EUROPEAN
COUNCIL FOR
CARDIOVASCULAR
RESEARCH
www.eccr.org
Registered UK Charity (1078280)
Registered Address
Hampton Medical Conferences Ltd., Rapier House, 4-6 Crane Mead, Ware, SG12 9PW, UK
Executive Committee
U. Steckelings
G.P. Rossi
(President)
(Secretary and
President-Elect)
Ordinary Members:
J. De Mey
F. Jaisser
C. Peiró
C. Aalkjaer
Advisory Board
L. Paulis
D. Strain
M. Baumann
G. Bianchi
P. Corvol
A. Hughes
X. Jeunemaitre
M.J. Mulvany
T. Unger
H.A.J. Struijker Boudier
P.S. Sever
M. Paul
GENERAL INFORMATION
The meeting will be held at the Poiano Resort (www.poiano.com) situated in the hills above Garda with a stunning
view to the gulf of Lake Garda. The Garda Valley is famous for its mild climate, and typical temperatures range around
20 degrees in October.
Please see the enclosed maps for directions.
COACH TRANSFERS:
Please note that there are no transfers arranged for guests.
TAXI TRANSFERS:
For price information and to book a transfer service please contact the Poiano Resort Reception on:
Tel. +39 045 7200100
Please note approximate transfer time is 40 minutes from Valerio Catullo (Verona) Airport to Poiano
Resort
SECRETARIAT AND REGISTRATION DESK:
The conference organisers will be pleased to assist you with any queries. The desk will be open as follows:
Friday 24th October:
10.00 – 19.15hrs
Saturday 25th October:
08.00 – 19.30hrs
Sunday 26th October:
08.30 – 14.00hrs
ACCOMMODATION AND MEALS:
All accommodation and meals are on site at Poiano Resort.
VENUE FACILITIES:
The venue has a small convenience shop, gym and a spa. The resort is located on a hill with the meeting room being
at the top, so please wear suitable footwear.
ANNUAL BUSINESS MEETING:
th
The Annual Business Meeting (for ECCR members only) will be held on Saturday 25 October at 15.30hrs. Matters
for inclusion on the agenda should be sent to the Secretariat.
TELEPHONE CALLS FOR THE CONFERENCE DESK:
Poiano Resort, Garda, Italy
Tel: +33 (0) 45 7200994 int.8853
FOR ANYONE EXTENDING THEIR STAY:
For those of you who are wishing to extend your stay, please see attached the request form for additional
accommodation. Poiano resort has various leisure activities available, some of which are below for your reference;
Leisure:
Outdoor swimming pool, tennis courts (please bring your own rackets/balls), volleyball, bowls and
archery.
Secretariat:
Hampton Medical Conferences Ltd., Rapier House, 4 – 6 Crane Mead, Ware, Hertfordshire, SG12 9PW, UK
Tel: +44 (0) 1920 88 5162
Fax: +44 (0) 870 900 7783
Email: [email protected]
Web: www.eccr.org
DIRECTIONS
LOCATION
On the east bank of Lake Garda, The Poiano Resort boasts a desirable position at the crossroads of Europe's main
transport links: nearby airports, motorways and railway stations, making it easily accessible.
BY CAR
Car Navigation System:
Via Poiano - 37016 Garda
GPS Coordinates:
Latitude: 45.580338 N
Longitude: 10.732306 E
The nearest motorway (autostrada) exits are:


Affi - Lago di Garda Sud if arriving from Modena, Brennero, "V. Catullo" Verona Villafranca Airport. To get to the
Poiano Resort follow the road signs for Costermano - Garda.
Peschiera del Garda if arriving from Milan or Venice. For the Poiano Resort enter the duel carriageway in the
direction of Affi and follow the signs for Costermano - Garda.
