1. health and fitness
2. aging

Lightenex® Max
Depigmentation peeling mask
THE PROFESSIONAL
CHOICE
8-12 HOUR MASK
Medium Depth Peel
Advanced Cosmeceuticals
Lightenex® Max Peel
Depigmentation peeling mask
A radical professional strength procedure of clinically
proven depigmenters & exfoliants that gives results
within 14 days !
with
Acnex® Face Mask
Pre-peel (20 mins)
Lightenex® Max Peel
Depigmentation peeling mask
Why Lightenex® Max Peeling mask?
This depigmentation formula offers many advantages over other types of
skin lightening products currently available in the market:
 Rapid skin lightening action. Dramatic improvement within 2 weeks.
 Exfoliates with minimal oedema (Retinoid effect)
 Very effective in:
- all types of melasma & sun damage.
- superficial wrinkles & scars
- acne patients with residual acne scarring.
 Suitable for all skin type (Fitzpatrick I-5)
 No risk of Hyperpigmentation. No need for neutralization
Lightenex® Max Peel
Depigmentation peeling mask
Why use Lightenex® Max Peel ?
 Completely inhibits the action of tyrosinase paralysing Melanocytes
 Reduce the activity of abnormal melanocytes, which cause Melasma & post
inflammatory hyper-pigmentation (PIH).
 Promotes entry of depigmenting agents, followed by:
 Intense deep exfoliation caused by the conversation of Retinol to Retinoic acid.
 Works by replacing the melanin carrying-keratinocytes with new cells from the Dermal-
Epidermal junction (inside-out) instead of conventional acid peels which cause outside-in
exfoliation.
 Extensively tested in the UK
 Radical treatment-quicker results.
Lightenex® Max Peel
Depigmentation peeling mask
Advantage of Lightenex® Max Peel over other peels:
 Suitable for all skin types, including Skin type 4-5, as there is no necrosis (which can result
in hyperpigmentation or scarring).
 Maintain at pH 2.2 using Mandelic acid, which makes it acidic without the irritation of
Glycolic acid in dar skin.
 Declared concentrations of active ingredients
 Airless pump ensuring stability & quality of actives
 No Hydroquinone or harmful chemicals
Lightenex® Max Peel works by eliminating the melanin patches on the face caused by melasma, chloasma,
sun damaged age spots, acne & post-inflammatory hyper-pigmentation (PIH).
INGREDIENTS
DEPIGMENTERS in pH 2.2
•
•
•
•
•
•
•
•
•
•
MANDELIC ACID 20%
AZELAIC ACID 10%
ALPHA-ARBUTIN 5%
DIOIC ACID 5%
ASCORBIC ACID 10%
PHYTIC ACID 5%
FERRULIC ACID & MIXED TOCOPHEROLS
NIACINAMIDE 5%
KOJIC ACID 5%
SALICYLIC ACID 2%
EXFOLIANT:
•
RETINOL 7% (ENCAPSULATED)
MANDELIC ACID
Mandelic acid is an excellent exfoliant and is:

The only ingredient proven to work in deep dermal hyperpigmentation.

Stronger acid than Glycolic acid.

Much larger molecule than Glycolic & penetrates the skin slowly & more evenly without
irritation & hot spots.

Safe in dark skins (unlike TCA & Glycolic acid it can be safely left on skin for 8-10 hours)

