolines. National Meeting of the American Peptide Society, Boston, April 2003. 2. Kwak J, Del Valle JR, Goodman M. Collagen Mimetics Incorporating Hydroxyproline and Fluoroproline Guest Residues. National Meeting of the American Peptide Society, San Diego, June 2001. 1. Del Valle JR, Goodman M. Synthesis of Novel Fluorinated Building Blocks for Peptidomimetic Drug Design. National Meeting of the American Chemical Society, San Diego, April 2001. RESEARCH SUPPORT Active Grants Targeting Akt with substrate-mimetic antagonists Grant #: 5R21CA167215 PI: Del Valle JR Dates: 9/12 – 08/15 Source: NIH/NCI Effort: 20% Role: Principal Investigator Direct Costs: $239,250 Total Award: $403,137 Targeting antigen-induced ER stress response in B-cell chronic lymphocytic leukemia Grant #: 1R01CA163910-01A1 PI: Hu, CA Dates: 9/13 – 06/18 Page 5 of 9 Juan R. Del Valle - CV Source: Effort: Role: Direct Costs: Total Award: NIH/NCI 10% Co-Investigator $1,037,500 $1,748,188 Inhibition of the IRE-1/XBP-1 pathway in B-cell cancer PI: Del Valle, JR, Hu CA (MPI) Source: Moffitt Team Science (Internal) Effort: 5% Role: Principal Investigator Direct Costs: $150,000 Total Requested: $150,000 Completed Grants Chemical and biological studies of marine-derived non-ribosomal peptides Grant #: 1BN03 PI: Del Valle JR Source: Bankhead Coley Research Program (FL DOH) Effort: 25% Role: Principal Investigator Direct Costs: $347,825 Total Award: $400,000 Natural product-inspired approaches targeting Mcl-1 Grant #: 1KN03 PI: Del Valle JR Source: James & Esther King Biomedical Research Program (FL DOH) Effort: 25% Role: Principal Investigator Direct Costs: $347,825 Total Award: $400,000 Synthetic methods toward antimicrobial tert-alkylamino carbocycles Grant #: SC2AI081526 PI: Del Valle JR Source: NIH/NIAID Effort: 50% Role: Principal Investigator Direct Costs: $200,00 Total Award: $282,800 Synthesis of functional probes for siderocalin-induced apoptosis Grant #: IRG9309214 PI: Pledger WJ Source: American Cancer Society Effort: 10% Role: Project Leader Direct Costs: $30,000 Total Award: $30,000 Probing novel mechanisms to target kinases for cancer drug discovery Grant #: n/a PI: Sebti SM Page 6 of 9 Juan R. Del Valle - CV Source: Effort: Role: Direct Costs: Total Award: Anna Valentine Cancer Fund FIG (Internal) 1% Project Leader $75,000 $75,000 Synthesis of new ligands for the characterization of siderophore-ExFABP interactions Grant #: U54CA132383 PI: O’Connell M Source: NIH/NCI Effort: 33% Role: Project Leader Direct Costs: $245,066 Total Award: $345,317 SEMINARS AND INVITED PRESENTATIONS 2014 USF Health, Dept. of Molecular Medicine 2014 Canadian Society for Chemistry National Meeting, Vancouver, BC 2014 University of Denver, Dept. of Chemistry and Biochemistry 2014 University of New Mexico, Dept. of Chemistry and Chemical Biology 2014 University of Florida, Department of Medicinal Chemistry 2013 Florida Annual Meeting of the American Chemical Society, Palm Harbor, FL 2012 Southeastern Regional Meeting of the American Chemical Society, Raleigh, NC 2008 Fred Hutchinson Cancer Research Center, Division of Basic Science 2007 New Mexico Institute of Mining and Technology, Dept. of Chemistry HONORS AND AWARDS 2010 CIBA Young Scientist Award, awarded by the CIBA Foundation and ACS YCC 2010 Milestone Award, awarded by the Miles for Moffitt Foundation 2004 Teddy Traylor Award for graduate research, awarded by the University of California at San Diego 2004 Exemplary Teaching Assistant Performance Award, awarded by the University of California at San Diego 2002 American Peptide Society Travel Award 1999-2001 San Diego Fellowship, awarded by the University of California at San Diego 1998 REU Fellowship, University of Utah TEACHING EXPERIENCE Courses Taught 2014-present Lecturer: Cancer Biology III (PCB 6205), Cancer Biology Program, MCC 2012-2013 Lecturer: Cancer Biology I (PCB 6230), Cancer Biology Program, MCC 2011-present Lecturer: Introduction to Medicinal Chemistry (CHEM 4932/6938), Department of Chemistry and Biochemistry, USF 2009-present Lecturer: Drug Discovery Colloquium (CHEM 6936), Department of Chemistry and Biochemistry, USF 2006-2009 