Route planner: www.viamichelin.com
BY TRAIN
The nearest train stations that can be reached by taxi or public transport are:


Peschiera del Garda (approx. 17 km. from Garda)
Verona Porta Nuova (approx. 32 km. from Garda)
Train Timetables: Ferrovie Italiane - www.ferroviedellostato.it
Bus timetables: APTV Azienda Provinciale Trasporti Verona - www.apt.vr.it
BY PLANE
Nearby airports can be reached by taxi, public transport or low cost transfer buses (taxi.limtours.it). These are:






Valerio Catullo di Villafranca Verona (approx. 31 km from Garda)
Gabriele D'Annunzio di Brescia Montichiari (approx. 55 km from Garda)
Bergamo Orio al Serio (approx. 112 km from Garda)
Venice Marco Polo (approx. 154 km from Garda)
Milan Linate (approx. 162 km from Garda)
Milan Malpensa (approx. 198 km from Garda)
For price information and to book a transfer service please contact the Poiano Resort Reception (Info and
Bookings: Tel. +39 045 7200100)
MAPS
Please complete clearly and in BLOCK CAPITALS
ECCR 2014 - ADDITIONAL ACCOMMODATION FORM
Family Name/Surname: ....................................................... First/Given Names:........................................................
Title (Prof/Dr/Ms/Miss/Mrs/Mr etc.): .... …. E-Mail: .....................................................................................................
Business Tel No: ................................................................... Fax No: ..........................................................................
IMPORTANT NOTE: Please read carefully before completing your reservation request.
Delegates who are considering bringing their partners and/or families should note the following important
information:
Poiano Resort is a business resort surrounded by 60 hectares of Mediterranean greenery, and is 40 minutes from
Verona Airport. Leisure activities include; gym, spa, outdoor swimming pool, tennis courts (please bring your own
rackets/balls), volleyball, bowls and archery.
Rooms can accommodate a maximum of two adults and two children. The child rate applies to those aged between
7 and 16 yrs old. There is no room charge for children under 6 yrs. Children over 16 yrs must pay the full adult rate.
Please complete the relevant section(s) below, for guests during the conference and/or supplementary nights.
Full payment is required in advance in order to make reservations. Room availability, rates and catering cannot be
guaranteed.
Should you have any queries please contact the Secretariat on +44 (0) 1920 885162
Shared occupancy - conference nights (Friday 24th October – Saturday 25th
October 2014)
The rates during the Conference are charged per person per night.
Adult:
Children (7-16yrs):
(Maximum of 2 adults and 2 children per room)
Bed and Breakfast: €37
Bed and Breakfast: €19
Rate per
No.
night
No.
nights
per person
children
(see left)
Adult:
Please tick () nights required: Friday 24th Saturday 25th
Children:
Children: Age of child(ren) …………………..
 ( ) cot required in room
Payment
€
€
€
€
Evening Meals - conference nights (Friday 24th October – Saturday 25th October 2014)
Please state how many extra guests you would like to attend
th
th
dinner on Friday 24 and/or Saturday 25 October 2014,
Rate per
person
(see left)
No.
Adults
No.
children
Payment
Adults €65 per person
Children € 16 per child (6- 14yrs)
Please note this price does not include the welcome reception
Adult:
€
€
Please tick () nights required:
th
th
Friday 24
Saturday 25
Children:
€
€
Additional accommodation - nights before / after the conference
Room rates outside of conference nights are per person, per night. Please indicate () board basis below
Single Occupancy Room:
Bed and Breakfast: €58
Double Occupancy Room:
Bed and Breakfast: €37
Children’s Rates (7-16yrs):
Bed and Breakfast: €19
No. Children:………. (Maximum of 2 adults and 2 children per room)
Please note the costs above are for accommodation only and do not include meals.
Total no.
Total
Total no.
Payment
Please state dates required:………………………………………………
occupants rate(s)
nights
…………………………………………………………………………………………..
€
No. of guests
……………
PAYMENT DETAILS
 Please deduct the
total sum due from:
If your card account is
not in euros, the
payment will be
converted into your
own currency by your
card issuer. The card
issuer will use the
exchange rate in effect
on the day payment is
taken, and they may
also charge you a
currency conversion fee
All payments to be in Euros
Credit Card:
 MasterCard
€
N/A
€
Total Payment: €
 Visa
Card No: ……………………………………………………………………..
Expiry Date: …………………………
Signature:
.....................................................
Cardholder’s
Signature: ………………………………………………
Card Security Code (last 3 digits of code on the back of the card):……………………………
Name, address & tel. no. of the cardholder:
…………………………………………………………….
……………………………………………………………………………………………………………………….
……………………………………………………………………………………………………………………….