Mandelic acid is naturally derived from almonds
Kojic Acid 4% &
Glycolic Acid 8%
DEPIGMENTERS
Kojic acid
Proven Synergy
Advanced Cosmeceuticals
EXFOLIANTS
Glycolic Acid
Alpha arbutin
(In Pre –peel)
Azelaic acid
Retinol
Phytic acid
Mandelic Acid
Dioic acid (Oct-Decenedioic acid)
Ascorbic acid
Ferulic acid & Vitamin E
Niacinamide
Aloesin
Salicylic Acid
TOTAL ACTIVES
55.35%
pH 2.2
Azelaic Acid &
Glycolic Acid Synergy
Advanced Cosmeceuticals
DOCUMENTED SYNERGY
39 patient split face study comparing
Kojic Acid 2% & Glycolic Acid 5% with
Hydroquinone 2% & GA 5%
showed better results with Kojic Acid.
REF-Dermat Surg 1996;22;443-447.Alica Garcia BS James F Fulton Jr MD.
Double Blind 80 patient Multi-ethnic study comparing
Hydroquinone 4% with KA & GA combination
showed both to be equally effective over 12 Weeks, with less side effects.
REF-Draelos ZD,Yatskayerm et al.Dermatology Consulting Services,High Point,N Carolina,USA.
Retinol as Exfoliant
Advanced Cosmeceuticals
The formation of all-trans retinoic acid is an oxidative process whereby
retinol is converted to retinaldehyde and then to retinoic acid
Retinol is the chosen exfoliant because it has been shown to penetrate skin more
effectively than Retinoic acid or Retinyl Palmitate to give the
best inside-out peeling possible.
This avoids the inflammation or necrosis involved with high strength AHAs.
REF-Unoccluded Retinol penetrates Human skin in vivo more effectively than unoccluded Retinoic acid or Retinyl palmitate.Journal of
Investigative Dermatology(1997)109,301-305;doi:10.1111/1523-1747.ep12335788.Dept of Dermatology ,University of Michigan Med
School,Ann Arbor,Michigan,USA.Elizabeth A Diell et al.
Azelaic acid
Advanced Cosmeceuticals
Azelaic acid only works on Hyperactive Melanocytes where DNA synthesis is
fast.
•
•
Powerful Inhibitor of enzyme Thioredoxin
reductase.
This enzyme adds electrons to Thioredoxin which
can then activate Tyrosinase & also helps make
DNA.
Ref-Arch Dermatol Res1990;282(3).168-171.A possible mechanism of action for Azelaic Acid in the human Epidermis.Schallenter KU et al,Dept of
Dermatology,University of Hamburg,Germany.
Alpha Arbutin 5%
Advanced Cosmeceuticals
Cultured Human Melanoma cells & three dimensional human skin
model treated with Alpha Arbutin showed:
•
60% reduction in Melanin
•
Melanin synthesis reduced by 24%
•
Cellular tyrosinase activity significantly reduced.
REF 1-Pharm Bull.2004 April;27(4):510-4.Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human
melanoma cells and a three-dimansional human skin model.Sugimoto K,Nishimura T,Nomura K,Kuriki T.Biochemical
Research Laboratory,Ezaki Glico Co Ltd.,4-6-5 Utajima,Nishiyadogawa-ku,Osaka 555-8502,Japan.
Dioic Acid
(Octadecene-dioc Acid) 5%
Advanced Cosmeceuticals
An open comparative study of NINETY SIX (96 female) Melasma
patients in an open, comparative, 12 week study between
Dioic Acid 1% & Hydroquinone 2% showed:
 no significant difference between treatments. (same results)
 more pruritus (itching) with hydroquinone.
This acid is a Di-carboxylic acid (dioic) like Azelaic but is 18 Carbon atoms long instead of 9 carbons like Azelaic.
It is made from Bio-fermentation of Oleic acid using Yeasts.
REF4-Efficacy of Dioc (Octadecene-dioic acid)compared with Hydroquinone in the treatment of Melasma.Int J
Dermatol.2009Aug;48(8):893-5.Tirado-Sanchez A,Santamaria-Roman A,Ponce-Olivera RM.
Dioic Acid
(Octadecene-dioc Acid) 5%
Advanced Cosmeceuticals
A twenty patient placebo study on patients of Indian and Pakistani
origin given Octadecene-dioic acid 2% over 8 weeks showed:
•
A significant reduction in melanin
•
(p<0.025) measured both by chromameter & mexameter.
REF 5-Inter Jour of Cosmetic Science,Volume 33,issue 3 June,pages 210-221.J M Gillbro,M J Olsson.The Melanogenesis&mechanisms of
skin lightening agents,existing &new approaches.
Ascorbic Acid 10%
Advanced Cosmeceuticals
16 patient slit-face randomized study in Melasma patients comparing
Ascorbic acid 5% with Hydroquinone 4% showed
no statistical Colorometric difference after 16 weeks.
Side effects recorded:
•
Hydroquinone significantly high side effects (68%)
•
Ascorbic acid only 6%