Course Instructor: Organic Chemistry I (CHEM 313), Department of Chemistry and Biochemistry, NMSU 2006-2009 Course Instructor: Advanced Organic Chemistry (CHEM 466/515), Department of Chemistry and Biochemistry, NMSU Undergraduate Mentoring Page 7 of 9 Juan R. Del Valle - CV 2008-2009 2007 2006 MARC (Minority Access to Research Careers) Mentor for Leticia A. Montoya Undergraduate Research Mentor for Christian Talamantes Undergraduate Research Mentor for Lee Uranga Graduate Mentoring 2014-present Ph.D. Graduate Student Advisor for Matthew Sarnowski 2006-2012 Ph.D. Graduate Student Advisor for Sujeewa R. Mahanthe Mudiyanselage 2006-2009 M.S. Graduate Student Advisorfor Wathsala Liyanage 2006-2009 Graduate Research Advisor for Laksiri Weerasinghe 2007-2008 Graduate Research Advisor for Yamuna Ariyarathna Postdoctoral Mentoring 2012-present Sujeewa Ranatunga, Ph.D. 2010-present Chang Won Kang, Ph.D. 2009-2013 Young B. Kim, Ph.D. 2010-2012 Yongmao Sun, Ph.D. 2009-2011 Jinsoo Kim, Ph.D. 2008-2009 Ujjwal Pal, Ph.D. Student Advising 2014 2012 2012 2012 2009 2009 2008 2008 2008 2008 2007 2007 2007 2006 2006 Ph.D. Thesis Committee, Brent Kuenzi Ph.D. Thesis Committee, Sujeewa Mudiyanselage, Chair Ph.D. Thesis Committee, Hyun Joo Kil, Member Ph.D. Thesis Committee, Courtney DeBoulay, Member M.S. Thesis Committee, Wathsala Liyanage, Chair Comprehensive Exam Committee, Sujeewa Mudiyanselage, Chair Ph.D. Thesis Committee, Kris Waynant, Member Comprehensive Exam Committee, Sarah Gibson, Member M.S. Thesis Committee, Jon Shirley, Member Comprehensive Exam Committee, Paul Wiget, Member Comprehensive Exam Committee, Kris Waynant, Member Comprehensive Exam Committee, Ritwik Burai, Member Ph.D. Thesis Committee, Shaofeng Duan, Member M.S. Thesis Committee, Jennifer Bell, Member Ph.D. Thesis Committee, Jacob Strousse, Member SERVICE Professional Service 2014 NIH/NCI Ad Hoc Reviewer, DMP Study Section 2013-present Member, Nominating Committee, American Peptide Society rd 2013 Session Chair, Peptidomimetics, 23 American Peptide Society Symposium 2013 NIH Early Career Reviewer, SBCB Study Section 2013 NIH/NCI Ad Hoc Reviewer, Developmental Cancer Therapeutics 2011-present Co-Chair, Student Affairs Committee, American Peptide Society 2006-present Reviewer of submitted manuscripts for the following publications: Journal of the American Chemical Society, Journal of Organic Chemistry, Organic Letters, Tetrahedron, Tetrahedron Letters, Chemical Communications, European Journal of Medicinal Chemistry, Bioorganic Medicinal Chemistry, Bioorganic Medicinal Chemistry Letters, PLoS One 2012 NIH/NCI Ad Hoc Reviewer, Anticancer Therapeutics Topic 255 SBIR Panel 2011 NIH/NCI Ad Hoc Reviewer, Anticancer Therapeutics Topic 255 SBIR Panel 2008 NSF Ad Hoc Reviewer, CRIF-MU Special Emphasis Panel Page 8 of 9 Juan R. Del Valle - CV Institutional Committees 2013-present Research Value Analysis Committee 2013-present Chemical Biology Advisory Committee 2011-2013 Institutional Product Evaluation Committee 2011-2013 Research Product Evaluation Committee 2012 ACS Internal Research Grant Review Committee 2012 OTMC Internship Program Review Committee 2009-2010 Investigator Webpage Committee 2006-2009 Stockroom Safety Committee 2006-2009 Chem Club Committee Community Outreach th 2014 Faculty Judge, 12 Annual Castle Conference, Tampa, FL rd 2013 Travel Award Judge, 23 American Peptide Society Symposium, Waikaloa, HI nd 2011 Faculty Judge, 22 American Peptide Society Symposium, San Diego, CA nd 2011 Travel Award Judge, 22 American Peptide Society Symposium, San Diego, CA th 2010 Faculty Judge, 8 Annual Castle Conference, Tampa, FL 2009 Faculty Judge, American Peptide Society Symposium, Bloomington, IN 2007 Volunteer, Regional Chemical Olympics Competition, Las Cruces, NM 2007 Faculty Judge, New Mexico Tech Senior Thesis Symposium, Socorro, NM PROFESSIONAL ASSOCIATIONS 2009-present American Association for Cancer Research, Member 2006-present American Association for the Advancement of Science, Member 2001-present American Peptide Society, Member 1999-present American Chemical Society, Member Page 9 of 9
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