Please return to:
[email protected]
ECCR Conference Registration, Hampton Medical Conferences Ltd. 4 – 6 Crane Mead, Ware Hertfordshire, SG12
9PW
www.eccr.org
18th Annual Meeting
of the
European Council
for Cardiovascular
Research (ECCR)
Friday 24th – Sunday 26th October 2014
Poiano, Lake Garda, ITALY
PROGRAMME
CONTENTS
Welcome......................................................................................................................................................................................................................................................................................................................................................................... 3
General Information................................................................................................................................................................................................................................................................................................................................. 4
ORAL PROGRAMME
Friday 24th October 2014....................................................................................................................................................................................................................................................................................................... 5 – 6
Saturday 25th October 2014.............................................................................................................................................................................................................................................................................................. 7 – 9
Sunday 26th October 2014........................................................................................................................................................................................................................................................................................................... 10
POSTER PROGRAMME
P1 Aldosterone/ Gasotransmitters/ Metabolism............................................................................................................................................................................................................................... 11
P2 Vasculature.................................................................................................................................................................................................................................................................................................................................................. 12
P3 Clinical Studies/Drug Development ............................................................................................................................................................................................................................................................... 13
P4 Heart/ Brain/ Kidney................................................................................................................................................................................................................................................................................................................... 14
P5 Renin-Angiotensin-System ............................................................................................................................................................................................................................................................................................. 15
ECCR
Executive
Committee
U.M. Steckelings (President)
G.P. Rossi (President-Elect & Secretary)
M. Baumann, J. De Mey, F. Jaisser,
L. Paulis, C. Peiró, D. Strain, C. Aalkjaer
ECCR
Advisory Board
G. BianchiP.S. Sever
P. Corvol
H.A.J. Struijker Boudier
X. Jeunemaitre
T. Unger
M. Paul M.J. Mulvany
A. Hughes
Charity
The ECCR is a Registered Charity in the U.K. Secretariat
Hampton Medical Conferences Ltd.
Tel:
+ 44 (0) 1920 885163
Rapier House Fax: + 44 (0) 8709 007783
4-6 Crane Mead
Email: [email protected]
Ware, SG12 9PW Web: www.eccr.org
U.K.www.hamptonmedical.com
Twitter: @eccrsociety
Charity No: 1078280
The Executive Committee wish to thank the following organisations for their support of the ECCR:
Major Sponsor: Amgen
Sponsors: Vicore Pharma
Attoquant
Supporters: DiaDexus
DMT
SMT
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
2
WELCOME
Dear Colleague,
On behalf of the Executive Committee, I would like to welcome you to The 18th Annual Meeting
of the European Council for Cardiovascular Research (ECCR) and to Lake Garda, Italy.
We should like to thank ECCR members and their colleagues who have submitted abstracts for
inclusion in the programme. We are also grateful to those members who have assisted the
Executive Committee in its difficult task of reviewing the abstracts and compiling the oral and
poster programme. Particular emphasis is placed on the participation of young clinicians and
scientists, to facilitate discussion with key opinion leaders and to promote rapid dissemination
of best clinical practice. This is reflected by ECCR’s collaboration with the European educational
networks SMARTER and COST-ENOG, which will be actively involved in the 2014 meeting.
As will be seen from the programme, it is intended that there will be ample time for discussion.
In addition, there are discussion periods for poster groups, and all posters will be displayed for
the duration of the conference.
The Executive Committee wishes to thank our sponsors and supporters for their invaluable
support of the Council and the Annual Scientific Meeting.
We are looking forward to another stimulating conference.
Ulrike Steckelings
President
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
3
GENERAL INFORMATION
SECRETARIAT AND REGISTRATION DESK
The conference organisers will be pleased to assist you with any queries. The desk will be open as follows:
Friday 24th October:
Saturday 25th October:
Sunday 26th October:
10.00 – 19.15hrs
08.00 – 19.30hrs
08.30 – 14.00hrs
TELEPHONE CALLS FOR THE CONFERENCE DESK
Poiano Resort, Garda, Italy
Tel: +39 (0) 45 7200994 int.8853
POSTER PRESENTATIONS
Posters will be displayed for the duration of the meeting.