Ref: A double blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma | International Journal of
Dermatology | Volume 43, Issue 8, pages 604-607, Aug 2004 | Liliana Elizabeth Espinal Perez MD et al.
Ferulic Acid &
Vitamin E synergy
Advanced Cosmeceuticals
An effective whitening agent
• Ferulic acid is a hydroxycinnamic acid that has significant anti-
oxidant and anti-melanogenic activity.
• Tocopheryl ferulate is a significant inhibitor of Tyrosinase
Ref-12-The depigmenting effect of tocopheryl ferulate on human melanoma cells. Br J Dermatol.1999 Jul;141(1)141(1):20-9.
Phytic Acid 5%
Advanced Cosmeceuticals
Phytic acid chelates Copper & Iron
in skin (makes them unavailable)
• Copper is essential part of the enzyme Tyrosinase which
makes Melanin.
• Gentle exfoliant
REF-Will Phytic acid replace Hydroquinone. Romulo Mene MD. Plastic Surgeon.Rio De Janiero,Brazil. Third Congress of
National Estetic Medicine.Milan,Italy 12 Oct 2001
Phytic Acid 5%
Advanced Cosmeceuticals
• Iron catalyses free Radical Formation & subsequent Oxidative damage
• Phytic acid prevents Iron-driven hydroxyl radicle generation & prevents
Lipid Peroxidation.
• Depigmenting agent, prevents Calcinosis cutis (calcium leaching) &
premature ageing.
• Very well absorbed into skin
REF-Journa.l Biol.Chem.1987 Aug 25;262(24):11647-50.Phytic acid .A Natural Anti-oxidant. Graf E,Empson KL et al
REF-Front Biosc 2005 Jan 1;10:799-802. Absorption of Myo-Inositol Hexakisphosphate through the skin; study of
the matrix effects .Mechanism of Phytate topical absorption.
Phytic Acid 5% &
Ascorbic Acid 10% synergy
Advanced Cosmeceuticals
A double blind, vehicle controlled trial in 30 healthy subjects with greater than 2
Solar Lentigines were randomly signed to apply
Ascorbic Acid 10% + Phytic Acid 2%
over 3 months showed statistically significant improvement between study drug
& vehicle.
Ref: Journal of Cosmetic Dermatology | volume 10, issue 4, pages 266-272, Dec 2011 | Randomozed controlled study to evaluate
the depigmenting activity of L-Ascorbic acid plus Phytic Acid | Abdullah Khemis MD et al.
Patient Choice
Advanced Cosmeceuticals
 Best for Dark Brown discreet Epidermal or
Intermediate Hyperpigmentation & Melasma
(Woods lamp positive)
 Excellent for oily skins with post-Acne PIH
 Superficial post acne scarring & superficial
wrinkles.
 Photo damaged skin.
Method of Application
Advanced Cosmeceuticals
IN CLINIC:
• Wash skin with water & gentle soap. Towel dry.
• Degrease the skin thoroughly with ACETONE/ALCOHOL with cotton gauze
swabs.
• Start massaging Acnex peeling mask into the Forehead and continue massaging
in circular motion until tingling.Stop massaging when the whole forehead is
tingling.Then go on to the nose followed by the chin&jaw line with the
cheeks&upper lip last.This order is very important.Now wash off the skin with
cold water&towel dry.
• Massage a thin Layer of Lightenex Max Peel into the forehead until the area is
hot.Now follow the same sequence as above ie Nose,chin , jaw
line,cheeks&upper lip.Now paste on a thicker layer all over the face.
• Leave on this mask for 8-10 hrs depending upon the skin type.8 hrs for very fair
skin&10 hrs for darker skin.
At Home
• The
Advanced Cosmeceuticals
patient washes off the mask using gentle soap & water.
• Pat dry the skin using a fresh, clean towel to leave the skin slightly moist.
• Massage Moisturix® spf 25 every two hours.
• Must use Sun Blockex® spf 50 if they are to leave home during day time.
• (The skin will be red & tight for 48 hours & then flaking of skin will commence.
This flaking continues for another 3 to 5 days.)
• The patient sees the Clinician on day 7 when the decision for touch up is made.
• The touch up is again applied after degreasing with acetone & left on for four hours
before washing off.
• Apply Lightenex® Plus cream (maintenance) three times daily after day 4.
• (Some patients will see blemishes appearing & disappearing during the first 7-10
days. This is because the Melanified dead keratin tend to bunch together before
shedding)
Lightenex® Max Peel
Depigmentation peeling mask
IT IS ESSENTIAL
TO AVOID THE SUN
for ONE WEEK
Advanced Cosmeceuticals
Conclusion
Lightenex® Max
Depigmentation peeling mask
Works
Pharmaclinix.com