SYMPROVE The Probiotic Market The probiotic market is worth $32 billion globally 60% of UK/Irish households regularly purchase them A wide variety of probiotics on the market that claim to work So, do they work? Do they contain the claimed number of viable organisms stated on the label? Scientists at University College Do they possess the London (UCL) independently robustness transit through conducted atostudy that compared the gut? probiotic brands to find leading out the truth.  Aim: To subject the products to three challenge tests to assess if the bacteria: ARRIVED In a live state SURVIVED Stomach acid transit THRIVED In the target area of the gut 4 ARRIVED Only dairy-based (Actimel, Yakult) or waterbased (Symprove) probiotics delivered 100% or more than the claimed content Arrived Delivers at least 75% of the amount claimed for the product Symprove Yakult Actimel 5 SURVIVED Only two products survived stomach transit time (120 minutes), with one of these continuing to decline. nly one product seems stable Survived After exposure, are the surviving bacteria still concentrated enough? Symprove VSL#3 Symprove survivability A real time measurement of the heat (growth) signature of the bacteria colony. Independent research at University College London (preliminary research – not yet published) 100 0 Faster and stronger growth than all others Even stronger if acid attrition in the stomach is considered Key: Symprove Dairy Dairy Dry Big Brand Dry Dry 600 P (µW) The only product to grow in a realistic time to give benefit 800 400 200 0 0 20 40 60 TIME (h) 80 100 120 Symprove survivability post pH shock A real time measurement of the heat (growth) signature of the bacteria colony after exposure to gastric juices. Independent research at University College London (preliminary research – not yet published) 1200 Key: Symprove Dairy Dairy Dry Big Brand Dry Dry P (µW) 100 0 800 600 400 200 0 0 20 40 60 TIME (h) 80 100 120 THRIVED Only three products showed signs of strong growth within 10 hours. Others showed very slow, or even no growth Thrived Colony starts growing strongly within 10 hours to hit the target areas in the gut VSL3 Actimel Symprove 9 Summary To be successful probiotic product needs to beat all three challenge tests Safely arrive, survive stomach acids, and thrive in the target area of the gut Only one product met all three challenges with several products failing all three challenges 10 Overall results 11 Irritable Bowel Syndrome 1 in 5 households contain someone with IBS Despite the high prevalence the condition is extremely poorly managed Sufferers try an average of 5 products each month but around half are still left battling the symptoms long-term + Probiotic efficacy A probiotic product not only has to reach the gut, it also has to do something beneficial once it arrives There is a rationale for the use of probiotics in reducing IBS symptoms but rigorous clinical testing has been lacking The efficacy of Symprove has been confirmed in a randomised, double-blind, placebo-controlled study by King’s College Hospital 13 + Study results Significant improvement was achieved in 4 weeks Improvement continued through the full 12 weeks Results show that this multi-strain probiotic is safe, welltolerated and efficacious in improving overall symptom severity in patients with IBS 14 + Study results The significant change in pain score is important as pain is regarded as the key measure for patient health 15 + Study results Patients report an objectively measurable improvement in their satisfaction with their bowel habit (constipation and diarrhoea) 16 INTRODUCING NEW SYMPROVE What do we know? • We know it works – KING’s • We know how it works – UCL • We know that 1 bottle doesn’t work • We know price is a barrier Symprove New Brand World  Proudly shows that Symprove is all about the gut  Clearly shows where it works  Links to Arrive, Survive and Thrive  Works on targeted A-S-T areas of the gut  The new packaging is consumer driven and supports our science  While it is keeping its natural and safety heritage 19 Symprove 12 week commitment • The consumer commits • Symprove commits • The consumer benefits through: a. Great value b. Encouragement to compliance • The retailer benefits from: a. A higher value sale b. Repeat visits and sales c. A higher rate of sale per customer d. Increased loyalty Recent press coverage Monday, 22 September 2014 Any questions….