Poster Sessions:
Sunday 26th October:
Sunday 26th October:
10.00 – 11.45hrs
11.45 – 13.00hrs
Chaired Poster Discussion
Poster Presentations by Group Winners
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
4
FRIDAY, 24th OCTOBER 2014
14.00-15.30
Session 1: Mineralocorticoid Receptor
Chairs: Gian Paolo Rossi and Ulrike Muscha Steckelings
14.00-14.30 Invited Speaker
Markus Hecker, University of Heidelberg, Germany
Endothelial cell-platelet-leukocyte interaction in vascular remodeling
14.30-14.40 1.1
Monica Schütten, Maastricht University, The Netherlands
Aldosterone-Renin Ratio and Renal Hemodynamics in Essential Hypertension
14.40-14.45Discussion
14.45-14.551.2
Daniela Cangiano, University of Padova, Italy
Detection of free-circulating DNA in patients with Aldosterone Producing
Adenoma
14.55-15.00Discussion
15.00-15.101.3
Nickolett Szarka, University of Pecs, Hungary
Hypertension Enhances Flow-Induced Constriction of Rat Cerebral Arteries, which
is lost prior to Stroke
15.10-15.15Discussion
15.15-15.251.4
M. Bencze, Institute of Physiology, Academy of Sciences of the Czech Republic,
Czech Republic
The Role of Canonical Transient Receptor Potential Channels in Contraction of
Isolated Arteries
15.25-15.30Discussion
15.30-16.00 Refreshment Break
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
5
FRIDAY, 24th OCTOBER 2014
16.00-18.30
Session 2: Small Arteries
Sponsored by the Marie Curie Training Programme on Small Arteries: SMARTER
Chairs: Jo De Mey and Olga Pechanova
16.00-16.30 Invited Speaker
Lydia Sorokin, University of Münster, Germany
The Impact of Vascular Basement Membrane Laminins on Small Artery Physiology
16.30-17.00
Invited Speaker
Ed Van Bavel, University of Amsterdam, The Netherlands
Small Artery Remodeling: Interplay Between Cells, Matrix and Forces
17.00-17.102.1
Grith Sorensen, University of Southern Denmark, Odense, Denmark
MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and
Neointima Formation
17:10- 17.15
Discussion
17.15-17.252.2
Concha F. García-Prieto, University CEU-San Pablo, Boadilla del Monte, Madrid
Mild Short-Term Caloric Restriction Improves Endothelial Function by Up
regulating Endothelial Ampk-Pi3k-Akt-Enos Pathway
17.25-17.30Discussion
17.30-17.402.3
Maziah Ghazaly, University of Surrey, UK
Redox Regulation of Endothelial Cell Cycle Progression and GRCR 43 Function: The
Role Of NADPH Oxidase 2
17.40-17.45Discussion
17.45-17.552.4
Maise Fredgart, University of Southern Denmark, Odense, Denmark
Relaxing Responses to the AT2 Receptor Agonist Compound 21 in Porcine and
Patient Pericardial Resistance Arteries Depend on the Type of Contractile
Stimulus
17.55-18.00
Discussion
18:00-18:30 Invited Speaker
Catherine Llorens-Cortes, College of France
Aminopeptidase A inhibitors as central-acting antihypertensive agents : from
target discovery to the clinical trial.
19.30
Dinner in Poiano Resort Restaurant
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
6
SATURDAY, 25th OCTOBER 2014
08.00-10.15
Session 3: Gasotransmitters
Sponsored by European Co-operation in Science and Technology (COST)
Network on Gasotransmitters: COST-ENOG
Chairs: Concha Peiro and Ingrid Fleming
08.00-08.30
Invited Speaker
Peter Brouckaert, Ghent University, Belgium
The Role and Therapeutic Potential of NO in Sepsis
08.30-09.00
Invited Speaker
Andreas Papapetropoulos, University of Athens, Greece
H2S Actions and Interactions with NO in the Cardiovascular System
09.00-09.30
Invited Speaker
Harry Van Goor, University of Groningen, The Netherlands
Sulfhydration and NOx as Predictors of Mortality in Renal Transplant Patients
09.30-09.403.1
Ksenija Cankar, University of Ljubljana, Slovenia
The Effect of Transcutaneous Carbon Dioxide Application on Cutaneous
Microcirculation
09.40-09.45Discussion
09.45-09.553.2
Elkahena Tarhouni, University of Angers, France
Chronic increase in blood flow in rat mesenteric resistance arteries improved
endothelium (NO)-mediated dilation: essential role of estrogens.
09.55-10.00Discussion
10.00-10.103.3
Emily Johnson, University of Leeds, UK
T-type Ca2+ channel regulation by CO: a mechanism for control of cell
proliferation
10.10-10.15Discussion
10.15-10.45
Refreshment Break
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
7
SATURDAY, 25th OCTOBER 2014
10.45-12.45
Session 4: New Drug Targets in Cardiovascular Medicine
Chairs: Thomas Unger and Alun Hughes
10.45-11.15
Invited Speaker
Jo De Mey, University of Southern Denmark, Odense, Denmark
New Drug Targets in Cardiovascular Medicine 11.15-11.45
Invited Speaker
Catherine Boileau, LVTS - Hôpital Bichat, Paris, France
The PCSK9 Story
11.45-11.554.1
Therese Tillin, University College London, UK
24 Hour Ambulatory Central and Brachial Blood Pressure in A Group at High Risk
of Cardiovascular Events
11.55-12.00Discussion
12.00-12.104.2
Sofie Brouwers, Vrije University of Brussels, Belgium
Selective Stimulation of Central Angiotensin II type 2 Receptors Induces
Hypotensive and Sympatho-inhibitory Responses in Neurogenic Hypertension.
12.10-12.15Discussion
12.15-12.254.3
Peter Toth, University of Oklahoma, USA
IGF-1 Deficiency and Dysfunction of Cerebral Myogenic Autoregulation in
Hypertensive Mice
12.25-12.30Discussion
12.30-12.404.4
Concha Peiró, University Autonoma de Madrid, Spain
The Angiotensin (1-7)/Mas Receptor Axis Protects Against Vascular Inflammation
12.40-12.45Discussion
12.45-13.45 Denervation
Lunch
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
8
SATURDAY, 25th OCTOBER 2014
13.45-14.45
Session 5
Chairs: Michael Bader and Ludovit Paulis
13.45-14.15
Invited Speaker
Gian Paolo Rossi, University of Padova, Italy
Biomarkers in CV Medicine
14.15-14.255.1
Giovanna Castoldi, University Milano-Bicocca. Monza, Italy
Differential Mir-29a-3p Expression In Glomeruli And Tubules In An Experimental
Model Of Angiotensin II-Dependent Hypertension: Potential Role In Renal Fibrosis.
14.25-14.30Discussion
14.30-14.405.2
Marcus Baumann, Klinikum rechts der Isar, München, Germany
TLR4 signaling mediates SBP increase with age- a translational investigation
14.40-14.45Discussion
14:45-15:30
Keynote Lecture
Ingrid Fleming, University of Frankfurt, Germany
Chairs: Ed Van Bavel and Daniel Henrion
Regulation of eNOS Activity by Phosphorylation
16.00
Optional Tour
19.30
Reception and Gala Dinner in Poiano Resort Restaurant
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
9
SUNDAY, 26th OCTOBER 2014
08.30 – 09:15
Young Investigators Competition
Chairs: Mike Mulvany and Rhian Touyz
08.30-08.40
6.1
Thomas Leurgans, University of Southern Denmark, Odense,
Denmark
Roles of EDRFS and H2o2 in Responses to Bradykinin and Insulin Depend on
Contractile Stimulus
08.40-08.45
08.45-08.55
08.55-09.00
Discussion
6.2
Anna Mai, University of Surrey, London
NADPH Oxidase Activation and Oxidative Stress in High-Fat Diet-Induced
Hypertension and Metabolic Disorders
Discussion
09.00-09.106.3
Francesca Gioco, University of Padova, Italy
Immuno-phenotypic Characterization of Lateralized Primary Aldosteronism with
Novel Monoclonal Antibodies against Human Aldosterone Synthase (CYP11B2)
and 11-beta hydroxylase (CYP11B1)
09.10-09.15Discussion
09.15-10.00 Keynote Lecture
Rhian Touyz, University of Glasgow, Scotland
Chairs: Christian Aalkjaer and Andreas Papapetropoulos
TRPM Chanzymes – Novel Paradigms in Vascular Signaling
10.00-11.45
Chaired Poster Discussion and Refreshment Break
11.45 – 13.00 Poster Presentations by Group Winners and Presentation of prizes
Chairs: Gian Paolo Rossi and Marcus Baumann
Poster Groups: P1 Aldosterone/ Gasotransmitters/ Metabolism
P2 Vasculature
P3 Clinical Studies/Drug Development
P4 Heart/ Brain/ Kidney
P5 Renin-Angiotensin-System
13.00 Close of meeting, Lunch available and Departures
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
10
POSTER PRESENTATIONS
POSTER GROUP P1 – ALDOSTERONE/GASOTRANSMITTERS/ METABOLISM
John Boyle and Peter Brouckaert
P1.1
Urotensin II Exerts A Transient Pressor Effects Via Enhanced Aldosterone Secretion
M Menegolo , B Caroccia, L Lenzini, C Maturi, G P Rossi (Padova)
P1.2
Angiotensin II type 1 and 2 receptors, and angiotensin-(1-7) receptor (Mas1R) are expressed in normal
adrenal gland and in aldosterone producing adenoma (APA)
P-E Vanderriele, B Caroccia, L Lenzini, F Gioco, T M Seccia, G P Rossi (Padova)
P1.3
17β-Estradiol Modulates the Synthesis of Aldosterone via Interaction between Gper-1 and Beta
Receptors: New Evidence with the Knock-Down of Er and GPER-1
B Caroccia, T M Seccia, F Gioco, E Guerzoni, M Kuppusamy, G Ceolotto, G P Rossi (Padua)
P1.5
NO-Donating Oximes Relax Corpora Cavernosa Through Mechanisms other than those Involved in
Arterial Relaxation.
B Pauwels, C Boydens, K Decaluwé, J Van de Voorde (Ghent)
P1.6
Matricellular Portein Microfibrillar-Associated Protein 4 in Abdominal Aortic Aneurysms
K L Kirketerp-Møller, J Stubbe, A Schlosser, J S Lindholt, P B.L. Hansen, G-P Shi, U Holmskov, G L Sørensen
(Odense; Boston)
P1.7
The Role of G-Protein Coupled Receptor 43 in High Glucose-Induced Oxidative Stress in Human Blood
Vessels.
M Ghazaly, M Newton, C Lee, J-M Li (Surrey)
P1.8
The Mechanism by which Inflammation Transforms Glucose into A Deleterious Agent in Human Vascular
Smooth Muscle Cells
C F Sánchez-Ferrer, C Peiró, T Romacho, V Azcutia, L Villalobos, E Fernández, J P Bolaños, S Moncada
(Madrid; Salamanca; London)
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
11
POSTER PRESENTATIONS
POSTER GROUP P2 – VASCULATURE
Markus Hecker and Jane Stubbe
P2.1
The Functional Role of the Putative Ca2+-Activated Cl- Channel, TMEM16A, in the Vascular Wall.
A Bisgaard Jensen, V Secher Dam, D. M. Boedtkjer, C Aalkjaer, V V. (Denmark)
P2.2
Soluble Guanylate Cyclase Involved in Hypoxic Vasoconstriction and KV7 Channels in Hypoxic
Vasodilatation in Porcine Coronary Microvasculature
J A Shanmuganthan, U Simonsen, E R Hedegaard (Aarhus)
P2.3 Thioredoxin, T-type Ca2+ channels, and Vascular Smooth Muscle Cell Proliferation.
E Johnson, J Scragg, C Peers (Leeds)
P2.4
The effect of L-arginine on Postocclusive reactive Hyperaemia
Z Melik, K Cankar (Ljubljana)
P2.5
Relaxant and Antioxidant Capacity of Red Wine Polyphenols on Isolated Mice Corpora Cavernosa
C Boydens, b Pauwels, K Decaluwé, P Brouckaert, J Van de Voorde (Ghent)
P2.6
Zyxin-Mediated Regulation of Vascular Smooth Muscle Cell Phenotype in Experimental Hypertension
S Ghosh, B Kollar, S Suresh Babu, A Wojtowicz, C Sticht, N Gretz, M Hecker (Heidelberg; Lausanne;
Mannheim)
P2.7
Abdominal aorta aneurysm: the role of reactive oxygen species in experimental model
C Tefé-Silva, P S. Prudente, K M Mata, C M, Prado, C R Fernandes, E M Floriano, S G Ramos (Ribeirão
Preto)
P2.8
Metabolic and Respiratory Acidosis Induced Relaxation Mediated by Potassium Channel Activation in
Thoracic Aorta
A A Albuquerque Fagundes, A C Celotto, V K Capellini, L G Ferreira, A P Cassiano Silveira, T R de Nadai, P
R Barbosa Evora (Ribeirão Preto; São)
P2.9
The Role of Mfap4 in the Induction of Integrin Mediated Intracellular Signaling
L E Hemstra, A Sclosser, U holmskov, G L Sørensen (Odense)
P2.10 In Vitro Vascular Response Induced by Extracellular Respiratory Acidosis. Endothelium-Dependent
Mechanisms.
T Nadai, M Nadai, A Celotto, A silveira, A Albuquerque, D Vento, V Augusto, A Rodrigues, P Evora
(Ribeirão Preto/SP)
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
12
POSTER PRESENTATIONS
POSTER GROUP P3 – CLINICAL STUDIES/DRUG DEVELOPMENT
Nish Chaturvedi and U.Muscha Steckelings
P3.1
Effect of the Angiotensin Type 2 Receptor Agonist, Compound 21, and the Angiotensin Type 2 Receptor
Antagonist, PD123319, on Proliferation of Murine Primary Aortic Vascular Smooth Muscle Cells
L Hollensberg, U M Steckelings, J Stubbe (Odense)
P3.2
Antihypertensive Effectiveness of Candesartan Encapsulated in Liposomal Carriers Containing Cationic
Derivatives of Polyisoprenoid Alcohols
O Gawrys, I Baranowska, K Gawarecka, T Chojnacki, E Swiezewska, M Masnyk, M Chmielewski, E
Kompanowska-Jezierska (Warsaw)
P3.3
Effects of Chymostatin, A Chymase Inhibitor, Alone or Combined with Captopril, A Classical ACE Inhibitor
on Systemic and Renal Haemodynamics, and Renal Excretion in Spontaneously Hypertensive Rats
E Kompanowska-Jezierska, M M Roszkowska-Chojecka, A Walkowska (Warsaw)
P3.4
Effects of Chronic Blockade of Chymostatin-Sensitive Enzymes on Blood Pressure and Renal
Haemodynamics in Spontaneously Hypertensive Rats (SHR).
B Bądzyńska, I Baranowska, M Roszkowska-Chojecka, E Kompanowska-Jezierska (Warsaw)
P3.5
Galectin-3 Predicts Long Term Cardiovascular Death in High-Risk Coronary Artery Disease Patients
G Maiolino, G Rossitto, L Pedon, M Cesari, A C Frigo, M Azzolini, M Plebani, G P Rossi (Padova; Cittadella)
P3.6
Leptin, Adiponectin and A-FABP in the Pericardial Fluid of Cardiovascular Disease Patients
J De Mey, P Søndergaard Jensen, M Bloksgaard, M Lyck Hansen, E Song, A Xu, Y Wang, A Irmukhamedov,
L Melholt Rasmussen, J De Mey (Odense; Hong Kong)
P3.7
Effect of Olmesartan Medoxomil on p63RhoGEF and RhoA/Rho Kinase Activity in Hypertensive Patients.
V Ravarotto, E Pagnin, G Maiolino, G P Rossi, L A Calò (Padova)
P3.8
Assessment of Physical Function in Older Adults: A Self-paced 6-minute Step Test Versus 6-minute Walk
Test.
S Jones, T Tillin, A D Hughes, N Chaturdevi (London)
P3.9
Assessment of Central Aortic Pressure and its Association to All Cause Mortality Critically Depends on
Wave Form Calibration.
S Wassertheurer, M Baumann (Vienna; Munich)
P3.10 The Role Of Carotid Intima-Media Thickness (CIMT) in The Prevention of Cardiovascular Disease
A Al-bahrani, P Rajdall, N Chloe, D Turner, K Ayush, S Heydari (Newport; Portsmouth)
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
13
POSTER PRESENTATIONS
POSTER GROUP P4 – HEART/BRAIN/KIDNEY
Hans Ibsen and Peter Toth
P4.1
Disturbance of Adherens Junction and Gap Junction Protein Expression Associated With Extracellular
Matrix Remodeling Contribute to the Transition from Experimental Compensated Cardiac Hypertrophy to
Decompensation.
C M Prado, S Ramos, H C Salgado, R Fazan Jr., E M Florian, C A Silva, V Blefari, F Prado, D O Dos Santos, A
Fernandes, T R F Pizzo (Ribeirao Preto, Araras)
P4.2
Morphological Study of Duchenne’s Cardiomyopathy in A Canine Model
L Malvestio, I Martins, C Prado, C Tefé-Silva, E Floriano, S Ramos, J Engrácia de Moraes (Sao Paulo)
P4.3
The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias, the Role of
Adenosine A1 Receptors.
E Gonca, F Darici (Zonguldak)
P4.4
The Effect of Melatonin and Compound 21 on Doxorubicin-Induced Toxicity in Rats.
R Rajkovicova, K Arendasova, J Hrenak, K Repova, A Brata, K Krajcirovicova, F Simko, L Paulis (Bratislava)
P4.5
Contractile Proteins in the Progression of Cardiac Hypertrophy to Heart Failure
C Tefé-Silva, C Prado, V Blefari, E Floriano, D Santos, F Prado, C Silva, H Salgado, S Ramos (Ribeirão Preto)
P4.7
Familial Hemiplegic Migraine Type 2 (FHM2) Associated Mutation in the Α2 Isoform of Na,K-Atpase Leads
to Elevated Contractility and Vasodilatation of Mice Cerebral Arteries
L Hangaard, K Lykke-Hartmann, Z Xie, V Matchkov, C Aalkjaer (Aarhus)
P4.8
Increased Metalloproteinase (MMP)2 and MMP9 Activity in Conditions of Albuminuria Despite WellControlled Hypertension
H Pulido-Olmo, L Agudo, C García-Prieto, B Somoza, I Aranguez, J Segura, R Kreutz, M Fernández-Alfonso,
L Ruilope, G Ruiz-Hurtado (Madrid; Berlin)
P4.9
Cardiac remodelling and myocardial (dys)function in animal model of heart failure: influence of
testosterone
L Paulis, R Rajkovicova, G Gubo, K Arendasova, A Barta, K Repova, D Kratka, F Simko, P Celec (Bratislava)
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
14
POSTER PRESENTATIONS
POSTER GROUP P5 – RENIN-ANGIOTENSIN-SYSTEM
Carmine Savoia and Markos Poglitsch
P5.1
Genetic deletion of ACE2 Induces Hepatic Steatosis in Mice
V Nunes-Souza, N Alenina, F Qadri, J Penninger, R Santos, M Bader, R Luiza (Berlin; Maceió,Alagos; Belo
Horizonte; Vienna)
P5.2
Neuroprotective Role of the Angiotensin Type 2 Receptor in Neuromyelitis Optica
C Hermansen, R Khorooshi, U M Steckelings, T Owens (Odense)
P5.3
ACE2 Independent Pathways of Angiotensin 1-7 Formation in the Murine Kidney
O Domenig, A Manzel, J Stegbauer, S B Gurley, M Antlanger, J Kovarik, M Saemann, R Linker, M Poglitsch
(Vienna; Erlangen; Dusseldorf; Durham; Vienna)
P5.4
Chronic Non-ACE Angiotensin Conversion Blockade with Chymostatin: Effects on Blood Pressure,
Metabolic Parameters and Renal Perfusion in Conscious Spontaneously Hypertensive Rats (SHR)
Iwona Baranowska, Bożena Bądzyńska, Olga Gawryś, Krzysztof H. Olszyński, Bartosz Kossowski, Jarosław Orzeł, Piotr Bogorodzki, Elżbieta Kompanowska-Jezierska
P5.5
Evidence for Functional Angiotensin II Receptors in the Human Parathyroid Gland Modulating the Tonic
Release of PTH
G P Rossi, V Sanga, G Maiolino, T M Seccia, L Lenzini, P E Vanderriele, L Calo‘ (Padova)
P5.6
Ex vivo Equilibrium Analysis of the Renin-Angiotensin-System: Clinical Implications for Diagnosis and
Treatment of Hypertension
O Domenig, C Schwager, D Van Oyen, M Poglitsch (Vienna)
P5.7
Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACEInhibition and Melatonin
F Simko, O Pechanova, K Repova Bednarova, K Krajcirovicova, P Celec, N Kamodyova, Š Zorad, J
Kucharska, A Gvozdjakova, M Adamcova, L Paulis (Slovak Republic and Czech Republic)
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
15
NOTES
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
16
NOTES
18th Annual Meeting of the European Council for Cardiovascular Research (ECCR)
17